2천건 · 관련도순
Use for the infrastructure implementation phase after the backend follows the model — turning documents/infra-design decisions into infra/ (local container stack, production IaC), wiring cradle.json infra.up / infra.containers, adding IaC validate and image build steps to CI, and, once E2E passes, applying production once in a sandbox and recording it in the deployment table. Not for designing infrastructure (infra-design).
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Design and implement scalable API gateways, RESTful APIs, GraphQL endpoints, WebSocket handlers, and microservice communication patterns. Use when creating API routes, designing endpoints, implementing middleware, or setting up service mesh architectures.
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Cognitive systems skill for reasoning, memory, and agent behavior; use when designing agent workflows or mental-model tooling.
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Database optimization, query tuning, indexing strategies, migration management, and performance monitoring for PostgreSQL with Drizzle ORM. Use when optimizing slow queries, designing schemas, creating migrations, or setting up database monitoring.
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Comprehensive testing strategies including unit tests, integration tests, E2E tests, property-based testing, visual regression, and test automation. Use when writing tests, setting up testing frameworks, or designing test coverage strategies.
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React composition patterns that scale. Use when refactoring components with boolean prop proliferation, building flexible component libraries, or designing reusable APIs. Triggers on tasks involving compound components, render props, context providers, or component architecture. Includes React 19 API changes.
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Author, save, and edit email templates in the PostHog workflows library — compose email design JSON with Liquid personalization and create and round-trip-edit templates over MCP. Use when asked to design, build, update, or fix an email template for workflows, broadcasts, or campaigns.
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Shared vocabulary for designing deep modules. Use when the user wants to design or improve a module's interface, find deepening opportunities, decide where a seam goes, make code more testable or AI-navigable, or when another skill needs the deep-module vocabulary.
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Google quantum computing framework. Use when targeting Google Quantum AI hardware, designing noise-aware circuits, or running quantum characterization experiments. Best for Google hardware, noise modeling, and low-level circuit design. For IBM hardware use qiskit; for quantum ML with autodiff use pennylane; for physics simulations use qutip.
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Designs Bayesian clinical trials including Phase I dose-finding (BOIN, CRM, EWOC, mTPI-2), meta-analytic-predictive (MAP) priors with robust mixtures for external data borrowing, EXNEX for basket trials, hierarchical models for safety AE (Berry-Berry), Bayesian platform trials (I-SPY 2, GBM AGILE, REMAP-CAP), and posterior probability stopping rules. Covers FDA Bayesian Devices Guidance (2010), FDA Bayesian Methodology in Drugs Draft (January 2026), BOIN Fit-for-Purpose qualification (December 2021), and Project Optimus dose-optimisation. Use when designing dose-finding studies, platform trials, or sensitivity analyses with informative priors.
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Implements multiplicity control for confirmatory clinical trials using graphical procedures (Bretz-Maurer-Hommel), gatekeeping (parallel, serial, mixed), Hochberg/Hommel/Holm with PRDS, and the closed-testing principle (Marcus-Peritz-Gabriel; Goeman 2021 admissibility). Covers FDA Multiple Endpoints Final Guidance (October 2022), graphical procedures via R gMCP, primary + key-secondary + subgroup hierarchies, and FWER vs FDR distinction. Use when designing the multiplicity strategy for confirmatory trials with multiple primary or key secondary endpoints.
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Orchestrates an end-to-end CRISPR editing experiment design from target gene to delivery-ready, validatable constructs. Sequences guide design, off-target assessment, edit-modality selection (knockout, base editing, prime editing, HDR knock-in), and template/donor design, with a QC checkpoint at each handoff. Use when designing a complete CRISPR experiment for knockout, point correction, or tagging and the order of operations, the modality decision, and the cross-cutting traps are needed rather than a single step. Defers each step's mechanics to the genome-engineering skills.
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Designs PROTACs, molecular glues, and bivalent degraders with explicit handling of E3 ligase choice (VHL, CRBN, IAP, MDM2, KEAP1), linker design (length, composition, rigidity), ternary complex prediction (PRosettaC, DeepTernary, AlphaFold3 with constraints), cooperativity (alpha), DC50 / Dmax characterization, hook effect, and prediction-experiment reconciliation. Use when designing targeted protein degraders, planning linker SAR, predicting ternary complex stability, or building generative degrader workflows.
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Designs covalent inhibitors and warheads targeting cysteine (most common, 98% of covalent drugs), lysine, serine, threonine, tyrosine, and aspartate residues, with explicit handling of warhead reactivity (acrylamide, chloroacetamide, vinyl sulfone, sulfonyl fluoride, fluorosulfate, aldehyde, boronate, nitrile), reversibility (kinact/Ki, t_residence), glutathione (GSH) stability, intrinsic reactivity assays, and covalent docking (DOCKovalent, GOLD, HCovDock). Use when designing covalent inhibitors for targeted covalent inhibition (TCI), KRAS G12C-style approaches, or rationalizing covalent SAR.
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Designs novel molecules using REINVENT 4 (de novo, scaffold decoration, linker design, R-group, molecular optimization), MolMIM, Diffusion-based generators (DiGress, DiffSMol), and JT-VAE with explicit handling of multi-parameter optimization (MPO), goal-directed scoring functions, transfer/reinforcement/curriculum learning, synthetic accessibility scoring, and chemical space exploration vs exploitation. Use when designing new chemical matter against a target, decorating a scaffold, linking fragments, or optimizing a hit for multiple ADMET / activity properties simultaneously.
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AdwHeaderBar layout rules: button placement, flat/icon-only buttons, tooltips, title widgets, split buttons. Use when designing or fixing a GNOME app's header bar.
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Create distinctive React and Tailwind interfaces with strong hierarchy and polished implementation. Use when building or redesigning pages, flows, or components, or when another better-react-web-ui skill needs shared design guidance. Pair with add-ui for direct implementation or requested alternatives.
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Agentic and machine-to-machine payments on Stellar. Covers x402 (HTTP 402 paid APIs via OZ Channels facilitator, fee-sponsored clients) and MPP (Machine Payments Protocol) in both Charge mode (per-request SAC) and Channel mode (off-chain commits, high-frequency). Defaults to USDC (SEP-41 SAC) on `stellar:testnet`/`stellar:pubnet` (CAIP-2). Use when selling a paid API to AI agents, building an x402 client, or designing a payment-channel architecture for high-frequency agent traffic.
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React composition patterns that scale. Use when refactoring components with boolean prop proliferation, building flexible component libraries, or designing reusable APIs. Triggers on tasks involving compound components, render props, context providers, or component architecture. Includes React 19 API changes.
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Generate ideas that don't sound logical, then validate them with cheap behavioural experiments — Rory Sutherland's 'the opposite of a good idea can be a good idea' plus revealed-preference testing. Use when the obvious/logical solution is saturated and the user wants genuinely different options, asks 'what's a creative/unconventional angle', 'how do we stand out', 'should we run a test/experiment', 'how do we know what people actually want', or is about to trust a survey/focus group. Covers deliberate inversion of the obvious move, why stated preferences lie, and designing small reversible experiments that watch behaviour. Inspired by Rory Sutherland's *Alchemy*. Routed to from psycho-logic. 日本語の相談（「競合と同じ案しか出ない」「アンケートは好評なのに売れない」「思い切った案を安く試したい」）にも使う。中文咨询（“只能想出和竞品一样的方案”“问卷好评却卖不动”）也适用。
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画面の設計判断（ナビゲーション・重ね方・通知と空状態と読み込み・外枠とトークンと状態表現）の型を決定表で選び、アプリ内の全画面で揃える。画面・ページ・レイアウト・ナビゲーション・ダイアログ・コンポーネントを新しく作る・作り直す時、モックやダッシュボードを作る時、サイドバー・タブ・モーダル・シート・toast・バナー・空状態のどれを使うか決める時に使用。PJ に components.json があれば shadcn の部品とトークンへの対応も扱う。主要なデザインシステム（Material・HIG・Carbon・Primer・Atlassian・Fluent・GOV.UK・NN/g・WAI-ARIA APG・WCAG）の一致点を規則にし、食い違いの採否を定めてある。境界: 画面の文言は writing-ui-text、画面に何を出すかと提示前の完了基準は context/ui-artifact-standards.md、コードの実装原則は writing-code、shadcn 部品の API と組み立ては shadcn。
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Build and configure Laravel 10+ applications, including creating Eloquent models and relationships, implementing Sanctum authentication, configuring Horizon queues, designing RESTful APIs with API resources, and building reactive interfaces with Livewire. Use when creating Laravel models, setting up queue workers, implementing Sanctum auth flows, building Livewire components, optimising Eloquent queries, or writing Pest/PHPUnit tests for Laravel features.
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Provides expert knowledge for designing, implementing, and managing REST API versioning strategies with deprecation workflows.
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Designs donor/repair templates for precise CRISPR knock-ins -- choosing the format (ssODN, long-ssDNA/Easi-CRISPR, dsDNA/plasmid, AAV6), sizing homology arms, placing the cut within ~10 bp of the edit, and adding a mandatory codon-checked blocking (PAM/seed) mutation so the edited allele is not re-cut. Frames the HDR-vs-NHEJ-vs-MMEJ pathway competition, the MMEJ (PITCh) and homology-independent (HITI/HMEJ) alternatives for post-mitotic cells, ssODN strand/asymmetry choice, phosphorothioate end-protection, and ranked HDR enhancers. Use when designing a donor for a point mutation, epitope/fluorophore tag, allele replacement, or knock-in, or when HDR efficiency is low. Guide design and base/prime editing are separate skills.
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