Modular design, interface stability, dependency management, AI-code health. Triggers: architecture, design, structure, modules, dependencies, coupling, system design.
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Modular design, interface stability, dependency management, AI-code health. Triggers: architecture, design, structure, modules, dependencies, coupling, system design.
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Predicts whether a DNA variant alters mRNA splicing using sequence-based deep-learning tools — SpliceAI (10kb context dilated CNN, clinical default), Pangolin (multi-tissue), MMSplice (modular per-region CNN with calibrated ΔPSI), SpliceTransformer/TrASPr (tissue-aware transformers), SpliceVault (empirical 300K-RNA lookup of likely mis-splicing outcomes), CADD-Splice (composite score). Applies the ClinGen SVI 2023 framework for ACMG/AMP variant interpretation (PVS1, PP3, BP4 evidence codes), HGVS splicing nomenclature (c.123+1G>A, c.123-3T>G, r.spl?), extended-window scoring for deep-intronic pseudoexons, tissue-specific predictions, branchpoint variant detection (BPHunter, LaBranchoR), and splice-switching ASO design. Use when interpreting splice impact of clinical variants, prioritizing VUS, identifying deep-intronic pathogenic variants, or designing ASOs.
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Analyzes, generates, and enhances CLAUDE.md files for any project type using best practices, modular architecture support, and tech stack customization. Use when setting up new projects, improving existing CLAUDE.md files, or establishing AI-assisted development standards.
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Expert-level toolkit for modular Godot 4.7+ CLI automation and headless build orchestration. Use when you need to: (1) Build complex scene trees or UI layouts programmatically, (2) Automate expert 3D asset pipelines (glTF -> Collision), (3) Optimize procedural geometry headlessly (CSG -> Static Mesh), or (4) Engineer production-grade CI/CD pipelines. Set GODOT_PATH env var for custom engine location. Keywords: Godot CLI, headless, CI, export, builder, 4.7.
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Expert patterns for 3D level design using GridMap with MeshLibrary, CSG constructive solid geometry, occlusion, and runtime GridMap builders. Use when building 3D levels, modular tilesets, or BSP-style geometry. For sky/fog/Environment recipes, route to godot-3d-lighting. Trigger keywords: GridMap, MeshLibrary, set_cell_item, get_cell_item, map_to_local, local_to_map, CSGCombiner3D, CSGBox3D, CSGSphere3D, CSGPolygon3D, OccluderInstance3D, bake CSG.
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Expert-level toolkit for modular Godot 4.7+ CLI automation and headless build orchestration. Use when you need to: (1) Build complex scene trees or UI layouts programmatically, (2) Automate expert 3D asset pipelines (glTF -> Collision), (3) Optimize procedural geometry headlessly (CSG -> Static Mesh), or (4) Engineer production-grade CI/CD pipelines. Set GODOT_PATH env var for custom engine location. Keywords: Godot CLI, headless, CI, export, builder, 4.7.
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Expert patterns for 3D level design using GridMap with MeshLibrary, CSG constructive solid geometry, occlusion, and runtime GridMap builders. Use when building 3D levels, modular tilesets, or BSP-style geometry. For sky/fog/Environment recipes, route to godot-3d-lighting. Trigger keywords: GridMap, MeshLibrary, set_cell_item, get_cell_item, map_to_local, local_to_map, CSGCombiner3D, CSGBox3D, CSGSphere3D, CSGPolygon3D, OccluderInstance3D, bake CSG.
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Domain-Driven Design architecture for claude-flow v3. Implements modular, bounded context architecture with clean separation of concerns and microkernel pattern.
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Core module implementation for claude-flow v3. Implements DDD domains, clean architecture patterns, dependency injection, and modular TypeScript codebase with comprehensive testing.
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Organize Flutter apps with modular feature-based clean architecture. Use when creating features under lib/features/ with domain, data, and presentation layers. Do not use for test-only, BlocBuilder, navigation, or spinner requests.
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Apply Clean Architecture layering, modularization, and Unidirectional Data Flow in Android projects. Use when setting up project structure, placing code in layers, configuring feature/core modules, or implementing UDF patterns; defer Compose state and ViewModel/StateFlow implementation to their specific skills.
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Python FastAPI development with uv package manager, modular project structure, SQLAlchemy ORM, and production-ready patterns.
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Analyzes, generates, and enhances CLAUDE.md files for any project type using best practices, modular architecture support, and tech stack customization. Use when setting up new projects, improving existing CLAUDE.md files, or establishing AI-assisted development standards.
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Typography pass covering font choice, modular scale, tracking, leading, weight hierarchy, and micro-typography details. Use when fonts feel generic (default Inter with no reason), the scale is ad hoc, hierarchy is flat, or the user says "fix the typography" / "the text doesn't feel right". Invoke when the user asks for typeset on their UI, or mentions 'typeset' alongside design / UI / frontend work.
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Core module implementation for claude-flow v3. Implements DDD domains, clean architecture patterns, dependency injection, and modular TypeScript codebase with comprehensive testing.
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Domain-Driven Design architecture for claude-flow v3. Implements modular, bounded context architecture with clean separation of concerns and microkernel pattern.
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Foundational software design principles applied specifically to robotics module development. Use this skill when designing robot software modules, structuring codebases, making architecture decisions, reviewing robotics code, or building reusable robotics libraries. Trigger whenever the user mentions SOLID principles for robots, modular robotics software, clean architecture for robots, dependency injection in robotics, interface design for hardware, real-time design constraints, error handling strategies for robots, configuration management, separation of concerns in perception-planning- control, composability of robot behaviors, or any discussion of software craftsmanship in a robotics context. Also trigger for code reviews of robotics code, refactoring robot software, or designing APIs for robotics libraries.
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Core module implementation for claude-flow v3. Implements DDD domains, clean architecture patterns, dependency injection, and modular TypeScript codebase with comprehensive testing.
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Domain-Driven Design architecture for claude-flow v3. Implements modular, bounded context architecture with clean separation of concerns and microkernel pattern.
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Optimize prefabrication and modular construction workflows. Plan module sequencing, factory scheduling, transportation logistics, and on-site assembly for maximum efficiency.
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Applies coarse-grained service architecture for deployment independence. Use when independent deployment is needed but shared databases rule out microservices.
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Use ComfyUI as a modular AI content-creation engine: launch and automate the server, submit API workflows, validate graph JSON, author custom nodes, and configure model paths/backends.
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Use when upgrading an application from Spring Boot 3.5 to Boot 4, completing a Framework 7 migration, replacing modular starters, adopting Jackson 3, or diagnosing post-upgrade failures.
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Plan, build, place, and validate physically meaningful Blender object assemblies, including manufactured part boundaries, mechanical seams, mounting interfaces, pivots, hierarchy, constraints, instancing, modular grids, connector planes, and precision snapping. Use when several objects must form one product, machine, architectural module, vehicle, furniture item, mechanism, or environment structure without incorrectly welding independent parts, eyeballing alignment, or leaving continuous shells as overlapping primitives.
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