39건 · 관련도순
Systematically interpret mass spectra to determine molecular formula, identify fragmentation pathways, and propose molecular structures. Covers ionization method assessment, molecular ion identification, isotope pattern analysis, common fragmentation losses, and purity evaluation.
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Expert mobile game developer specializing in iOS and Android game optimization, touch input design, battery and thermal management, device fragmentation handling, and App Store/Play Store submission. Deep knowledge of mobile-specific constraints and best practices for shipping performant, player-friendly mobile games. Use when "mobile game, ios game, android game, touch input, mobile optimization, mobile performance, app store, play store, mobile battery, thermal throttling, mobile porting, tablet game, phone game, mobile monetization, mobile build, mobile, ios, android, touch, optimization, performance, battery, thermal, app-store, play-store, game-development, unity-mobile, godot-mobile, device-fragmentation" mentioned.
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Evaluate older Wi-Fi clients and embedded devices for KRACK and FragAttacks vulnerabilities. Covers test suites, likely patch status, practical impact, and reporting findings by device, firmware version, and vulnerability identifier.
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Analyzes cfDNA fragment size distributions and fragmentomics features using FinaleToolkit or Griffin. Extracts nucleosome positioning patterns, fragment ratios, and DELFI-style fragmentation profiles for cancer detection. Use when leveraging fragment patterns for tumor detection or tissue-of-origin analysis.
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Role profile — a reviewer who is fact-seeking, bedrock-seeking, honest, and rejecting. Demands that arguments rest on small facts that cannot be wrong (not on stacked assumptions dressed up as foundation), and that deliberately-unclear concepts be quarantined — never leaked into solid layers, never mixed with each other. Catches the failure mode where designs ship after partial grounding: most of the spec researched, the design feels finished, and the unresearched remainder holds the deal-breaker. Invoke with `/pedantic <target>` (e.g. `/pedantic review this design doc`, `/pedantic review the SDK design`, `/pedantic review this PR`). Probes cover logical structure (definitions, assumptions, boundaries, contradictions, unfalsifiability, vague quantifiers, counterexamples), epistemic honesty (researchable vs. discoverable-only-by-doing), bedrock integrity (assumed-bedrock, leaked uncertainty, mixed unclarity), and design pathology (YAGNI, wrong-layer abstraction, unclear responsibility, fragmentation, over-engineering). Use when you want a hard critique of a plan, design doc, technical doc, code change, or PR description — not a copy edit, not a vibe check.
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Choose placements that preserve useful residual capacity. Use for bin packing, GPU sharing, accelerator placement, and multi-resource scheduling where stranded capacity hurts future fit.
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Treat context switches as the budget line they are — the switch census (how fragmented the week really is), the batching moves that consolidate scattered same-kind work, the calendar defrag that turns Swiss cheese into slabs, and the switch-cost line for saying no. Use when asked my day is fragmented to death, count my context switches, batch my meetings and reviews, or defend against calendar Swiss cheese. Produces the fragmentation census, the batching plan, the defrag moves, and the protective phrases.
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Defragment a work calendar through a tool-using agent — find the meeting debt, propose the consolidation, and (approval-gated) execute the moves. Use when asked to defrag my calendar, get me focus time, audit my meetings, or fix my week. Produces the calendar audit (cost per meeting, fragmentation map), a defrag proposal with focus blocks, and an approval-gated execution plan.
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Model gene-family birth-death dynamics across a species tree using CAFE5 (Mendes et al 2020 Bioinformatics 36:5516 gamma-distributed rate categories), CAFE5-error (annotation-error-aware), Count (Csurös 2010 ancestral state reconstruction), BadiRate (Librado 2012 likelihood + parsimony), DupliPHY-Family, and ALE/AleRax (for per-family DTL; see [[gene-tree-species-tree-reconciliation]]). Test lineage-specific gene-family expansions and contractions, distinguish biological dynamics from annotation artifacts, account for assembly fragmentation, identify functional enrichment in expanded / contracted families. Use when correlating gene-family changes with phenotype evolution, ranking lineages by adaptive gene-family-rate shifts, post-WGD dosage-balance analysis, or building Birth-death models from OrthoFinder presence/absence matrices.
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Assesses ChIP-seq quality across antibody specificity, fragmentation, enrichment, replicate concordance, and library complexity. Computes FRiP, NSC/RSC (phantompeakqualtools), library complexity (NRF/PBC1/PBC2), deepTools plotFingerprint (JS distance, AUC, synthetic JS), ChIPQC, IDR with ENCODE Nself/Nt rules, and detects hyper-ChIPable artifacts. Use when validating an antibody, diagnosing failed peak calls, deciding whether to proceed with downstream analysis, grading against ENCODE thresholds, or auditing replicate concordance.
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Enumerates virtual chemical libraries via reaction SMARTS transformations using RDKit and reaction templates, with explicit handling of atom mapping, RDChiral template extraction, product validation, RECAP/BRICS fragmentation, R-group decomposition, matched molecular pair analysis (MMPA), and Free-Wilson analysis. Use when generating combinatorial libraries from building blocks, enumerating analog series, deriving structure-activity rules, or extracting transformations from reaction data.
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Protect, design, and measure focused work — block defence, session structure, interruption budgets, and deep-work ratio. Use when the calendar is fragmented, focus blocks keep getting eaten, or output has stalled.
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Use when a native app, service, or user-mode driver host allocation fails; distinguish VA exhaustion, fragmentation, and commit pressure. Not for managed .NET heap growth, proving a leak from one snapshot, or corruption.
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Pythonic RDKit wrapper with sensible defaults for drug discovery. SMILES parsing, standardization, descriptors, fingerprints, similarity, clustering, diversity selection, scaffold analysis, BRICS/RECAP fragmentation, 3D conformers, and visualization. Returns native rdkit.Chem.Mol. Prefer datamol for standard workflows; use RDKit directly for advanced control.
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Audit your calendar with Cowork's calendar tools -- measure meeting load and fragmentation, identify which recurring meetings earn their slot, propose consolidations and focus blocks, and draft the diplomatic messages that reclaim your week.
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Think and work like an expert Mass Spectrometrist. Use when a task calls for Mass Spectrometrist judgment. Reasons from ion formation, m/z resolution and mass accuracy, fragmentation, and calibrated ion statistics through ESI/APCI/MALDI tuning, CID/HCD/ETD MS/MS, isotope-pattern formula assignment, and spectral libraries (NIST, mzCloud, GNPS) under FDA/ICH M10/MSI tiers, while treating matrix suppression, PEG/siloxane/keratin contamination, decoy-driven FDR inflation, and unassigned adducts as first-class failure modes.
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Analyzes cfDNA fragment size distributions and fragmentomics features using FinaleToolkit or Griffin. Extracts nucleosome positioning patterns, fragment ratios, and DELFI-style fragmentation profiles for cancer detection. Use when leveraging fragment patterns for tumor detection or tissue-of-origin analysis.
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Assesses ChIP-seq quality across antibody specificity, fragmentation, enrichment, replicate concordance, and library complexity. Computes FRiP, NSC/RSC (phantompeakqualtools), library complexity (NRF/PBC1/PBC2), deepTools plotFingerprint (JS distance, AUC, synthetic JS), ChIPQC, IDR with ENCODE Nself/Nt rules, and detects hyper-ChIPable artifacts. Use when validating an antibody, diagnosing failed peak calls, deciding whether to proceed with downstream analysis, grading against ENCODE thresholds, or auditing replicate concordance.
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Google and Meta paid media account structure evaluation. Audits campaign/ad set architecture against conversion volume minimums, budget thresholds, and targeting overlap. Identifies over-segmentation, under-segmentation, budget fragmentation, and structural anti-patterns blocking algorithmic learning. Provides consolidation roadmaps with migration plans. Use when inheriting accounts, quarterly health checks, or before scaling budgets.
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Adapts LLMs: SFT dataset loss masking, LoRA and QLoRA, full FT vs PEFT, distillation, pruning, tokenizer fragmentation. Use when fine-tuning or compressing a model.
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Assessing anthropogenic environmental impacts — pollution pathways, habitat destruction and fragmentation, land-use change, invasive species, overharvest, and extinction debt. Covers environmental impact assessment (EIA) methodology, exposure-effect relationships, population viability analysis, IPAT and ecological footprint frameworks, and strategic environmental assessment. Use when quantifying or forecasting human impacts on ecosystems, designing monitoring programs, or evaluating a proposed intervention against a baseline.
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Develops PE sector theses with industry mapping, secular trends, fragmentation opportunity, and target universe identification. Use when building sector strategies, mapping investment themes, or identifying subsector opportunities.
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Number antibody variable domains, annotate CDRs, and assess developability from sequence. Use this skill to apply IMGT, Kabat, Chothia, Martin, or AHo numbering with ANARCI, delimit CDRs and framework regions, scan for chemical liabilities (N-glycosylation sequons, deamidation NG, isomerisation DG, oxidation, unpaired cysteine, fragmentation), compute pI, net charge, extinction coefficient and hydrophobicity, and plan humanisation by CDR grafting. Also trigger on antibody, nanobody, VHH, scFv, Fab, CDR, framework, ANARCI, abnumber, IgBLAST, OAS, SAbDab, humanization, Vernier residues, or developability.
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Pythonic wrapper around RDKit with a simplified interface and sensible defaults. Preferred for standard drug discovery work — SMILES/SELFIES/InChI conversion, molecule standardization and sanitization, descriptors, ECFP and other fingerprints, Tanimoto distance matrices, Butina clustering and diverse subset picking, Bemis-Murcko scaffolds and scaffold splits, BRICS/RECAP fragmentation, 3D conformer generation, SDF/CSV/Excel and cloud I/O, and parallel processing via n_jobs. Returns native rdkit.Chem.Mol objects, so it composes with RDKit throughout. Also trigger on datamol, `import datamol as dm`, dm.to_mol, dm.standardize_mol, dm.cluster_mols, or dm.pick_diverse. For advanced control or custom parameters, use the rdkit skill directly.
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