'pir' 검색 결과

Prepares statistical reports for clinical trials following CONSORT 2025, SPIRIT 2025, ICH E9(R1) estimands, and FDA 2023 covariate adjustment guidance. Covers Table 1 generation, analysis populations (ITT/FAS/PP/Safety), the 5 ICH E9(R1) intercurrent-event strategies, MMRM under MAR (mmrm), reference-based MI (rbmi J2R/CR/CIR), Permutt tipping-point sensitivity, and Rubin's-rules vs frequentist variance debate. Use when preparing regulatory submissions, defining estimands, or implementing missing-data sensitivity analyses.

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Generates 3D conformer ensembles using RDKit ETKDGv3 with knowledge-enhanced distance geometry, MMFF94/UFF force-field optimization, CREST + GFN2-xTB semi-empirical refinement, and macrocycle-aware torsion preferences. Provides explicit decision rules for single vs ensemble conformer use, RMSD pruning, energy windows, conformer count, and force-field choice. Use when preparing 3D ligands for docking, generating descriptor input for 3D QSAR, or sampling macrocycle/peptide conformational ensembles.

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Predicts whether a DNA variant alters mRNA splicing using sequence-based deep-learning tools — SpliceAI (10kb context dilated CNN, clinical default), Pangolin (multi-tissue), MMSplice (modular per-region CNN with calibrated ΔPSI), SpliceTransformer/TrASPr (tissue-aware transformers), SpliceVault (empirical 300K-RNA lookup of likely mis-splicing outcomes), CADD-Splice (composite score). Applies the ClinGen SVI 2023 framework for ACMG/AMP variant interpretation (PVS1, PP3, BP4 evidence codes), HGVS splicing nomenclature (c.123+1G>A, c.123-3T>G, r.spl?), extended-window scoring for deep-intronic pseudoexons, tissue-specific predictions, branchpoint variant detection (BPHunter, LaBranchoR), and splice-switching ASO design. Use when interpreting splice impact of clinical variants, prioritizing VUS, identifying deep-intronic pathogenic variants, or designing ASOs.

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Detects differential alternative splicing between conditions using rMATS-turbo (binomial LRT on junction counts), leafcutter (Dirichlet-multinomial GLM on intron clusters), MAJIQ V3 deltapsi/HET (Bayesian posterior on LSVs), SUPPA2 (empirical-null on TPM-derived PSI), or Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage). Reports FDR-corrected significance and delta PSI effect sizes. Tools differ in statistical model, annotation dependence, calibration regime, and replicate-count requirements. Use when comparing splicing patterns between treatment groups, tissues, or disease states.

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Provides patterns for implementing Spring Boot caching: configures Redis/Caffeine/EhCache providers with TTL and eviction policies, applies @Cacheable/@CacheEvict/@CachePut annotations, validates cache hit/miss behavior, and exposes metrics via Actuator. Use when adding caching to Spring Boot services, configuring cache expiration, evicting stale data, or diagnosing cache misses.

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Design patterns for building autonomous coding agents, inspired by [Cline](https://github.com/cline/cline) and [OpenAI Codex](https://github.com/openai/codex).

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Extract typical annual GPP, annual evapotranspiration, mid-season LAI, mid-season root biomass, mid-season shoot biomass, median canopy height, maximum primary-root depth, Vcmax at 25oC, and Jmax at 25oC from EcoSIM h0 NetCDF output files. Use when asked to derive these EcoSIM output targets from a selected .ecosim.h0.*.nc file for model-output processing, trait checks, or benchmark summaries.

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Create a delightful, unexpected "wow" experience for the user by dynamically discovering and creatively combining other enabled skills. Triggers when the user says "surprise me" or any request expressing a desire for an unexpected creative showcase. Also triggers when the user is bored, wants inspiration, or asks for "something interesting".

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Supply chain investigation, evidence recovery, and forensic analysis for GitHub repositories. Covers deleted commit recovery, force-push detection, IOC extraction, multi-source evidence collection, hypothesis formation/validation, and structured forensic reporting. Inspired by RAPTOR's 1800+ line OSS Forensics system.

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Shadcn/ui-inspired design with minimal, clean components, monochrome palette, and utility-first patterns.

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A cyber-slick, dark-only Matrix-inspired interface defined by minimalist fashion, high-tech digital elements

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Throwback design with vintage-inspired typography, high-contrast retro palettes, and nostalgic visual elements.

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A playful, arcade-inspired interface for games — built on the VT323 pixel typeface, hard-edged 0px corners, chunky pill buttons that physically press into solid offset blocks

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A friendly, hand-drawn sketch interface inspired by pencil illustrations on warm cream paper. Soft teal brand accents, hand-written display headings, rounded pill controls.

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Classic block-game inspired design with playful colors, bold display fonts, and compact, high-energy layouts.

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Print-inspired visual language for books, magazines, and reports with editorial grids and expressive typography.

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Retro arcade-inspired design with pixel fonts, dotted borders, playful high-contrast colors, and 8-bit game aesthetics.

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Apple-inspired premium aesthetic with precise spacing, modern typography, and a refined, polished visual language.

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A playful, energetic, cartoonesque interface inspired by friendly children's-book illustrations — warm cream backgrounds, big bold custom display typography, saturated brand color blocks, thick black outlines, generously rounded shapes

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Magazine-inspired editorial layout with refined serif typography, structured grids, and elegant reading experiences.

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Monospace-driven, matrix-inspired design with high-contrast elements, compact density, and a hacker-chic aesthetic.

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Forward-looking design with tech-inspired typography, modern layouts, and a sleek, innovation-driven aesthetic.

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Game-inspired fantasy aesthetic with bold, premium visuals, rich color palettes, and immersive thematic elements.

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Paper-textured, print-inspired design with minimal colors, clean serif/sans typography, and tactile surface qualities.

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