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cccskills

'distribution' 검색 결과

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Annotate CLIP-seq peaks or crosslink sites to RNA features (5'UTR, CDS, 3'UTR, intron, splice junction, snoRNA, tRNA, ncRNA, repeat elements) with ChIPseeker, RCAS, RBP-Maps (Yeo splicing regulatory maps), and bedtools, applying feature-priority hierarchies, transcript-context resolution, and metagene aggregation. Use when characterizing where in transcripts an RBP binds, comparing peak distribution across regions, generating splicing-regulatory maps relative to alternative-splicing events, or distinguishing exonic vs intronic vs UTR binding.

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peacezha/HPClaw32026년 10월 11일 업데이트

Detect, date, and contextualize whole-genome duplication (WGD / paleopolyploidy) events using wgd v2 (Chen & Zwaenepoel 2024), KsRates (Sensalari 2022 substitution-rate-corrected Ks dating), DupGen_finder (Qiao 2019), MAPS (Li 2018 phylogenomic), POInT (Conant 2008 ordered-block), SLEDGe (2024 ML-based), Whale.jl (Bayesian DTL+WGD), and synteny-anchored paranome construction. Use when identifying ancient polyploidy from Ks distributions and synteny block analysis, positioning WGD events relative to speciation, distinguishing tandem from segmental from WGD duplications, dating the 2R/3R vertebrate / fish / salmonid WGDs, building paranome and Ks-age mixture models, applying KsRates substitution-rate correction across lineages, or testing alternative biased-fractionation / dosage-balance models post-WGD.

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peacezha/HPClaw32026년 10월 11일 업데이트

Detect horizontal gene transfer (HGT / LGT) using compositional methods (GC%, codon usage, tetranucleotide z-scores via SIGI-HMM, AlienHunter, IslandViewer 4, IslandPath-DIMOB), phylogenetic-incongruence methods (AvP, HGTphyloDetect, ALE / GeneRax / AleRax reconciliation, RANGER-DTL), and BLAST-distribution methods (HGTector v2, DarkHorse, Alien Index). Use when screening prokaryote genomes for genomic islands and HGT events, distinguishing HGT from incomplete lineage sorting / differential gene loss / hybridization, mapping donor lineages via phylogenetic placement, separating eukaryotic HGT from contamination, ruling out gBGC as a false signal, or quantifying DTL rates with ALE/GeneRax on bacterial trees.

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peacezha/HPClaw32026년 10월 11일 업데이트

Segments the genome into chromatin states from combinatorial histone modification and chromatin factor ChIP-seq data. Uses ChromHMM (multivariate HMM on binarized signal, v1.27), Segway (Dynamic Bayesian Network on continuous signal), EpiSegMix (flexible-distribution HMM with duration modeling, 2024), EpiLogos (multi-biosample visualization), IDEAS (cell-type-aware joint), and full-stack ChromHMM (Vu Ernst 2022) for cross-cell-type segmentations. Handles state-count selection (15 vs 18 vs 25 states), binarization choice, OverlapEnrichment / NeighborhoodEnrichment downstream analysis, and cross-biosample integration. Use when learning chromatin states from a histone mark panel, characterizing learned states by genomic feature enrichment, or comparing chromatin landscapes across cell types.

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peacezha/HPClaw32026년 10월 11일 업데이트

Validate alignment quality with insert size distribution, proper pairing rates, GC bias, strand balance, and other post-alignment metrics. Use when verifying alignment data quality before variant calling or quantification.

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peacezha/HPClaw32026년 10월 11일 업데이트

Assesses RNA-seq data quality specifically for alternative splicing analysis. QC layers include experimental design audit (library prep, read length, depth, replicates), STAR 2-pass cohort-style alignment, junction saturation curves and discovery plateau detection, novel-vs-known junction ratio diagnostics, junction-overhang distribution, splice-site strength scoring (MaxEntScan intrinsic + SpliceAI context-aware), strandedness verification, GENCODE basic vs comprehensive choice, and rRNA contamination screening. Splicing analysis is more demanding than DGE on read length, depth, library prep, alignment strategy, and annotation choice — failures silently bias PSI estimates and inflate novel-junction false positives. Use when evaluating data suitability for splicing analysis, troubleshooting low event detection, or designing sequencing experiments where AS is a primary endpoint.

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peacezha/HPClaw32026년 10월 11일 업데이트

Use when an owner-operator (1099 or LLC/S-corp) asks how to lower their tax bill, what they can deduct, per diem treatment, depreciation choices (Section 179, bonus, MACRS), quarterly estimated payments, S-corp salary vs distributions, retirement plan options (SEP-IRA, Solo 401(k)), or recordkeeping requirements. Covers federal income tax + self-employment tax basics; not state-specific.

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x3allamerican/skills32026년 5월 17일 업데이트

Principled action selection for autonomous agents using Expected Free Energy (EFE) under the Active Inference framework. Each candidate action is scored as G(n) = w_prag * (-E[p_n] * damping) + w_epist * (-Var[p_n] * novelty(n)), where agent beliefs are maintained as per-node Beta distributions and updated via Bayesian observation. Selection is a softmax over -gamma * G, making exploration an automatic consequence of uncertainty rather than a hardcoded epsilon. Precision weights w_prag and w_epist self-adapt via surprise history, shifting the agent between exploitation and exploration regimes without any manually tuned schedule.

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curiositech/port-daddy32026년 10월 19일 업데이트

Expert-level idiomatic Rust API design — the patterns that make illegal states unrepresentable and abstractions zero-cost. Type-state programming (PhantomData state machines), newtype + sealed + extension traits, typestate builders, RAII guards & Drop ordering, the interior-mutability decision tree (Cell/RefCell/Mutex/RwLock/Atomic/OnceLock), enum-driven state machines, error architecture (thiserror vs anyhow), dyn vs generic dispatch & object safety, the impl Trait / GAT / RPITIT toolbox, and Deref-for-smart-pointers (and its abuse). Use when designing a Rust library's public API, encoding invariants in the type system, choosing a dispatch or error strategy, or reviewing Rust for idiom. NOT for borrow-checker firefighting / toolchain / test-runner workflow (use rust-development-workflow), NOT for pd-console GPUI rendering/layout/panes (use gpui-rust-console), NOT for app packaging/notarization (use rust-app-distribution).

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curiositech/port-daddy32026년 10월 19일 업데이트

Backlink profile analysis: referring domains, anchor text distribution, toxic link detection, competitor gap analysis. Works with free APIs (Moz, Bing Webmaster, Common Crawl) and DataForSEO extension. Use when user says backlinks, link profile, referring domains, anchor text, toxic links, link gap, link building, disavow, or backlink audit.

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balsm-health/website32026년 10월 18일 업데이트

Decision-ready scouting record for a user-connected provider access campaign. Use when an assigned Provider Access Launch task needs its easiest official route, minimum scopes, cost, account needs, approval path, implementation consumer, and easy-execute verdict established before submission. NOT for client Local Listings distribution.

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armanisadeghi/ai-matrx32026년 10월 20일 업데이트

Discovery batch that grows the Provider Access Launch queue. Use when asked to find more user-connected OAuth, API, API-key, remote MCP, marketplace, or partner-access campaigns for a capability, provider family, MCP/plugin catalog, or competitive gap. NOT for client Local Listings distribution.

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armanisadeghi/ai-matrx32026년 10월 20일 업데이트

When the user needs to set up multiple academic courses in a learning management system (Canvas/LMS) from structured data sources. This skill automates the entire workflow extracting course schedules from emails/attachments, matching instructors from CSV files, creating courses, enrolling teachers, publishing announcements with class details, uploading syllabi, enabling resource sharing for instructors teaching multiple courses, and publishing all courses. Triggers include course schedule setup, Canvas/LMS administration, academic term preparation, instructor assignment, syllabus distribution, and multi-course management.

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MikeCheng1208/BattleTree22026년 7월 22일 업데이트

Complete workflow for heat transfer analysis - steady-state and transient thermal. Use when user asks about temperature distribution, conduction, convection, or heat flow.

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MikeCheng1208/BattleTree22026년 7월 22일 업데이트

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무료

Multi-platform content distribution across X, LinkedIn, Threads, and Bluesky. Adapts content per platform using content-engine patterns. Never posts identical content cross-platform. Use when the user wants to distribute content across social platforms.

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sayasaya8039/ZWG_Terminal22026년 6월 8일 업데이트

Azure Queue Storage SDK for Python. Use for reliable message queuing, task distribution, and asynchronous processing.

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MMEHDI0606/ai-agent-foundation-template22026년 5월 21일 업데이트

Azure Cosmos DB SDK for Java. NoSQL database operations with global distribution, multi-model support, and reactive patterns.

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MMEHDI0606/ai-agent-foundation-template22026년 5월 21일 업데이트

Optimize multi-agent systems with coordinated profiling, workload distribution, and cost-aware orchestration. Use when improving agent performance, throughput, or reliability.

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MMEHDI0606/ai-agent-foundation-template22026년 5월 21일 업데이트

Quarterly Silicon Agent performance evaluation with ByteDance-style calibration, forced distribution ranking, dual-track (technical/management) assessment, and automated score calculation. Includes real evaluation forms, calibration meeting scripts, and PIP templates.

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aAAaqwq/openclaw-team22026년 6월 18일 업데이트

Optimize multi-agent systems with coordinated profiling, workload distribution, and cost-aware orchestration. Use when improving agent performance, throughput, or reliability.

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aAAaqwq/openclaw-team22026년 6월 18일 업데이트

Elite content marketing strategist specializing in AI-powered content creation, omnichannel distribution, SEO optimization, and data-driven performance marketing. Masters modern content tools, social media automation, and conversion optimization with 2024/2025 best practices. Use PROACTIVELY for comprehensive content marketing.

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itsimonfredlingjack/codex-dev-plugin22026년 2월 5일 업데이트

Chooses CLI output format. AOT vs framework-dependent, RID matrix, single-file, dotnet tool.

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rudironsoni/Synaxis22026년 3월 17일 업데이트

Builds automated threat intelligence feed integration pipelines connecting STIX/TAXII feeds, open-source threat intel, and commercial TI platforms into SIEM and security tools for real-time IOC matching and alerting. Use when SOC teams need to operationalize threat intelligence by automating feed ingestion, normalization, scoring, and distribution to detection systems.

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aniket2348823/Vul-Agent22026년 6월 9일 업데이트

Analyze the threat landscape using MISP (Malware Information Sharing Platform) by querying event statistics, attribute distributions, threat actor galaxy clusters, and tag trends over time. Uses PyMISP to pull event data, compute IOC type breakdowns, identify top threat actors and malware families, and generate threat landscape reports with temporal trends.

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aniket2348823/Vul-Agent22026년 6월 9일 업데이트