'report' 검색 결과

Constructs and validates polygenic risk scores using LDpred2-auto, SBayesRC, MegaPRS, PRS-CS, PROSPER, MUSSEL, BridgePRS, JointPRS, PRSmix, or PGS Catalog Calculator with ancestry-aware reference panels (HapMap3, UKB-LD), Pejaver-style calibration, and PRS-RS reporting standards. Use when computing PRS for cohorts, applying Whiffin-style absolute-risk transformation, assessing cross-ancestry portability (Martin 2017 / Ding 2023 continuous ancestry), or auditing PRS manuscripts against the 22-item PRS-RS reviewer checklist.

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Prioritizes rare-disease variants from trio/quad WES/WGS with de novo (DeNovoGear, Triodenovo), compound-heterozygous phasing (WhatsHap), mosaic VAF tiering, phenotype-driven ranking (Exomiser, Phen2Gene, AMELIE), ClinGen gene-disease validity gating, and ACMG SF v3.2 secondary findings reporting. Use when running diagnostic exome / genome pipelines, identifying candidate Mendelian disease genes, screening for incidental findings, or auditing VUS reclassification cycles. The ACMG/AMP classification framework (PVS1 decision tree, Pejaver PP3/BP4 calibration, Tavtigian point system) is in clinical-databases/acmg-classification.

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Calculates tumor mutational burden from WES/WGS/panel data with Friends of Cancer Research harmonization equations, per-assay calibration (FDA 10/Mb = 7.8 TSO500 = 8.4 OncomineTML), synonymous/indel/germline filtering, hypermutator tiering, blood TMB, and integration with HLA-LOH and neoantigen quality (Luksza 2017 fitness). Use when assessing ICI eligibility under tumor-specific cutoffs (McGrail 2021), comparing tissue vs bTMB, or auditing TMB-H reporting against ESMO 2024 and FDA pembrolizumab pan-tumor 2020.

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Performs logistic regression for clinical trial outcomes (binary, ordinal, multinomial) with marginal-vs-conditional estimand reporting per FDA 2023 covariate adjustment guidance, g-computation/standardisation for marginal effects, modified Poisson for RR, Brant test for proportional odds, Firth penalty for separation, and Hauck-Donner detection. Use when modeling binary or ordinal endpoints in confirmatory or exploratory clinical trials.

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Detects differential alternative splicing between conditions using rMATS-turbo (binomial LRT on junction counts), leafcutter (Dirichlet-multinomial GLM on intron clusters), MAJIQ V3 deltapsi/HET (Bayesian posterior on LSVs), SUPPA2 (empirical-null on TPM-derived PSI), or Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage). Reports FDR-corrected significance and delta PSI effect sizes. Tools differ in statistical model, annotation dependence, calibration regime, and replicate-count requirements. Use when comparing splicing patterns between treatment groups, tissues, or disease states.

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Generate alignment statistics using samtools flagstat, stats, depth, coverage, and mosdepth. Use when assessing alignment quality, calculating coverage, or generating QC reports.

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Run a structured code review — produces a Review Report with CRITICAL, WARNING, and SUGGESTION findings; CRITICAL findings block merge.

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Run technical quality checks across accessibility, performance, theming, responsive design, and anti-patterns. Generates a scored report with P0-P3 severity ratings and actionable plan. Use when the user wants an accessibility check, performance audit, or technical quality review.

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docs (editable docs people share and comment on; the default for any document, named as a doc or not: a document, report, proposal, resume, cover letter, letter, contract, policy, form, template, worksheet, essay, handbook, guide, how-to, cheat sheet, SOP or other writing to keep, share, collaborate on, send, submit, print or sign; a doc exports to Word, PDF, Markdown or Google Docs, so needing a file to send, attach, upload, submit or print is no reason to pick Word, and a file nobody asked for is a doc, not Word; a plan, comparison, summary or notes asked in chat stays in chat; a pasted claude.ai artifact link may be a doc: check with docs tools first; Word or another file format named, tracked changes wanted, or a .docx to change or use as a template → that format's skill): making one → if no docs-connector instructions are in context, call its `guide` (topic.instructions) first; then create the doc (headings only, no body) before any search, file read or plan, even with files attached.

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Use this skill whenever the user wants to create, read, edit, or manipulate Word documents (.docx) or Word templates (.dotx). Triggers include: any mention of Microsoft Word Documents, such as 'Word doc', 'word document', '.docx', '.dotx', 'microsoft doc'. Also use when extracting or reorganizing content from .docx or .dotx files, inserting or replacing images in documents, find-and-replace in Word files, working with tracked changes or comments, or converting content into a polished Word document. If the user asks for a deliverable as a Word or .docx file (to download, email or print), use this skill. However, if they ask for a document, page, report, memo, or notes WITHOUT naming a file format and the session offers Claude's own dedicated document or page skill or connector, use that instead, even if they will email or print it. Do NOT use for PDFs, spreadsheets, Google Docs, or coding unrelated to document generation.

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Scan a codebase for deepening opportunities, present them as a visual HTML report, then grill through whichever one you pick.

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Use this skill any time a spreadsheet file is the primary input or output. This means any task where the user wants to: open, read, edit, or fix an existing .xlsx, .xlsm, .xltx, .csv, or .tsv file (e.g., adding columns, computing formulas, formatting, charting, cleaning messy data); create a new spreadsheet from scratch or from other data sources; or convert between tabular file formats. Trigger especially when the user references a spreadsheet file by name or path — even casually (like "the xlsx in my downloads") — and wants something done to it or produced from it. Also trigger for cleaning or restructuring messy tabular data files (malformed rows, misplaced headers, junk data) into proper spreadsheets. The deliverable must be a spreadsheet file. Do NOT trigger when the primary deliverable is a Word document, HTML report, standalone Python script, database pipeline, or Google Sheets API integration, even if tabular data is involved.

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Use this skill when the user's prompt requires (1) researching a topic across multiple sources, comparing options or alternatives, analyzing trends or history, understanding markets or industries, or reviewing literature or studies and (2) synthesizing that research into a comprehensive, narrative report. If you're planning to search the web or internal knowledge bases, consider using this skill. This skill coordinates research subagents, so use it only when you have a tool for spawning subagents (the Agent or Task tool); otherwise, research the question directly.

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Run Playwright tests at scale with cloud-hosted browsers and integrated Azure portal reporting.

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Send SMS messages with Azure Communication Services SMS Java SDK. Use when implementing SMS notifications, alerts, OTP delivery, bulk messaging, or delivery reports.

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XML-specified Android UI journey testing, interactive step execution, assertion verification, and JSON outcome reporting.

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Diff a live page's accessibility violations against a baseline — by default compares uncommitted changes (stash-based), or pass --branch [<name>] to diff against a branch. Reports only new violations introduced, violations fixed, and pre-existing count. Use `scan` for a full audit with no diffing.

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Evaluates LLMs across 60+ academic benchmarks (MMLU, HumanEval, GSM8K, TruthfulQA, HellaSwag). Use when benchmarking model quality, comparing models, reporting academic results, or tracking training progress. Industry standard used by EleutherAI, HuggingFace, and major labs. Supports HuggingFace, vLLM, APIs.

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Conduct multi-round deep research on any GitHub Repo. Use when users request comprehensive analysis, timeline reconstruction, competitive analysis, or in-depth investigation of GitHub. Produces structured markdown reports with executive summaries, chronological timelines, metrics analysis, and Mermaid diagrams. Triggers on Github repository URL or open source projects.

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Supply chain investigation, evidence recovery, and forensic analysis for GitHub repositories. Covers deleted commit recovery, force-push detection, IOC extraction, multi-source evidence collection, hypothesis formation/validation, and structured forensic reporting. Inspired by RAPTOR's 1800+ line OSS Forensics system.

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Comprehensive end-to-end validation of the Archon Web UI using browser automation and codebase review. Use when: User wants to validate, test, or audit the Archon web interface, find UI/UX bugs, test workflow management, verify parallel agent orchestration, or run comprehensive browser-based E2E tests. Triggers: "validate ui", "test the ui", "e2e test", "browser test", "validate archon", "test archon ui", "ui audit", "ux review", "comprehensive test", "validate everything". Capability: Starts Archon, runs exhaustive browser automation tests via agent-browser CLI, performs codebase review, and produces a detailed bug/UX report. NOT for: Unit tests (use `bun test`), CLI-only validation (use /validation:validate-simple).

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The PRIMARY development workflow for the Archon project (remote-coding-agent). Use this skill instead of any PRP skills when working on Archon code. Routes to 10 specialized cookbooks based on what the user is trying to do: RESEARCH — "how does the orchestrator work?", "where is session state defined?", "trace the workflow execution flow", "what is IWorkflowStore?" INVESTIGATE — "should we use Drizzle or Prisma?", "what's the best way to add WebSockets?", "can we migrate to Turso?", "how do other projects handle rate limiting?" PRD — "write a PRD for dark mode", "spec out the notification feature", "product requirements for webhook retry" PLAN — "plan the auth refactor", "design the caching layer", "create an implementation plan for #42" IMPLEMENT — "implement the plan", "execute .claude/archon/plans/auth.plan.md", "build the feature from the plan", "code this up" REVIEW — "review PR #123", "review my changes", "code review the diff" DEBUG — "debug the failing test", "why is streaming broken?", "root cause analysis on the timeout issue" COMMIT — "commit these changes", "commit the auth refactor" PR — "create a PR", "open a pull request for this branch" ISSUE — "report this to gh", "create a gh issue", "log it in github", "file a bug for this", "create a feature request" This skill triggers on ANY development task: researching, investigating, planning, building, reviewing, debugging, committing, or shipping code. NOT for: Running Archon CLI workflows in worktrees (use /archon instead).

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Verify a released archon binary works end-to-end via a specific install path. Use when: cutting a new release, reproducing a user bug report on the released version, or validating that a hotfix binary actually works after a re-tag. Triggers: "test the release", "test 0.3.1 via brew", "verify the curl install", "smoke test the binary", "did the release binary work", "run /test-release", "verify the release". NOT for: testing dev work (use bun link directly), testing unreleased changes (build locally via scripts/build-binaries.sh first), or running the full validate suite (bun run validate is separate).

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Migrate a user's OpenClaw customization footprint into Hermes Agent. Imports Hermes-compatible memories, SOUL.md, command allowlists, user skills, and selected workspace assets from ~/.openclaw, then reports exactly what could not be migrated and why.

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