'discovery' 검색 결과

Analyze spatial cell-cell interactions, neighborhoods, and niches in IMC/MIBI data with squidpy and imcRtools, covering neighborhood-enrichment permutation nulls, the abundance-vs-density confound, inhomogeneous Ripley's K, cellular-neighborhood discovery, graph-construction (contact vs proximity), and edge effects. Use when testing whether cell types co-locate, choosing a spatial null, building a neighbor graph, discovering tissue niches, or deciding whether a spatial pattern is real or a density/segmentation artifact.

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Infer or annotate TCR antigen specificity by unsupervised clustering (TCRdist/tcrdist3, GLIPH2, clusTCR, GIANA) and database lookup (VDJdb, IEDB, McPAS-TCR), and rank candidates with supervised predictors (ERGO-II, NetTCR-2.x, pMTnet) under explicit caveats. Encodes the central truth that general TCR-epitope prediction for UNSEEN epitopes essentially does not work (collapses to near-random; IMMREP22, Grazioli 2022) because labeled data is dominated by a few immunodominant epitopes and there is no true negative set — so clustering for discovery is the honest task and de-novo binding needs wet-lab validation. Use when annotating TCR specificity or grouping a repertoire. Epitope/MHC context lives in mhc-binding-prediction.

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Nominates and assesses CRISPR off-target sites genome-wide. Enumerates candidate sites by mismatch and bulge tolerance with Cas-OFFinder/CRISPRitz, ranks them with the published CFD score (SpCas9-only, relative ranker) or MIT/CRISTA/energy models, runs variant-aware screening against gnomAD/individual genomes (CRISPRme), and frames the empirical genome-wide discovery assays (GUIDE-seq, CIRCLE-seq, CHANGE-seq, DISCOVER-seq, Digenome-seq) and high-fidelity nuclease choice (HiFi Cas9, Sniper-Cas9, eSpCas9, SpCas9-HF1). Use when assessing guide RNA specificity, choosing among candidate guides, screening a therapeutic guide against population variation, or planning empirical off-target validation. Distinguishes predicted vs detected vs validated. On-target activity scoring and deaminase (Cas-independent) base/prime-editor off-targets are separate skills.

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Predict RBP binding from RNA sequence using deep learning models (RBPNet sequence-to-signal, RNAProt RNN, GraphProt2 GCN with structure, DeepCLIP, DeepRiPe multi-modal CNN) for variant-effect prediction, in silico binding-site discovery, model interpretation, and transfer learning from CLIP and RBNS datasets. Use when computational prediction of RBP binding from sequence is needed, evaluating variant effects on binding without further wet-lab experiments, comparing model performance, or training a custom model on ENCODE eCLIP data.

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Trains and applies base-resolution deep learning models on ChIP-seq / ChIP-nexus / CUT&RUN data. Uses BPNet (Avsec 2021 Nat Genet 53:354; soft motif syntax from ChIP-nexus), chromBPNet (Pampari A et al 2025 Nat Genet; bias-factorized base-resolution profiles), EnFormer (Avsec 2021 Nat Methods 18:1196; 196 kb input, ~100 kb effective receptive field), DeepSEA (Zhou 2015; multi-task CNN), and JASPAR 2026 deep-learning collection (1259 BPNet ChIP models). Performs in silico mutagenesis for variant-effect prediction, DeepLIFT/Grad attribution, and TF-MoDISco motif discovery from attribution scores. Use when predicting variant effects on TF binding, discovering soft motif syntax / cooperativity, integrating ChIP-seq with sequence-only predictions, or applying precomputed JASPAR Deep Learning models to new variants.

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Predict enhancer-gene regulatory connections from ATAC-seq using ABC, ENCODE-rE2G, HiChIP, or Cicero. Use when linking distal enhancers to target genes, choosing between contact-aware (ABC, ENCODE-rE2G), accessibility-only (Cicero), and orthogonal (HiChIP H3K27ac, EpiMap) approaches, validating predictions against CRISPRi-FlowFISH gold-standard, or building cell-type-specific regulatory maps for fine-mapping or therapeutic target discovery.

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Assesses RNA-seq data quality specifically for alternative splicing analysis. QC layers include experimental design audit (library prep, read length, depth, replicates), STAR 2-pass cohort-style alignment, junction saturation curves and discovery plateau detection, novel-vs-known junction ratio diagnostics, junction-overhang distribution, splice-site strength scoring (MaxEntScan intrinsic + SpliceAI context-aware), strandedness verification, GENCODE basic vs comprehensive choice, and rRNA contamination screening. Splicing analysis is more demanding than DGE on read length, depth, library prep, alignment strategy, and annotation choice — failures silently bias PSI estimates and inflate novel-junction false positives. Use when evaluating data suitability for splicing analysis, troubleshooting low event detection, or designing sequencing experiments where AS is a primary endpoint.

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Ranks eligible skill candidates with explicit retrieval evidence, capability coverage, and uncertainty. NOT for discovery, authorization, or execution planning.

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OpenLineage, DataHub, Marquez for data lineage tracking and impact analysis. Activate on: data lineage, OpenLineage, DataHub, Marquez, impact analysis, data catalog, column lineage, data discovery. NOT for: data quality validation (use data-quality-guardian), dbt documentation (use dbt-analytics-engineer).

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Matches natural language task descriptions to appropriate skills using semantic similarity. Handles fuzzy matching, intent extraction, and capability alignment. Activate on 'find skill', 'match task', 'semantic search', 'skill lookup', 'what skill for'. NOT for ranking matches (use dag-capability-ranker) or skill catalog (use dag-skill-registry).

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Pipeline that turns a big system idea into briefs for an agent fleet. Use when Arman says 'let's plan out X', 'build or overhaul the X system', 'create the vision and plan for X', 'do the full discovery process', 'get this ready for a fleet', or 'do what we did for education', or when carrying forward a VISION, COMPETITIVE_INSIGHTS, roadmap, or briefs doc. NOT for one feature in a live system (use build-sub-feature).

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Discovery batch that grows the Provider Access Launch queue. Use when asked to find more user-connected OAuth, API, API-key, remote MCP, marketplace, or partner-access campaigns for a capability, provider family, MCP/plugin catalog, or competitive gap. NOT for client Local Listings distribution.

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Create an Agent SKILL.md fallback for an existing find-XXXX finder that relies on a fragile discovery foundation — above all LLM_DECOMPILE (patterns C/D/E), which matches the decompiled shape of a predecessor function against a stored reference and breaks when a symbol is inlined or de-inlined in a way the reference does not cover. The generated fallback coexists with the preprocessor and runs only when it returns failure, recovering every target robustly by decompiling the predecessor and following the inline/de-inline boundary with semantic anchors. Use when a finder broke on a game update, or you want to durably backstop one before it does. The recipe generalizes to any finder foundation. Triggers: create agent skill fallback, add SKILL.md fallback, robust fallback for finder, backstop LLM_DECOMPILE finder, final guarantee skill

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Create a new find-XXXX preprocessor Python script from scratch (no existing SKILL.md), add configs/<GAMEVER>.yaml skill and symbol entries. Covers xref-string-based and LLM_DECOMPILE-based discovery patterns. Use when a GitHub issue or user instruction specifies a new function to find.

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Convert an existing find-XXXX SKILL.md into a preprocessor Python script, updating configs/<GAMEVER>.yaml and removing the old SKILL.md. Covers xref-string-based and LLM_DECOMPILE-based discovery patterns.

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Academic paper search across 14+ scholarly platforms including arXiv, PubMed, Google Scholar, Web of Science, Semantic Scholar, Sci-Hub, and more. Use for literature review, research discovery, and citation management.

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Index-based file discovery using ABOUTME headers. Use INSTEAD of grep or Explore agent when searching for files by purpose or feature. Faster and more accurate than scanning code. Invoke this skill when user asks "which files handle X", "where is Y implemented", or when you need to find files related to a feature or task.

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Executive coaching skill that helps you plan your 2026 using research-backed process goals. Guides you through discovery questions, creates outcome goals, converts them to daily behaviors, and sets up accountability systems. Use when you want to plan your year, set goals, or need a coach to help you stay focused.

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Azure API Center SDK for .NET. Centralized API inventory management with governance, versioning, and discovery.

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Find and evaluate influencers for brand partnerships, verify authenticity, and track collaboration performance across Instagram, Facebook, YouTube, and TikTok.

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Provide comprehensive techniques for testing REST, SOAP, and GraphQL APIs during bug bounty hunting and penetration testing engagements. Covers vulnerability discovery, authentication bypass, IDOR exploitation, and API-specific attack vectors.

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Universal AI-powered web scraper for any platform. Scrape data from Instagram, Facebook, TikTok, YouTube, LinkedIn, X/Twitter, Google Maps, Google Search, Google Trends, Reddit, Airbnb, Yelp, and 15+ more platforms. Use for lead generation, brand monitoring, competitor analysis, influencer discovery, trend research, content analytics, audience analysis, review analysis, SEO intelligence, recruitment, or any data extraction task.

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World-class autonomous sales and revenue skill system. Use ANY time the user asks to sell, pitch, prospect, close, negotiate, launch, monetize, build funnels, write outreach, craft proposals, develop pricing, design offers, write sales copy, create email sequences, plan campaigns, position products, handle objections, create playbooks, build pipeline, forecast revenue, develop GTM strategy, optimize conversions, write ad copy, create sales decks, score leads, nurture prospects, upsell, cross-sell, retain customers, write case studies, price products, structure enterprise deals, create battle cards, script discovery calls, build affiliate programs, plan product launches, create webinar funnels, design pricing pages, A/B test offers, analyze unit economics, calculate LTV/CAC, or ANY other sales, revenue, monetization, go-to-market, or commercial growth task. If it involves selling, revenue, deals, pipeline, or commercial strategy — USE THIS SKILL. Trigger aggressively.

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Track TikTok ad activity and monitor advertiser changes using PipiAds tools for TikTok ad discovery and Facebook-based monitoring workflows.

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