'mbr' 검색 결과

Think and work like an expert Dentist-Scientist. Use when a task calls for Dentist-Scientist judgment. Reasons from oral biofilm-host ecology, tissue healing capacity, and patient-level clinical endpoints (DMFS, PD/CAL, implant survival) through PICO/PROSPERO protocols, CAMBRA and 2017 AAP/EFP staging, ISO 4049/14801 bench tests with thermocycling, and GRADE-rated reviews while treating in-vitro-to-chairside leaps, plaque-index surrogates without caries reduction, and examiner calibration drift as first-class failure modes.

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Think and work like an expert Cellular Neuroscientist. Use when a task calls for Cellular Neuroscientist judgment. Treat the neuron as a cable with active channels, not a point integrator unless you have shown it is one for your question. Separate voltage, calcium, and fluorescence observables. GCaMP reports Ca²⁺-driven fluorescence with indicator kinetics; it is not membrane potential. FRET sensors (ArcLight, ASAP) trade speed and dynamic range differently.

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Think and work like an expert Cell Biologist. Use when a task calls for Cell Biologist judgment. Reasons from compartment thermodynamics, membrane electrophysics, and necessity-plus-sufficiency logic through STR authentication, confocal/TIRF imaging, CRISPR and siRNA perturbation with rescue, and Western blot, treating mycoplasma, passage and serum-lot drift, edge effects, antibody cross-reactivity, siRNA seed off-targets, and well-as-n pseudoreplication as first-class failure modes.

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Guidance for cell-free protein synthesis (CFPS) optimization. Use when: (1) Planning CFPS experiments, (2) Troubleshooting low yield or aggregation, (3) Optimizing DNA template design for CFPS, (4) Expressing difficult proteins (disulfide-rich, toxic, membrane).

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Cell-free protein synthesis (CFPS) planning and optimization guidance. Use when: (1) Planning CFPS experiments, (2) Troubleshooting low yield or aggregation, (3) Optimizing DNA template design for CFPS, (4) Expressing difficult proteins (disulfide-rich, toxic, membrane).

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Go is the language of infrastructure. From Docker to Kubernetes to the entire cloud-native ecosystem, Go powers the systems that run the internet. It's not about what you can build - it's about what you won't break at 3 AM. This skill covers idiomatic Go patterns, error handling, concurrency with goroutines and channels, HTTP servers, microservice architecture, and the standard library that makes Go so powerful. Key insight: Go's simplicity is a feature. Fight the urge to abstract. Embrace boring, readable code. 2025 lesson: The teams succeeding with Go are the ones who resist overengineering. A main.go with 500 lines beats a "clean architecture" with 50 packages. Use when "golang, go service, go microservice, goroutine, channels, go http, go api, go backend, gin, fiber, chi router, go concurrency, go, golang, microservices, backend, concurrency, goroutines, channels, http, api" mentioned.

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Use this skill whenever you need to reason about public health, epidemiology, preventive medicine, healthy aging, longevity, lifestyle vs. genetics, or dietary patterns. Kay-Tee Khaw, an epidemiologist at the University of Cambridge, focuses on population health and how modest lifestyle changes impact chronic disease. Trigger this skill when evaluating health interventions, discussing longevity, analyzing real-world health data, or giving advice on diet and lifestyle. Apply her frameworks to shift focus from extreme interventions and isolated nutrients toward whole-food patterns, population-level risk shifts, and the compression of morbidity.

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Reviews BubbleTea TUI code for proper Elm architecture, model/update/view patterns, and Lipgloss styling. Use when reviewing terminal UI code using charmbracelet/bubbletea.

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Comprehensive BubbleTea TUI code review for terminal applications. Use when reviewing charmbracelet/bubbletea, lipgloss, bubbles, or Wish SSH code; optionally reviews each area concurrently.

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Reviews Wish SSH server code for proper middleware, session handling, and security patterns. Use when reviewing SSH server code using charmbracelet/wish.

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Licensed insurance agent with 10+ years specializing in personal and commercial insurance. Conducts needs analysis, compares policies, advises on coverage, and advocates for clients during claims. Use when: insurance-agent, buy-life-insurance, umbrella-policy, coverage-gap-analysis, auto-insurance-quote, homeowners-insurance, business-insurance, term-vs-whole-life.

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Produces requirement-by-requirement CRE insurance certificate compliance reviews by analyzing ACORD 25 certificates and endorsements against Access Agreement terms. Use when the user mentions COI review, insurance compliance, ACORD 25 analysis, Additional Insured verification, primary/non-contributory status, waiver of subrogation, vendor insurance audit, CGL compliance, umbrella follow-form, broker-ready deficiency instructions, certificate holder vs. additional insured, AI endorsements (CG 20 10, CG 20 37), or carrier rating checks.

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Performs contract-driven compliance review of insurance certificates and endorsements against CRE/site-access and vendor agreement requirements. Produces pass/fail/conditional determinations, deficit lists, and broker-ready remediation instructions. Use when reviewing COI packets, ACORD 25 forms, or endorsements for additional insured, primary and non-contributory, waiver of subrogation, completed operations, umbrella alignment, limits adequacy, or insurer rating compliance. Trigger terms: COI, ACORD, additional insured, certificate holder, cancellation notice.

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Reviews CRE insurance certificates (ACORD 25) and endorsements against Access Agreement insurance requirements, producing a pass/fail compliance determination with broker-ready deficiency instructions. Verifies coverage limits, Additional Insured status, primary/non-contributory language, waiver of subrogation, umbrella alignment, and carrier qualifications. Use when reviewing COIs, ACORD forms, vendor or contractor insurance, site access insurance, or Additional Insured endorsements in commercial real estate transactions.

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Diagnosis of why structural materials fail — ductile overload, brittle cleavage, fatigue, creep, stress-corrosion cracking, hydrogen embrittlement, and corrosion. Covers Griffith fracture mechanics, the ductile-to-brittle transition, the S-N and Paris fatigue frameworks, fractographic interpretation, and the J.E. Gordon view that strength, stiffness, and toughness are distinct properties that must be understood together to prevent collapse.

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Run and analyze molecular dynamics simulations with OpenMM and MDAnalysis. Set up protein and protein-ligand systems with PDBFixer, choose force fields and water models (AMBER14, CHARMM36m, ff19SB, GAFF2, TIP3P), solvate and add ions, run energy minimization, NVT/NPT equilibration and production MD on GPU, then analyze trajectories for RMSD, RMSF, radius of gyration, hydrogen bonds, native contacts, PCA and free energy surfaces. Use this skill for protein stability under mutation, ligand binding-mode and residence-time questions, conformational sampling, membrane proteins, and disordered ensembles. Also trigger on OpenMM, MDAnalysis, mdtraj, Simulation.step, LangevinMiddleIntegrator, PDBFixer, DCD or XTC trajectory, RMSD analysis, or production MD.

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Protein language models through the EvolutionaryScale `esm` Python SDK. Generate and embed sequences with ESM3 (multimodal sequence, structure and function prompting), extract per-residue and mean-pooled embeddings with ESM C, fold sequences with ESMFold2, and run inference locally or against the Forge and Biohub hosted clients. Use this skill for protein representation learning, variant effect and mutational scanning from likelihoods, sequence generation and inpainting, structure prediction from sequence alone, and embedding features for downstream models. Also trigger on esm, ESM3, ESMC, ESM Cambrian, ESMFold2, `from esm.models`, ESMProtein, GenerationConfig, forge.evolutionaryscale.ai, biohub.ai, or ESM_API_KEY.

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"Apply Upper Echelons Theory (Hambrick and Mason, 1984) to analyze how top management team characteristics — demographics, experiences, values — shape strategic choices and organizational outcomes. Use this skill when the user needs to evaluate TMT composition effects on strategy, predict strategic direction from leadership profiles, assess whether managerial discretion enables or constrains executive influence, or when they ask 'does leadership background matter for strategy', 'how does TMT composition affect decisions', or 'why did this management team make that choice'.".

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"Apply Smith and Lewis's paradox theory to identify and manage organizational tensions across performing, organizing, belonging, and learning dimensions. Use this skill when the user needs to diagnose persistent either/or tensions, design dynamic equilibrium strategies that embrace both poles, or when they ask 'why does solving this problem make it worse', 'how do we pursue exploration AND exploitation simultaneously', or 'why do our strategic tensions keep recurring despite resolution attempts'.".

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Triage the Gaia issue backlog and skill-batch intake queue. Use this skill when someone asks to: "triage issues", "clean up the issue tracker", "review the backlog", "close stale issues", "process the intake queue", "review skill-batches", "evaluate draft skill proposals", "approve or reject pending skills", "is this issue still valid?", "what's clogging the backlog?", "run a triage pass", or /gaia-triage. Covers two workstreams: (1) GitHub issue lifecycle — identifying resolved, stale, or need-more-info issues and acting on them via gh CLI; (2) skill-batch intake — evaluating draft proposals in registry-for-review/skill-batches/ and routing them toward promotion or rejection. This is the gatekeeping step before new skills enter the canonical registry; and (3) a cross-repo triage sweep — sizing, P0-P4 prioritization, umbrella/epic synthesis, and assignment across every gaia-research org repo, on the one headquarters tracker.

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Build an MPE-aware Pulp synth — opt into MPE via PluginDescriptor, consume per-note pitch bend / pressure / timbre from MpeBuffer, and route voices through MpeVoiceAllocator without reinventing channel tracking.

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Produces structured asset and liability summaries from financial documents for legal proceedings. Extracts valuations, ownership classifications, and encumbrances, then outputs net-worth overview, categorized schedules, disputed items, and documentation gaps. Use when preparing financial summaries for divorce/dissolution, estate planning, bankruptcy, business valuation, or settlement negotiations. Trigger on: net worth summary, marital estate, balance sheet, asset schedule, liability schedule, community/separate property.

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Genera una nueva especificación de cambio ligera copiando el directorio de plantilla de especificación en una carpeta de especificación con nombre. Úsalo cuando la persona quiera iniciar una especificación, planificar un cambio/funcionalidad o crear un documento de diseño antes de implementar (p. ej. "especifica el rediseño del checkout", "crea una especificación para el nuevo flujo de autenticación").

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Calculates tumor mutational burden from WES/WGS/panel data with Friends of Cancer Research harmonization equations, per-assay calibration (FDA 10/Mb = 7.8 TSO500 = 8.4 OncomineTML), synonymous/indel/germline filtering, hypermutator tiering, blood TMB, and integration with HLA-LOH and neoantigen quality (Luksza 2017 fitness). Use when assessing ICI eligibility under tumor-specific cutoffs (McGrail 2021), comparing tissue vs bTMB, or auditing TMB-H reporting against ESMO 2024 and FDA pembrolizumab pan-tumor 2020.

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