'global' 검색 결과

Generates, normalizes, and converts bedGraph signal tracks (4-column chrom/start/end/value, 0-based half-open) with bedtools genomecov, deepTools bamCoverage/bamCompare/bigwigCompare, bedtools unionbedg, and UCSC bedGraphToBigWig. Covers why a raw coverage bedGraph is not comparable across samples until normalized, the CPM/RPKM/BPM/RPGC normalization menu and the conserved-total assumption that makes them wrong under a global perturbation, the strict sorted-non-overlapping-chrom.sizes bedGraphToBigWig contract that silently corrupts a bigWig, effective-genome-size selection, and bin-size aliasing. Use when building or normalizing a coverage/signal track from a BAM, comparing tracks across samples or conditions, converting bedGraph to a browser-ready bigWig, or diagnosing a track that looks plausible but reports wrong heights.

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Estimate bivariate genetic correlation (rg) between traits from GWAS summary statistics or individual-level genotypes using cross-trait LDSC, HDL, LAVA, rho-HESS, GREML-bivariate, Popcorn, and HDL-L. Use when quantifying shared genetic architecture between two traits, screening MR validity before causal inference, distinguishing global from locus-level rg, estimating trans-ancestry rg, separating partial from full causation via LCV gcp, or producing a STROBE-MR-compliant cross-trait sensitivity battery. Cross-trait LDSC intercept absorbs sample overlap and is NOT a bias; HDL is biased under sample overlap above ~5%. High rg between exposure and outcome motivates CHP-aware MR sensitivity (CAUSE, LHC-MR).

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Normalizes ChIP-seq data using exogenous spike-in (ChIP-Rx with Drosophila chromatin per Orlando 2014 / Egan 2016; E. coli carryover for CUT&RUN/CUT&Tag). Distinguishes RRPM from Rx-Input scaling, integrates with DiffBind / DESeq2 / edgeR / csaw via sizeFactors and DiffBind library-size vectors, and applies the Patel et al 2024 *Nat Biotechnol* review's failure-mode framework to validate that normalization is correctly applied at the read level (not peak counts). Use when global signal shifts are expected (HDACi, BETi, EZH2i, dosage, target knockdown), when ChIPseqSpikeInFree detects post-hoc shifts, or when validating internal-control regions before publication.

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Visualizes ChIP-seq data using deepTools (computeMatrix, plotHeatmap, plotProfile, bamCoverage, bamCompare), pyGenomeTracks (modern INI-driven track plots), Gviz (R browser-style), EnrichedHeatmap (ComplexHeatmap-based), ChIPseeker tag heatmaps, and IGV batch screenshots. Handles bigWig normalization choices (CPM, BPM, RPGC, spike-in scaled), bamCompare operations (log2 ratio, subtract, SES), k-means clustering of heatmaps for biological subgrouping, and spike-in-scaled tracks for global-shift experiments. Use when generating publication-quality ChIP-seq signal heatmaps, profile plots, genome-browser tracks, or comparing samples visually.

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Perform pairwise sequence alignment using Biopython Bio.Align.PairwiseAligner. Use when comparing two sequences, finding optimal alignments, scoring similarity, and identifying local or global matches between DNA, RNA, or protein sequences.

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Designs, reconciles, and reviews an end-to-end Drydock program for safely staging agent runtimes: immutable worktree provenance, disposable VM containment, typed effect brokerage, global body accounting, resurrection, subscription-capacity economics, context compaction, operator control, evidence, and promotion. Use when several Drydock contracts must compose into one architecture, implementation hypertree, diagram set, or release plan. NOT for launching Port Daddy, running an untrusted subject, replacing focused containment/resurrection/capacity audits, or treating a design packet as runtime authority.

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An innate exploratory drive that guarantees no graph node remains permanently invisible to an agent population. After a warm-up period (step > 3), each agent fires a coverage scan with probability |unseen_nodes| / |all_nodes|. When triggered, the agent teleports directly to the globally unseen node with the highest belief uncertainty, works it, and returns control to the normal action-selection loop. Probability is self-annealing: it starts near 1.0 when almost everything is unseen and decays toward 0.0 as coverage saturates, requiring no manual schedule. The mechanism is "innate" (hard-coded into the agent step loop) as distinct from the "adaptive" EFE path, which requires local neighbors and learned precision weights. Together they form a two-layer exploration architecture: adaptive for locally-guided foraging, innate for topological completeness.

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Apply GPGP/TAEMS coordination as local-scheduler constraints under explicit task, view, commitment, and delivery assumptions. NOT for assuming global task visibility, reliable delivery, or modern execution authority.

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Design or audit an agent identity, credential, session, continuity, and reputation plan. Use when attributed outcomes must survive key rotation, restart, recovery, or review; when choosing Elo, TrueSkill, a contextual bandit, or an LLM judge; and when making Sybil, newcomer, calibration, collusion, and evidence limits explicit. Produces a supplied-plan consistency audit, never proof of observed delivery, cryptographic identity, or live enforcement. NOT for proving personhood, global Sybil resistance, or an unobserved delivery.

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Find and identify the CCSGameRules__sm_mapGcBanInformation global variable in CS2 binary using IDA Pro MCP. Use this skill when reverse engineering CS2 server.dll or libserver.so to locate the GC ban information map structure by decompiling CCSPlayerController_ResourceDataThink's sub-function (Linux) or searching for the "Notification about user penalty" string (Windows).

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Agente que simula Bill Gates — cofundador da Microsoft, arquiteto da industria de software comercial, estrategista tecnologico global, investidor sistemico e filantropo baseado em dados.

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Azure Cosmos DB SDK for Python (NoSQL API). Use for document CRUD, queries, containers, and globally distributed data.

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Azure Cosmos DB SDK for Java. NoSQL database operations with global distribution, multi-model support, and reactive patterns.

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Azure Cosmos DB SDK for Rust (NoSQL API). Use for document CRUD, queries, containers, and globally distributed data.

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Master modern Angular state management with Signals, NgRx, and RxJS. Use when setting up global state, managing component stores, choosing between state solutions, or migrating from legacy patterns.

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Access 20+ years of global financial data: equities, options, forex, crypto, commodities, economic indicators, and 50+ technical indicators.

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用于在PyQt5应用程序中管理类内部变量作用域，通过实例变量(self.variable)替代全局变量(global)，实现跨函数的数据共享、默认值初始化及条件更新。

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Merges mature lessons from a domain memory file into its instruction file. Syntax: `/memory-merger >domain [scope]` where scope is `global` (default), `user`, `workspace`, or `ws`.

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Expert network engineer specializing in modern cloud networking, security architectures, and performance optimization. Masters multi-cloud connectivity, service mesh, zero-trust networking, SSL/TLS, global load balancing, and advanced troubleshooting. Handles CDN optimization, network automation, and compliance. Use PROACTIVELY for network design, connectivity issues, or performance optimization.

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Detects TFM/SDK from .csproj, global.json, Directory.Build.props. Runs first.

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Installs and manages .NET tools. Global, local, manifests, restore, version pinning.

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Complete guide for ASP.NET Core Web API integration testing. Use when performing integration testing on Web API endpoints or validating ProblemDetails error format. Covers WebApplicationFactory, IExceptionHandler, Testcontainers multi-container orchestration, Flurl URL construction, and AwesomeAssertions HTTP validation. Keywords: webapi integration testing, WebApplicationFactory, asp.net core integration test, webapi integration test, IExceptionHandler, ProblemDetails, ValidationProblemDetails, AwesomeAssertions, Flurl, Respawn, Be201Created, Be400BadRequest, multi-container testing, Collection Fixture, global exception handling

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Authors .editorconfig rules. IDE/CA severity, AnalysisLevel, globalconfig, code style enforcement.

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MITRE ATT&CK is a globally-accessible knowledge base of adversary tactics, techniques, and procedures (TTPs) based on real-world observations. This skill covers systematically mapping threat actor beh

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