720건 · 관련도순
Select colormaps and qualitative palettes for scientific figures using perceptual-uniformity, color-vision-deficiency safety, and luminance-monotonicity criteria. Covers Crameri scientific colormaps, viridis/cividis/magma, Okabe-Ito categorical, ColorBrewer, and the rainbow/jet critique. Use when choosing palettes for heatmaps, scatter, networks, or any encoding where color carries quantitative or categorical meaning.
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Designs and analyzes pooled prime-editor (PE) screens for installing precise genetic variants without bystander confounding. Covers pegRNA design with PRIDICT and PRIDICT2 (Mathis 2023/2024) for predicting per-pegRNA editing efficiency, pegRNA architecture (spacer + scaffold + PBS + RTT), PE2 / PE3 / PE3b / PEmax / PEAR variants, MOSAIC in situ saturation mutagenesis (Hsu JY et al 2024 bioRxiv), the PRIME pooled-screen methodology (Erwood/Doman 2023 Nat Biotechnol 41:885; ~3,699 ClinVar variant screens), chromatin context as a primary determinant of PE efficiency, scaffold-incorporation and indel byproduct quantification with CRISPResso2, and the cross-modal validation strategy of PE + base-editor screens for variant function. Use when designing a pegRNA library for variant installation, choosing between BE and PE for a specific edit, predicting pegRNA efficiency before library synthesis, analyzing PE screen output, distinguishing intended-edit from scaffold-incorporation, or scaling PE screens to thousands of variants.
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Analyzes base-editing screens for variant function. Covers library design (Sanson 2020 GRACE, Hanna 2021 BRCA1/2 SNV scanning, Cuella-Martin 2021), CBE vs ABE chemistry choice (BE3/BE4 vs ABE7.10/ABE8.20/ABE8e), editing-window math (positions 4-8 from PAM-distal end, wider for ABE8e), bystander-edit quantification and the variant-call ambiguity it creates, sgRNA-efficiency filtering before hit calling, indel byproduct interpretation, the substitution-vs-indel diagnostic, variant annotation against ClinVar / COSMIC, and the Broad be-validation-pipeline. Use when designing a BE variant screen, choosing CBE vs ABE for a specific edit, interpreting bystander-confounded hits, distinguishing functional signal from indel artifact, integrating CRISPResso2 output with screen scoring, or deciding BE vs PE for SNV installation.
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Reconstruct ancestral states at internal phylogenetic nodes for sequences (PAML codeml, IQ-TREE --ancestral, GRASP, FastML), discrete traits (corHMM hidden-rate Markov, ape::ace, phytools::make.simmap stochastic mapping, BayesTraits), and continuous traits (phytools::fastAnc, geiger Brownian/OU, RPANDA). Use when designing constructs for ancestral protein resurrection, tracing trait evolution along a tree, performing stochastic character mapping, testing models of trait evolution (BM vs OU vs EB), inferring ancestral genome content via Dollo or DTL reconciliation, or quantifying ancestral-state uncertainty for downstream comparative analyses.
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Quantify homologous recombination deficiency (HRD) from tumor copy number using the three genomic-scar metrics — loss of heterozygosity (LOH), large-scale state transitions (LST), and telomeric allelic imbalance (TAI) — with scarHRD, and via the whole-genome HRDetect and CHORD models. Covers the genomic instability score, the PARP-inhibitor clinical context, whole-genome-doubling correction, and the scar-versus-state distinction. Use when computing an HRD score for PARP-inhibitor eligibility, deriving LOH/LST/TAI scars from allele-specific copy number, deciding between scar-based and mutational-signature HRD methods, or interpreting an HRD result in a BRCA-reverted or low-purity tumor.
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Detect horizontal gene transfer (HGT / LGT) using compositional methods (GC%, codon usage, tetranucleotide z-scores via SIGI-HMM, AlienHunter, IslandViewer 4, IslandPath-DIMOB), phylogenetic-incongruence methods (AvP, HGTphyloDetect, ALE / GeneRax / AleRax reconciliation, RANGER-DTL), and BLAST-distribution methods (HGTector v2, DarkHorse, Alien Index). Use when screening prokaryote genomes for genomic islands and HGT events, distinguishing HGT from incomplete lineage sorting / differential gene loss / hybridization, mapping donor lineages via phylogenetic placement, separating eukaryotic HGT from contamination, ruling out gBGC as a false signal, or quantifying DTL rates with ALE/GeneRax on bacterial trees.
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Validates docked / generated protein-ligand poses using PoseBusters physical-validity tests, strain energy quantification, geometric checks (planarity, vdW overlap, bond/angle distortion), and pose-energy reasonableness. Filters AI-docking outputs (DiffDock, EquiBind, NeuralPLexer) where ~50% of poses fail physical-validity tests. Use when QC-ing docking results, comparing classical vs ML docking outputs, or filtering pose lists before SAR analysis.
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Estimate bivariate genetic correlation (rg) between traits from GWAS summary statistics or individual-level genotypes using cross-trait LDSC, HDL, LAVA, rho-HESS, GREML-bivariate, Popcorn, and HDL-L. Use when quantifying shared genetic architecture between two traits, screening MR validity before causal inference, distinguishing global from locus-level rg, estimating trans-ancestry rg, separating partial from full causation via LCV gcp, or producing a STROBE-MR-compliant cross-trait sensitivity battery. Cross-trait LDSC intercept absorbs sample overlap and is NOT a bias; HDL is biased under sample overlap above ~5%. High rg between exposure and outcome motivates CHP-aware MR sensitivity (CAUSE, LHC-MR).
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Validate alignment quality with insert size distribution, proper pairing rates, GC bias, strand balance, and other post-alignment metrics. Use when verifying alignment data quality before variant calling or quantification.
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Locate CEconItemView::CEconItemView in CS2 server.dll / libserver.so via IDA Pro MCP and emit a fresh, minimal-unique signature or offset for the WeaponPaints gamedata entry "CEconItemView::CEconItemView" (symbol CEconItemView_CEconItemView). This is the CONSTRUCTOR of CEconItemView. Shortlist via allocation sites: callers of operator-new whose result is immediately stored with the CEconItemView vtable (RTTI), followed by zeroing and initialization of definition-index/quantity/attribute-list fields. Distinguish from subobject constructors of derived classes by the vtable identity. Trigger: CEconItemView_CEconItemView, CEconItemView::CEconItemView
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Scope creep check — current scope versus the original plan. Flags additions, quantifies bloat, recommends cuts. 'Any scope creep?'
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Evaluate design from a UX perspective, assessing visual hierarchy, information architecture, emotional resonance, cognitive load, and overall quality with quantitative scoring, persona-based testing, and actionable feedback. Use when the user asks to review, critique, evaluate, or give feedback on a design or component.
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Search academic paper repositories (arXiv, Semantic Scholar) for scholarly articles in physics, mathematics, computer science, quantitative biology, AI/ML, and related fields
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Expert guidance for reviewing academic manuscripts submitted to journals, particularly in political science, economics, and quantitative social sciences. Use when asked to review, critique, or provide feedback on academic papers, research designs, or empirical strategies. Emphasizes methodological rigor, causal identification strategies, and constructive feedback on research design.
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量化交易核心skill套件 — 因子挖掘、Alpha衰减监控、多市场套利、订单路由、压力测试、归因分析、仓位管理、样本外验证、A股T0、加密资金费率套利、Polymarket机器人。对标国际顶级量化基金（Renaissance/Two Sigma/Citadel/DE Shaw）的工程与策略水平。
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Guide a startup to set a single quantified traction goal and define the critical path of milestones to reach it. Use whenever a founder needs to prioritize activities, set growth goals, define milestones, decide what NOT to work on, plan quarterly/yearly execution, cascade goals to teams, escape the 'too many things to do' trap, or apply a binary on-path/off-path filter to proposed work. Activates on phrases like 'traction goal', 'critical path', 'what should we focus on', 'too many priorities', 'prioritization', 'milestones', 'quarterly planning', 'yearly goals', 'OKRs', 'where should I spend my time', 'what NOT to do', 'company planning', 'goal setting', 'DuckDuckGo', 'roadmap'.
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Enterprise-grade security vetting protocol for AI agent skills. Automated threat detection, quantified risk scoring, and zero-trust code analysis.
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Optimizes LLM inference with NVIDIA TensorRT for maximum throughput and lowest latency. Use for production deployment on NVIDIA GPUs (A100/H100), when you need 10-100x faster inference than PyTorch, or for serving models with quantization (FP8/INT4), in-flight batching, and multi-GPU scaling.
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A 股量化实验室：基于 zvt 框架的数据采集 + 因子研究 + 回测执行一站式。 覆盖 31 个场景——机构持仓、财报、指数成分、MACD/MA/量能择时。仅限中国 A 股。
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You are a technical debt expert specializing in identifying, quantifying, and prioritizing technical debt in software projects. Analyze the codebase to uncover debt, assess its impact, and create actionable remediation plans.
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Create, edit, fix, or explain Mermaid diagrams for relationships, decision branches, interactions, lifecycles, and data models; also use when the parent selects a diagram to materially clarify an explanation. Do not trigger for simple status, one fact, short lists, quantitative charts, or marketing slides.
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Business logic vulnerability testing for web/mobile/API engagements. Covers workflow bypass, state machine violations, multi-step process abuse, price/quantity/discount manipulation, currency confusion, coupon stacking, refund/chargeback abuse, race conditions on logic boundaries, parameter tampering for hidden flows, role/tenant boundary violations, time-of-check vs use, anti-automation defeat, fraud-detection evasion, and subscription/quota abuse. Use when scoping an application after surface-level OWASP Top 10 has been covered, or when the asset is a transactional/marketplace/fintech/e-commerce/SaaS app where logic flaws produce direct financial impact.
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Hunting skill for business logic vulnerabilities. Built from 12 public bug bounty reports. Covers coupon-race-stacking (Instacart, Stripe, Reverb), negative-quantity-in-cart price tampering (Upserve, Eternal/Zomato), decimal/fraction price-field overflow (Shipt), client-side checkout amount trust on PayPal redirect (WordPress.org), price-per-unit mass-assignment (Krisp), and archived-price swap / cart-TOCTOU (Stripe). Use when hunting business logic — heavy emphasis on financial-impact-demonstrated cases.
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A specialized tool for sending quantitative trading signals to the FMZ platform via HTTP API.
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