'protocols' 검색 결과

Think and work like an expert Genetic Counselor. Use when a task calls for Genetic Counselor judgment. Reasons from probabilistic penetrance, Bayesian pretest probability, and patient autonomy through three-generation pedigrees, ACMG/AMP variant criteria, ClinVar/ClinGen/gnomAD, NCCN and CPIC guidelines, and cascade-testing protocols while treating VUS over-upgraded to pathogenic, screening-versus-diagnostic confusion (NIPT vs amnio/CVS), and unaddressed psychosocial and GINA discrimination risk as first-class failure modes.

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Think and work like an expert Computer Graphics Researcher. Use when a task calls for Computer Graphics Researcher judgment. Reasons from the rendering equation, Monte Carlo bias/variance, sampling theory, and BSDF energy conservation through pbrt-v4/Mitsuba 3 references, MIS/ReSTIR/path guiding, DXR 1.2 real-time stacks, 3DGS and NerfBaselines protocols, FLIP/ColorVideoVDP evaluation, OpenUSD/MaterialX/OpenPBR interchange, and ACES 2/OCIO color while treating unconverged references, unequal-time comparisons, denoiser and temporal-reuse bias, scene- vs display-referred color errors, and white-furnace energy failures as first-class failure modes.

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Think and work like an expert Construction Engineer. Use when a task calls for Construction Engineer judgment. Reasons from design intent versus means-and-methods through CPM/P6 and Last Planner scheduling, Revit/Navisworks BIM coordination, IBC Chapter 17 special inspections, ASTM C31/C39 cylinder acceptance, and ACI 318 low-break/core protocols while treating formwork collapse, honeycombing, tolerance stack-up, and schedule logic errors as first-class failure modes.

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Think and work like an expert Dentist-Scientist. Use when a task calls for Dentist-Scientist judgment. Reasons from oral biofilm-host ecology, tissue healing capacity, and patient-level clinical endpoints (DMFS, PD/CAL, implant survival) through PICO/PROSPERO protocols, CAMBRA and 2017 AAP/EFP staging, ISO 4049/14801 bench tests with thermocycling, and GRADE-rated reviews while treating in-vitro-to-chairside leaps, plaque-index surrogates without caries reduction, and examiner calibration drift as first-class failure modes.

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Think and work like an expert Comparative Medicine Researcher. Use when a task calls for Comparative Medicine Researcher judgment. Reasons from species biology, translational validity, and the 3Rs through model-validity frameworks, IACUC protocols, ARRIVE 2.0 reporting, and FELASA/AALAS health surveillance while treating substrain drift, subclinical colony infection (murine norovirus, pinworm, Mycoplasma), analgesia-pathway confounds, and unstated husbandry variables as first-class failure modes.

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Think and work like an expert Anesthesiologist. Use when a task calls for Anesthesiologist judgment. Reasons from control of consciousness, analgesia, autonomic response, and oxygen delivery through the ASA Difficult Airway Algorithm, capnography and arterial-waveform trends, quantitative TOF monitoring, and ASRA/ERAS protocols while treating cannot-ventilate airways, local anesthetic systemic toxicity, malignant hyperthermia, and residual neuromuscular blockade as first-class failure modes.

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Designs adaptive clinical trials including group-sequential (O'Brien-Fleming, Pocock, Lan-DeMets spending), sample-size re-estimation (blinded Friede-Kieser, unblinded Cui-Hung-Wang, Mehta-Pocock promising zone), seamless Phase 2/3 with treatment-arm selection, population enrichment, and response-adaptive randomisation. Covers FDA 2019 Final Adaptive Designs Guidance, FDA 2022 Master Protocols, and ICH E20 Step 2b/3 draft (June 2025, NOT final). Use when planning interim analyses, sample-size re-estimation, or master/platform-trial designs.

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End-to-end binder design using BindCraft hallucination. Use this skill when: (1) Designing protein binders with built-in AF2 validation, (2) Running production-quality binder campaigns, (3) Using different design protocols (fast, default, slow), (4) Need joint backbone and sequence optimization, (5) Want high experimental success rate. For backbone-only generation, use rfdiffusion. For QC thresholds, use protein-qc. For tool selection guidance, use binder-design.

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Use Amazon SNS for pub/sub messaging and notifications. Create topics and manage subscriptions across protocols (SQS, Lambda, HTTP, email, SMS). Configure message filtering, mobile push notifications, and fan-out architectures.

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Comprehensive expertise in decentralized perpetual futures protocols, including GMX, dYdX, Hyperliquid, and similar platforms. Covers funding rate mechanics, liquidation engines, position management, oracle integration, and protocol risk management. Use when "perpetual futures, perps, funding rate, liquidation, GMX, dYdX, Hyperliquid, leverage trading, margin trading, long position, short position, mark price, index price, open interest, basis trading, " mentioned.

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DeFi protocol specialist for AMMs, lending protocols, yield strategies, and economic securityUse when "defi, amm, liquidity pool, lending protocol, yield farming, oracle, liquidation, tokenomics, tvl, impermanent loss, defi, amm, lending, yield, liquidity, oracle, tokenomics, protocol, ethereum, web3" mentioned.

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Infrastructure and practices for reproducible computational research. Covers environment management, data versioning, code documentation, and sharing protocols that enable others to reproduce your results. Use when ", " mentioned.

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Use when building DeFi protocols, implementing AMMs, yield farming strategies, or integrating with Ethereum/L2s - covers smart contract patterns, liquidity pools, and security considerationsUse when ", " mentioned.

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CEO (Chief Executive Officer) — 一家公司「最高操作员」的工艺, 与泛泛「领导力 / 管理学」不同: (a) 设定战略与凝结愿景 (Drucker 的「企业的经营理论」+ Porter 论定位 + Hamilton Helmer 的「七力」+ Andy Grove 的「战略转折点」+ Roger Martin 《Playing to Win》); (b) 资本配置是 CEO 单一最高杠杆的工作 (Buffett/Munger Berkshire 致股东信 + William Thorndike 《The Outsiders 商界局外人》论 8 位非常规 CEO + Michael Mauboussin 论 hurdle rate + Bezos 年度致股东信「invariants vs bets」+ Mark Leonard Constellation Software); (c) 组建与领导高管班子 (Patrick Lencioni 《团队的五大障碍》+ Ben Horowitz 《艰难的事》+ Reed Hastings 《No Rules Rules》人才密度 + Andy Grove HOP《高产出管理》+ Lou Gerstner IBM 转型 + Marshall Goldsmith); (d) 董事会与投资人关系 (Larcker & Tayan 《公司治理重要》+ Bill George 《True North》+ 正式 CEO-董事长 / CEO-独立董事 protocol + 维权投资人 playbook + 资本市场沟通); (e) 企业文化与价值观作为操作系统 (Netflix 文化手册 + Amazon Leadership Principles + Bridgewater 《Principles》Ray Dalio + Schein 论组织文化 + 任正非 灰度 + 张瑞敏 人单合一 + 稻盛和夫 阿米巴); (f) 高不确定下的高风险决策 (Bezos Type 1/Type 2 决策 + premortem Klein + Kahneman 论 executive bias + RAPID/DACI + base rates + 情景规划 + 反思 premortem); (g) 对内对外沟通 (创始人 / CEO 致股东信作为机构构建工具: Bezos / Buffett / Reed Hastings 备忘录 / 任正非 内部讲话 + Town Hall + 危机沟通 Tylenol/Boeing/Wells Fargo + 应对维权投资人); (h) 跨阶段规模化 (创业 0→1 / 扩张 1→100 / 成熟期掌舵 / 危机转型): Steve Blank + Brian Chesky founder-mode + Marc Andreessen + Pierre Lassonde + Lou Gerstner 转型; (i) 创始人 CEO vs 职业经理人 CEO 的差异 (Paul Graham 「Founder Mode」2024 + Brian Chesky + Reed Hastings (创始人→职业过渡) + BCG/McKinsey 的「manager mode」+ 两者各自代价 + 什么时候切换)。诚实处理: 幸存者偏差 (单个 CEO 的打法 ≠ 普适规律, 学术研究显示 CEO 个人方差约 ⅓, 约 70% 来自行业 / 时代 / 运气 / 资本结构), 创始人崇拜, 区分可复制工艺与不可移植个人魅力, 治理与利益相关者责任 (员工 / 股东 / 社会), 反对 CEO 神话与 Welch 退休金扭曲 / Theranos / WeWork / FTX / Uber-Kalanick 时代 / Musk 80h+ / 996 工时崇拜。覆盖 founder-CEO (Bezos/Hastings/黄仁勋/Chesky/Brin/任正非) 与职业 CEO (Nadella/Gerstner/Pichai/Mulally/Lafley)。不含: 泛泛管理理论 (商业书已覆盖, 本 skill 专谈 C-suite 这个具体岗位), 不含: 「领导力」作为个人成长自助 (Robbins/Tracy/Maxwell 励志体裁), 不含: 「如何创业」早期战术 — 一旦有员工 / 董事会 / 资本, CEO 的工艺才开始。 (CEO (Chief Executive Officer) — the craft of being the top operator of a company, distinct from generic 'leadership/management': (a) setting the strategy and crystallizing the vision (Drucker's 'theory of the business' + Porter on positioning + Hamilton Helmer's 7 powers + Andy Grove's strategic inflection points + Roger Martin Playing to Win); (b) capital allocation as the CEO's single highest-leverage job (Buffett/Munger Berkshire letters + William Thorndike 'The Outsiders' on 8 unconventional CEOs + Michael Mauboussin on hurdle rates + Bezos's annual shareholder letter approach to invariants vs bets + Mark Leonard Constellation Software); (c) building and leading the executive team (Patrick Lencioni 'Five Dysfunctions' + Ben Horowitz 'Hard Things About Hard Things' + Reed Hastings 'No Rules Rules' on talent density + Andy Grove HOP + Lou Gerstner IBM turnaround + Marshall Goldsmith); (d) board and investor relations (Larcker & Tayan 'Corporate Governance Matters' + Bill George 'True North' + the formal CEO-Chair / CEO-Lead Director protocols + activist investor playbooks + capital markets communication); (e) culture and values as operating system (Netflix culture deck + Amazon Leadership Principles + Bridgewater 'Principles' Ray Dalio + Schein on org culture + 任正非 Ren Zhengfei 灰度 + 张瑞敏 Zhang Ruimin 人单合一 + 稻盛和夫 阿米巴); (f) high-stakes decision-making under uncertainty (Bezos Type 1 vs Type 2 + premortem Klein + Kahneman 'Thinking Fast and Slow' for executive bias + RAPID/DACI + base rates + scenario planning + premortem); (g) internal and external communication (founder/CEO letters as institution-builders: Bezos shareholder letters / Buffett letters / Reed Hastings memos / 任正非 内部讲话 + Town Halls + crisis communication Tylenol/Boeing/Wells Fargo + activist responses); (h) cross-stage scaling (founder-CEO of 0→1 / scaling 1→100 / mature-stage stewardship / turnaround): Steve Blank + Brian Chesky founder-mode + Marc Andreessen + Pierre Lassonde mining vs steady-state + Lou Gerstner turnaround; (i) the founder-CEO vs professional-manager-CEO distinction (Paul Graham 'Founder Mod

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Suede AI full-stack surface builder that runs design, copy, and visual QA as one pass: landing pages, brand surfaces, product UI, dashboards, campaigns, launch pages, and reference-to-target restyles (suedify). Use when a build needs layout and words together, when a redesign or launch surface has to ship end to end, when the request is 'make this site look like that one', or when design, copy, asset, and QA lanes have to move at once. NOT FOR: a design-token, dark-mode, or single-component decision (use suede-design); copy with no layout work (use johnny-suede-write, or suede-copy for one standalone conversion surface); conversion and funnel architecture (use suede-site-alchemy); multi-agent orchestration protocols, WIP protection, and rollback trees (use suede-agent-teams).

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Design REST/GraphQL APIs with OpenAPI 3.1, error handling, pagination, rate limiting, webhooks, and idempotency. Use when user asks to design an API, create endpoints, define REST/GraphQL schema, or generate OpenAPI spec. Do NOT use for database schema design, frontend API integration, or non-HTTP protocols (gRPC, WebSocket, MQTT).

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End-to-end production workflow guidance for Blender — the order to assemble scenes (block-out → camera → light → forms → materials → detail → render → composite → export), critique protocols, time budgets, and recovery patterns. Use whenever the user asks to "make a complete scene / hero shot / production-quality render", "what's the right order to do this", "set up a full pipeline", or has a multi-step request crossing modeling + lighting + materials + rendering. Make sure to use this skill for any request that spans multiple phases of 3D work, even if the user does not say "workflow" — also covers "make a final image of X", "produce a hero render", "professional-looking result".

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Designs and executes compatibility-preserving migrations across APIs, schemas, frameworks, dependencies, protocols, storage, and infrastructure with baselines, coexistence, staged cutover, rollback or forward-fix paths, and explicit removal criteria. Use for deprecations, upgrades, data moves, contract changes, and replacing live implementations. Not for a local refactor with no external state or compatibility boundary.

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Designing cryptographic architecture: algorithm selection, key management, E2EE, KMS integration, signature verification, TLS. Use when designing crypto protocols or key rotation flows.

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Generate a coaching conversation guide with questions, protocols, and follow-up actions for a teaching focus. Use when preparing for coaching sessions, mentoring, or peer feedback conversations.

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Select and configure a structured discussion protocol matched to the purpose, topic, and group readiness. Use when planning classroom discussions, Socratic seminars, or structured debate.

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Amazon Bedrock Automated Reasoning for mathematical verification of AI responses against formal policy rules with up to 99% accuracy. Use when validating healthcare protocols, financial compliance, legal regulations, insurance policies, or any domain requiring deterministic verification of AI-generated content.

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Document and strengthen company culture - values articulation, team norms, communication protocols, and culture health diagnostics. Use when asked to "define our values", "document how we work", "diagnose culture health", or "write team norms".

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Provides incident response best practices covering severity classification, on-call rotation, war room protocols, runbook templates, escalation policies, and blameless postmortems. Use when handling an incident, setting up on-call, writing a postmortem, creating a runbook, configuring PagerDuty or OpsGenie, or building incident management processes.

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