'binding' 검색 결과

API + Python SDK for ordering cell-free protein expression and binding assays. Submit sequences for expression (10–100 µg), measure binding affinity (KD) against targets, track status, and retrieve results programmatically — no wet-lab setup. Built for ML-guided directed evolution and antibody/nanobody optimization. Requires Adaptyv account and API key.

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Provides patterns for unit testing `@ConfigurationProperties` classes with `@ConfigurationPropertiesTest`. Validates property binding, tests validation constraints, verifies default values, checks type conversions, and mocks property sources for Spring Boot configuration properties. Use when testing application configuration binding, validating YAML or application.properties files, verifying environment-specific settings, or testing nested property structures.

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Technical enforcement of GDPR Article 5(1)(b) purpose limitation principle. Covers purpose-tagged data stores, access control per purpose, Article 6(4) compatibility assessment factors, and system design for preventing purpose creep. Includes purpose binding architecture and compatibility test implementation.

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Identifies differentially bound ChIP-seq regions between conditions using DiffBind, csaw (sliding windows), DESeq2/edgeR/PyDESeq2 on count matrices, NormR (control-aware), or MAnorm2. Distinguishes three distinct normalization problems (composition bias, trended bias, global shifts) and matches each to its appropriate fix including spike-in scaling. Use when comparing ChIP-seq binding between experimental conditions, choosing normalization for global vs local changes, integrating spike-in data, or reconciling DiffBind/DESeq2 disagreement.

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Identify differentially bound regions across CLIP-seq conditions (knockdown vs control, treatment vs vehicle, disease vs healthy) using DEWSeq (sliding-window DESeq2), Flipper (Skipper-downstream), ASpeak, edgeR, or limma-voom. Use when computing condition-level changes in RBP binding intensity, choosing peak-level vs window-level vs crosslink-level testing, designing replicate experiments, or distinguishing biological binding shifts from technical confounders.

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End-to-end CLIP-seq pipeline from FASTQ to ENCODE-compliant binding sites, single-nucleotide crosslink maps, annotation, motifs, and (optionally) differential binding. Use when running the full Yeo lab eCLIP / iCLIP / iCLIP2 / iCLIP3 / irCLIP / PAR-CLIP analysis with SMInput control, protocol-specific UMI extraction, ENCODE STAR parameters, CLIPper or Skipper peak calling with stringent log2 FC and -log10 p thresholds, IDR rescue and self-consistency QC, and downstream motif registration with mCross or PEKA.

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Annotate CLIP-seq peaks or crosslink sites to RNA features (5'UTR, CDS, 3'UTR, intron, splice junction, snoRNA, tRNA, ncRNA, repeat elements) with ChIPseeker, RCAS, RBP-Maps (Yeo splicing regulatory maps), and bedtools, applying feature-priority hierarchies, transcript-context resolution, and metagene aggregation. Use when characterizing where in transcripts an RBP binds, comparing peak distribution across regions, generating splicing-regulatory maps relative to alternative-splicing events, or distinguishing exonic vs intronic vs UTR binding.

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Query STRING for protein-protein interactions. Use when user asks about protein interactions, interaction networks, binding partners, or interactome. Triggers on "string", "protein interaction", "interaction network", "binding partners", "interactome", "PPI".

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Binder design ranking using ipSAE (interprotein Score from Aligned Errors). Use this skill when: (1) Ranking binder designs for experimental testing, (2) Filtering BindCraft or RFdiffusion outputs, (3) Comparing AF2/AF3/Boltz predictions, (4) Predicting binding success rates, (5) Need better ranking than ipTM or iPAE. For structure prediction, use chai or alphafold. For QC thresholds, use protein-qc.

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Ligand-aware protein sequence design using LigandMPNN. Use this skill when: (1) Designing sequences around small molecules, (2) Enzyme active site design, (3) Ligand binding pocket optimization, (4) Metal coordination site design, (5) Cofactor binding proteins. For standard protein design, use proteinmpnn. For solubility optimization, use solublempnn.

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Internal downstream skill for ctf-sandbox-orchestrator. CTF-sandbox workflow for Kubernetes API analysis, service-account trust, RBAC edges, admission and controller behavior, cluster secrets, workload mutation, and namespace-scoped drift. Use when the user asks to inspect kube API permissions, service-account tokens, RoleBinding or ClusterRoleBinding edges, admission webhooks, controller-created pods, secret exposure, or why live workloads differ from manifests. Use only after `$ctf-sandbox-orchestrator` has already established sandbox assumptions and routed here.

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Implement electronic signatures compliant with 21 CFR Part 11 Subpart C and EU Annex 11. Covers signature manifestation (signer, date/time, meaning), signature-to-record binding, biometric vs non-biometric controls, policy creation, and user certification requirements. Use when a computerized system requires legally binding electronic signatures for GxP records, when replacing wet-ink signatures in regulated workflows, when implementing batch release or document approval workflows, or when a regulatory gap reveals missing signature controls.

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Use when diagnosing NPU + PyTorch or LLM Serving Host CPU affinity, NUMA locality, cgroup/cpuset constraints, CPU range conflicts, PyTorch/runtime threading, DataLoader, tokenizer, scheduler, vLLM-Ascend, SGLang, TTFT, TPOT, tokens/s, QPS, or multi-rank/multi-worker CPU binding issues.

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DNS rebinding attack playbook. Use when testing applications that trust DNS resolution for origin checks, interact with internal services from browser context, or when SSRF is not possible server-side but the target has client-side fetch/XHR to attacker-controlled domains.

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Diagnoses Workload Identity Federation for GKE authentication failures for Pods (403 "iam.serviceAccounts.getAccessToken" / permission denied, "could not find default credentials", or GKE metadata server unreachable) by verifying cluster and node-pool Workload Identity configuration, the Kubernetes ServiceAccount (KSA) to IAM binding (direct principal binding and legacy Google ServiceAccount impersonation), target-resource IAM roles, and gke-metadata-server health. Use when a Pod cannot authenticate to Google Cloud APIs even though Workload Identity is expected to be in effect. Don't use for in-cluster Kubernetes RBAC errors (API-server authorization), general workload crashes (use gke-workload-troubleshooting), or Workload Identity setup and hardening (use gke-workload-security).

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Query the UCSC Genome Browser REST API to retrieve regulatory tracks, DNA sequences, cCRE annotations, TF binding clusters, and track schemas for any genomic region. Use when the user wants to look up what regulatory elements exist at a genomic locus, retrieve DNA sequence under peaks, query ENCODE cCREs or TF rPeak clusters from UCSC, check what tracks are available for a genome assembly, get chromatin accessibility across cell types, or cross-reference ENCODE data with UCSC-hosted annotations. Also use when the user mentions UCSC, genome browser, cCRE lookup, SCREEN, TF binding clusters, DNA sequence retrieval, or track data extraction.

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Use when designing or troubleshooting CRM Analytics dashboards — chart types, bindings, faceting, dashboard interactions, mobile layout, and filters. NOT for standard Salesforce reports and dashboards — use admin/reports-and-dashboards-fundamentals. NOT for hand-editing dashboard JSON or a SAQL step — use admin/analytics-dashboard-json.

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Drafts a U.S. asset purchase letter of intent (LOI) separating binding from non-binding terms and capturing deal points, diligence, exclusivity, and closing path. Trigger on "letter of intent", "LOI", "asset purchase", "M&A LOI", "no-shop", "exclusivity", "purchase price", "due diligence".

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Create modern Angular standalone components following v20+ best practices. Use for building UI components with signal-based inputs/outputs, OnPush change detection, host bindings, content projection, and lifecycle hooks. Triggers on component creation, refactoring class-based inputs to signals, adding host bindings, or implementing accessible interactive components.

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Slack Gateway operations guide. Socket Mode credentials, config.toml bindings, serve restart, receiver debugging, reaction behavior. Triggers on "serve", "gateway", "slack", "바인딩", "binding", "소켓", "socket", "폴러", "poller", "config.toml".

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Agent system design patterns distilled from the OpenClaw codebase. Gateway-centric control, Session Key hierarchy, Binding routing, Lane Queue concurrency, Sub-agent Spawn+Announce, 4-tier automation, Plugin architecture, Policy Chain, Failover strategies. Triggered by "gateway", "session", "binding", "lane", "spawn", "announce", "heartbeat", "cron", "hook", "plugin", "policy", "failover" keywords.

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Annotate CLIP-seq peaks or crosslink sites to RNA features (5'UTR, CDS, 3'UTR, intron, splice junction, snoRNA, tRNA, ncRNA, repeat elements) with ChIPseeker, RCAS, RBP-Maps (Yeo splicing regulatory maps), and bedtools, applying feature-priority hierarchies, transcript-context resolution, and metagene aggregation. Use when characterizing where in transcripts an RBP binds, comparing peak distribution across regions, generating splicing-regulatory maps relative to alternative-splicing events, or distinguishing exonic vs intronic vs UTR binding.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Identify differentially bound regions across CLIP-seq conditions (knockdown vs control, treatment vs vehicle, disease vs healthy) using DEWSeq (sliding-window DESeq2), Flipper (Skipper-downstream), ASpeak, edgeR, or limma-voom. Use when computing condition-level changes in RBP binding intensity, choosing peak-level vs window-level vs crosslink-level testing, designing replicate experiments, or distinguishing biological binding shifts from technical confounders.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.

Identifies differentially bound ChIP-seq regions between conditions using DiffBind, csaw (sliding windows), DESeq2/edgeR/PyDESeq2 on count matrices, NormR (control-aware), or MAnorm2. Distinguishes three distinct normalization problems (composition bias, trended bias, global shifts) and matches each to its appropriate fix including spike-in scaling. Use when comparing ChIP-seq binding between experimental conditions, choosing normalization for global vs local changes, integrating spike-in data, or reconciling DiffBind/DESeq2 disagreement.

한국어 요약은 준비 중입니다. 원문 설명을 표시하고 있습니다.