'glm' 검색 결과

Generate a single-file industrial-archive product landing page (Nordic museum aesthetic, hash-routed detail pages). Takes a natural-language description of one or more "exhibit-style" products (objects, tools, hardware, watches, kitchenware, lighting, audio, instruments, anything with a designed/forged/restrained quality); outputs ONE working .html file. Visitors see a black-framed cover that flips between exhibits, sidebar index, side meta column (material/origin/year/dimension), and click any exhibit → full detail page (giant italic title, spec table, hero image, lead + 3 prose paragraphs, gallery, prev/next). Runs in BOTH Claude Code (writes to ~/Desktop) and GLM / online chat (outputs HTML inline). Trigger: "做个工业风产品落地页", "做克制之物风格的展品页", "industrial-archive-gen ...", or when user drags this skill folder into chat asking for a product page in the Nordic-industrial archive style.

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Generate a single-file VR-style portfolio website — works are tiled on the inside of a 3D cylinder/sphere (concave wraparound, like an immersive headset), with mouse-controlled head tilt, long-press to drag and browse the infinite canvas, click to open work detail. Includes overlays for About / CV / Contact / Filter. Takes a natural-language description of the studio and works (images + brief copy); outputs ONE working .html file. Runs in BOTH Claude Code (writes to ~/Desktop) and GLM / online chat (outputs HTML inline). Trigger phrases: "做个 VR 作品集", "做个无限画布作品集", "做个穹顶包裹的作品集", "vr-canvas-gen ...", or when user drags this skill folder into chat asking for a wraparound/immersive portfolio site.

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Generate a single-file product landing page with a layered ASCII cosmos hero (rotating ASCII planet, drifting irregular asteroids, comet trails, nebula gas clouds — each in its own harmonious color) plus full marketing sections (about / features grid / showcase / spec / pricing / CTA / footer). Takes a natural-language description of one product (any kind — a note app, a coffee subscription, a CLI tool, an indie hardware, a hosting service…) and outputs ONE working .html file with deep-space dark or warm-letterpress theme. Runs in BOTH Claude Code (writes to ~/Desktop) and GLM / online chat (outputs HTML inline). Trigger phrases: "做个宇宙风产品落地页", "生成 ASCII 产品官网", "ascii-cosmos-gen ...", "做个独立软件 / 独立硬件落地页", or when user drags this skill folder into chat asking for an atmospheric product landing page.

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Generate a single-file Chinese atelier-style portfolio website (horizontal-row list + hover-reveal thumb interaction, art lishu typography "Alimama DaoLiTi" via CDN, light/dark theme, hash-routed detail pages). Takes a natural-language description of the studio (name, director, discipline, works) and outputs ONE working .html file. Runs in BOTH Claude Code (writes to ~/Desktop) and GLM / online chat (outputs HTML inline). Trigger phrases include "做个中式工作室作品集", "做个隶书作品集", "lishu-portfolio-gen ...", "做个白屋风格的作品集", or when user drags this skill folder into chat asking for an atelier-style site.

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Compares Hi-C contact maps between conditions across the right scale -- differential bin-pair contacts (multiHiCcompare, diffHic), differential A/B compartments (dcHiC), differential TAD boundaries (delta insulation), and differential loops (diffloop, DiffHiChIP) -- with distance-stratified between-sample normalization, replicate-aware NB-GLM FDR, HiCRep SCC reproducibility gating, and CNV correction for cancer/aneuploid samples. Use when comparing Hi-C between treatment and control, finding differential contacts/compartments/boundaries/loops, normalizing two maps of unequal depth, choosing a replicate-aware test, gating replicates with SCC, or correcting copy-number artifacts before a tumor-vs-normal comparison.

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Calls m6A peaks from MeRIP-seq / m6A-seq paired IP-vs-input data using exomePeak2 (transcript-aware, GC-bias-corrected Poisson GLM; Liu 2022 *NAR Genom Bioinform* 4:lqac046), MeTPeak (HMM over sliding windows; Cui 2016 *Bioinformatics* 32:i378), MACS3 / MACS2 with --nomodel --broad --keep-dup all (genome-wide broad alternative), and DRACH motif enrichment confirmation via HOMER or ggseqlogo as a sanity check (NOT a filter). Covers BED12 vs narrowPeak output formats, exonic vs intronic peak handling, multi-tool reconciliation (intersection vs union; cross-caller IDR-equivalent), the m6A-vs-m6Am ambiguity at 5'UTR peaks that antibody-based methods cannot resolve, and orthogonal-validation routes (miCLIP / GLORI / m6A-SAC-seq / m6Anet). Use when calling peaks from paired IP/input genome BAMs, choosing exomePeak2 (transcript-aware default) vs MACS3 (broad genomic) vs MeTPeak (HMM-smoothed low-coverage), confirming DRACH enrichment as a sanity check on the peak set as a whole, reconciling differing peak sets across tools, validating MeRIP peaks against orthogonal single-base methods, interpreting peaks at the 5' end where m6Am contamination is possible, or recommending a multi-tool consensus strategy.

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Differential abundance (DA) and differential state (DS) analysis for flow and mass cytometry - tests which cell populations change in frequency or marker expression between conditions using diffcyt (edgeR/voom/GLMM for DA, limma/LMM for DS), with cydar, CITRUS, and compositional methods (sccomp, scCODA, DCATS) as alternatives. Covers the sample-is-the-experimental-unit principle, design/contrast and mixed-model formulas, compositionality of cluster proportions, and FDR across clusters. Use when comparing populations between groups, choosing a DA method, handling paired/batch designs, or deciding whether compositional correction is needed.

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Creates DE-specific diagnostic and result visualizations using DESeq2/edgeR built-in functions and lightweight ggplot2 wrappers. Covers MA plot (with the shrunken-LFC compression effect), volcano (with the apeglm caveat that p-values are unchanged), PCA on VST/rlog (never raw counts), sample distance heatmaps, top-DE-gene heatmaps with the row-scaling trap, dispersion / BCV plot interpretation, p-value histogram diagnostics, plotCounts for individual genes, blind=TRUE vs FALSE rationale, and the n=3 visualization stake. Use when generating DE diagnostic plots, choosing VST vs rlog for visualization, troubleshooting suspicious plot patterns (shifted MA cloud, batch-dominated PCA, anti-conservative p-value histogram), or building a standard QC figure panel.

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Analyzes single-cell pooled CRISPR screens (Perturb-seq, CROP-seq, Perturb-CITE-seq, ECCITE-seq, multiome) where each cell carries an sgRNA and a scRNA-seq / surface-protein / chromatin readout. Covers experimental design (direct-capture Perturb-seq Dixit 2016 vs CROP-seq 3'UTR-barcoded Datlinger 2017 vs ECCITE-seq vs Multiome), MOI for sgRNA assignment, escaper-cell filtering (Mixscape, Papalexi 2021), SCEPTRE NB GLM + permutation for low-MOI (Barry 2024 Genome Biol 25:124), the Pertpy framework, factor decomposition, genome-scale Perturb-seq (Replogle 2022 Cell, 2.5M cells), and per-perturbation single-cell DE. Use when running a single-cell CRISPR screen, choosing direct-capture vs CROP-seq architecture, filtering escaper cells, performing single-cell DE, integrating Perturb-seq with pathway analysis, scaling to GW CRISPRi via Replogle protocol, or analyzing multi-omics screens.

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Build volcano and MA plots from differential-expression / association results with LFC shrinkage, FDR-adjusted thresholds, sensible label placement, and axis-truncation conventions. Covers EnhancedVolcano, ggplot2, matplotlib, and the apeglm/ashr/normal shrinkage decision. Use when visualizing differential-expression results (RNA-seq, ChIP-seq, ATAC-seq, proteomics) or any per-feature effect-size + p-value table.

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Detects differential alternative splicing between conditions using rMATS-turbo (binomial LRT on junction counts), leafcutter (Dirichlet-multinomial GLM on intron clusters), MAJIQ V3 deltapsi/HET (Bayesian posterior on LSVs), SUPPA2 (empirical-null on TPM-derived PSI), or Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage). Reports FDR-corrected significance and delta PSI effect sizes. Tools differ in statistical model, annotation dependence, calibration regime, and replicate-count requirements. Use when comparing splicing patterns between treatment groups, tissues, or disease states.

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Use when the user explicitly authorizes automatic execution or resume of exactly one OpenSpec task on Codex or Claude. Drives the single-task native goal lifecycle through Keel gates, keeps the current agent the sole holder of write authority, and stops at the task boundary. Never activate for ordinary apply, proposal work, ambiguous or multiple tasks, or OpenCode.

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Implement tasks from an OpenSpec change. Use when the user wants to start implementing, continue implementation, or work through tasks.

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Create, validate, or clear the optional keel-handoff/v1 pointer override when human intent cannot be inferred uniquely.

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Align explicit requirements, implicit expectations, non-goals, observable acceptance, evidence, and decision authority before OpenSpec specs and executable tasks finalize. Use when authoring or updating a proposal, design, specs, or tasks, or when a request hides a material product choice. Do not use for routine implementation of an already-authorized task, unrelated conversation, or facts the repository can answer.

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Drive Keel agent test-first or evidence-first execution for a selected OpenSpec task. Use when a task needs software tests, hardware testbench, assertions, lint, new behavior proof, regression coverage, or red/green evidence before implementation.

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Archive a completed change in the experimental workflow. Use when the user wants to finalize and archive a change after implementation is complete.

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Debug Keel agent command or validation failures under Keel's selected OpenSpec task contract. Use when `/opsx:apply` or a selected task reports failed commands, failing tests, validation errors, retry-fuse decisions, or needs an evidence-bound failure report.

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Enter explore mode - a thinking partner for exploring ideas, investigating problems, and clarifying requirements. Use when the user wants to think through something before or during a change.

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Run the current agent's thin semantic consistency review after shared Keel Core gates and before task completion, sync, archive, or meaningful handoff.

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Propose a new change with all artifacts generated in one step. Use when the user wants to quickly describe what they want to build and get a complete proposal with design, specs, and tasks ready for implementation.

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Sync delta specs from a change to main specs. Use when the user wants to update main specs with changes from a delta spec, without archiving the change.

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