'glm' 검색 결과

Differential abundance (DA) and differential state (DS) analysis for flow and mass cytometry - tests which cell populations change in frequency or marker expression between conditions using diffcyt (edgeR/voom/GLMM for DA, limma/LMM for DS), with cydar, CITRUS, and compositional methods (sccomp, scCODA, DCATS) as alternatives. Covers the sample-is-the-experimental-unit principle, design/contrast and mixed-model formulas, compositionality of cluster proportions, and FDR across clusters. Use when comparing populations between groups, choosing a DA method, handling paired/batch designs, or deciding whether compositional correction is needed.

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Calls m6A peaks from MeRIP-seq / m6A-seq paired IP-vs-input data using exomePeak2 (transcript-aware, GC-bias-corrected Poisson GLM), MeTPeak (HMM over sliding windows), MACS3/MACS2 with --nomodel --broad --keep-dup all (genome-wide broad alternative), and DRACH motif enrichment via HOMER or ggseqlogo as a sanity check (NOT a filter). Covers BED12 vs narrowPeak output, exonic vs intronic peak handling, multi-tool reconciliation (intersection vs union), the m6A-vs-m6Am ambiguity at 5'UTR peaks that antibody methods cannot resolve, and orthogonal validation (miCLIP/GLORI/m6A-SAC-seq/m6Anet). Use when calling peaks from paired IP/input genome BAMs, choosing exomePeak2 (transcript-aware default) vs MACS3 (broad genomic) vs MeTPeak (HMM-smoothed low-coverage), confirming DRACH enrichment as a sanity check on the peak set, reconciling differing peak sets across tools, validating MeRIP peaks against single-base methods, interpreting 5' peaks where m6Am contamination is possible, or recommending a consensus strategy.

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Analyzes single-cell pooled CRISPR screens (Perturb-seq, CROP-seq, Perturb-CITE-seq, ECCITE-seq, multiome) where each cell carries an sgRNA and a scRNA-seq / surface-protein / chromatin readout. Covers experimental design (direct-capture Perturb-seq Dixit 2016 vs CROP-seq 3'UTR-barcoded Datlinger 2017 vs ECCITE-seq vs Multiome), MOI for sgRNA assignment, escaper-cell filtering (Mixscape, Papalexi 2021), SCEPTRE NB GLM + permutation for low-MOI (Barry 2024 Genome Biol 25:124), the Pertpy framework, factor decomposition, genome-scale Perturb-seq (Replogle 2022 Cell, 2.5M cells), and per-perturbation single-cell DE. Use when running a single-cell CRISPR screen, choosing direct-capture vs CROP-seq architecture, filtering escaper cells, performing single-cell DE, integrating Perturb-seq with pathway analysis, scaling to GW CRISPRi via Replogle protocol, or analyzing multi-omics screens.

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Creates DE-specific diagnostic and result visualizations using DESeq2/edgeR built-in functions and lightweight ggplot2 wrappers. Covers MA plot (with the shrunken-LFC compression effect), volcano (with the apeglm caveat that p-values are unchanged), PCA on VST/rlog (never raw counts), sample distance heatmaps, top-DE-gene heatmaps with the row-scaling trap, dispersion / BCV plot interpretation, p-value histogram diagnostics, plotCounts for individual genes, blind=TRUE vs FALSE rationale, and the n=3 visualization stake. Use when generating DE diagnostic plots, choosing VST vs rlog for visualization, troubleshooting suspicious plot patterns (shifted MA cloud, batch-dominated PCA, anti-conservative p-value histogram), or building a standard QC figure panel.

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Build volcano and MA plots from differential-expression / association results with LFC shrinkage, FDR-adjusted thresholds, sensible label placement, and axis-truncation conventions. Covers EnhancedVolcano, ggplot2, matplotlib, and the apeglm/ashr/normal shrinkage decision. Use when visualizing differential-expression results (RNA-seq, ChIP-seq, ATAC-seq, proteomics) or any per-feature effect-size + p-value table.

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Detects differential alternative splicing between conditions using rMATS-turbo (binomial LRT on junction counts), leafcutter (Dirichlet-multinomial GLM on intron clusters), MAJIQ V3 deltapsi/HET (Bayesian posterior on LSVs), SUPPA2 (empirical-null on TPM-derived PSI), or Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage). Reports FDR-corrected significance and delta PSI effect sizes. Tools differ in statistical model, annotation dependence, calibration regime, and replicate-count requirements. Use when comparing splicing patterns between treatment groups, tissues, or disease states.

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Use this skill when you develop, design, build, deploy, debug, migrate, or troubleshoot CloudBase (腾讯云开发, 云开发, TCB, 微信云开发) projects — Web, 微信小程序, 小程序, uni-app, mobile (iOS, Android, Flutter, React Native). Covers UI (页面, 界面, 表单, dashboard, prototype, 原型); auth (登录, 注册, OAuth, publishable key); databases (NoSQL 文档数据库, MySQL 关系型数据库, PostgreSQL/CloudBase PG, app.rdb(), queryPgDatabase/managePgDatabase, CRUD, security rules); 云函数/cloud functions (serverless, scf_bootstrap); CloudRun (云托管, Dockerfile); 云存储; built-in AI (内置大模型, AI 对话, streaming, 流式输出, 图片生成, generateText, streamText, createModel, generateImage, TokenHub, Hunyuan, DeepSeek, GLM, Kimi, Token Credits 资源包, 小程序成长计划); third-party/custom model onboarding (第三方大模型接入, 大模型调用, LLM API); AI agent (智能体, AG-UI, LangGraph); ops troubleshooting (巡检, 诊断, 日志); spec workflow (需求文档, 技术方案, requirements, tasks.md). Do NOT use for non-CloudBase projects, pure frontend without CloudBase, or self-hosted backends without CloudBase.

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Use this skill for Node.js backend AI via @cloudbase/node-sdk (>=3.16.0) — cloud functions, CloudRun, Express/Koa/NestJS, serverless APIs, scheduled jobs, LLM proxies, agent orchestration. The only SDK supporting image generation (ai.createImageModel + generateImage). Text via ai.createModel with groups cloudbase, hunyuan-exp, or custom-*; model ids (e.g. deepseek-v4-flash, glm-5, kimi-k2.6) go in the `model` field of generateText/streamText. MUST run two-step preflight before code — see body. NOT for browser/Web (use ai-model-web) or Mini Program (use ai-model-wechat).

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Z.AI CLI providing: - Vision: image/video analysis, OCR, UI-to-code, error diagnosis (GLM-4.6V) - Search: real-time web search with domain/recency filtering - Reader: web page to markdown extraction - Repo: GitHub code search and reading via ZRead - Tools: MCP tool discovery and raw calls - Code: TypeScript tool chaining Use for visual content analysis, web search, page reading, or GitHub exploration. Requires Z_AI_API_KEY.

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Fit linear models to overdispersed count data. The package can estimate the overdispersion and fit repeated models for matrix input. It is designed to handle large input datasets as they typically occur in single cell RNA-seq experiments.

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Python statistical modeling: regression (OLS, WLS, GLM), discrete (Logit, Poisson, NegBin), time series (ARIMA, SARIMAX, VAR), with rigorous inference, diagnostics, and hypothesis tests. Use scikit-learn for ML; statistical-analysis for test choice.

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Think and work like an expert Limnologist. Use when a task calls for Limnologist judgment. Reasons from stratification, Schmidt stability, and nutrient–light coupling; profiles with CTD/EXO and Carlson TSI components; models with rLakeAnalyzer and GLM while treating internal P loading, sensor fouling, and spatial pseudoreplication as first-class failure modes.

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Think and work like an expert Fisheries Scientist. Use when a task calls for Fisheries Scientist judgment. Reasons from recruitment, growth, and natural and fishing mortality through state-space assessment models (SS3, SAM, JABBA), CPUE/GLM standardization, and reference points like F_MSY and B_lim under ICES and Magnuson-Stevens frameworks, while treating hyperstability, retrospective bias (Mohn's rho), unaccounted discard mortality, and misspecified M or selectivity as first-class failure modes.

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Think and work like an expert Entomologist. Use when a task calls for Entomologist judgment. Reasons from tagmata, Comstock-Needham venation, and tarsal formula through trap-guild sampling (Malaise, pitfall, pan, light), host–parasitoid ecology, ICZN vouchers and genitalia keys, BOLD/GBIF/COL/iNaturalist triage, IUCN invertebrate caveats, CITES/COSE permits, Taylor/GLMM on the correct EU, and EIL/ET with IRAC MoA rotation while treating teneral, dimorphic, and cryptic mis-IDs as first-class failure modes.

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Think and work like an expert Computational Neuroscientist. Use when a task calls for Computational Neuroscientist judgment. Reasons from encoding/decoding, GLM/LNP spike-train likelihood, mean-field E-I balance, and neural manifolds through NEST/Brian/NEURON/BMTK, GPFA/LFADS, Brain-Score alignment, and trained-RNN reverse engineering while treating spike-sorting contamination, model non-identifiability, nested-CV leakage, and task-optimization≠mechanism as first-class failure modes.

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Think and work like an expert Cognitive Neuroscientist. Use when a task calls for Cognitive Neuroscientist judgment. Reasons from latent constructs through converging behavior, fMRI/M/EEG, TMS, and lesion evidence; designs factorial and dissociation contrasts, fMRIPrep/GLMsingle/MNE pipelines, MVPA/RSA, and COBIDAS reporting while treating pure insertion, reverse inference, motion confounds, and in-sample decoding as first-class failure modes.

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Think and work like an expert Actuarial Scientist. Use when a task calls for Actuarial Scientist judgment. Reasons from mortality tables (qx, period/cohort, select/ultimate) and Chain-Ladder/Mack reserving through GLM/GAM frequency–severity and Tweedie pricing, limited-fluctuation and Bühlhmann-Straub credibility, Solvency II SCR standard formula, and IFRS 17 CSM/RA while treating triangle truncation, overfitting, and tail risk as first-class failure modes.

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Think and work like an expert Behavioral Ecologist. Use when a task calls for Behavioral Ecologist judgment. Reasons from versioned ethograms, Altmann focal/scan sampling, and activity budgets; scores with BORIS (Cohen’s κ), analyzes sequences with Markov/HMM tools, runs sham-controlled playbacks under ARRIVE 2.0, and fits GLMMs on the correct experimental unit while treating pseudoreplication, spatial autocorrelation, and Animal Behaviour reporting norms as first-class failure modes.

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Detects differential alternative splicing between conditions using rMATS-turbo (binomial LRT on junction counts), leafcutter (Dirichlet-multinomial GLM on intron clusters), MAJIQ V3 deltapsi/HET (Bayesian posterior on LSVs), SUPPA2 (empirical-null on TPM-derived PSI), or Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage). Reports FDR-corrected significance and delta PSI effect sizes. Tools differ in statistical model, annotation dependence, calibration regime, and replicate-count requirements. Use when comparing splicing patterns between treatment groups, tissues, or disease states.

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Start long-lived provider LLM teammates as native Claude Code agent-team members (the native Agent tool with a ccf-<provider> type) that you message with SendMessage — multi-turn, collaborative, watchable in tmux panes. Use for sustained parallel build/work ("start 3 glm teammates", N teammates on N files), or when you need a collaborator you message across turns, from a terminal `claude` session. NOT a fire-and-forget one-shot or a flat batch of independent prompts — that is /cc-fleet:subagent. NOT a scripted multi-phase run — that is /cc-fleet:workflow.

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Fan out a one-shot or flat parallel batch of cc-fleet PROVIDER subagents (headless `cc-fleet subagent`) that return a result — DeepSeek / GLM / Kimi / Qwen / MiniMax, or a Codex/Claude subscription. Trigger ONLY to delegate a task to a cc-fleet provider worker (parallel research, bulk per-file work, a specialized model). Do NOT trigger for a multi-phase pipeline (that is /cc-fleet:workflow), for ordinary local shell/coding, or for editing or researching cc-fleet's own code.

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Run a one-shot or flat parallel batch of provider LLM subagents (headless `cc-fleet subagent`) that return a result. Use when fanning out N independent tasks, doing bulk per-file work, or calling a specialized provider model (DeepSeek / GLM / Kimi / Qwen / MiniMax). NOT a long-lived collaborator you message back and forth (that is /cc-fleet:team); NOT a multi-phase pipeline with dependencies or resume (that is /cc-fleet:workflow); NOT trivial work the main session should just do.

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Build one-page HTML/PDF resumes from copy-paste YAML using one of 12 official templates. HARD GATES: deliver exactly one A4 page; never invent a layout — copy assets/templates/<id> into output/<id>/ and edit that copy only. Keep a full inventory in raw.data.yaml. For each job, COPY selected entries into resume.data.yaml (polish there), then apply that file to a template. Apply pasted YAML by replacing visible text in the official resume.html, then run QA. Default template is basic-a4. Use when creating, iterating, polishing copy, migrating, exporting, or designing resume/CV HTML/PDF. For polishing resume copy, prefer writing-oriented models (Claude Fable 5 / Claude Opus 4.6-4.7 or Opus 5 / Kimi K3 / GLM-5.1-5.3-max / Qwen 3.8 Max); do not use GPT-5.6 Terra/Luna or GPT-5.5 Instant.

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Multi-platform Chinese & multilingual TTS text-to-speech via Edge/Doubao/CosyVoice/Qwen3/StepFun/GLM-TTS/Azure/Tencent/Baidu/MiniMax/Xunfei plus ElevenLabs/OpenAI/Google/Atlas Cloud — 15 backends, word-level timestamps, [PAUSE:x] pause markers, pinyin pronunciation overrides

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