'expression' 검색 결과

Normalizes and transforms RNA-seq count matrices for DE, visualization, clustering, and ML. Covers between-sample (TMM, TMMwsp, RLE/median-of-ratios, upper quartile), within-sample (TPM, FPKM/RPKM), variance-stabilizing (VST, rlog, log-CPM), GC-content correction (cqn, EDASeq), and single-cell (scran deconvolution, scanpy normalize_total). Encodes the composition-bias rationale, the "most genes not DE" assumption and its catastrophic failure modes (MYC amplification, apoptosis, viral host shutoff, prokaryotic stress), the "lengthScaledTPM is not TPM" naming trap, the "TPM is not for DE" rule, the blind=TRUE vs FALSE decision, ERCC spike-in normalization (SBN), and the single-cell zero-inflation breakdown of TMM/RLE. Use when choosing or applying normalization, debugging shifted-MA-plot diagnostics, handling zero-heavy single-cell data, or correcting GC bias.

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Calculates statistical power for high-dimensional genomics experiments (bulk RNA-seq, scRNA-seq, ATAC-seq, ChIP-seq, methylation, proteomics) under negative-binomial count models using RNASeqPower, PROPER, and simulation via powsimR, distinguishing per-gene from marginal (transcriptome-wide) power, the role of mean expression and dispersion, and the sequencing-depth-versus-replicate tradeoff. Covers simulation as the honest default for overdispersed counts, FDR-aware average power versus single-test power, observed/post-hoc power as an anti-pattern, and the winner's-curse / Type-S / Type-M consequences of underpowering. Use when planning replicate number for a sequencing experiment, deciding whether to add depth or samples, choosing closed-form versus simulation power, estimating power from pilot dispersions, or justifying replication in a grant. For clinical-trial power see clinical-biostatistics/power-and-sample-size; for the inverse sample-size question see experimental-design/sample-size.

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Plot per-group distributions of continuous data using boxplots, violins, beeswarms, quasirandom jitter, and raincloud plots with sample-size honesty (Weissgerber 2015), KDE-bandwidth awareness, and N-aware encoding choices. Use when comparing distributions across a small number of groups — expression per cluster, biomarker per arm, scores per condition — and the bar-of-mean default is misleading.

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Visualize biological networks (PPI, gene-regulatory, co-expression, pathway) with layout algorithm choice (ForceAtlas2, Fruchterman-Reingold, Kamada-Kawai, hive plots), edge bundling, community-based coloring, and reproducible seeds using NetworkX, PyVis, igraph, and Cytoscape automation. Use when rendering biological networks for static publication, interactive HTML exploration, or Cytoscape-format export.

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Performs gene-level association from GWAS summary statistics via genetically predicted tissue expression using FUSION, PrediXcan, S-PrediXcan, S-MultiXcan, UTMOST, MOSTWAS, kTWAS, EpiXcan, TIGAR-V2, and probabilistic fine-mapping with FOCUS and MA-FOCUS. Use when running TWAS from GWAS sumstats, prioritising candidate causal genes from a GWAS lead locus, picking single-tissue vs cross-tissue models, identifying LD-induced TWAS false positives, choosing ancestry-matched prediction weights, fine-mapping co-regulated TWAS hits, or triangulating TWAS with cis-eQTL Mendelian randomization and colocalization to nominate a causal gene.

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Decompose total effects into direct and indirect paths through mediators using mediation, CMAverse 4-way, HIMA/HIMA2 high-dimensional, BAMA, two-step / MVMR mediation, or double-ML medDML. Use when testing whether a molecular phenotype (expression, methylation, protein) mediates a treatment-outcome relationship, decomposing exposure-mediator interaction via VanderWeele 4-way, screening high-dimensional EWAS mediators, or running MR-based mediation when sequential ignorability is implausible.

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Provides bidirectional translation (Chinese/English), grammar checking, and sentence polishing. Supports specific tense constraints, context-aware tone adjustment, and natural expression optimization. Outputs direct text without formatting.

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Debug failing Power Automate cloud flows using the FlowStudio MCP server. The Graph API only shows top-level status codes. This skill gives your agent action-level inputs and outputs to find the actual root cause. Load this skill when asked to: debug a flow, investigate a failed run, why is this flow failing, inspect action outputs, find the root cause of a flow error, fix a broken Power Automate flow, diagnose a timeout, trace a DynamicOperationRequestFailure, check connector auth errors, read error details from a run, or troubleshoot expression failures. Requires a FlowStudio MCP subscription — see https://mcp.flowstudio.app

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Using records, pattern matching, primary constructors, collection expressions. C# 12-15 by TFM.

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Scans GitHub Actions workflows and CI/CD pipeline configurations for supply chain attack vectors including unpinned actions, script injection via expressions, dependency confusion, and secrets exposure. Uses PyGithub and YAML parsing for automated audit. Use when hardening CI/CD pipelines or investigating compromised build systems.

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Parse Windows PowerShell Script Block Logs (Event ID 4104) from EVTX files to detect obfuscated commands, encoded payloads, and living-off-the-land techniques. Uses python-evtx to extract and reconstruct multi-block scripts, applies entropy analysis and pattern matching for Base64-encoded commands, Invoke-Expression abuse, download cradles, and AMSI bypass attempts.

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Hunt Spring Boot specific vulnerabilities — Actuator endpoints (heapdump, env, loggers, mappings, shutdown), Spring Expression Language (SpEL) injection → RCE, H2 console RCE, Jolokia JMX exposure, Spring4Shell (CVE-2022-22965), Spring Cloud Function SPEL (CVE-2022-22963), heap dump credential extraction. Use when target runs Spring Boot — detected via X-Application-Context header, /actuator, Whitelabel Error Page, or Java stack traces.

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Comprehensive CI/CD pipeline exploitation methodology covering GitHub Actions injection vectors (expression injection via PR titles and issue bodies, workflow_run event abuse, GITHUB_TOKEN over-scoping, composite action supply chain compromise), Jenkins attack paths (Groovy sandbox escapes, script console remote code execution, Java remoting deserialization, credential store dumping, shared library injection), GitLab CI exploitation (YAML anchor injection, runner registration token abuse, CI variable extraction, protected branch bypass via merge request pipelines), and Azure DevOps pipeline agent compromise with service connection theft. Includes artifact poisoning techniques across all platforms, tooling guidance for gato and jenkins-attack-framework, and maps to MITRE ATT&CK T1195.002 (Supply Chain Compromise: Compromise Software Supply Chain). Covers enumeration of pipeline configurations, privilege escalation from contributor to code execution, lateral movement through pipeline trust boundaries, and p...

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Detect Regular Expression Denial of Service (ReDoS) where crafted input causes catastrophic backtracking in regex patterns applied to user-controlled strings.

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