'mbr' 검색 결과

Calculates tumor mutational burden from WES/WGS/panel data with Friends of Cancer Research harmonization equations, per-assay calibration (FDA 10/Mb = 7.8 TSO500 = 8.4 OncomineTML), synonymous/indel/germline filtering, hypermutator tiering, blood TMB, and integration with HLA-LOH and neoantigen quality (Luksza 2017 fitness). Use when assessing ICI eligibility under tumor-specific cutoffs (McGrail 2021), comparing tissue vs bTMB, or auditing TMB-H reporting against ESMO 2024 and FDA pembrolizumab pan-tumor 2020.

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Implement tasks from an OpenSpec change. Use when the user wants to start implementing, continue implementation, or work through tasks.

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Run an extremely strict maintainability review for abstraction quality, giant files, and spaghetti-condition growth. Use for a thermo-nuclear code quality review, thermonuclear review, deep code quality audit, or especially harsh maintainability review.

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Pragmatic testing guidance focused on confidence, behavior over implementation details, and integration-first coverage. Use when designing a test strategy, writing or reviewing tests, reducing brittle mocks, or deciding what is worth testing in an application or library.

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Verify Next.js runtime behavior after editing app code. Use this skill to confirm a change actually works in a running app — not just that it compiles or type-checks. Combines /_next/mcp (Next.js's view) with agent-browser (the browser's view). Requires a running `next dev`.

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Call this skill when faced with "wicked problems", complex challenges, or when a user asks for strategic innovation, root-cause analysis, or long-term problem solving. Do not use for simple, linear tasks. This skill forces the agent to bypass superficial symptoms, map the entire ecosystem, and anticipate second-order consequences before proposing an intervention.

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Migrates React projects and components from Radix UI to Base UI. Use when asked to migrate from radix, move to base-ui, convert radix primitives, or switch a shadcn project's base library. Handles single components ("migrate accordion") and whole projects.

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Next.js best practices - file conventions, RSC boundaries, data patterns, async APIs, metadata, error handling, route handlers, image/font optimization, bundling

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Expert in SQLite embedded database development for Tauri/desktop applications with focus on SQL injection prevention, migrations, FTS search, and secure data handling

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Propose a new change - create it and generate all artifacts in one step

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Archive a completed change in the experimental workflow

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Implement tasks from an OpenSpec change (Experimental)

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Review the current branch for bugs, intent fit, and test coverage; run or write tests; commit focused work; open or update a PR.

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This skill should be used when the user asks about "plugin settings", "store plugin configuration", "user-configurable plugin", ".local.md files", "plugin state files", "read YAML frontmatter", "per-project plugin settings", or wants to make plugin behavior configurable. Documents the .claude/plugin-name.local.md pattern for storing plugin-specific configuration with YAML frontmatter and markdown content.

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Apply npm/pnpm supply-chain hardening when adding a dependency, editing package.json/.npmrc/pnpm-workspace.yaml, reviewing a lockfile change, or configuring CI install steps. Covers the 17 practices from lirantal/npm-security-best-practices.

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Guide for creating high-quality MCP (Model Context Protocol) servers that enable LLMs to interact with external services through well-designed tools. Use when building MCP servers to integrate external APIs or services, whether in Python (FastMCP) or Node/TypeScript (MCP SDK).

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Enter explore mode - a thinking partner for exploring ideas, investigating problems, and clarifying requirements. Use when the user wants to think through something before or during a change.

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Manages shadcn components and projects — adding, searching, fixing, debugging, styling, and composing UI, including chat interfaces. Provides project context, component docs, and usage examples. Applies when working with shadcn/ui, component registries, presets, --preset codes, or any project with a components.json file. Also triggers for "shadcn init", "create an app with --preset", or "switch to --preset".

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Enter explore mode - think through ideas, investigate problems, clarify requirements

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Find deepening opportunities in a codebase, informed by the project's own domain language and prior design decisions. Use when the user wants to improve architecture, find refactoring opportunities, consolidate tightly-coupled modules, or make a codebase more testable and AI-navigable.

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Helps users discover and install agent skills when they ask questions like "how do I do X", "find a skill for X", "is there a skill that can...", or express interest in extending capabilities. This skill should be used when the user is looking for functionality that might exist as an installable skill.

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This skill should be used when the user asks to "create a plugin", "scaffold a plugin", "understand plugin structure", "organize plugin components", "set up plugin.json", "use ${CLAUDE_PLUGIN_ROOT}", "add commands/agents/skills/hooks", "configure auto-discovery", or needs guidance on plugin directory layout, manifest configuration, component organization, file naming conventions, or Claude Code plugin architecture best practices.

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Create and scaffold plugin directories for Codex with a required `.codex-plugin/plugin.json`, optional plugin folders/files, and baseline placeholders you can edit before publishing or testing. Use when Codex needs to create a new local plugin, add optional plugin structure, or generate or update repo-root `.agents/plugins/marketplace.json` entries for plugin ordering and availability metadata.

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Propose a new change with all artifacts generated in one step. Use when the user wants to quickly describe what they want to build and get a complete proposal with design, specs, and tasks ready for implementation.

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