'fuse' 검색 결과

Identify tumor neoantigens from somatic variants with pVACtools (pVACseq/pVACfuse/pVACbind/pVACvector/pVACview) for personalized cancer vaccines and checkpoint biomarkers. Encodes the field's hard truth that binding prediction is the easy, near-solved part and single-digit-percent PPV lives downstream — so it centers clonality/CCF, HLA LOH (the silent invalidator), expression, proximal-variant phasing, agretopicity/foreignness quality, and the predicted->presented->immunogenic validation tiers. Use when nominating vaccine targets, ranking neoantigens, or building a tumor-to-candidate pipeline. Binding details in mhc-binding-prediction; ranking in immunogenicity-scoring.

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Normalize read-depth copy-ratio profiles and segment them into copy-number regions using circular binary segmentation (CBS, DNAcopy), hidden Markov models, HaarSeg, and fused-lasso methods. Covers GC-content, mappability, and replication-timing (wave-artifact) bias correction, panel-of-normals/PCA denoising, diploid-baseline centering, and algorithm selection by sequencing depth and event size. Use when choosing a segmentation algorithm, correcting depth bias, diagnosing oversegmentation or a mis-centered baseline, tuning CBS or HMM parameters, or understanding why a downstream CNV caller produced fragmented or shifted segments.

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Analyzes alternative splicing at single-cell resolution. The first decision is library chemistry — 10X 3' is fundamentally limited (RT primes from poly-A, R2 falls in 3' UTR, <0.1 junction read per cell per AS event). Plate-based full-length methods (Smart-seq3, FLASH-seq, VASA-seq, STORM-seq) and single-cell long-read (MAS-Iso-seq, scISOr-Seq2) are the chemistries that give per-cell isoform structure. Tools include MARVEL (R, Smart-seq integrated), BRIE2 (Bayesian PSI with regulatory features and ELBO_gain test), scQuint (junction-cluster, plate-based; not for 10X), SpliZ (annotation-free Z-score), Psix (graph-smoothness regulated AS), and Sierra (alternative polyadenylation, often confused with AS). Use when analyzing isoform usage in scRNA-seq, identifying cell-type-specific splicing, or determining whether scRNA-seq chemistry supports splicing analysis at all.

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Analyzes sensor configurations and creates inertial fusion filters in MATLAB Navigation Toolbox. Manages filter selection (imufilter, ahrsfilter, complementaryFilter, insfilterMARG, insfilterAsync, insfilterNonholonomic, insfilterErrorState, insEKF, insCF), construction, tuning, and fusion loops. Use when fusing IMU/AHRS/INS/GPS+IMU data, estimating orientation or pose, or choosing a filter. Do NOT use for vision-only SLAM, Simulink fusion, or IMU simulation.

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Optimize MongoDB client connection configuration (pools, timeouts, patterns) for any supported driver language. Use this skill when working/updating/reviewing on functions that instantiate or configure a MongoDB client (eg, when calling `connect()`), configuring connection pools, troubleshooting connection errors (ECONNREFUSED, timeouts, pool exhaustion), optimizing performance issues related to connections. This includes scenarios like building serverless functions with MongoDB, creating API endpoints that use MongoDB, optimizing high-traffic MongoDB applications, creating long-running tasks and concurrency, or debugging connection-related failures.

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AWS EC2 virtual machine management — instances, security groups, key pairs, AMIs, EBS volumes, Auto Scaling Groups, Spot Instances, Session Manager, placement groups, and instance lifecycle automation. Trigger on ANY of these, even when EC2 isn't named explicitly: - Launching or provisioning: "spin up a server", "create a VM", "new instance", "run-instances", mention of instance types (t3, m5, c5, r6, g5, p4d, t4g, c7g, etc.) - SSH / connectivity problems: "connection refused", "connection timed out", "permission denied publickey", "can't connect to my instance", "SSH not working" - Instance management: resize, stop, start, terminate, reboot, change instance type - Cost optimization: stop dev instances overnight, save money on EC2, spot vs on-demand, reserved instances - Auto Scaling: ASG, launch template, mixed instances policy, scale to zero, scheduled scaling - Spot Instances: spot fleet, spot interruption, capacity-optimized, price-capacity-optimized - AMIs and backups: create image, custom AMI, EBS snapshot, DLM lifecycle policy, copy AMI - Monitoring: EC2 CPU utilization, CloudWatch metrics for instance, instance status checks, console output - Access methods: Session Manager, EC2 Instance Connect, bastion host, port forwarding - Security: IMDSv2, instance metadata, IAM role on instance, security group rules - User data and bootstrap scripts, cloud-init

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CloudBase declarative deployment from a cloudbaserc config (声明式部署, 配置式部署, cloudbaserc 部署) through the deployBuild / deployPlan / deployApply MCP tools. Use when deploying database, functions, app, hosting, or gateway resources described in cloudbaserc.json/yaml as a single desired-state config, when a user wants to build static hosting artifacts locally first (deployBuild), or wants a dry-run plan before applying (deployPlan), or when handling multi-environment deploys via mode / envOverrides. Covers build-plan-apply flow (deployBuild local build → deployPlan dry-run → deployApply confirm=true), hosting build-output neutralization, envId resolution priority, only/skip filtering, concurrency, and continueOnError. Prefer deployBuild (when hosting declares a buildCommand) and deployPlan before deployApply; do not confuse with per-resource tcb CLI deploy or single-function deploy.

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Builds an offer too good to refuse. Lists every problem the buyer hits on the way to the result they want, turns each into a solution, trims to what is cheap to deliver and valuable to the buyer, and stacks it with honest bonuses, a guarantee the CFO can afford, real urgency and a clear name. Scores it on the value equation (outcome, likelihood, time, effort) and re-tests it on a quick buyer panel. Use when the user says "make my offer better", "why won't people buy", "what should I include", "guarantee", "bonuses", "grand slam offer", or after the panel shows people passing.

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Use when an agent drives Unreal Engine 5.8 on a Mac for any task: Editor Python (the unreal module), headless UnrealEditor-Cmd -run=pythonscript jobs, Epic's Unreal MCP server, the Remote Control API, console commands and cvars; when a script breaks on 5.8 (EditorLevelLibrary, Remote Control calls refused, Substrate materials black, MRQ presets); when a level, material, shot or build must be judged by numbers and a screenshot before it is called done; or when a brief must go to the right scenario-unreal-* specialist.

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Design a variation theory task using contrast, separation, and fusion to teach critical features of a concept. Use when students confuse similar concepts or fail to discern key distinctions.

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Expertise complète en droit français des étrangers, de l'asile et de la nationalité — entrée et visas, séjour (CESEDA livre IV, AES, étranger malade, regroupement familial, métiers en tension), éloignement et contentieux (OQTF, IRTF, rétention, référés, TA/CAA/CE), asile (OFPRA, CNDA, Dublin, CMA/ADA), nationalité et droits sociaux des étrangers (AME, PUMa, RSA, AAH, ASPA). Interroge en priorité trois connecteurs MCP complémentaires — OpenLegi (textes, jurisprudence administrative), LibreJustice (recherche sémantique tous ordres) et Legal Data Hunter (rétention/JLD, graphe de citations, statut de validité) — puis les sources officielles (Légifrance, ANEF, OFPRA, CNDA) et la doctrine associative (GISTI, Cimade, ADDE, Comede, Anafé). Déclencher dès qu'une question porte sur un étranger en France, même sans vocabulaire juridique — « papier de la préfecture », « récépissé périmé », « la CAF refuse le RSA » — et pour toute consultation, recours, note ou vérification de références dans ces matières.

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Searches the domestic courts of 122 jurisdictions — 153 databases, 49 automated — for extradition and arrest-warrant surrender decisions, each in its own language and vocabulary. Answers the question no commercial database does: how are OTHER executing states treating this requesting state, or this ground? Searching by requesting state localises its name per jurisdiction (AE becomes 'Emiratele Arabe Unite' in Romania, 'Emirati Arabi Uniti' in Italy), so the sweep finds what those courts actually wrote. Every hit passes a relevance gate; every search leaves a dated report, so the research is reconstructable months later. Use when asked what foreign courts have said about surrender to a given state, whether any European court has refused extradition on prison conditions, assurances or Article 3, for comparative extradition research, or to build a foreign-authority section of an extradition argument. Not for domestic case law of the user's own jurisdiction, and never a substitute for reading the judgment.

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An end-to-end method for drafting and finalising a complex, multi-pillar regulated fintech agreement — from intake to signature. Authored from a senior fintech lawyer's manual: a licensed payment-services provider engaging a counterparty across agent cash-in/cash-out, QR payments, wallet e-payments, and a marketplace, each with its own regulatory profile. Runs five phases and fourteen steps: regulatory mapping (activity-to-licence matrix, grey-zone classification gates), architecture (framework-plus-sub-agreement structure, ring-fenced marketplace), the regulatory–commercial balance (what flexes vs what cannot), core drafting (authority, float mechanics, hard-coded regulator caps, liability — all tracking control), execution-blocker triage, and a pre-signature check closing open blockers as conditions precedent. It refuses to invent licence-specific values or draft a representation as true without executed evidence. Use it to structure, draft, negotiate, or review any regulated payments contract.

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Claude skill that turns Claude into a Connecticut-specific divorce planner — nine operating modes from pre-flight intake to post-judgment modification, modeled on Untangle.us's feature surface and grounded in C.G.S. Title 46b, Practice Book Chapter 25, and the 2026-08-01 CCSG schedule. Covers eligibility triage (nonadversarial under § 46b-44a vs standard), financial affidavit (JD-FM-6), child support (JD-FM-220 / CCSG-1 / 1A), alimony (§ 46b-82 fourteen factors), parenting plan (with GAL/AMC escalation under JD-FM-224), settlement agreement (JD-FM-172, TCJA-aware), filing packet (marshal 12-day rule, $360 + $50 fees, JD-FM-75 waiver), and post-judgment motion practice. Hard UPL gate: refuses non-CT, domestic violence (refers CTCADV 1-888-774-2900), hidden assets, courtroom advocacy. Heppner-aware: AI prompts are not privileged. First family-law skill in the Lawvable registry.

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Rédaction d'assignations en référé devant le tribunal de commerce ou des activités économiques pour le droit de communication d'un associé. Utiliser ce skill quand l'utilisateur demande de rédiger, préparer ou créer une assignation en référé fondée sur l'article L. 238-1 du code de commerce pour obtenir la communication forcée de documents sociaux (comptes annuels, rapports de gestion, PV d'assemblées, etc.) lorsqu'un dirigeant refuse ou fait obstruction à la communication de ces documents à un associé.

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When a solution seems impossible and the path forward is blocked. Refuses to take no for an answer: classifies what kind of "no" you hit, then runs lateral-thinking techniques (assumption autopsy, inversion, first principles, constraint toggling, analogical transfer, and more) until the wall cracks or is proven load-bearing. Generates at least 10 angles before evaluating any. AGENTS: use this on yourself when an API doesn't support what you need, an approach has failed twice, or a "that's not possible" sentence is forming — run the fast path BEFORE reporting a dead end. Archives walls to ~/.config/makerskills/unstuck/archive/. Sits upstream of decide. Triggers on "/unstuck," "I'm stuck," "this seems impossible," "we hit a wall," "there's no way to," "they said no," "dead end," "out of options," "I've tried everything," "work around this."

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Probe IoT/embedded targets for exposed SWD/JTAG debug interfaces using a SEGGER J-Link. Detects whether debug is OPEN, LOCKED (readout-protected), or DEAD (fused off). Use when assessing whether a target's on-chip debug port can be reached, identifying the silicon vendor from DPIDR/IDCODE, and confirming halt+memory access for full debugger control.

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Author ComfyUI-LoRA-Manager nodes from the panel. Use when adding a LoRA Manager loader, stacker, prompt, or text node, or when panel_add_node refuses AUTOCOMPLETE_TEXT_LORAS / AUTOCOMPLETE_TEXT_PROMPT after waiting for a widget.

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.NET / C# 二进制逆向。当目标是 .NET assembly（PE 头含 CLR、.exe/.dll 托管程序）、C# 编译产物（含 NativeAOT）、红队 Sharp* 工具（Rubeus / SharpHound / SharpHound 等）、.NET 混淆程序（ConfuserEx / SmartAssembly / Babel / Eazfuscator）、.NET loader / info-stealer / 套壳 malware 时使用。优先用 dnSpyEx + de4dot，需要 AI 直接操作时联动 dnSpy MCP。不用于纯 native 二进制（走 reverse-engineering / ida-reverse）。

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Use when a finished GSD workspace and its worktrees should be deleted. Confirms first, runs git worktree remove for each member repo, and refuses if any repo has uncommitted changes.

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Drive Codeman, the session manager this agent is running inside, over its HTTP API, from any agent CLI (Claude Code, Codex, Gemini CLI, OpenCode, Antigravity, Grok Build, DeepSeek Harness, OMP): list sessions, start worker sessions in any installed CLI, send them prompts, block until they finish (wait / wait-output / send-and-wait), read their output, and clean up; where available, message claude workers directly (Claude Code cross-session messaging). Use when asked to orchestrate or parallelize work across Codeman sessions, get a second opinion from another CLI or model, watch another session, or start and manage workers. Only usable inside a Codeman-managed session (CODEMAN_MUX=1); refuse to act otherwise.

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Expert knowledge for Azure Blob Storage development including troubleshooting, best practices, decision making, limits & quotas, security, configuration, integrations & coding patterns, and deployment. Use when using tiers/archival, NFS/SFTP, BlobFuse, Storage Mover, SAS/RBAC auth, or static website hosting, and other Azure Blob Storage related development tasks. Not for Azure Files (use azure-files), Azure Queue Storage (use azure-queue-storage), Azure Table Storage (use azure-table-storage).

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Monitor external web and social mentions of the operator's active projects - surface what people are discovering, where they're confused, and where to engage

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Provides guidance for writing, optimizing, and benchmarking Triton kernels for Intel XPU GPUs (Battlemage/Arc Pro B50) using the Xe-Forge optimization framework. Includes an LLM-driven trial-loop workflow (analyze, validate, benchmark, profile, finalize), XPU-specific patterns (tensor descriptors, GRF mode, tile swizzling), KernelBench fused kernels, and Flash Attention.

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