'cohort' 검색 결과

Call copy number variants with the GATK best-practices workflows — the somatic CNV pipeline (CollectReadCounts, DenoiseReadCounts with tangent normalization, ModelSegments, CallCopyRatioSegments) and the germline GATK-gCNV pipeline (DetermineGermlineContigPloidy, GermlineCNVCaller cohort/case mode, PostprocessGermlineCNVCalls). Covers panel-of-normals construction, AnnotateIntervals/FilterIntervals, allelic-count integration, and QS-based filtering. Use when integrating CNV calling into a GATK variant pipeline, calling rare germline CNVs from an exome cohort, deciding between the somatic and germline GATK workflows, or diagnosing why tangent normalization removed a real event or why gCNV output has low precision.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Identify recurrent and driver copy number alterations across a tumor cohort with GISTIC2 (G-score, Ziggurat deconstruction, focal vs broad/arm-level analysis, q-values from permutation) and quantify copy-number signatures with the Steele 2022 COSMIC framework and the Drews 2022 CINSignatures framework. Covers driver-gene localization from recurrence peaks, distinguishing focal drivers from arm-level passengers, and the caller-sensitivity caveats of copy-number signatures. Use when finding recurrently amplified or deleted regions in a cohort, localizing driver genes, separating focal from broad events, running GISTIC2, or extracting copy-number mutational signatures.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Batch effect correction for CRISPR screens covering ComBat empirical-Bayes, RUV, SVA, control-sgRNA normalization, and the model-based alternative of including batch as a covariate in MAGeCK MLE or Chronos. Covers screen-specific batch sources (passage cohort, library lot, infection day, sequencing run, Cas9 lot, FBS lot), PCA + variance-decomposition diagnostic to decide if correction is needed, when correction harms biology by over-correcting condition into batch, limma removeBatchEffect for visualization-only correction, and relationship to multi-condition design matrices. Use when combining screens for joint analysis, when passage cohort confounds biology, when DepMap-style panels need Chronos with batch covariates, when picking ComBat vs RUV, or when correction harms biology and should be replaced with explicit covariate modeling.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Use when comparing process cohorts, departments, periods or before-and-after results under matched definitions.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

How to actually instrument product analytics correctly. Event taxonomy, property design, naming conventions, schema versioning, identity stitching, funnel design, retention cohorts, North Star metric selection, dashboard hygiene, instrumentation debt, and the failure modes that produce data nobody trusts. Triggers on product analytics setup, event taxonomy, tracking plan, instrumentation, schema versioning, North Star metric, retention cohorts, funnel design, naming conventions, instrument new feature, audit existing analytics, dashboard reconciliation, instrumentation debt, Mixpanel setup, Amplitude setup, PostHog setup, warehouse-native analytics. Also triggers when the team has data but cannot trust it, or when designing instrumentation for a new feature, or when auditing an existing setup that has drifted.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Running closed and open betas that produce real signal. Beta participant selection, structured feedback collection, beta-to-GA decision criteria, and the difference between soft-launch (no structure, no signal), kitchen-sink (everyone in, no actionable feedback), and structured beta (calibrated cohort, intentional feedback loops, clear graduation criteria). Triggers on beta program, alpha test, beta cohort, beta participant, beta feedback, beta to GA decision, design partner, early access program, closed beta, open beta, RC release. Also triggers when a feature is approaching launch and the team needs structured pre-GA validation, when prior betas produced noise rather than signal, or when the team has soft-launched before but wants more structured feedback this time.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

This skill should be used when the user asks to "calculate MRR", "analyze churn", "compute SaaS metrics", "do cohort retention analysis", "calculate LTV or CAC", "evaluate unit economics", or "track subscription revenue growth".

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Use when raw data exists — Meta, Google, TikTok, GA4, Shopify, a CRM export, or a spreadsheet — and has to become insight and decisions: descriptive, diagnostic, predictive, and prescriptive layers, cuts by channel, campaign, creative, audience, and time, cohorts, and a decision log. Trigger on 'analyze this data', 'read these numbers for me', 'what does this export say', 'pull insight from GA4', 'cohort analysis', 'here is the spreadsheet'. Also use when the user pastes a table and asks what it means. Not for — diagnosing ad root cause, see `03-performance-eval-global`; writing the report a stakeholder reads, see `07-marketing-report-global`; auditing account setup, see `21-ads-audit-global`.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Use when one validated cohort analysis must be repeated across many exposure/outcome pairs. Generates one R/Python script per combination from a single methodology template, changing only the variables, and aggregates the results into a summary matrix.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Visualize copy number profiles, segments, allele-specific tracks, and cohort patterns from CNVkit, GATK, ASCAT, FACETS, Sequenza, and other callers. Covers genome-wide and per-chromosome log2 scatter plots, B-allele-frequency/minor-allele-fraction tracks, ideograms, cohort heatmaps, circos views, and caller-native plots. Use when creating publication CNV figures, choosing which plot answers a given question, diagnosing a wrong diploid baseline visually, displaying loss of heterozygosity, or deciding what depth-only plots cannot reveal.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Batch effect correction for CRISPR screens covering ComBat empirical-Bayes, RUV, SVA, control-sgRNA normalization, and the model-based alternative of including batch as a covariate in MAGeCK MLE or Chronos. Covers screen-specific batch sources (passage cohort, library lot, infection day, sequencing run, Cas9 lot, FBS lot), PCA + variance-decomposition diagnostic to decide if correction is needed, when correction harms biology by over-correcting condition into batch, limma removeBatchEffect for visualization-only correction, and relationship to multi-condition design matrices. Use when combining screens for joint analysis, when passage cohort confounds biology, when DepMap-style panels need Chronos with batch covariates, when picking ComBat vs RUV, or when correction harms biology and should be replaced with explicit covariate modeling.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Customer retention analysis, churn prediction, cohort analysis, win-back campaigns, and loyalty program design. Use when the user asks about churn, retention, customer lifetime value, cohort analysis, or win-back strategies.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

The practice of collecting, analyzing, and acting on data to drive product decisions. Great analytics isn't about dashboards—it's about insights that lead to action. Every metric should answer a question that changes behavior. This skill covers event tracking, metrics design, dashboards, user behavior analysis, and data-driven decision making. The best analytics teams measure what matters, not what's easy to measure. Use when "analytics, metrics, tracking, dashboard, funnel, cohort, retention, events, KPI, measure, data, insights, conversion, engagement, analytics, metrics, data, dashboards, tracking, funnels, cohorts, KPIs, insights" mentioned.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

把用户按同一批/同一类分组，比较各群体后续表现。触发条件：对话涉及同期群分析、分群后表现对比、用户生命周期分群跟踪等任务时触发，如出现「同期群」「cohort」「按起始特征分群后表现如何」「不同客群后续转化/留存对比」「注册周/获客渠道分群跟踪」等相似问题时触发。

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Call germline SNPs and indels with GATK HaplotypeCaller and the GVCF joint-genotyping workflow. Covers the local-reassembly + PairHMM mechanism (why HC beats pileup callers on indels), the -ERC GVCF reference-confidence model and <NON_REF> allele, BQSR-vs-DRAGSTR and --dragen-mode error modeling, allele-specific (AS_) annotations, and edge cases (ploidy, Mutect2 mitochondria mode, sex chromosomes/PAR, contamination gating). Use when deciding whether to use HaplotypeCaller vs a pileup or DRAGEN caller, whether BQSR still earns its place, whether to call per-sample GVCFs for a cohort, or how to handle non-diploid, mitochondrial, sex-chromosome, or contaminated samples. Not for post-calling filtering depth (see variant-calling/filtering-best-practices) or cohort joint-genotyping scaling (see variant-calling/joint-calling).

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Call copy number variants with the GATK best-practices workflows — the somatic CNV pipeline (CollectReadCounts, DenoiseReadCounts with tangent normalization, ModelSegments, CallCopyRatioSegments) and the germline GATK-gCNV pipeline (DetermineGermlineContigPloidy, GermlineCNVCaller cohort/case mode, PostprocessGermlineCNVCalls). Covers panel-of-normals construction, AnnotateIntervals/FilterIntervals, allelic-count integration, and QS-based filtering. Use when integrating CNV calling into a GATK variant pipeline, calling rare germline CNVs from an exome cohort, deciding between the somatic and germline GATK workflows, or diagnosing why tangent normalization removed a real event or why gCNV output has low precision.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Visualize copy number profiles, segments, allele-specific tracks, and cohort patterns from CNVkit, GATK, ASCAT, FACETS, Sequenza, and other callers. Covers genome-wide and per-chromosome log2 scatter plots, B-allele-frequency/minor-allele-fraction tracks, ideograms, cohort heatmaps, circos views, and caller-native plots. Use when creating publication CNV figures, choosing which plot answers a given question, diagnosing a wrong diploid baseline visually, displaying loss of heterozygosity, or deciding what depth-only plots cannot reveal.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Batch effect correction for CRISPR screens covering ComBat empirical-Bayes, RUV, SVA, control-sgRNA normalization, and the model-based alternative of including batch as a covariate in MAGeCK MLE or Chronos. Covers screen-specific batch sources (passage cohort, library lot, infection day, sequencing run, Cas9 lot, FBS lot), PCA + variance-decomposition diagnostic to decide if correction is needed, when correction harms biology by over-correcting condition into batch, limma removeBatchEffect for visualization-only correction, and relationship to multi-condition design matrices. Use when combining screens for joint analysis, when passage cohort confounds biology, when DepMap-style panels need Chronos with batch covariates, when picking ComBat vs RUV, or when correction harms biology and should be replaced with explicit covariate modeling.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Identify recurrent and driver copy number alterations across a tumor cohort with GISTIC2 (G-score, Ziggurat deconstruction, focal vs broad/arm-level analysis, q-values from permutation) and quantify copy-number signatures with the Steele 2022 COSMIC framework and the Drews 2022 CINSignatures framework. Covers driver-gene localization from recurrence peaks, distinguishing focal drivers from arm-level passengers, and the caller-sensitivity caveats of copy-number signatures. Use when finding recurrently amplified or deleted regions in a cohort, localizing driver genes, separating focal from broad events, running GISTIC2, or extracting copy-number mutational signatures.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Expert en analyse du churn (cohort analysis, survival curves, predictive models, at-risk signals)

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Churn analysis v3 — cohort analysis, survival curves, predictive models, DZ context

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Orchestrates the end-to-end germline short-variant pipeline from FASTQ to a filtered, normalized, benchmarked VCF, chaining QC/trim, BWA-MEM2 alignment, duplicate marking, optional BQSR, calling (bcftools/GATK HaplotypeCaller/DeepVariant/DRAGEN), normalization, site+genotype filtering, annotation, and hap.py/vcfeval benchmarking. Use when deciding the pipeline-wide reference-genome commitment (GRCh38 analysis set vs T2T, ALT/decoy handling), sequencing the steps in the defensible order (normalize BEFORE annotate, filter site- then genotype-level), choosing the calling engine and single-sample vs cohort joint-calling, picking a filtering strategy by cohort size, or benchmarking stratified within GIAB confident regions. Hands off mechanism to the variant-calling and read-alignment component skills; not a re-teach of any single step.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Orchestrates an end-to-end long-read structural-variant pipeline - basecalling to minimap2 alignment (platform-matched preset) to Sniffles2/cuteSV/pbsv calling to optional assembly-based calling (dipcall/PAV) to two-step .snf cohort merging to Truvari benchmarking - chaining ONT and PacBio HiFi runs while handing the SV signal mechanism off to the component skills. Use when running a long-read SV workflow from reads to a benchmarked callset, choosing the minimap2 preset and SV caller by platform and goal, deciding when long reads are worth it for the insertions and repeat-mediated SVs short reads physically miss, building a joint-genotyped cohort with the two-step .snf design, or parameterizing a Truvari benchmark against GIAB HG002 Tier 1 plus CMRG. Not for the SV signal mechanism itself (see variant-calling/structural-variant-calling) or short-read SV.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

End-to-end alternative splicing analysis from FASTQ to differential splicing results for short-read bulk RNA-seq. Aligns with STAR 2-pass cohort-style, performs junction QC (RSeQC, MaxEntScan, SpliceAI), runs rMATS-turbo and leafcutter for concordant differential analysis, optionally MAJIQ V3 for complex events / heterogeneous cohorts, isoform-switching with NMD/ORF/domain consequences (IsoformSwitchAnalyzeR v2 + DRIMSeq+DEXSeq+stageR DTU), and sashimi visualizations. Use when performing comprehensive splicing analysis from raw bulk RNA-seq data; for variant-driven splice prediction see splice-variant-prediction; for rare-disease single-patient outlier detection see outlier-splicing-detection; for full-isoform PacBio/ONT analysis see long-read-splicing.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.