'sha' 검색 결과

Runs cis-pQTL Mendelian randomization for drug-target validation using UKB-PPP (Olink), deCODE (SomaScan), Fenland, INTERVAL, ARIC, and FinnGen-PPP proteomes plus colocalization triangulation, phenome-wide on-target adverse-effect scans, cross-platform Olink/SomaScan replication, and PAV (protein-altering variant) sensitivity. Use when nominating or de-risking a drug target from plasma-proteome GWAS, mimicking pharmacological inhibition via cis-pQTL instruments, separating shared-causal from LD-confounded signal under the Schmidt 2020 cis-MR framework, screening on-target adverse phenotypes pheWAS-style, or producing publication-grade STROBE-MR plus PP.H4 evidence for a target gene.

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Detect and adjust for horizontal pleiotropy in two-sample Mendelian randomization by distinguishing uncorrelated (UHP) from correlated (CHP) pleiotropy and choosing among Egger, MR-PRESSO, MR-RAPS, CAUSE, LHC-MR, LCV, MR-Clust, MR-Mix, and contamination-mixture methods. Use when validating an MR causal claim, running the STROBE-MR sensitivity battery, suspecting a shared heritable confounder, working under weak-instrument or polygenic-exposure regimes, or reconciling discordant estimates across robust methods.

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Fits structural equation models to GWAS summary statistics using GenomicSEM (Grotzinger 2019), including common-factor models, confirmatory factor models, ESEM, common-factor GWAS with Q_SNP heterogeneity, multivariate Wald tests, and stratified GenomicSEM partitioned heritability. Reconciles results against MTAG multi-trait analysis. Handles sample overlap via the LDSC sampling-covariance matrix, identifies and resolves Heywood cases, and verifies model fit with CFI / RMSEA. Use when modeling latent genetic architecture across correlated traits, running multivariate GWAS on a shared factor, distinguishing factor-mediated from trait-specific SNP effects, or comparing GenomicSEM common-factor results against MTAG when both depend on accurate sampling covariance.

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Estimate bivariate genetic correlation (rg) between traits from GWAS summary statistics or individual-level genotypes using cross-trait LDSC, HDL, LAVA, rho-HESS, GREML-bivariate, Popcorn, and HDL-L. Use when quantifying shared genetic architecture between two traits, screening MR validity before causal inference, distinguishing global from locus-level rg, estimating trans-ancestry rg, separating partial from full causation via LCV gcp, or producing a STROBE-MR-compliant cross-trait sensitivity battery. Cross-trait LDSC intercept absorbs sample overlap and is NOT a bias; HDL is biased under sample overlap above ~5%. High rg between exposure and outcome motivates CHP-aware MR sensitivity (CAUSE, LHC-MR).

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集群数据管理 Skill —— 涵盖数据使用规范、压缩优化、数据共享（ACL）、文件扫描与清理、文件完整性校验、genozip 基因组压缩等全流程。Use when the user asks about: managing data on the HPC cluster, compressing genomic files (fq/bam/vcf), sharing data between users/groups, scanning for large files or cleaning up disk space, checking file integrity (md5/gzip/bam), using genozip, checking disk quota, or any data lifecycle management task on the NCPGR HPC cluster.

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Use this skill when the user asks about driver ergonomics — back/neck/shoulder injury prevention, seat adjustment + lumbar support, entering and exiting cab safely, load handling techniques, vibration reduction, stretching protocols, and how ergonomics affects workers compensation costs in trucking. Reference OSHA + ATA ergonomics research.

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Use when a carrier needs to build an internal dispatcher training program, onboard new dispatchers, or certify dispatcher competency. Covers job description, required skills, training modules, certification frameworks (CDS, CTP), shadowing, evaluation, and career path.

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Use this skill when the user asks about cybersecurity for a trucking carrier — protecting ELD data, customer information, financial systems, EDI integrations, fleet telematics, ransomware risk, vendor / shipper data sharing, incident response, and FMCSA cyber-recommendations. Reference NIST + CISA cybersecurity frameworks.

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Digital equity and trauma-informed design for marginalized populations. Activate on "accessibility", "offline-first", "trauma-informed", "reentry", "recovery population", "shared device", "unstable phone", "digital equity", "design justice", "low-literacy", "intermittent access". NOT for general UX, marketing optimization, or enterprise SaaS design.

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Choose, compare, and decompose work into the right coordination topology: dag, workflow, manager-driven team, swarm, blackboard, team-builder, or recurring loop. Use when the coordination shape is unclear, when you need topology-native breakdown instructions instead of a generic DAG, or when planning topology and runtime topology may differ. NOT for actual execution, node-level skill matching, or framework/tool installation.

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Use when designing or fixing a Content Security Policy on a real site, choosing between nonce-based and hash-based CSP, adding strict-dynamic, debugging "Refused to execute inline script" errors, deploying CSP in report-only mode first, configuring report-to / report-uri, or auditing an existing policy for unsafe-inline / unsafe-eval / wildcards. Triggers: "CSP blocks legitimate inline script", strict-dynamic, nonce-{RANDOM}, sha256-{HASH}, object-src none, base-uri none, frame-ancestors, Trusted Types, X-Content-Security-Policy obsolete, report-only vs enforced. NOT for general HTTP security headers (HSTS, COOP/COEP), Trusted Types deep dive, CORS configuration, or building a WAF.

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Treat tokens as a coding swarm's cost-of-goods-sold and legibility engine while accounting for finite subscription allowance when per-call price is unknown. Covers provider windows, remaining-usage evidence, burn forecasts, preemptive checkpoint/model switching, per-agent budgets, compaction, shared digests, context degradation, and spend metering. Activate on: "token budget", "context budget", "compaction strategy", "briefing as compression", "context rot", "summarization collapse", "COGS for agents", "subscription usage remaining", "five-hour or weekly limit", "burn forecast", "model switch before limit", or "/context-economics-for-agent-swarms". NOT for: memory architecture (use always-on-agent-architecture), single-prompt wording (use prompt-engineer), mechanism-design proofs (use nisan-et-al-2007-algorithmic-game-theory), physical containment (use sandboxed-adversarial-test-harness), or production rebodiment and fencing (use agent-resurrection-and-body-continuity).

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Marketing and promotion specialist for Claude ecosystem technology - MCP servers, skills, plugins, and agents. Expert in community engagement, registry submissions, content marketing, and developer relations. Activate on 'promote MCP', 'share skill', 'market plugin', 'launch agent', 'developer marketing', 'MCP registry'. NOT for creating MCPs/skills (use agent-creator), general marketing (use content-marketer), or SEO optimization (use seo-visibility-expert).

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Designing HTTP cache headers that work correctly across browsers, CDNs, and shared proxies — `Cache-Control` directives per RFC 9111, `stale-while-revalidate` and `stale-if-error` per RFC 5861, the Vary header for varying responses, and surrogate keys for tag-based purging. Grounded in IETF RFCs and Cloudflare/Fastly docs. NOT for service-worker or browser-only caching, Redis/memcached application caching, or edge-function compute.

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Collage as a web design aesthetic — overlapping elements, mixed media, cut-out shapes, scrapbook layouts, and editorial magazine spreads adapted for the web. CSS techniques for layered compositions using z-index stacking, clip-path, mix-blend-mode, parallax layering, and grid-breaking layouts. Activate on 'collage web', 'editorial layout', 'magazine layout', 'overlapping elements', 'scrapbook', 'cut-out aesthetic', 'mixed media web', 'layered composition', 'grid-breaking', 'editorial web design', 'fashion website layout', 'David Carson'. NOT for photo collage/gallery grids (use collage-layout-expert), maximalist density (use maximalist-web-design), neobrutalism (use neobrutalist-web-designer).

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Audits an Articles of Agreement contract — the daemon-witnessed agreement every official Port Daddy agent signs covering registration, transcript reporting, tool-use gating, file claims, parley conduct, budget limits, and operator control — against the enforcement-beats-hope bar: a clause counts as safe only when it resolves to a concrete, daemon-observable mechanism with a defined denial shape, never a promise the agent might honor. Use when drafting a new agent's Articles, reviewing a compliance-level (C0-C6) claim, deciding whether a clause is genuinely enforced or merely documented, or auditing whether an agent's claimed identity can be trusted. NOT for securing the inbound event-to-spawn path (fleet-event-spawn-trust), designing the relay's transport PKI and signing keys (pd-relay-zero-trust), or tracking an agent's identity and reputation across its whole lifetime after it signs (agent-identity-continuity-reputation).

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Discipline an AI agent needs to work an issue/task tracker (Jira, Linear, GitHub Issues) as the shared source of truth: pull the right next item instead of inventing work, search before creating to avoid duplicates, write actionable items with checkable acceptance criteria, keep status transitions honest, and link work to items via branches/PRs/commits so progress is legible. Use when an agent picks up tracker work, files a new issue, updates status, or closes an item. NOT for authoring the PR itself (use agent-pr-authoring), roadmap-level planning and prioritization (use legible-roadmap-with-sidequests), or the mechanics of multiple agents coordinating on the same codebase (use multi-agent-coordination).

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Design a normalized, machine-readable "work receipt" that answers what changed, why, by whom, and with what validation, for any AI-coding-agent task regardless of backend (Claude Code, Codex, Cursor, Aider, CI, or homegrown). Use when defining a receipt schema, normalizing heterogeneous agent logs into one evidence shape, gating PR merges on artifact-backed proof, or designing an OSS maintainer's fast-reject/fast-merge workflow. NOT for validating a DAG node's output against its own schema (use output-contract-enforcer), continuous runtime monitoring of a live coordination daemon (use runtime-verification-for-agents), or general Port Daddy claims/notes/salvage mechanics (use port-daddy-agent-skill).

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Design discovery, directories, and guilds for agent swarms at scale. Use when agents need to find each other on a shared surface: capability indices, yellow-pages directories, whois/phonebook routing, reputation-aware discovery, and guild structures that scope trust. Covers the canonical prior art (FIPA Directory Facilitator, Contract Net, Chord/DHT, DNS-SD/Consul, EigenTrust, Greif's merchant guilds) and the failure modes (read-poverty, Sybil reset, Goodhart on rank, directory staleness, cold-start). Triggers: "agents can't find each other", "who owns this file/skill", "route a question to the right agent", "capability registry", "agent reputation", "guild / federation of fleets". NOT for issuing identities, granting authority, or automatically assigning work from a directory entry.

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Use when the user wants to design, redesign, shape, critique, audit, polish, clarify, distill, harden, optimize, adapt, animate, colorize, extract, or otherwise improve a frontend interface. Covers websites, landing pages, dashboards, product UI, app shells, components, forms, settings, onboarding, and empty states. Handles UX review, visual hierarchy, information architecture, cognitive load, accessibility, performance, responsive behavior, theming, anti-patterns, typography, fonts, spacing, layout, alignment, color, motion, micro-interactions, UX copy, error states, edge cases, i18n, and reusable design systems or tokens. Also use for bland designs that need to become bolder or more delightful, loud designs that should become quieter, live browser iteration on UI elements, or ambitious visual effects that should feel technically extraordinary. Not for backend-only or non-UI tasks.

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SE Ranking AI visibility analyst (extension). Tracks AI Share-of-Voice across ChatGPT, Gemini, Perplexity, AI Overviews, and AI Mode in a single query.

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Doctrine for fixing TypeScript errors against generated types (database.types.ts, api-types.ts). Use when fixing tsc or type-check failures or a type-errors batch, writing supabase .rpc()/.from() calls or DB shape guards, errors mention Json/unknown/Database, or you are tempted to cast or suppress.

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One-route pattern: public marketing landing plus signed-in workspace. Use when creating or fixing a landing page or a feature's front door, guests see an error, 'make /X work signed out', signed-in users land on a pitch, or ModuleLanding / AuthedWorkspaceCTA. NOT for (public) share viewers or free tools.

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Next.js route metadata, per-route favicons, OpenGraph, and Twitter cards. Use when adding a route or layout, adding a favicon or social share image, auditing missing metadata, naming tab titles, or touching createRouteMetadata, createDynamicRouteMetadata, generateFaviconMetadata, or titlePrefix.

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