254건 · 관련도순
MiCA compliance evidence and stablecoin risk scoring. Use when the user asks about stablecoin compliance, MiCA status, peg stability, or needs verifiable evidence for audit workflows.
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Comprehensive guide for dependency injection (DI) in Golang. Covers why DI matters (testability, loose coupling, separation of concerns, lifecycle management), manual constructor injection, and DI library comparison (google/wire, uber-go/dig, uber-go/fx, samber/do). Use this skill when designing service architecture, setting up dependency injection, refactoring tightly coupled code, managing singletons or service factories, or when the user asks about inversion of control, service containers, or wiring dependencies in Go. For a specific DI library, → See `samber/cc-skills-golang@golang-google-wire`, `samber/cc-skills-golang@golang-uber-dig`, `samber/cc-skills-golang@golang-uber-fx`, or `samber/cc-skills-golang@golang-samber-do` skills.
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Comprehensive quality control for flow cytometry and CyTOF data. Covers flow rate stability, signal drift, margin events, dead cell exclusion, and batch QC. Use when assessing acquisition quality or identifying problematic samples before analysis.
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Cloud laboratory platform for automated protein testing and validation. Use when designing proteins and needing experimental validation including binding assays, expression testing, thermostability measurements, enzyme activity assays, or protein sequence optimization. Also use for submitting experiments via API, tracking experiment status, downloading results, optimizing protein sequences for better expression using computational tools (NetSolP, SoluProt, SolubleMPNN, ESM), or managing protein design workflows with wet-lab validation.
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Separate a strategy return series into declared baseline exposure and residual edge with returns-based OLS attribution, HAC inference, rolling stability, alternate-baseline sensitivity, and regime breakdowns. Use when evaluating whether backtest, out-of-sample, or live returns contain independent alpha beyond market, equal-weight, momentum, sector, or user-supplied factor returns; when explaining whether a drawdown came from baseline exposure or strategy-specific behavior; or when a strategy needs an attribution quality gate after backtesting. Do not use for holdings-based Brinson attribution, feature-level Shapley explanations, or analysis from summary metrics without a dated return series.
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When the user wants to monitor, triage, or reduce their app's crash rate — including setting up Crashlytics, prioritizing which crashes to fix first, interpreting crash data, and understanding how crashes affect App Store ranking. Use when the user mentions "crash", "crashlytics", "crash rate", "ANR", "app not responding", "crash-free sessions", "crash-free users", "symbolication", "stability", "firebase crashes", "app crashing", or "crash report". For overall analytics setup, see app-analytics.
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VERIFY your changes work. Measure CLS, detect theme flicker, test visual stability, check performance. Use BEFORE and AFTER making changes to confirm fixes. Includes ready-to-run scripts: measure-cls.ts, detect-flicker.ts
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Vercel's comprehensive UI guidelines for building accessible, performant web interfaces. Use this skill when reviewing or building UI components for compliance with best practices around accessibility, performance, animations, and visual stability.
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**IMPORTANT**: Any change to React or Next.js code must read through this skill first. React and Next.js guidelines from Vercel Engineering covering visual instability, layout shifts, CLS, flickering, hydration issues, and font loading.
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Diagnostic guide for RL-based post-training of language models (GRPO, PPO, REINFORCE, DPO). Use proactively when debugging a training pipeline that shows no improvement, loss anomalies, reward stagnation, NaN gradients, or other unexpected behavior during reinforcement learning fine-tuning. Work through all pipeline stages — reward, advantages, log-probs, loss, generation/decoding — before concluding the diagnosis is complete; stopping after one or two fixes is a common failure mode. Covers log-probability math, advantage estimation, numerical stability, reward processing, and generation/decoding pipeline issues.
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Comprehensive diagnostic analysis of time series data. Use when users provide CSV time series data and want to understand its characteristics before forecasting - stationarity, seasonality, trend, forecastability, and transform recommendations.
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Write a compounding worksheet and record that reproduces the preparation exactly and survives inspection — formula, calculations shown, components with lot numbers, in-process checks, and the beyond-use date with its basis. Use when asked to document a compounded preparation, write a master formulation record, create a compounding worksheet, or prepare compounding documentation for inspection. Produces the master formula, the batch record, the component and lot table, in-process checks, labelling, and the beyond-use-date rationale. Documentation only; standards and stability data must come from current official references.
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Prepare for recruitment at a Chinese state-owned enterprise (国企 / 央企), including its written test and interview: what these employers assess, the typical stages, answers that show fit and stability, and the questions to ask about the role. Use when asked 国企面试怎么准备, 央企校招, 国企笔试考什么, 国企和互联网怎么选, 国企面试问题, or prepare for a state-owned enterprise interview in China. Produces a stage map to confirm against the recruitment notice, a written-test preparation plan, a question bank with answer points, a mock interview with feedback, and a comparison with private-sector offers.
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Comprehensive diagnostic analysis of time series data. Use when users provide CSV time series data and want to understand its characteristics before forecasting - stationarity, seasonality, trend, forecastability, and transform recommendations.
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Modular design, interface stability, dependency management, AI-code health. Triggers: architecture, design, structure, modules, dependencies, coupling, system design.
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Critical Akka.NET best practices including EventStream vs DistributedPubSub, supervision strategies, error handling, Props vs DependencyResolver, work distribution patterns, and cluster/local mode abstractions for testability.
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Unsupervised clustering and cell-type identification for high-dimensional flow, spectral, and mass cytometry - FlowSOM, PhenoGraph, FlowSOM-via-CATALYST, with UMAP/tSNE for visualization. Covers the type-vs-state marker distinction (cluster on lineage, test state within clusters), over-provision-then-metacluster, the Weber-Robinson benchmark, seed dependence and metacluster stability, why embeddings are for looking not measuring, and median-heatmap annotation/merging. Use when discovering populations without predefined gates, choosing a clustering algorithm, selecting the number of metaclusters, or annotating clusters into cell types.
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Infer transcription factor regulons from single-cell RNA-seq with pySCENIC by combining GRNBoost2 co-expression, cisTarget motif-enrichment pruning, and AUCell per-cell activity scoring. Covers the motif-pruning-as-directionality principle, regulon specificity scoring, run-to-run stability, and database/species matching. Use when identifying TF regulons, scoring TF activity per cell, finding master regulators of cell identity, or comparing regulon activity across conditions. For enhancer-driven multiomic GRNs see multiomics-grn; for bulk inference and VIPER protein-activity see grn-inference.
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Query the Ensembl REST API for gene/transcript/protein lookup, sequence retrieval, comparative genomics (Compara), variant effect prediction (VEP), regulatory features, and cross-species ortholog/paralog calls. Use when pulling Ensembl-native data (Ensembl Gene IDs, version-pinned releases, archive endpoints for reproducibility), gene/transcript/exon structure with stable IDs, or VEP for variant annotation. Encodes the 15 req/sec rate limit, archive (e110.rest.ensembl.org) for reproducibility, Ensembl divisions (vertebrates / plants / fungi / metazoa / bacteria), and the symbol-vs-ID stability problem.
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Quantify homologous recombination deficiency (HRD) from tumor copy number using the three genomic-scar metrics — loss of heterozygosity (LOH), large-scale state transitions (LST), and telomeric allelic imbalance (TAI) — with scarHRD, and via the whole-genome HRDetect and CHORD models. Covers the genomic instability score, the PARP-inhibitor clinical context, whole-genome-doubling correction, and the scar-versus-state distinction. Use when computing an HRD score for PARP-inhibitor eligibility, deriving LOH/LST/TAI scars from allele-specific copy number, deciding between scar-based and mutational-signature HRD methods, or interpreting an HRD result in a BRCA-reverted or low-purity tumor.
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Designs PROTACs, molecular glues, and bivalent degraders with explicit handling of E3 ligase choice (VHL, CRBN, IAP, MDM2, KEAP1), linker design (length, composition, rigidity), ternary complex prediction (PRosettaC, DeepTernary, AlphaFold3), cooperativity (alpha), DC50 / Dmax characterization, hook effect, and prediction-experiment reconciliation. Use when designing targeted protein degraders, planning linker SAR, predicting ternary complex stability, or building generative degrader workflows.
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Calls microsatellite instability from WES/WGS/targeted-panel with MSIsensor, MSIsensor-pro, MSIsensor-ct (panel-aware), mSINGS, and MANTIS for FDA pembrolizumab MSI-H pan-tumor / Lynch syndrome / dMMR ICI biomarker. Use when stratifying ICI eligibility (Le 2015), pairing MSI with TMB-H (Sha 2020 / Salem 2018), screening Lynch syndrome (universal IHC + MSI), or distinguishing MSI-H tumors from POLE-exo hypermutator with overlapping signatures.
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Designs covalent inhibitors and warheads targeting cysteine, lysine, serine, threonine, tyrosine, and aspartate residues, with explicit handling of warhead reactivity (acrylamide, chloroacetamide, vinyl sulfone, sulfonyl fluoride, fluorosulfate, aldehyde, boronate, nitrile), reversibility (kinact/Ki, t_residence), glutathione (GSH) stability, intrinsic reactivity assays, and covalent docking (DOCKovalent, GOLD, HCovDock). Use when designing covalent inhibitors for targeted covalent inhibition (TCI), KRAS G12C-style approaches, or rationalizing covalent SAR.
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Three modes for CS-conference papers (CVPR/ICCV/ECCV vision, ACL/EMNLP/NAACL NLP, ICLR/NeurIPS/ICML/AAAI ML). DIRECT-EDIT mode (common): the user describes a change in Chinese or English and the manuscript (LaTeX or Markdown) is edited directly through a CS-venue writing toolkit with author sign-off (use for 改这段 / 把中文想法写成 latex / polish / de-AI / translate / compress a passage). REVIEW mode (occasional, pre-submission): harden the paper through an adversarial courtroom review engine (N holistic domain reviewers / contestability routing / two-sided trial / three-way verdict / clerk-converged multi-round loop) with consensus-gated, author-signed revisions (use for review / critique / 审稿 / 评审 / mock-review). AUTO mode (unattended, opt-in via /goal): run the review-revise loop toward a verifiable goal, applying safe fixes under a drift-bounded policy and queueing risky ones. Resolves all inputs at runtime, no hardcoded paths. Not a from-scratch drafter (use ml-paper-writing) and not an official-venue rebuttal.
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