'state' 검색 결과

Recommend the next official ATM guidance action from current state.

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Orchestrate persistent agent memory across coding sessions, repos, and tools. Load when the user asks to remember, recall context, save project memory, create a handoff, manage global memory, update memory, compact memory, audit memory, forget memory, continue from prior sessions, or before commit/push/git operations that checkpoint project state.

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Load bounded working context at the start of a coding session. FIRES ON EVERY FIRST USER MESSAGE in a fresh session, regardless of content — including bare greetings ("hi", "hello", "hey"), task-only openers, or "let's start". Also triggers on: "fresh session", "session start", "first message in a new thread", "new chat", "cold start", "begin work in this repo", "starting work", "continue from prior session", "what were we working on", "resume", "what happened last time", "load memory", "recall context", "create a handoff", "prior session context", "latest handoff", "current state", "decision context". Skip ONLY if the user explicitly says "fresh start" or "ignore prior context". Self no-ops if invoked mid-session when context is already loaded.

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Design state-of-the-art multi-agent systems, orchestration patterns, and wiring from scratch. Load when the user asks to build an agent system from scratch, design agent orchestration patterns, choose between sequential/parallel/hierarchical workflows, or define how multiple agents should collaborate. Also triggers on "agent architecture", "multi-agent wiring", "agent orchestration pattern", "how to connect these agents", "design the communication structure". Called by agent-builder for complex topologies (>4 agents or hierarchical). For process-driven agent design, use agent-builder instead.

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Turn a chosen design direction into a canonical DESIGN.md plus production tokens that don't look vibecoded — state-level colors (8-step neutral ramp, rest/hover/active/ disabled, focus ring), APCA-checked contrast, typography, spacing/radius/motion/elevation, an icon strategy, and component contracts for the core atoms. Emits tokens in the project's stack format (shadcn HSL vars or Tailwind v4 @theme). Load when the user asks to build a design system, generate design tokens, create a DESIGN.md, set up a theme, design a color or type system, pick icons, or when frontend-design routes here. Replaces design-tokens-craft and icon-craft. Sub-skill of frontend-design. Reads DIRECTION.md first.

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Capture the "why" behind technical choices to prevent architectural drift. Load when the user makes a major technical decision, chooses a library/framework, defines a system boundary, or changes a core architectural pattern. Also triggers on "record a decision", "write an ADR", "why did we do this", "document this architectural choice", or "architectural decision record". Supports `SYNTHESIS=true` mode for retrospective ADR backfill from observed repo state — used by `retroactive-project-setup` and any future backfill skill. Essential for long-term project maintainability and agent alignment.

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Orchestrator + builder for distinctive, production-grade frontends that don't look AI-generated. Derives stack and design context from product-soul/PRD/specs, then runs the anti-slop chain — explore distinct directions, lock a DESIGN.md system, build from golden examples with mandatory polish + every interactive/empty/loading/error state, then review. Load when the user asks to build a UI, design a frontend, build a landing page or dashboard or web app, beautify or redesign a page, make a UI look premium/playful/editorial, says "build me a frontend", "make this not look AI-generated", "design this interface", "give this real polish", or "frontend design". Routes to design-direction, design-system, design-review.

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Review a built frontend against its chosen direction, catch drift back to generic AI defaults, enforce state coverage, ethical patterns, UX heuristics, and polish, and check contrast with APCA (not the legacy WCAG ratio). Produces specific, prioritized fixes — never vibes-based feedback. Works with pasted screenshots or Playwright MCP automated capture. Load when the user asks to review a UI, audit a design, check if a frontend looks generic or vibecoded, evaluate visual quality or polish, says "review this UI", "is this design good", "audit my frontend", "does this feel like [product]", "design QA", or when frontend-design routes here. Sub-skill of frontend-design.

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Write copy following Sentry brand guidelines. Use when writing UI text, error messages, empty states, onboarding flows, 404 pages, documentation, marketing copy, or any user-facing content. Covers both Plain Speech (default) and Sentry Voice tones.

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Frontend development patterns for React, Next.js, state management, performance optimization, and UI best practices.

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Expert guidance for building modern Android UIs with Jetpack Compose, covering state management, navigation, performance, and Material Design 3.

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Assign cell types from marker expression in IMC/MIBI data using clustering (PhenoGraph/FlowSOM/Leiden/Pixie), marker-based probabilistic classifiers (Astir), or image-context CNNs (CellSighter), covering the double-positive segmentation artifact, lineage-vs-state markers, the two spillover types, and why a "cell type" in imaging is conditioned on a segmentation guess. Use when phenotyping segmented IMC cells, choosing clustering vs classification, diagnosing implausible double-positive populations, separating lineage from functional markers, or transferring labels across a cohort.

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Balances Hi-C contact matrices (ICE via cooler.balance_cooler, KR/SCALE/VC context), computes distance-decay expected with cooltools (expected_cis per-diagonal P(s), expected_trans scalar), builds observed/expected (O/E) matrices, and diagnoses polymer state from the P(s) log-derivative. Covers the within-matrix-vs-cross-sample distinction (balancing is NOT a normalizer), the equal-visibility assumption that CNV/aneuploidy violates (use raw counts for copy-number), cis-only balancing, mad_max/blacklist masking before balancing, multiplicative cooler weights vs divisive juicer weights, and the resolution-vs-depth budget. Use when balancing a .cool/.mcool, computing expected or P(s), making O/E matrices for compartments/loops, deciding ICE vs KR vs SCALE, choosing a resolution for a given depth, or troubleshooting NaN/all-NaN balanced matrices; route cross-sample comparison to hic-differential.

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Differential abundance (DA) and differential state (DS) analysis for flow and mass cytometry - tests which cell populations change in frequency or marker expression between conditions using diffcyt (edgeR/voom/GLMM for DA, limma/LMM for DS), with cydar, CITRUS, and compositional methods (sccomp, scCODA, DCATS) as alternatives. Covers the sample-is-the-experimental-unit principle, design/contrast and mixed-model formulas, compositionality of cluster proportions, and FDR across clusters. Use when comparing populations between groups, choosing a DA method, handling paired/batch designs, or deciding whether compositional correction is needed.

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Simulate transcription factor perturbation effects on cell state in silico with CellOracle and Dynamo, and predict transcriptional responses to genetic perturbations with GEARS, scGen, and CPA. Covers the direction-not-magnitude principle, local-linear validity, the GRN/velocity error it inherits, baseline discipline (mean and additive baselines), and the validation gap. Use when predicting TF knockout or overexpression effects, ranking driver TFs for fate transitions, or planning perturbation experiments. For GRN construction see multiomics-grn; for experimental Perturb-seq see single-cell/perturb-seq.

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Resolve subclonal copy number, whole-genome doubling, and copy-number tumor evolution from bulk sequencing with Battenberg, TITAN, and MEDICC2. Covers clonal versus subclonal copy-number states, haplotype phasing for subclonal resolution, cancer cell fraction, whole-genome-doubling detection and timing relative to mutations, mirrored subclonal allelic imbalance, and copy-number phylogenies. Use when a tumor is heterogeneous and bulk data shows non-integer copy number, when calling subclonal CNAs, detecting or timing whole-genome doubling, reconstructing copy-number evolution, or deciding between Battenberg and TITAN.

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Model gene-family birth-death dynamics across a species tree using CAFE5 (Mendes et al 2020 Bioinformatics 36:5516 gamma-distributed rate categories), CAFE5-error (annotation-error-aware), Count (Csurös 2010 ancestral state reconstruction), BadiRate (Librado 2012 likelihood + parsimony), DupliPHY-Family, and ALE/AleRax (for per-family DTL; see [[gene-tree-species-tree-reconciliation]]). Test lineage-specific gene-family expansions and contractions, distinguish biological dynamics from annotation artifacts, account for assembly fragmentation, identify functional enrichment in expanded / contracted families. Use when correlating gene-family changes with phenotype evolution, ranking lineages by adaptive gene-family-rate shifts, post-WGD dosage-balance analysis, or building Birth-death models from OrthoFinder presence/absence matrices.

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Detect somatic and germline copy number variants from targeted, exome, and whole-genome sequencing with CNVkit, a read-depth caller that combines on-target and off-target (antitarget) coverage. Covers panel-of-normals construction, flat-reference tumor-only calling, hybrid/amplicon/WGS modes, CBS vs HMM segmentation selection, purity-aware integer calling, and reconciliation against GATK and allele-specific callers. Use when calling CNVs from hybrid-capture panels or exomes, deciding whether CNVkit (depth-only) is the right tool versus an allele-specific caller, building a panel of normals, diagnosing flat-reference false positives, or interpreting log2 ratios into copy-number states.

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Detects differential alternative splicing between conditions using rMATS-turbo (binomial LRT on junction counts), leafcutter (Dirichlet-multinomial GLM on intron clusters), MAJIQ V3 deltapsi/HET (Bayesian posterior on LSVs), SUPPA2 (empirical-null on TPM-derived PSI), or Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage). Reports FDR-corrected significance and delta PSI effect sizes. Tools differ in statistical model, annotation dependence, calibration regime, and replicate-count requirements. Use when comparing splicing patterns between treatment groups, tissues, or disease states.

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Sequence-based deep learning for ATAC-seq using chromBPNet, BPNet, scBasset, or EnFormer. Use when correcting Tn5 bias with neural networks beyond k-mer models, predicting per-base accessibility profiles, scoring in silico variant effects at GWAS or rare-variant SNPs, discovering motifs via DeepLIFT/TF-MoDISco from a trained model, or generating cell-type-specific accessibility predictions for unobserved cell states.

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Use this skill to understand defensive driving course expectations for CMV drivers. Covers federal vs state vs carrier-specific requirements.

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Use when an owner-operator (1099 or LLC/S-corp) asks how to lower their tax bill, what they can deduct, per diem treatment, depreciation choices (Section 179, bonus, MACRS), quarterly estimated payments, S-corp salary vs distributions, retirement plan options (SEP-IRA, Solo 401(k)), or recordkeeping requirements. Covers federal income tax + self-employment tax basics; not state-specific.

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Use this skill when the user asks about FMCSA financial assistance + grants — Motor Carrier Safety Assistance Program (MCSAP), High Priority Grants, CMV Operator Apprenticeship Program (CMV-DAP), workforce development funding, hazmat preparedness grants, small carrier financial relief, and state-level grants for trucking infrastructure. Reference fmcsa.dot.gov/grants.

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Use this skill to understand which MVR violations disqualify a driver under federal rules. Covers § 391.15 disqualifications, varying state rules, and CSA impact.

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