169건 · 관련도순
Agent fallback for CBaseEntity_dtor (auto-generated, category: func). Locate CBaseEntity::~CBaseEntity in the CS2 server module via IDA Pro MCP and emit a fresh, minimal-unique artifact. The deterministic preprocessor could not resolve this symbol on the current gamever - your job is the re-sign. Trigger: CBaseEntity_dtor, CBaseEntity::~CBaseEntity
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Implement REST APIs in ABP Framework with AppServices, DTOs, pagination, filtering, and authorization. Use when building API endpoints for ABP applications.
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Build NestJS APIs with TypeScript code for modules, request handlers, services, authentication, input validation, and database access. The skill also prepares Swagger API documentation and unit and end-to-end tests for the implemented features.
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Assess AWS, Azure, and GCP environments by identifying identities, permissions, and paths to broader access or data exposure. Covers cloud storage, secrets, cross-account trust, and CI/CD, the automated systems used to build and deploy software.
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Review domain code for classes that hold data while business logic lives elsewhere. Using domain-driven design patterns, diagnose problems and refactor objects to keep business rules, state changes, and validation together, with before-and-after diffs.
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Computes and interprets sequencing read depth and coverage over a genome, windows, or target regions with mosdepth (windowed depth, cumulative distribution, --quantize callable BEDs), bedtools genomecov/coverage (bedGraph tracks, per-target stats), samtools depth/coverage (per-base depth, per-contig depth+breadth). Covers the breadth-vs-mean distinction, the cumulative-coverage curve, evenness (CV/Fano/fold-80/Gini), what each tool silently counts (duplicates, secondary/supplementary, MAPQ, read span vs fragment, mate-overlap), the samtools-depth 8000-cap version trap, and the bedtools coverage -a/-b orientation flip. Use when assessing sequencing adequacy, building coverage tracks, computing breadth at a depth threshold, defining callable regions, or QCing target-capture uniformity.
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Performs set operations on genomic intervals - intersect (-wa/-wb/-wo/-wao/-loj/-c/-v/-u), subtract (-A), merge (-d, -c/-o), complement, cluster, multiinter, unionbedg, map, and groupby - with bedtools (CLI) and pybedtools/pyranges/bioframe (Python). Covers the sorted-input contract and the -sorted chromosome-order footgun, reciprocal/fractional overlap (-f/-F/-r/-e) and the A-vs-B asymmetry, -split for spliced/BED12/BAM features, and jaccard/fisher as mechanics only. Use when finding overlapping or unique regions between BED/peak/feature files, building consensus peaksets, removing blacklisted regions, transferring annotation values onto intervals, or computing interval-set similarity; route overlap-significance testing to overlap-significance.
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Tests whether two genomic interval sets overlap (colocalize) more than expected by chance using a permutation test against a structured-genome null model. Covers bedtools fisher (analytic 2x2 screen), bedtools shuffle + jaccard permutation, GAT (isochore/GC-conditioned simulation with FDR), regioneR (flexible permutation, randomizeRegions vs circularRandomizeRegions, localZScore), LOLA (universe-relative Fisher against a region database), and GREAT/rGREAT (regulatory-domain binomial + hypergeometric for ontology-from-regions). Stresses the universe/background choice, matched background, blacklist exclusion, and multiple-testing control. Use when asking whether peaks/regions are enriched at enhancers/TFBS/features, scoring region-set colocalization or region-set enrichment, comparing CNV/SV concordance, or turning an overlap count into a defensible p-value.
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Generates, normalizes, and converts bedGraph signal tracks (4-column chrom/start/end/value, 0-based half-open) with bedtools genomecov, deepTools bamCoverage/bamCompare/bigwigCompare, bedtools unionbedg, and UCSC bedGraphToBigWig. Covers why a raw coverage bedGraph is not comparable across samples until normalized, the CPM/RPKM/BPM/RPGC normalization menu and the conserved-total assumption that makes them wrong under a global perturbation, the strict sorted-non-overlapping-chrom.sizes bedGraphToBigWig contract that silently corrupts a bigWig, effective-genome-size selection, and bin-size aliasing. Use when building or normalizing a coverage/signal track from a BAM, comparing tracks across samples or conditions, converting bedGraph to a browser-ready bigWig, or diagnosing a track that looks plausible but reports wrong heights.
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Performs proximity operations on genomic intervals with bedtools (closest, window, flank, slop) and pybedtools - nearest-feature queries with signed/strand-aware distance, fixed-radius window searches, strand-aware promoter construction, and interval extension. Covers the closest -d/-D a/b/ref/-t/-k/-io/-iu/-id flags, the -D ref strand sign-flip, silent chromosome-end clipping in slop/flank, -t all tie double-counting, and the critical distinction between a geometry answer (nearest TSS) and a biology answer (which gene an element regulates). Use when assigning peaks or variants to genes, defining promoters from a gene model, building distance-to-TSS distributions, finding features within a window, or extending intervals - and when deciding whether nearest-gene is a fair prior (GWAS locus) or a trap (distal enhancer).
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Annotate copy number variant segments with overlapping genes, dosage-sensitivity scores, cancer driver databases, population frequencies, and clinical-variant content. Covers bedtools/pybedtools interval intersection, AnnotSV comprehensive annotation and ranking, ClinGen haploinsufficiency/triplosensitivity scoring, gnomAD-SV/DGV frequency filtering, COSMIC Cancer Gene Census, and ClinVar overlap. Use when interpreting which genes a CNV affects, distinguishing the driver gene of a focal event from passengers, filtering against population CNVs, separating whole-gene from partial-gene overlap, or preparing CNVs for clinical classification.
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Точечное редактирование пакета XDTO 1С. Используй когда нужно добавить, изменить или удалить тип или свойство в существующем пакете, переименовать пакет, сменить пространство имён
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Выгрузка пакета XDTO 1С в XML-схему (XSD). Используй когда нужно получить схему существующего пакета — чтобы переработать её целиком, отдать контрагенту или перенести пакет в другую конфигурацию
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Build secure, reusable data access patterns with DTOs, taint checks, and colocated authorization in Next.js. Use when centralizing database queries, transforming raw data to DTOs, adding server-only guards, or preventing sensitive data from reaching Client Components.
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Implement Domain-Driven Design with typed DTOs, repository interfaces, and single-responsibility Action classes in Laravel. Use when creating domain folders, binding repository contracts in providers, or passing DTOs between layers.
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Use when you need to design, review, or improve REST APIs with Micronaut — including @Controller routes, HTTP status codes, DTOs, Bean Validation, exception handlers, pagination, idempotency, ETag/If-Match, caching headers, versioning, contract-first OpenAPI (OpenAPI Generator), optional runtime OpenAPI via micronaut-openapi, and security annotations. This should trigger for requests such as Review or improve Micronaut @Controller REST APIs; Add validation, error handling, or align controllers with the OpenAPI contract on Micronaut HTTP layer; Design Micronaut controllers and DTO validation; Add Micronaut exception handlers and Problem Details responses; Improve pagination filtering or OpenAPI alignment in Micronaut APIs. Part of Plinth Toolkit
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Use when you need to design, review, or improve validation in Spring Boot applications — including Bean Validation on request DTOs, @Valid/@Validated at API boundaries, constraint groups, custom constraints, @ConfigurationProperties validation, nested DTO validation, and consistent validation error handling. This should trigger for requests such as Add validation support in Spring Boot; Review Spring Boot validation rules; Improve request validation in Spring Boot REST APIs; Add custom Bean Validation constraints in Spring Boot; Validate configuration properties in Spring Boot. Part of Plinth Toolkit
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Use when you need data access with Quarkus Hibernate ORM Panache — including PanacheEntity / PanacheEntityBase, PanacheRepository, named queries, JPQL, native SQL, DTO projections (project(Class)), pagination (Page.of()), N+1 avoidance (JOIN FETCH), optimistic locking (@Version / OptimisticLockException), @NamedQuery for validated reusable queries, transactions, @TestTransaction for test isolation, and immutable-friendly patterns. This is the Quarkus analogue to Spring Data for relational persistence. This should trigger for requests such as Review Panache entities or repositories in Quarkus; Improve Hibernate ORM data access with Panache; Add DTO projections, JOIN FETCH, pagination, or optimistic locking to Panache queries; Fix N+1 query problems or add @Version concurrency control in Quarkus Panache; Improve Panache active record versus repository design. Part of Plinth Toolkit
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PowerX CRUD DTO 规则（输入输出分离、分页、校验）。
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Provides patterns for unit testing mappers, converters, and bean mappings. Validates entity-to-DTO and model transformation logic in isolation. Generates executable mapping tests with MapStruct and custom converter test coverage. Use when writing mapping tests, converter tests, entity mapping tests, or ensuring correct data transformation between DTOs and domain objects.
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Provides comprehensive NestJS best practices including modular architecture, dependency injection scoping, exception filters, DTO validation with class-validator, and Drizzle ORM integration. Use when designing NestJS modules, implementing providers, creating exception filters, validating DTOs, or integrating Drizzle ORM within NestJS applications.
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Owns repositories, data sources and mapping for Compose and Compose Multiplatform apps: DTO to domain to UiModel boundaries, Ktor clients and bearer auth, WebSocket and SSE, Room, DataStore, Paging 3, offline-first and data-layer tests. Use when writing or reviewing a repository, data source, DTO, mapper, HttpClient, bearer token, WebSocket, SSE, Room DAO, migration, DataStore, PagingSource, RemoteMediator, offline cache or MockEngine test. Do NOT use for ViewModel or UI wiring (compose-feature), composables (compose-ui), the MVI contract or error tiers (compose-architecture), Gradle modules (compose-project), or commonMain vs platform splits (compose-platform).
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Annotate copy number variant segments with overlapping genes, dosage-sensitivity scores, cancer driver databases, population frequencies, and clinical-variant content. Covers bedtools/pybedtools interval intersection, AnnotSV comprehensive annotation and ranking, ClinGen haploinsufficiency/triplosensitivity scoring, gnomAD-SV/DGV frequency filtering, COSMIC Cancer Gene Census, and ClinVar overlap. Use when interpreting which genes a CNV affects, distinguishing the driver gene of a focal event from passengers, filtering against population CNVs, separating whole-gene from partial-gene overlap, or preparing CNVs for clinical classification.
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BED file format fundamentals, creation, validation, and basic operations. Covers BED3 through BED12 formats, coordinate systems, sorting, and format conversion using bedtools and pybedtools. Use when working with genomic coordinates or preparing interval files for downstream tools.
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