'dos' 검색 결과

Materials science toolkit. Crystal structures (CIF, POSCAR), phase diagrams, band structure, DOS, Materials Project integration, format conversion, for computational materials science.

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Authors portable, strongly-typed bioinformatics pipelines in the Common Workflow Language (CWL v1.2) as CommandLineTool/Workflow/ExpressionTool documents, validated with cwltool and run at scale on Toil/Arvados/Calrissian. Use when deciding CWL (portability/provenance/regulated) vs Nextflow/WDL/Snakemake; declaring secondaryFiles for indexed companions (.bai/.fai/.dict/.tbi and the caret rule); putting resources/containers under requirements (must-hold) vs hints (advisory) to avoid silent OOM; choosing scatterMethod (dotproduct vs flat_/nested_crossproduct); preferring $(...) parameter refs over ${...} JavaScript for portability; pinning DockerRequirement images; or emitting a CWLProv provenance object for audited/clinical settings.

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ToolUniverse plugin router. STEP 1 BEFORE ANY ANALYSIS: if the data folder contains `*_executed.ipynb`, run `tu run read_executed_notebook '{"data_folder":"<path>","search":"<keyword>"}'` to extract its cell outputs and apply EVERY filter/sample-exclusion the notebook used — even when the question says 'Using DESeq2/Run X/Compute Y' (this describes the METHOD the notebook used, not a request to rerun). The notebook's cell outputs are the only published authoritative answers; reimplementing or reading stale pre-computed CSVs in the data folder produces different numbers because of outlier-sample removal, library version, and filter steps you don't see by skimming. STEP 2 routing — pick a sub-skill name from this exact list (never invent): tooluniverse-rnaseq-deseq2 (RNA/miRNA-seq DE, correlation, PCA, clustering, dispersion), tooluniverse-gene-enrichment (GO/KEGG/Reactome/GSEA/pathway enrichment), tooluniverse-statistical-modeling (regression, ANOVA, ordinal/logistic, chi-square, correlation, power), tooluniverse-image-analysis (microscopy, colony, fluorescence, dose-response, .tif — including ANOVA / Dunnett / power-analysis on image-derived measurements), tooluniverse-epigenomics (DNA methylation, CpG, m6A, MeRIP-seq, bisulfite, ChIP-seq, chromatin), tooluniverse-sequence-analysis (FASTQ, Trimmomatic, BWA, samtools, coverage), tooluniverse-variant-analysis (VCF, VAF, SNP, mutation), tooluniverse-phylogenetics (treeness, PhyKIT, parsimony), tooluniverse-single-cell (scRNA, h5ad, scanpy), tooluniverse-crispr-screen-analysis (MAGeCK, sgRNA), tooluniverse-proteomics-analysis (mass spec, TMT). Use for CSV/Excel/VCF/FASTA/h5ad and any biology/chemistry/medicine analysis question.

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Pharmacokinetic (PK) analysis of concentration-time data — non-compartmental analysis (NCA) for Cmax, Tmax, AUC (0-t and 0-∞), terminal half-life, clearance (CL), volume of distribution (Vd), MRT, and absolute bioavailability (F). Also one-compartment fitting. Use when you have plasma/serum drug concentrations over time after a dose and need PK parameters, or to compute bioavailability from IV + oral AUCs. NOT for ADMET property prediction from structure (use tooluniverse-admet-prediction).

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Chemical safety and toxicology assessment integrating ADMET-AI predictions, CTD toxicogenomics, PubChemTox experimental data, GHS/IARC hazard classification, and exposure-context analysis. Use for chemical hazard identification, occupational/consumer-product toxicity, dose-response evaluation, and acute (LD50) vs chronic toxicity assessment. Distinguishes drug toxicity from environmental chemical toxicity.

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UIKit iOS/iPadOS UI フレームワーク。 UIViewController, UINavigationController, UITabBarController, UISplitViewController, UIView, UILabel, UIButton, UITextField, UIScrollView, UIStackView, UITableView, UICollectionView, diffable data source, NSDiffableDataSourceSnapshot, UICollectionViewCompositionalLayout, Auto Layout, NSLayoutConstraint, NSLayoutAnchor, UILayoutGuide, intrinsicContentSize。 UIArrangementViewController, UISplitArrangement, UIOverlayArrangement, UIView.ReservedRegion, UIHingeInteraction, 縦軸バー, iPhone Duo adaptive layout (iOS 27.1+), scene-based life cycle 移行, UISceneAccessory。SwiftUI ArrangementView とは別 API。

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Classify constitutional (germline) copy number variants for clinical reporting using the 2019 ACMG/ClinGen technical standards points-based framework, with ClassifyCNV and AnnotSV for semi-automated scoring. Covers the separate copy-number-loss and copy-number-gain rubrics, the five-tier classification, ClinGen haploinsufficiency/triplosensitivity and dosage-sensitive regions, de novo and segregation evidence, and population-frequency benign evidence. Use when assigning pathogenic/likely-pathogenic/VUS/likely-benign/benign to a constitutional CNV, scoring a CNV against ACMG/ClinGen criteria, or distinguishing the automatable evidence from the case-specific evidence requiring manual input.

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Detect, date, and contextualize whole-genome duplication (WGD / paleopolyploidy) events using wgd v2 (Chen & Zwaenepoel 2024), KsRates (Sensalari 2022 substitution-rate-corrected Ks dating), DupGen_finder (Qiao 2019), MAPS (Li 2018 phylogenomic), POInT (Conant 2008 ordered-block), SLEDGe (2024 ML-based), Whale.jl (Bayesian DTL+WGD), and synteny-anchored paranome construction. Use when identifying ancient polyploidy from Ks distributions and synteny block analysis, positioning WGD events relative to speciation, distinguishing tandem from segmental from WGD duplications, dating the 2R/3R vertebrate / fish / salmonid WGDs, building paranome and Ks-age mixture models, applying KsRates substitution-rate correction across lineages, or testing alternative biased-fractionation / dosage-balance models post-WGD.

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Model gene-family birth-death dynamics across a species tree using CAFE5 (Mendes et al 2020 Bioinformatics 36:5516 gamma-distributed rate categories), CAFE5-error (annotation-error-aware), Count (Csurös 2010 ancestral state reconstruction), BadiRate (Librado 2012 likelihood + parsimony), DupliPHY-Family, and ALE/AleRax (for per-family DTL; see [[gene-tree-species-tree-reconciliation]]). Test lineage-specific gene-family expansions and contractions, distinguish biological dynamics from annotation artifacts, account for assembly fragmentation, identify functional enrichment in expanded / contracted families. Use when correlating gene-family changes with phenotype evolution, ranking lineages by adaptive gene-family-rate shifts, post-WGD dosage-balance analysis, or building Birth-death models from OrthoFinder presence/absence matrices.

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Annotate copy number variant segments with overlapping genes, dosage-sensitivity scores, cancer driver databases, population frequencies, and clinical-variant content. Covers bedtools/pybedtools interval intersection, AnnotSV comprehensive annotation and ranking, ClinGen haploinsufficiency/triplosensitivity scoring, gnomAD-SV/DGV frequency filtering, COSMIC Cancer Gene Census, and ClinVar overlap. Use when interpreting which genes a CNV affects, distinguishing the driver gene of a focal event from passengers, filtering against population CNVs, separating whole-gene from partial-gene overlap, or preparing CNVs for clinical classification.

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Normalizes ChIP-seq data using exogenous spike-in (ChIP-Rx with Drosophila chromatin per Orlando 2014 / Egan 2016; E. coli carryover for CUT&RUN/CUT&Tag). Distinguishes RRPM from Rx-Input scaling, integrates with DiffBind / DESeq2 / edgeR / csaw via sizeFactors and DiffBind library-size vectors, and applies the Patel et al 2024 *Nat Biotechnol* review's failure-mode framework to validate that normalization is correctly applied at the read level (not peak counts). Use when global signal shifts are expected (HDACi, BETi, EZH2i, dosage, target knockdown), when ChIPseqSpikeInFree detects post-hoc shifts, or when validating internal-control regions before publication.

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Orientación legal y guía de procesos contractuales para el equipo de Vambe (Chile/MX). Usar SIEMPRE ante preguntas legales o de contratos: 'quiero enviar un contrato', 'cómo mando el NDA', 'el cliente quiere cambios', 'cliente M vs L', '¿me pueden demandar?', 'el cliente no paga', 'cómo finiquito a un empleado', 'protección de datos', 'qué le digo al cliente sobre sus datos', 'nos acusan de incumplimiento', 'me llegó carta de abogados', 'quién puede firmar', 'quién es dueño del código', o cualquier consulta sobre contratos, NDAs, reclamos, laboral, RRHH, PI o cumplimiento normativo.

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Genera tickets profesionales de soporte para Meta Business Suite / WhatsApp Business API optimizados para recibir prioridad URGENTE 24hr resolution. Úsala SIEMPRE que el usuario mencione crear un ticket a Meta, escalar un caso WABA, apelar un ban o restricción, reportar un false positive, abrir caso de soporte WhatsApp Business, problema de onboarding, rechazo de template, errores de Cloud API, OTP delivery, verification stuck, BM restricted, display name rejection, o cualquier issue de una WhatsApp Business Account. También activa cuando el usuario dice frases como "ayúdame a redactar un caso para Meta", "necesito reportar esto a soporte", "hay que escalar esto a WhatsApp", "ticket para Meta", o describe un problema de una cuenta de cliente de Vambe sin pedir ticket explícitamente pero claramente necesita uno. También activa ante preguntas del tipo "¿cómo apelar esto?" o "¿qué hago si Meta dice X?" relacionadas con WABA, BM o verificación.

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Automate Basecamp project management, to-dos, messages, people, and to-do list organization via Rube MCP (Composio). Always search tools first for current schemas.

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Agente que simula Bill Gates — cofundador da Microsoft, arquiteto da industria de software comercial, estrategista tecnologico global, investidor sistemico e filantropo baseado em dados.

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Meta-skill que orquestra todos os agentes do ecossistema. Scan automatico de skills, match por capacidades, coordenacao de workflows multi-skill e registry management.

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Core coding guidelines for iOS, iPadOS, macOS, watchOS, tvOS, and visionOS app development using SwiftUI and Swift. Use when implementing Views, working with @State/@Binding/@Observable/@StateObject, using NavigationStack/List/LazyVStack, designing components, or asking about SwiftUI patterns (infinite scroll, pull-to-refresh, search). Covers best practices, implementation patterns, and anti-patterns to avoid.

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Migration guide for Swift and iOS. Use when migrating ObservableObject to @Observable (iOS 17), enabling Swift 6/6.2 Strict Concurrency, fixing @MainActor/Sendable warnings, adopting Approachable Concurrency (Swift 6.2), or handling iPadOS 26 windowing system changes (UIRequiresFullScreen deprecation). Covers breaking changes and version upgrade tasks.

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Arquiva briefs, peças e aprendizados no Obsidian (pasta local) e no Notion (via MCP). Use quando o usuário disser "salvar no Obsidian", "arquivar", "registrar no Notion", "biblioteca de peças", "documentar a campanha", "onde ficou aquela peça". Obsidian é filesystem direto — não precisa de MCP.

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Compõe a peça final no Figma sobre os ativos gerados — texto, marca, layout e grid. Camada OPCIONAL: use quando houver Figma conectado e o time precisar do arquivo editável. Dispara em "montar no Figma", "compor a peça", "colocar o texto na imagem", "aplicar a marca", "arquivo editável". Sem Figma, entrega especificação de composição.

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Exporta peças aprovadas do Figma e monta o pacote de entrega — arquivos nomeados, legendas, texto alternativo e instruções de publicação. Use quando o usuário disser "exportar", "baixar as peças", "pacote final", "entregar para publicação", "handoff", "mandar para o social". Só exporta o que passou na revisão.

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Cria e mantém o contexto de criativos — Figma, brand kit, formatos ativos, geradores configurados e restrições. Use quando o usuário disser "configurar criativos", "setup do social", "cadastrar a marca", "qual o design system", "iniciar campanha", ou quando qualquer skill deste plugin não encontrar .claude/pwdev-social-context.md. É a fundação: toda skill lê este arquivo antes de perguntar.

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Use quando o usuário perguntar o estado da integração com o GitHub — 'status do github', 'qual project está configurado', 'o que já foi publicado' — gh, scopes, repo, Project e roadmaps publicados. Somente leitura.

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Leitura, escrita e edição estruturada de notas, busca, tags, arquivo ativo e comandos da paleta no Obsidian via MCP (plugin Local REST API). Use quando o usuário disser "Obsidian", "vault", "nota", "anotação", "criar nota", "buscar nota", "tag", "daily note", "frontmatter", "abrir arquivo no Obsidian", ou pedir para ler/editar/organizar conteúdo do vault.

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