905건 · 관련도순
Detect transcription factor binding footprints in ATAC-seq using TOBIAS, HINT-ATAC, Wellington, or scprinter. Use when identifying bound TF sites within accessible regions, correcting Tn5 insertion bias before footprinting, choosing between cleavage-based and aggregate-based footprinters, or comparing differential TF activity between conditions.
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Query BindingDB for measured drug-target binding affinities (Ki, Kd, IC50, EC50). Search by target (UniProt ID), compound (SMILES/name), or pathogen. Essential for drug discovery, lead optimization, polypharmacology analysis, and structure-activity relationship (SAR) studies.
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Vue 3 authoring/review: components, composables, reactivity, Pinia, Pinia Colada, file routing, forms. Composition API + script setup. Auto-activates on .vue files. Deep review: mk:vue-best-practices.
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Use when writing, reviewing, or refactoring Vue 3 code — components, composables, reactivity, Pinia state, Pinia Colada data-fetching, file-based routing, and forms. Targets Composition API + <script setup> + TypeScript. Auto-activates on .vue files. For deep best-practices review/recommendations or the full ordered workflow (built-in components, animations, performance pass), use mk:vue-best-practices.
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Load relevant memories at session start for context continuity. IMPORTANT: Use this AUTOMATICALLY at the START of every session. Search for memories related to: - Current working directory/project - Recent activity (last 7 days) - Topics the user mentions in their first message Execute silently - do not announce what you're loading.
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Determines if primary aldosteronism is confirmed based on upright plasma aldosterone ≤6 ng/dL (170 nmol/L) on day 4 at 10 AM of fludrocortisone suppression test, provided plasma renin activity ≥1 ng/mL/h and plasma cortisol concentration lower than the 7 AM value to exclude ACTH confounding. Use when reviewing FST results to diagnose PA; triggers include "FST", "upright aldosterone ≤6 ng/dL", "PRA ≥1 ng/mL/h", and "cortisol drop".
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Evaluates likelihood of primary aldosteronism by measuring plasma aldosterone suppression after oral captopril; normal suppression ≥30% makes PA unlikely, while lack of suppression with persistently suppressed plasma renin activity suggests PA. Use when assessing captopril challenge test (CCT) results for PA diagnosis in patients with positive aldosterone-to-renin ratio.
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In patients with primary aldosteronism receiving mineralocorticoid receptor antagonist therapy, the guideline recommends titrating the MRA dose upward to raise renin when blood pressure remains uncontrolled and renin is suppressed. Consider this step when hypertension is not at goal despite MRA therapy and plasma renin activity (or direct renin concentration) is low.
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Calculates the lowest effective glucocorticoid dose (dexamethasone or prednisone) to normalize blood pressure and serum potassium in glucocorticoid-remediable aldosteronism (GRA/FH-I) by titrating to biochemical and clinical targets. Indicated when initiating medical treatment for confirmed GRA, triggered by findings such as early-onset hypertension, family history of stroke before age 40, spontaneous hypokalemia, or suppressed plasma renin activity with elevated aldosterone.
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Automate Amplitude tasks via Rube MCP (Composio): events, user activity, cohorts, user identification. Always search tools first for current schemas.
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Monitor DX clusters for rare station spots, track active DX expeditions, and get daily band activity digests.
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Talk to your Apple Health data — ask questions about your workouts, heart rate, activity rings, and fitness trends.
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Expert-level medicinal chemistry knowledge. Use when working with drug design, structure-activity relationships, ADMET properties, pharmacophores, lead optimization, target identification, drug metabolism, or pharmaceutical development. Also use when the user mentions 'SAR', 'drug design', 'pharmacophore', 'ADMET', 'lead compound', 'hit to lead', 'drug metabolism', 'bioavailability', 'selectivity', 'binding affinity', 'scaffold hopping', or 'bioisostere'.
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Track a Linear ticket or GitHub PR in today's daily note with fields and timestamped activity. Use when invoked as `$work-track-item` or when the user asks to track a work item.
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Generates Angular code and provides architectural guidance. Trigger when creating projects, components, or services, or for best practices on reactivity (signals, linkedSignal, resource), forms, dependency injection, routing, SSR, accessibility (ARIA), animations, styling (component styles, Tailwind CSS), testing, or CLI tooling.
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Generates Angular code and provides architectural guidance. Trigger when creating projects, components, services, or HTTP communication, or for best practices on reactivity (signals, linkedSignal, resource, httpResource), forms, dependency injection, routing, SSR, accessibility (ARIA), animations, styling (component styles, Tailwind CSS), testing, naming conventions, or CLI tooling.
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Use when designing or implementing feedback, status, progress, alerts, errors, success states, and live activity indicators in Apple-platform apps — inline status, banners, alerts, notifications, and loading states.
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Use this skill when a company with a security applicability statement extends its management system to privacy or to AI, and asks "extend our SoA for privacy", "which privacy controls apply to a processor", "AI controls applicability", "SoA for our AI management system", "are we controller or processor for this" or "do the AI development controls apply if we only use a model". Settles the company's role per processing activity and per AI system, decides applicability of the additional controls from those roles and the risk or impact assessments, and writes an extension to the applicability statement plus role and scope notes.
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Use this skill when a company needs its record of processing activities for the first time, or has one that is really a list of tools, and asks "build our RoPA", "records of processing", "data map for GDPR", "Article 30 record", "what personal data do we process and why", "data inventory for privacy" or "our DPO needs a processing register". Drafts the record by processing activity from systems, vendors and team interviews, with purposes, data and subject categories, proposed legal bases, recipients, transfers and concrete retention, plus a separate processor record when the company processes data for customers, and a notes file of open questions per owner.
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Use this skill when an audit, attestation period or customer review is coming and someone asks "is our evidence up to date", "check the evidence folder before the auditor sees it", "which screenshots are stale", "do we have evidence for the whole period", "find undated evidence" or "what will the auditor reject". Indexes every evidence artefact with the date inside it, its owner and the period it covers, flags what is stale, undated, unowned, outside the audit period or missing for a recurring activity, and writes an index plus a refresh list per owner.
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Builds a compact profile of a GitHub user or PR author — identity, activity, company, commit history, and trust signals. Use during pull request review or triage, especially for contributions from unfamiliar authors.
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Use when building or modifying user-facing interfaces: new components and pages, responsive layouts, interactivity and state management, or fixing visual and UX issues. Covers component architecture, styling, accessibility, and state boundaries.
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Appwrite Kotlin SDK skill. Use when building native Android apps or server-side Kotlin/JVM backends with Appwrite. Covers client-side auth (email, OAuth with Activity integration), database queries, file uploads, real-time subscriptions with coroutine support, and server-side admin via API keys for user management, database administration, storage, and functions.
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Generate a daily "where are we?" digest from this repo's GitHub epics — a render-only HTML + plain-text email summarising the last 24h of activity plus a progress snapshot of every open epic. Use when asked for a "daily digest", "epic report", "status rapport", "what moved this week", or "where are we on the epics".
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