AI-powered design of armored CAR-T cells with cytokine/chemokine expression for enhanced solid tumor efficacy, including IL-12, IL-15, IL-18, and IL-7 armoring strategies.
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AI-powered design of armored CAR-T cells with cytokine/chemokine expression for enhanced solid tumor efficacy, including IL-12, IL-15, IL-18, and IL-7 armoring strategies.
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Deploy and configure web frameworks on Netlify — build settings and SSR/edge adapters plus local platform emulation and env vars. Use when setting up or fixing a framework deploy (Next.js / Astro / Nuxt / SvelteKit / Remix / React Router / TanStack Start / SolidStart / Gatsby / Angular / Vite / Express / Hydrogen / Hugo / Eleventy / Vue / React), adding SSR or edge functions or middleware wired to Netlify context, fixing SPA redirect and catch-all rules, setting a build command or publish directory, or debugging "why isn't my env var updating" and framework build failures.
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Expert en clean architecture (use cases, entities, interface adapters, dependency inversion)
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Modern SwiftUI patterns for iOS 18+, including @Observable, navigation, state management, and view composition following SOLID principles
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Extract and consolidate reusable components, design tokens, and patterns into your design system. Identifies opportunities for systematic reuse and enriches your component library. Use when the user asks to create components, refactor repeated UI patterns, build a design system, or extract tokens.
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Use when: Good night Team, EOD, Wrapping up, or end-of-day consolidation. Archives session context, promotes durable patterns, and compacts live agent memory files for the next session.
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Expert blockchain developer specializing in smart contract development, DApp architecture, and DeFi protocols. Masters Solidity, Web3 integration, and blockchain security with focus on building secure, gas-efficient, and innovative decentralized applications.
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Code review: IoC, RESTful, Contracts, Security (OWASP), Clean Architecture, SOLID.
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Reflective pass over your memory files — merge duplicates, fix stale facts, prune the index.
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Produce a single consolidated hardening report for the DSH node. Runs audit.sh, dome-check.sh, and machine-probe.py, parses their outputs, and writes one markdown file listing every passing check, every failure with a specific remediation command, and a top-line verdict (ALL GREEN / N ISSUES). Non-destructive — reads only, no auto-fix.
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Consolidate PostHog error tracking issues that are the same actual error reported under different fingerprints. Use when the user asks "why do I have so many TypeError issues that look the same?", "merge these duplicates", "stop splitting this error into new issues", or wants to clean up fingerprint sprawl. Decides between a one-shot merge of existing issues and a durable grouping rule that keeps future events from creating new fingerprints. Does NOT group conceptually similar bugs across different runtimes, SDKs, or call sites.
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Extract reusable components, product patterns, and design tokens into a clearer design system with shared APIs, documented defaults, and better reuse. Use when the user wants to refactor repeated UI, consolidate buttons/cards/forms/sections, build a component library, or turn one-off values into reusable tokens.
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Stryker-driven test cull: delete slop, consolidate redundants, fill mutation-coverage gaps. Score up, test count and lines down. Use when the user says 'trim tests', '/trim-tests', or wants to clean up LLM-generated test bloat. No args picks the worst-scored file; argument scopes to a section, service, or file.
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Generate composited images from layers — solid colors, gradients, text, images, QR codes, barcodes, and layouts.
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Ark UI headless / unstyled コンポーネントライブラリ。Zag.js ベース、Chakra UI v3 基盤。 React / Solid / Vue / Svelte 対応。asChild, RootProvider, createListCollection, createTreeCollection, Presence hideMode, useHotkey / useHotkeys, data-* セレクタ。 Navigation Menu, TOC, Tour, Signature Pad, Image Cropper, Floating Panel, Angle Slider 等のコンポーネント API。
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CadQuery (Python 製 3D CAD スクリプティングライブラリ) リファレンス。 Workplane API (lineTo / extrude / revolve / sweep / loft / fillet / chamfer / shell)、 Sketch API、Assemblies (Constraint solver)、Free Function API (hollow / prism / draft / offset2D, History)、 Selectors、Shape / Vertex / Edge / Wire / Face / Shell / Solid、 Import / Export (STEP / DXF / STL / glTF / SVG)、Visualization (VTK, cadquery.fig 非ブロッキング, Jupyter)、CQGI。
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Assembles microbial-community sequencing into metagenome-assembled genomes (MAGs) with metaFlye (ONT), metaSPAdes/MEGAHIT (Illumina), and hifiasm-meta/metaMDBG (PacBio HiFi), then recovers genomes via multi-binner consolidation (MetaBAT2, MaxBin2, CONCOCT, SemiBin2, VAMB -> DAS_Tool) and QCs them against MIMAG with CheckM2, GUNC, and GTDB-Tk. Covers why a metagenome is not a genome (uneven coverage, micro-diversity, strain collapse to consensus), differential-coverage binning, co-assembly vs per-sample, the rRNA-operon collapse that fails short-read MAGs, and strain resolution with inStrain. Use when reconstructing genomes from a microbiome, soil, ocean, or gut community, recovering MAGs, or resolving strain-level variation.
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Calls HLA class I and class II alleles at 2/4/6/8-field resolution from WGS/WES/RNA-seq/long-read data using OptiType, HLA-LA, T1K, Polysolver, HLA-HD, arcasHLA, StarPhase, or HIBAG imputation. Use when typing for HSCT, solid-organ transplant, neoantigen prediction, PGx screening (B*57:01, B*15:02, etc.), or disease-association studies, with reconciliation across tools and IPD-IMGT/HLA version mismatch handling.
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Refactor Spring Boot and Java code to improve maintainability, readability, and adherence to enterprise best practices. This skill transforms messy Spring Boot applications into clean, well-structured solutions following SOLID principles and Spring Boot 3.x conventions. It addresses fat controllers, improper transaction boundaries, field injection anti-patterns, and scattered configuration. Leverages Java 21+ features including record patterns, pattern matching for switch, virtual threads, and sequenced collections.
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Extract and consolidate reusable components, design tokens, and patterns into your design system. Identifies opportunities for systematic reuse and enriches your component library. Use when the user asks to create components, refactor repeated UI patterns, build a design system, or extract tokens.
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Targeted deep research to fill a specific gap in an existing thesis. Use when user says "deepen", "flesh out", "expand on", "fill in", or specifies a thesis section to improve. Also supports --sync-metrics mode — detects stale financial metrics across every in-scope analytical section of a thesis (not just Key Metrics or Summary) and coherently updates every sentence that depends on them, using a Key-Metrics-table / FMP / web-search waterfall. Use when user says "sync metrics", "update the numbers throughout the note", or "fix stale figures across the whole thesis". The batch form `--sync-metrics --all-flagged` syncs every thesis flagged by the latest `/numbers --all-open` in one operation — detection fanned out to capped READ-ONLY agents, one consolidated confirmation gate, direct sequential writes (agents never write).
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Targeted deep research to fill a specific gap in an existing thesis. Use when user says "deepen", "flesh out", "expand on", "fill in", or specifies a thesis section to improve. Also supports --sync-metrics mode — detects stale financial metrics across every in-scope analytical section of a thesis (not just Key Metrics or Summary) and coherently updates every sentence that depends on them, using a Key-Metrics-table / FMP / web-search waterfall. Use when user says "sync metrics", "update the numbers throughout the note", or "fix stale figures across the whole thesis". The batch form `--sync-metrics --all-flagged` syncs every thesis flagged by the latest `$numbers --all-open` in one operation — detection fanned out to capped READ-ONLY agents, one consolidated confirmation gate, direct sequential writes (agents never write).
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A playful, arcade-inspired interface for games — built on the VT323 pixel typeface, hard-edged 0px corners, chunky pill buttons that physically press into solid offset blocks
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Read-only consolidated snapshot of an SDD Composy workspace: lifecycle stage, task contracts, trace integrity, loops, fleets, and the next action, without changing any file. Use for 'em que pé está o SDD', 'status do fluxo', 'qual a próxima ação', 'where are we in the workflow'. Do NOT use for git, CI, infrastructure, or other plugins' status, or to change state.
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