'logic' 검색 결과

Build publication-quality figures with matplotlib using the object-oriented Figure/Axes API, constrained_layout, rcParams customization, TrueType (Type-42) font embedding for journal submission, and CVD-safe palettes. Covers seaborn integration, common chart types, axis formatting, and the small gotchas that distinguish reproducible matplotlib from notebook scratch. Use when producing publication figures in Python — RNA-seq scatter, single-cell embeddings, generic biological plotting.

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Analyzes pooled CRISPR screens with MAGeCK (Li et al 2014), covering count generation (mageck count), the RRA two-condition workflow (mageck test using alpha-RRA over per-sgRNA negative-binomial p-values), the MLE multi-condition workflow (mageck mle with explicit design matrix and beta-score output), normalization choice (median vs total vs control-sgRNA vs spike-in), sgRNA efficiency injection, paired-sample testing, time-course design, drug-screen versus dropout-screen design matrices, MAGeCKFlute and MAGeCK-VISPR downstream visualization, and decision logic for when to use MAGeCK vs JACKS / BAGEL2 / drugZ / Chronos. Use when running a fresh CRISPR screen analysis, picking RRA vs MLE for the experimental design, choosing a normalization method from QC signatures, debugging MLE convergence failure or NaN beta scores, comparing MAGeCK output across tools, or building a batch-aware multi-cell-line / multi-condition MLE design matrix.

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Download large datasets from NCBI efficiently using EPost, history server, batching, rate limiting, and retry logic. Use when bulk-fetching tens of thousands of sequences, pulling all results of a large ESearch, designing reproducible pipelines, comparing E-utilities to NCBI Datasets v2 CLI, or implementing checksum-validated downloads. Encodes WebEnv TTL (~8h), EPost 200-ID limit, retmax caps, parallelization design, and integrity verification.

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Identify differentially bound regions across CLIP-seq conditions (knockdown vs control, treatment vs vehicle, disease vs healthy) using DEWSeq (sliding-window DESeq2), Flipper (Skipper-downstream), ASpeak, edgeR, or limma-voom. Use when computing condition-level changes in RBP binding intensity, choosing peak-level vs window-level vs crosslink-level testing, designing replicate experiments, or distinguishing biological binding shifts from technical confounders.

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Model gene-family birth-death dynamics across a species tree using CAFE5 (Mendes et al 2020 Bioinformatics 36:5516 gamma-distributed rate categories), CAFE5-error (annotation-error-aware), Count (Csurös 2010 ancestral state reconstruction), BadiRate (Librado 2012 likelihood + parsimony), DupliPHY-Family, and ALE/AleRax (for per-family DTL; see [[gene-tree-species-tree-reconciliation]]). Test lineage-specific gene-family expansions and contractions, distinguish biological dynamics from annotation artifacts, account for assembly fragmentation, identify functional enrichment in expanded / contracted families. Use when correlating gene-family changes with phenotype evolution, ranking lineages by adaptive gene-family-rate shifts, post-WGD dosage-balance analysis, or building Birth-death models from OrthoFinder presence/absence matrices.

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Runs cis-pQTL Mendelian randomization for drug-target validation using UKB-PPP (Olink), deCODE (SomaScan), Fenland, INTERVAL, ARIC, and FinnGen-PPP proteomes plus colocalization triangulation, phenome-wide on-target adverse-effect scans, cross-platform Olink/SomaScan replication, and PAV (protein-altering variant) sensitivity. Use when nominating or de-risking a drug target from plasma-proteome GWAS, mimicking pharmacological inhibition via cis-pQTL instruments, separating shared-causal from LD-confounded signal under the Schmidt 2020 cis-MR framework, screening on-target adverse phenotypes pheWAS-style, or producing publication-grade STROBE-MR plus PP.H4 evidence for a target gene.

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Visualizes ChIP-seq data using deepTools (computeMatrix, plotHeatmap, plotProfile, bamCoverage, bamCompare), pyGenomeTracks (modern INI-driven track plots), Gviz (R browser-style), EnrichedHeatmap (ComplexHeatmap-based), ChIPseeker tag heatmaps, and IGV batch screenshots. Handles bigWig normalization choices (CPM, BPM, RPGC, spike-in scaled), bamCompare operations (log2 ratio, subtract, SES), k-means clustering of heatmaps for biological subgrouping, and spike-in-scaled tracks for global-shift experiments. Use when generating publication-quality ChIP-seq signal heatmaps, profile plots, genome-browser tracks, or comparing samples visually.

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Calculates molecular fingerprints (ECFP/Morgan, FCFP, MACCS, RDKit, AtomPair, TopologicalTorsion, Avalon, MAP4, MHFP6) and physicochemical descriptors (Lipinski, QED, TPSA, Crippen LogP, 3D shape) with explicit choice tables, bit vs count semantics, and partial-charge model selection. Use when featurizing molecules for similarity, QSAR, virtual screening, or ML, or selecting the correct fingerprint for a chemotype-aware task.

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Analyzes CUT&RUN (Skene Henikoff 2017) and CUT&Tag (Kaya-Okur 2019) chromatin profiling data. Handles SEACR vs MACS2 peak calling (with the btaf375 2025 benchmark guidance), pA-MNase vs pA-Tn5 vs pAG-Tn5 chimera differences, E. coli spike-in carryover normalization, IgG-only control logic (no input), characteristic fragment-size signatures (25-75 bp for CUT&Tag), and lower depth requirements (5M reads typical vs 25M for ChIP). Use when calling peaks from CUT&RUN/CUT&Tag, scaling by E. coli spike-in carryover, choosing SEACR norm mode, or comparing CUT&RUN/Tag results to traditional ChIP.

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Use this skill when the user asks about accident registers, DOT-recordable accident definitions, what counts as a "reportable accident" under 49 CFR 390.5 + 390.15, accident register retention, post-accident testing trigger logic, FMCSA accident reporting (no longer required to FMCSA directly for non-fatal accidents), insurance reporting timelines, and what to do after a CMV crash. Cite 49 CFR 390.5 + 390.15.

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Design resilient React error handling with Error Boundaries, Sentry integration, recovery UI, retry patterns, and graceful degradation. Activate on: error boundary, crash recovery, Sentry, error fallback UI, retry logic, unhandled exceptions. NOT for: form validation errors (use form-validation-architect), API error codes (use api-architect).

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Design error handling strategies for TypeScript and Python applications — exception hierarchies, Result/Either types, retry patterns, error boundaries, and structured error logging. Use when designing error handling architecture, choosing between exceptions and Result types, implementing retry logic, or building error recovery flows. Activate on "error handling", "exception hierarchy", "Result type", "retry pattern", "circuit breaker", "error boundary", "Pokemon exception". NOT for debugging specific runtime errors, logging infrastructure setup, or monitoring/alerting configuration.

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An innate exploratory drive that guarantees no graph node remains permanently invisible to an agent population. After a warm-up period (step > 3), each agent fires a coverage scan with probability |unseen_nodes| / |all_nodes|. When triggered, the agent teleports directly to the globally unseen node with the highest belief uncertainty, works it, and returns control to the normal action-selection loop. Probability is self-annealing: it starts near 1.0 when almost everything is unseen and decays toward 0.0 as coverage saturates, requiring no manual schedule. The mechanism is "innate" (hard-coded into the agent step loop) as distinct from the "adaptive" EFE path, which requires local neighbors and learned precision weights. Together they form a two-layer exploration architecture: adaptive for locally-guided foraging, innate for topological completeness.

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Meta-skill that orchestrates the discourse skill suite: routes between steel-man-argument, socratic-questioning, toulmin-argument-analysis, logical-fallacy-detector, bad-faith-rhetoric-detector, discourse-elision-analyzer, forensic-speech-structure, and productive-discourse-facilitator. Use when analyzing conversations, facilitating discourse, or operating as a dialogue copilot. Maintains mode (silent analysis, coaching overlay, active facilitator) and decides which skills to invoke based on conversation dynamics.

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Tracks cumulative LLM costs across DAG execution and makes real-time decisions to stay within budget. Downgrades models, skips optional nodes, or stops early when cost exceeds thresholds. Use when managing execution budgets, analyzing cost breakdowns, or optimizing model routing for cost. Activate on "cost budget", "too expensive", "reduce cost", "cost optimization", "model downgrade", "budget exceeded". NOT for LLM model selection logic (use llm-router), pricing comparisons across providers, or billing/invoicing.

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Build production computer vision pipelines for object detection, tracking, and video analysis. Handles drone footage, wildlife monitoring, and real-time detection. Supports YOLO, Detectron2, TensorFlow, PyTorch. Use for archaeological surveys, conservation, security. Activate on "object detection", "video analysis", "YOLO", "tracking", "drone footage". NOT for simple image filters, photo editing, or face recognition APIs.

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Design and build mathematically rigorous, high-density, interactive data graphics and streaming telemetry visualizations following Mike Bostock's D3.js and Observable methodologies. Use when crafting custom SVG/Canvas charts, reactive streaming time-series, multi-dimensional brush-and-link coordinates, small multiples, or topological swarm graphs. NOT for generic dashboard template clones, basic spreadsheet charts, or off-the-shelf low-effort wrapper libraries.

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Frame multi-agent designs through explicit environment, autonomy, information, coordination, commitment, incentive, and verification assumptions. NOT for endorsing multi-agent architecture without need or claiming runtime correctness from conceptual methods.

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Doctrine for all Supabase realtime: postgres_changes, broadcast, presence. Use before writing a `.channel(`/useChannel subscription, echo suppression, reconnect logic, an autosave loop beside realtime, or replacing polling with live updates, or when the tab freezes, messages duplicate, or a subscription delivers nothing.

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Locate CCSPlayer_WeaponServices::DropWeapon in CS2 server.dll / libserver.so via IDA Pro MCP and emit a fresh, minimal-unique signature or offset for the WeaponPaints gamedata entry "CCSPlayer_WeaponServices::DropWeapon" (symbol CCSPlayer_WeaponServices_DropWeapon). This is a VIRTUAL function — emit the vtable slot, NOT a byte signature. Resolve the CCSPlayer_WeaponServices vtable via RTTI and identify the DropWeapon slot: the body takes a CBasePlayerWeapon handle/pointer, detaches it from the player, spawns the dropped weapon entity and transfers ownership. Verify by xrefs from weapon-drop commands (!!drop) and pickup logic. vtable slots commonly differ between platforms — never assume identical indices. Trigger: CCSPlayer_WeaponServices_DropWeapon, CCSPlayer_WeaponServices::DropWeapon

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When the user wants to apply psychological principles, mental models, or behavioral science to marketing. Also use when the user mentions 'psychology,' 'mental models,' 'cognitive bias,' 'persuasion,' 'behavioral science,' 'why people buy,' 'decision-making,' or 'consumer behavior.' This skill provides 70+ mental models organized for marketing application.

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Security review checklist for Convex functions, auth logic, public queries, admin routes, webhooks, uploads, components, and AI-generated code. Use when reviewing code that touches user data, PII, or access control, or before any deploy of an app with auth.

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Layout structure for web interfaces, from grouping and alignment to reading order, progressive disclosure, and adaptive breakpoints. Use when structuring a page or component, spacing or aligning controls, deciding what collapses at small sizes, handling RTL layout direction, or reviewing frontend code for layout. Triggers on layout, spacing, alignment, grouping, negative space, whitespace, visual hierarchy, reading order, progressive disclosure, breakpoints, responsive layout, container queries, safe area, full-bleed, edge-to-edge, layout margins, RTL layout, logical properties.

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Build reactive, type-safe, production-grade backends. ALWAYS use this skill when the user asks to build, plan, design, or implement backend features, APIs, data models, server logic, database schemas, web apps, full stack apps, or mobile apps. This includes planning and architecture discussions.

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