1.8천건 · 관련도순
Process-based discrete-event simulation framework in Python. Use this skill when building simulations of systems with processes, queues, resources, and time-based events such as manufacturing systems, service operations, network traffic, logistics, or any system where entities interact with shared resources over time.
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Authors reproducible Nextflow DSL2 pipelines built on reactive dataflow, where processes communicate only through channels and execution order is not guaranteed. Use when deciding channel/dataflow (Nextflow) vs rule-based (Snakemake) authoring; wiring queue vs value channels and fixing shared-reference exhaustion with .first(); composing DSL2 modules and subworkflows with take/main/emit; selecting container/conda profiles and pinning images by digest for portability across local/SLURM/LSF/AWS Batch/Google Batch/Kubernetes executors; diagnosing why -resume misses the cache (nondeterministic input order, mtime on network filesystems, mutable :latest tags) with cache 'lenient' and -dump-hashes; managing work/ vs publishDir and dynamic retry escalation; and choosing whether to adopt an nf-core community pipeline or author from scratch.
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Infer gene regulatory networks (GRNs) from gene expression data using scalable algorithms (GRNBoost2, GENIE3). Use when analyzing transcriptomics data (bulk RNA-seq, single-cell RNA-seq) to identify transcription factor-target gene relationships and regulatory interactions. Supports distributed computation for large-scale datasets.
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PyTorch-native graph neural networks for molecules and proteins. Use when building custom GNN architectures for drug discovery, protein modeling, or knowledge graph reasoning. Best for custom model development, protein property prediction, retrosynthesis. For pre-trained models and diverse featurizers use deepchem; for benchmark datasets use pytdc.
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Identify drug repurposing candidates via target-based, compound-based, and disease-based strategies. Combines drug-target-disease network reasoning with mechanism rationale, clinical-trial precedent, and patent/regulatory feasibility. Use for hypothesis-generating repurposing for orphan diseases, finding existing drugs for new indications, and prioritizing candidates by evidence and feasibility.
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Maps metabolomics results to biological pathways via over-representation (ORA), metabolite-set enrichment (MSEA/QEA), mummichog/PSEA on raw m/z peaks, and network-diffusion enrichment (FELLA), with correct background-set construction and honest interpretive ceilings. Use when interpreting differential metabolites or an untargeted LC-MS feature table in pathway context, choosing ORA vs MSEA vs mummichog vs topology, or setting the reference/background set. For annotation confidence levels feeding ORA see metabolomics/metabolite-annotation; for gene-set concepts see pathway-analysis/go-enrichment and pathway-analysis/gsea; for joint gene+metabolite pathways see multi-omics-integration/mofa-integration.
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Molecular ML with diverse featurizers and pre-built datasets. Use for property prediction (ADMET, toxicity) with traditional ML or GNNs when you want extensive featurization options and MoleculeNet benchmarks. Best for quick experiments with pre-trained models, diverse molecular representations. For graph-first PyTorch workflows use torchdrug; for benchmark datasets use pytdc.
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Turns untargeted LC-MS/MS features (m/z, RT, MS/MS) into confidence-stratified metabolite annotations using spectral-library matching (matchms), in-silico tools (SIRIUS/CSI:FingerID, MetFrag) and molecular networking, and assigns a defensible MSI/Schymanski confidence level to each. Use when naming detected features, scoring MS/MS against a reference library, running SIRIUS, or deciding what confidence level an evidence set actually supports. For upstream feature extraction see metabolomics/xcms-preprocessing and metabolomics/msdial-preprocessing; for downstream enrichment that must respect these levels see metabolomics/pathway-mapping; for lipid-specific structural annotation see metabolomics/lipidomics.
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Create or review Terraform infrastructure and plans. Use for cloud resources, IAM, networking, state management, and infrastructure changes.
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Plan 5G network deployment with coverage. TRIGGERS - Use when user needs help with 5g-deployment-plan related tasks.
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Explores a CARLA map's road network through the Map/Waypoint API — a natural-language rundown of the whole map ("give me the topology"), drawing the topology to confirm the modelled map matches the visible one, enumerating junctions to resolve phrases like "the 4-way junction in the middle", nearest-waypoint lane facts, and next/previous lane navigation. Use when the user asks about the map's layout, lanes, junctions, topology, or to locate/navigate specific map elements.
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Inspects and visualises a ROS-2-enabled CARLA server from Docker containers, with no local ROS 2 install — list/echo/rate-check topics (the "are the topics actually on the wire" check), run the bundled map-and-lidar demo stack (hero vehicle with camera/lidar/GNSS/IMU on autopilot), and open RViz2 with the lane-network preset. Use when the user asks to "check the ROS topics", "echo /carla/map", "is CARLA publishing to ROS", "visualise the lidar in RViz", "open rviz", or "run the ROS 2 demo".
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Upstash サーバーレスデータプラットフォーム (マネージド SaaS の JS SDK)。 @upstash/redis (REST, pipelining, transactions, JSON, Redis Search, VECTOR/Array/Functions コマンド)、 @upstash/ratelimit (Fixed/Sliding Window, Token Bucket, blockUntilReady)、 QStash (publishJSON, schedules, queues, URL Groups, flow-control, DLQ)、 @upstash/vector (upsert, query, ANN, namespace, hybrid/sparse index, embedding models, reranking)、 @upstash/workflow (serve, durable execution, context.run/sleep/call/invoke, waitForEvent, parallel steps, agents)、 Upstash Search (@upstash/search, search, upsert, fetch, range, filtering, reranking, algorithm)、 @upstash/box (サンドボックス, filesystem, git, CDP, browser, network policy, snapshots, custom harness)、 upstash CLI。Rust 製 fandhe-db とは別。
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Windows アプリ開発 (Windows App SDK / WinRT) の OS 統合 API リファレンス。 DeviceInformation, DeviceWatcher, センサー (Accelerometer, Gyrometer, Pedometer, Compass, OrientationSensor, ActivitySensor), Bluetooth LE, USB, Serial, HID, Battery, HttpClient, StreamSocket, WebSocket, BackgroundDownloader/Uploader, NetworkInformation, PointerInput, KeyboardInput, IME/TextInput, FocusManager, DragAndDrop, ResourceLoader (多言語化・地域化), Calendar, DateTimeFormatter, CurrencyFormatter, PasswordVault, OAuth2Manager, Web Account Manager (WAM) / MSAL, WebAuthenticationBroker, WindowsHello/Passkeys, Age signals, CryptographicBuffer, Clipboard, DataTransferManager, Launcher, ProtocolActivation, JumpList, TaskbarManager, SecondaryTile, StartupTask, Smart App Control, Phone Link。
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Claude Code (code.claude.com) の権限・セキュリティ・企業管理リファレンス。 permissions (allow / ask / deny), permission modes, auto mode (classifier billing), sandboxing, sandbox environments, sandboxed Bash, zero data retention, data usage, HIPAA, managed settings (MDM / plist / registry), server-managed settings, managedMcpServers, allowedProviders, admin setup, authentication (SSO), network config, corporate launcher, OpenTelemetry monitoring, analytics, costs, large codebases, communications kit / champion kit。
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NVIDIA DGX Spark User Guide リファレンス。GB10 Grace Blackwell Superchip 仕様、 first-boot / UEFI、ConnectX-7 Networking (旧 Spark Stacking)、複数 Spark 接続、 NVIDIA Sync Cluster Assistant、DGX OS / NGC / container runtime、 Release Notes (DGX OS 7.5.0)、known issues、PXE / cloud-init、fleet 運用、 apt / fwupdmgr、recovery、PSIRT、 NVIDIA Developer Forums 由来 troubleshooting、 build.nvidia.com/spark playbook (vLLM / vLLM cluster / TensorRT-LLM / Ollama / ComfyUI / NIM / NeMo / VLM fine-tuning / NVIDIA PAIR / NCCL)、Tailscale、VS Code。
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Read a liarjs fingerprint report and attribute each failing check to the component that produced it - what the check id measures, whether the signal comes from the launch configuration, the page-modifying layer, the network path or the machine image, and which failures are inherent to headless or datacenter environments. Use when a fingerprint scan came back with a low score, or when a check id such as webdriver, worker-consistency, gpu-triad, native-integrity or tz needs explaining.
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Analyzes species-environment relationships with constrained ordination (CCA, RDA, db-RDA), variance partitioning, indicator species (indicspecies IndVal.g group-equalized), PERMANOVA paired MANDATORILY with PERMDISP (Anderson & Walsh 2013; dispersion confounds centroid tests), Joint Species Distribution Models (HMSC, sjSDM, gjam) with explicit rejection of "residual covariance equals biotic interaction", phylogenetic community ecology (SES_MPD/MNTD), trait-environment via RLQ + fourth-corner with corrected modeltype=6 (Dray 2014), bipartite network metrics (NODF, modularity) with curveball null (Strona 2014), and Mantel-test replacements (dbRDA, GDM) for spatial data. Use when testing how environmental gradients structure communities, identifying habitat indicator taxa, partitioning variance among predictors, deciding whether PERMANOVA significance is location vs dispersion, picking among HMSC/sjSDM/gjam, or replacing Mantel tests for landscape data.
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Detects m6A modifications from Oxford Nanopore direct-RNA-sequencing (ONT DRS) signal data using m6Anet (Hendra 2022 *Nat Methods* 19:1590; multiple-instance-learning neural network over DRACH 5-mer signal). Covers the required upstream pipeline (Dorado / Guppy basecalling -> minimap2 transcriptome alignment with `-ax map-ont -uf -k14 --secondary=no` -> nanopolish eventalign with `--scale-events --signal-index` (m6Anet-required) plus `--summary` / `--threads` housekeeping -> m6anet dataprep -> m6anet inference), per-site vs per-read probability interpretation including the `mod_ratio` per-site stoichiometry column, the DRACH-only modeling constraint, minimum-coverage thresholds (20-50 reads per site for stable probability estimates), multi-condition comparison via xPore (Pratanwanich 2021 *Nat Biotechnol* 39:1394), Nanocompore (Leger 2021 *Nat Commun* 12:7198), ELIGOS (Jenjaroenpun 2021 *NAR* 49:e7), and Dorado native modification calling (RNA004 chemistry, 2024+), reference-transcriptome version pinning, the cDNA-vs-DRS chemistry distinction (cDNA-Nanopore CANNOT be used for modification detection), and orthogonal validation against MeRIP / GLORI. Use when calling m6A from ONT DRS without immunoprecipitation, choosing m6Anet vs xPore vs Nanocompore vs ELIGOS vs Dorado native, interpreting per-site `probability_modified` vs `mod_ratio` vs per-read modification probabilities, comparing methylation between conditions from ONT data, deciding between m6Anet for known DRACH sites and Dorado/Remora for genome-wide screening, pinning RNA002 vs RNA004 chemistry and basecaller model versions, or troubleshooting eventalign / dataprep failures.
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Simulate transcription factor perturbation effects on cell state in silico with CellOracle and Dynamo, and predict transcriptional responses to genetic perturbations with GEARS, scGen, and CPA. Covers the direction-not-magnitude principle, local-linear validity, the GRN/velocity error it inherits, baseline discipline (mean and additive baselines), and the validation gap. Use when predicting TF knockout or overexpression effects, ranking driver TFs for fate transitions, or planning perturbation experiments. For GRN construction see multiomics-grn; for experimental Perturb-seq see single-cell/perturb-seq.
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Infer transcription factor regulons from single-cell RNA-seq with pySCENIC by combining GRNBoost2 co-expression, cisTarget motif-enrichment pruning, and AUCell per-cell activity scoring. Covers the motif-pruning-as-directionality principle, regulon specificity scoring, run-to-run stability, and database/species matching. Use when identifying TF regulons, scoring TF activity per cell, finding master regulators of cell identity, or comparing regulon activity across conditions. For enhancer-driven multiomic GRNs see multiomics-grn; for bulk inference and VIPER protein-activity see grn-inference.
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Infers person-to-person transmission from pathogen genomes using outbreaker2 (Campbell 2018), TransPhylo (Didelot 2017), phybreak (Klinkenberg 2017), BadTrIP (De Maio 2018), SCOTTI (De Maio 2016), BEASTLIER (Hall 2015), and SNP-distance / cluster-picker approaches (HIV-TRACE for HIV; transcluster). Defines outbreak clusters using pathogen-specific SNP thresholds (NOT a universal cutoff -- TB <=12 SNPs / Walker 2013; MRSA <=15 / Coll 2017; C. difficile <=2 / Eyre 2013; Klebsiella <=21 / Snitkin 2012), models within-host diversity and transmission bottlenecks (Worby-Lipsitch-Hanage 2014; McCrone 2018; Sobel Leonard 2017; Lythgoe 2021 SARS-CoV-2), integrates contact-tracing data, distinguishes generation interval from serial interval (Britton & Scalia Tomba 2019; Ali 2020), attributes source via Bayesian source attribution (Mather 2013 DT104; islandR), and reconciles transmission-network reconstruction with epi metadata. Use when investigating outbreaks for who-infected-whom, defining SNP-cluster outbreak definitions, accounting for unsampled intermediates, choosing between outbreaker2 (rich epi data) and TransPhylo (genomic-only after dated phylogeny), running source attribution between host populations, calling HIV-TRACE thresholds appropriate to the local subtype, or distinguishing recent transmission from reactivation in TB / chronic HIV.
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Build Sankey, alluvial, river, and CONSORT-style flow diagrams to visualize cohort transitions, cell-state changes, or pipeline filtering using ggalluvial, networkD3, plotly, and consort. Use when showing how entities move between categories across timepoints (cell states, drug response classes, patient flow through a trial) or filtering pipelines (variants filtered through QC stages).
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Query protein-protein and gene interaction databases (STRING, BioGRID, IntAct, SIGNOR, Reactome, HuRI, HuMAP, OmniPath, ConsensusPathDB, DIP). Use when building PPI networks, choosing between physical vs functional vs genetic interactions, signed/directed vs undirected, high-throughput vs curated, picking confidence thresholds, aggregating across resources, or navigating license constraints. Encodes the database decision matrix, STRING v12 channel semantics, OmniPath as meta-database, SIGNOR for signed signaling, and per-resource rate limits.
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