'performing' 검색 결과

Process and analyze single-cell ATAC-seq data with Signac, ArchR, SnapATAC2, or Cell Ranger ATAC. Use when handling 10X scATAC or 10X Multiome (paired RNA+ATAC) data, performing per-cell QC, choosing between ArchR/Signac/SnapATAC2 ecosystems, building per-cluster consensus peaksets, integrating with paired scRNA-seq, doublet detection (AMULET vs ArchR vs scDblFinder), or running pseudobulk differential accessibility per cluster.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Critical Git safety rules to prevent destructive operations. Use whenever performing git operations, reverting changes, or managing commits. Prevents accidental loss of work.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Azure Key Vault Keys Java SDK for cryptographic key management. Use when creating, managing, or using RSA/EC keys, performing encrypt/decrypt/sign/verify operations, or working with HSM-backed keys.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

State-of-the-art text-to-image generation with Stable Diffusion models via HuggingFace Diffusers. Use when generating images from text prompts, performing image-to-image translation, inpainting, or building custom diffusion pipelines.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Review code changes by analyzing git diffs, leaving inline comments on PRs, and performing thorough pre-push review. Works with gh CLI or falls back to git + GitHub REST API via curl.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Review or refactor an existing SKILL.md and its bundled resources — a smaller always-loaded core, conditional references, preserved behavior, lean/guided consumer profiles, and an A/B protocol to compare a candidate with the previous version. Use when a skill repeats itself, loads references on every run, triggers too broadly or misses legitimate requests, or needs its efficiency measured across models. Do NOT use for writing a new skill from scratch, refactoring application code, translating a skill verbatim, or performing the target skill's own task.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Systematically review pull requests, feature implementations, and code changes to ensure quality, maintainability, security, and adherence to best practices. Use when reviewing code before merging, conducting peer reviews, performing self-reviews, auditing code quality, checking for security vulnerabilities, ensuring consistent coding standards, verifying test coverage, assessing performance implications, evaluating architectural decisions, or providing constructive feedback to improve team code quality.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Proactively search for security threats, vulnerabilities, and suspicious patterns in applications and infrastructure before they cause damage. Use when conducting security audits, identifying vulnerabilities, analyzing security logs, detecting suspicious patterns, investigating potential breaches, performing penetration testing, or implementing security monitoring.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Implement React Server Actions in Next.js 14+ for secure, progressively enhanced form handling and server mutations without API routes. Use when handling form submissions, performing server-side mutations, implementing progressive enhancement, creating actions that work without JavaScript, validating data on the server, revalidating cached data after mutations, handling file uploads server-side, implementing optimistic UI updates, or building forms that gracefully degrade without client-side JavaScript.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

When the user wants to optimize signup, registration, account creation, or trial activation flows. Also use when the user mentions "signup conversions," "registration friction," "signup form optimization," "free trial signup," "reduce signup dropoff," "account creation flow," "people aren't signing up," "signup abandonment," "trial conversion rate," "nobody completes registration," "too many steps to sign up," or "simplify our signup." Use this whenever the user has a signup or registration flow that isn't performing. For post-signup onboarding, see onboarding-cro. For lead capture forms (not account creation), see form-cro.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Check the health of published EAS Updates: crash rates, install/launch counts, unique users, payload size, and the split between embedded and OTA users per channel. Use when the user asks how an update is performing, whether a rollout is healthy, how many users are on the embedded build vs OTA, or wants to gate CI on update health.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Azure Key Vault Keys Java SDK for cryptographic key management. Use when creating, managing, or using RSA/EC keys, performing encrypt/decrypt/sign/verify operations, or working with HSM-backed keys.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Identifies non-coding RNAs (tRNA, rRNA, snoRNA, snRNA, riboswitches, sRNAs) using Infernal covariance-model search against Rfam, tRNAscan-SE 2.0 for tRNA, barrnap for rRNA, and ARAGORN for tmRNA, plus the small-RNA-seq boundary for miRNA and the transcript-assembly boundary for lncRNA. Covers the structure-conserved-not-sequence-conserved principle (why BLAST fails), GA-threshold and clan-competition correctness, tRNAscan-SE domain modes and pseudogene flags, rDNA copy-number collapse, and why homology annotation is a recall floor. Use when performing genome-wide ncRNA annotation, choosing the right tool for an RNA class, or interpreting ncRNA counts.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Analyzes single-cell pooled CRISPR screens (Perturb-seq, CROP-seq, Perturb-CITE-seq, ECCITE-seq, multiome) where each cell carries an sgRNA and a scRNA-seq / surface-protein / chromatin readout. Covers experimental design (direct-capture Perturb-seq Dixit 2016 vs CROP-seq 3'UTR-barcoded Datlinger 2017 vs ECCITE-seq vs Multiome), MOI for sgRNA assignment, escaper-cell filtering (Mixscape, Papalexi 2021), SCEPTRE NB GLM + permutation for low-MOI (Barry 2024 Genome Biol 25:124), the Pertpy framework, factor decomposition, genome-scale Perturb-seq (Replogle 2022 Cell, 2.5M cells), and per-perturbation single-cell DE. Use when running a single-cell CRISPR screen, choosing direct-capture vs CROP-seq architecture, filtering escaper cells, performing single-cell DE, integrating Perturb-seq with pathway analysis, scaling to GW CRISPRi via Replogle protocol, or analyzing multi-omics screens.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Reconstruct ancestral states at internal phylogenetic nodes for sequences (PAML codeml, IQ-TREE --ancestral, GRASP, FastML), discrete traits (corHMM hidden-rate Markov, ape::ace, phytools::make.simmap stochastic mapping, BayesTraits), and continuous traits (phytools::fastAnc, geiger Brownian/OU, RPANDA). Use when designing constructs for ancestral protein resurrection, tracing trait evolution along a tree, performing stochastic character mapping, testing models of trait evolution (BM vs OU vs EB), inferring ancestral genome content via Dollo or DTL reconciliation, or quantifying ancestral-state uncertainty for downstream comparative analyses.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Detect positive (diversifying / episodic / pervasive) selection using codon dN/dS frameworks. Implements PAML codeml site models (M0/M1a/M2a/M7/M8/M8a), branch models, branch-site model A (Zhang 2005), and HyPhy methods (BUSTED, BUSTED-S, BUSTED-MH, BUSTED-PH, MEME, FEL, FUBAR, aBSREL, SLAC, RELAX, GARD, FUBAR-MH). Includes McDonald-Kreitman framework (asymptotic alpha, impMKT, polyDFE, DFE-alpha, GRAPES) for within-species + divergence inference, RERconverge for trait-correlated rate shifts, CSUBST for convergent substitution, and PhyloAcc for accelerated noncoding evolution. Use when testing adaptive evolution at codons, branches, or full gene; running GARD recombination pre-screen; controlling alignment-error and gBGC false positives; reconciling PAML vs HyPhy results; or performing genome-scale selection scans.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Analyzes chemical libraries by scaffold using Bemis-Murcko scaffolds, generic frameworks, cyclic skeletons, matched molecular pair (MMP) analysis via mmpdb, R-group decomposition, Free-Wilson analysis, scaffold hopping, and chemotype-aware ML train/test splits. Use when identifying chemotype clusters in a library, deriving SAR transformation rules, decomposing series into R-groups, performing scaffold-balanced QSAR splits, or planning analog campaigns.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Performs alchemical free-energy calculations including relative binding free energy (RBFE / FEP+) and absolute binding free energy (ABFE) via OpenFE, FEP+, GROMACS, AMBER pmemd, and OpenMM with explicit lambda window scheduling, soft-core potentials, REST2 enhanced sampling, MBAR/BAR analysis, and cycle closure validation. Compares ML alternatives (Boltz-2 affinity, DeepDock). Use when ranking analogs by binding affinity beyond docking accuracy, performing prospective lead optimization, or validating SAR predictions.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Estimate causal effects of an exposure on an outcome from GWAS summary statistics using genetic instruments. Implements IVW (fixed/random), MR-Egger, weighted median/mode, MR-RAPS, CAUSE, GSMR-HEIDI, MR-PRESSO, MVMR, MR-Clust, LCV, and LHC-MR via TwoSampleMR, MendelianRandomization, MR-PRESSO, cause, and lhcMR. Use when testing causal direction between traits, evaluating drug-target effects via cis-pQTL/cis-eQTL, performing multivariable mediation MR, distinguishing causation from correlated horizontal pleiotropy, or producing STROBE-MR-compliant sensitivity batteries.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Process and analyze single-cell ATAC-seq data with Signac, ArchR, SnapATAC2, or Cell Ranger ATAC. Use when handling 10X scATAC or 10X Multiome (paired RNA+ATAC) data, performing per-cell QC, choosing between ArchR/Signac/SnapATAC2 ecosystems, building per-cluster consensus peaksets, integrating with paired scRNA-seq, doublet detection (AMULET vs ArchR vs scDblFinder), or running pseudobulk differential accessibility per cluster.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Critical Git safety rules to prevent destructive operations. Use whenever performing git operations, reverting changes, or managing commits. Prevents accidental loss of work.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Quality assurance review for implementations. Use when reviewing code quality, checking implementation standards, performing QA cycles, or validating feature quality.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Codified expertise for quality control, non-conformance investigation, root cause analysis, corrective action, and supplier quality management in regulated manufacturing. Informed by quality engineers with 15+ years experience across FDA, IATF 16949, and AS9100 environments. Includes NCR lifecycle management, CAPA systems, SPC interpretation, and audit methodology. Use when investigating non-conformances, performing root cause analysis, managing CAPAs, interpreting SPC data, or handling supplier quality issues.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Azure Key Vault Keys Java SDK for cryptographic key management. Use when creating, managing, or using RSA/EC keys, performing encrypt/decrypt/sign/verify operations, or working with HSM-backed keys.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.