'summary' 검색 결과

Estimate bivariate genetic correlation (rg) between traits from GWAS summary statistics or individual-level genotypes using cross-trait LDSC, HDL, LAVA, rho-HESS, GREML-bivariate, Popcorn, and HDL-L. Use when quantifying shared genetic architecture between two traits, screening MR validity before causal inference, distinguishing global from locus-level rg, estimating trans-ancestry rg, separating partial from full causation via LCV gcp, or producing a STROBE-MR-compliant cross-trait sensitivity battery. Cross-trait LDSC intercept absorbs sample overlap and is NOT a bias; HDL is biased under sample overlap above ~5%. High rg between exposure and outcome motivates CHP-aware MR sensitivity (CAUSE, LHC-MR).

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Test whether two or more traits share a causal variant at a locus using Bayesian colocalization (coloc.abf, coloc.susie, HyPrColoc, moloc, eCAVIAR, SMR/HEIDI, PWCoCo, SharePro). Use when integrating GWAS with eQTL/sQTL/pQTL/mQTL, distinguishing shared causal variants from LD-driven coincidence, handling allelic heterogeneity, choosing between single-causal vs multi-causal methods, picking PP.H4 thresholds, running sensitivity over p12, or harmonising summary statistics for colocalization.

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生成图文并茂的分析报告/实验报告/质检报告（固定模版）。当用户要求"生成报告/总结报告/实验报告/质检报告/QC报告"，或分析流程收尾需要交付报告时使用。报告必须基于真实分析输出，包含固定章节结构、关键指标表格和真实结果图。

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docs (editable docs people share and comment on; the default for any document, named as a doc or not: a document, report, proposal, resume, cover letter, letter, contract, policy, form, template, worksheet, essay, handbook, guide, how-to, cheat sheet, SOP or other writing to keep, share, collaborate on, send, submit, print or sign; a doc exports to Word, PDF, Markdown or Google Docs, so needing a file to send, attach, upload, submit or print is no reason to pick Word, and a file nobody asked for is a doc, not Word; a plan, comparison, summary or notes asked in chat stays in chat; a pasted claude.ai artifact link may be a doc: check with docs tools first; Word or another file format named, tracked changes wanted, or a .docx to change or use as a template → that format's skill): making one → if no docs-connector instructions are in context, call its `guide` (topic.instructions) first; then create the doc (headings only, no body) before any search, file read or plan, even with files attached.

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Use this skill any time a .pptx or .potx file is involved in any way — as input, output, or both. This includes: creating slide decks, pitch decks, or presentations as PowerPoint (.pptx) files; reading, parsing, or extracting text from any .pptx or .potx file (even if the extracted content will be used elsewhere, like in an email, summary, or creating a different type of slide deck); editing, modifying, or updating existing presentations; combining or splitting slide files; working with templates (.potx), layouts, speaker notes, or comments. Trigger whenever the user asks for a PowerPoint or .pptx file, or references a .pptx or .potx filename, regardless of what they plan to do with the content afterward. However, when the user asks for a deck, slides, a slide deck, or a presentation without naming a file format, default to using a dedicated slide-deck artifact type or a separate slides skill if this session offers one; otherwise, use this skill.

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Refresh the Key Metrics table in a thesis with current data from Financial Modeling Prep, with a scoped web-search fallback (Step 4b) when FMP has no data or resolved the wrong company. Use when user says "numbers", "refresh metrics", "update key metrics", or "refresh [TICKER]" with no other action implied. Surgical edit only — does NOT create research notes or propagate via $sync. Also flags (never auto-edits) stale price/valuation framing in the thesis Summary — see Step 10b.

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Refresh the Key Metrics table in a thesis with current data from Financial Modeling Prep, with a Quartr standardized-statement tie-break for Revenue Growth / Gross Margin gaps (Step 4b-Q) and a scoped web-search fallback (Step 4b) when FMP has no data or resolved the wrong company. Use when user says "numbers", "refresh metrics", "update key metrics", or "refresh [TICKER]" with no other action implied. Surgical edit only — does NOT create research notes or propagate via /sync. Also flags (never auto-edits) stale price/valuation framing in the thesis Summary — see Step 10b.

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Targeted deep research to fill a specific gap in an existing thesis. Use when user says "deepen", "flesh out", "expand on", "fill in", or specifies a thesis section to improve. Also supports --sync-metrics mode — detects stale financial metrics across every in-scope analytical section of a thesis (not just Key Metrics or Summary) and coherently updates every sentence that depends on them, using a Key-Metrics-table / FMP / web-search waterfall. Use when user says "sync metrics", "update the numbers throughout the note", or "fix stale figures across the whole thesis". The batch form `--sync-metrics --all-flagged` syncs every thesis flagged by the latest `/numbers --all-open` in one operation — detection fanned out to capped READ-ONLY agents, one consolidated confirmation gate, direct sequential writes (agents never write).

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Targeted deep research to fill a specific gap in an existing thesis. Use when user says "deepen", "flesh out", "expand on", "fill in", or specifies a thesis section to improve. Also supports --sync-metrics mode — detects stale financial metrics across every in-scope analytical section of a thesis (not just Key Metrics or Summary) and coherently updates every sentence that depends on them, using a Key-Metrics-table / FMP / web-search waterfall. Use when user says "sync metrics", "update the numbers throughout the note", or "fix stale figures across the whole thesis". The batch form `--sync-metrics --all-flagged` syncs every thesis flagged by the latest `$numbers --all-open` in one operation — detection fanned out to capped READ-ONLY agents, one consolidated confirmation gate, direct sequential writes (agents never write).

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Earnings-season triage across ALL active theses (not just Live Portfolio holdings) — every earnings call reported inside the window gets a Quartr event summary, a Conviction-Trigger/Outstanding-Questions cross-reference, and a coverage check against existing Research notes, producing a ranked deep-read queue for /transcript. Use when user says "earnings sweep", "who reported", "triage earnings", "catch up on earnings season", or after any earnings-heavy stretch. Default window 14 days; `/earnings-sweep 90` covers a full season.

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Use this skill when the user requests to generate, create, write, or draft a newsletter, email digest, weekly roundup, industry briefing, or curated content summary. Supports topic-based research, content curation from multiple sources, and professional formatting for email or web distribution. Trigger on requests like "create a newsletter about X", "write a weekly digest", "generate a tech roundup", or "curate news about Y".

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Use this skill any time a .pptx file is involved in any way — as input, output, or both. This includes: creating slide decks, pitch decks, or presentations; reading, parsing, or extracting text from any .pptx file (even if the extracted content will be used elsewhere, like in an email or summary); editing, modifying, or updating existing presentations; combining or splitting slide files; working with templates, layouts, speaker notes, or comments. Trigger whenever the user mentions "deck," "slides," "presentation," or references a .pptx filename, regardless of what they plan to do with the content afterward. If a .pptx file needs to be opened, created, or touched, use this skill.

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Use when the user asks about the pwdev-prd audit trail — 'auditoria do prd', 'eventos', 'decisões registradas', 'audit report', 'exportar relatório de auditoria' — querying the shared SQLite database read-only (summary, events, decisions, artifacts, stats, export, query).

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Use when the user wants to query the local pwdev audit trail — 'ver auditoria', 'relatório de auditoria', 'audit stats', 'exportar auditoria em PDF' — summary, events, decisions, artifacts, statistics, a Markdown/PDF export or a custom read-only SELECT. Do NOT use to enable the audit (feat-init) or for plan status (feat-status).

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Systematically QA test a web application and fix bugs found. Runs QA testing, then iteratively fixes bugs in source code, committing each fix atomically and re-verifying. Use when asked to "qa", "QA", "test this site", "find bugs", "test and fix", or "fix what's broken". Proactively suggest when the user says a feature is ready for testing or asks "does this work?". Three tiers: Quick (critical/high only), Standard (+ medium), Exhaustive (+ cosmetic). Produces before/after health scores, fix evidence, and a ship-readiness summary. For report-only mode, use /qa-only. (gstack) Voice triggers (speech-to-text aliases): "quality check", "test the app", "run QA".

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Produces a compact KPI digest showing how key metrics changed over a period and what's driving the movement. Use this skill when someone asks for a performance summary, a weekly recap, a morning briefing, a KPI update, or any variation of "how did we do this week/month." Also trigger for "give me a performance overview," "what moved in the last 7 days," "pull our AA KPI report," or "summarize our metrics."

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Produces a compact KPI digest showing how key metrics changed over a period and what's driving the movement. Use this skill when someone asks for a performance summary, a weekly recap, a morning briefing, a KPI update, or any variation of "how did we do this week/month." Also trigger for requests like "give me a performance overview," "what moved in the last 7 days," "pull our KPI report," or "summarize our metrics."

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Write a continuation summary for governed work.

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UI brief 生成 SKILL — 從 docs/keep.summary.md、正式規格書、task shard、cross-reference-index 與參考圖整理成可執行的 UI brief 或 task-ready brief。USE FOR: 新 UI 畫面開工前、既有畫面補 task shard 欄位、需要收斂 family / proof / normalized recipe / content_contract / smoke_route。DO NOT USE FOR: 直接修改 ui-spec JSON、直接做視覺 QA。

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Write or revise AI-learning-notes article pages in "寫文章模式" when the user asks for articles, technical articles, blog posts, bilingual versions, article formatting consistency, shared article-base alignment, responsive layout, summary/TOC decisions, contrast, or publishing-flow compatibility.

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Author pull requests with intent-separated commits, blast-radius disclosure, and verification evidence. Load when opening a PR, writing a PR description, separating refactor from feature commits, or summarizing a change set for review. Also triggers on "write the PR", "PR body", "intent-separated commits", "split refactor from feature", "pr summary", or after safe-change cycles complete. Extends git-workflow-and-versioning — does not replace it.

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Generate user-facing or internal release notes and changelogs. Load when the user prepares a release, tags a version, or wants to summarize recent progress. Also triggers on "write a changelog", "prepare release notes", "what's new in this version", "summarize my commits", or "create a release summary". Auto-triggered by library-skill after major repo changes (new skills added, skills renamed, structure changes). Applicable to any project, including this skill library itself.

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Use this skill when the user requests to generate, create, write, or draft a newsletter, email digest, weekly roundup, industry briefing, or curated content summary. Supports topic-based research, content curation from multiple sources, and professional formatting for email or web distribution. Trigger on requests like "create a newsletter about X", "write a weekly digest", "generate a tech roundup", or "curate news about Y".

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Detects m6A modifications from Oxford Nanopore direct-RNA-sequencing (ONT DRS) signal data using m6Anet (Hendra 2022 *Nat Methods* 19:1590; multiple-instance-learning neural network over DRACH 5-mer signal). Covers the required upstream pipeline (Dorado / Guppy basecalling -> minimap2 transcriptome alignment with `-ax map-ont -uf -k14 --secondary=no` -> nanopolish eventalign with `--scale-events --signal-index` (m6Anet-required) plus `--summary` / `--threads` housekeeping -> m6anet dataprep -> m6anet inference), per-site vs per-read probability interpretation including the `mod_ratio` per-site stoichiometry column, the DRACH-only modeling constraint, minimum-coverage thresholds (20-50 reads per site for stable probability estimates), multi-condition comparison via xPore (Pratanwanich 2021 *Nat Biotechnol* 39:1394), Nanocompore (Leger 2021 *Nat Commun* 12:7198), ELIGOS (Jenjaroenpun 2021 *NAR* 49:e7), and Dorado native modification calling (RNA004 chemistry, 2024+), reference-transcriptome version pinning, the cDNA-vs-DRS chemistry distinction (cDNA-Nanopore CANNOT be used for modification detection), and orthogonal validation against MeRIP / GLORI. Use when calling m6A from ONT DRS without immunoprecipitation, choosing m6Anet vs xPore vs Nanocompore vs ELIGOS vs Dorado native, interpreting per-site `probability_modified` vs `mod_ratio` vs per-read modification probabilities, comparing methylation between conditions from ONT data, deciding between m6Anet for known DRACH sites and Dorado/Remora for genome-wide screening, pinning RNA002 vs RNA004 chemistry and basecaller model versions, or troubleshooting eventalign / dataprep failures.

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