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概要と使いどころ
Implement proven backend architecture patterns including Clean Architecture, Hexagonal Architecture, and Domain-Driven Design. Use when architecting complex backend systems or refactoring existing applications for better maintainability.
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Complete guide for building accessible, high-UX forms in modern stacks (React/Next.js, Tailwind, Zod). Includes specific patterns for clickable areas, range sliders, output-inspired design, and WCAG compliance.
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Apple's approach to interface design and fluid, physical motion, translated for the web. Use when building or reviewing gesture-driven UI, spring animations, drag/swipe/sheet interactions, momentum and interruptible transitions, translucent materials and depth, typography (optical sizing, tracking, leading), reduced-motion, or the design foundations (feedback, spatial consistency, restraint) behind Apple-style interfaces.
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Master REST and GraphQL API design principles to build intuitive, scalable, and maintainable APIs that delight developers. Use when designing new APIs, reviewing API specifications, or establishing API design standards.
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Draft Project Manual specification sections from accepted project requirements using CSI MasterFormat identities, three-part sections and review flags. Use for design requirements; use product-cut-sheet for source-faithful product entries and epd-to-spec for EPD requirements.
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Evaluating scientific evidence and claims. Covers study design hierarchy (RCT to expert opinion), effect sizes (OR, RR, NNT, Cohen's d), confounding, p-value vs clinical significance, GRADE quality assessment, reproducibility, and bias types (selection, information, confounding, reporting). Use when reading a paper or assessing claims.
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Medicinal chemistry filters for compound triage. Drug-likeness rules (Lipinski Ro5, Veber, Oprea, CNS, leadlike, REOS, Golden Triangle, Ro3), structural alerts (PAINS, NIBR, Lilly Demerits), chemical group detectors, complexity metrics, and filter composition query language. Built on RDKit/datamol. For hit-to-lead filtering, library design, ADMET pre-screening. For molecular I/O use rdkit-cheminformatics or datamol.
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Multi-Omics Factor Analysis v2 (MOFA+) with mofapy2. Jointly decompose omics layers (scRNA, ATAC, proteomics, methylation) into latent factors capturing major variation. Multi-group designs. AnnData views → MOFA object → train → variance explained → correlate factors with metadata → visualize/cluster → enrich top loadings.
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Constraint-based (COBRA) analysis of genome-scale metabolic models: FBA, FVA, knockouts, flux sampling, production envelopes, gapfilling, media optimization. Use for strain design, essential gene ID, flux analysis. For kinetic modeling use tellurium; for visualization use Escher.
日本語の概要は準備中です。原文の説明を表示しています。
Python framework for single- and multi-objective optimization with evolutionary algorithms. Define vectorized objectives and constraints; solve with NSGA-II, NSGA-III, MOEA/D, GAs, or differential evolution. Analyze Pareto fronts, visualize trade-offs, customize operators and callbacks. For engineering design, hyperparameter search, and conflicting objectives. Alternatives: scipy.optimize (single-objective, gradient), platypus, jMetalPy (Java).
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Predict RNA secondary structure, MFE folding, base-pair probabilities, RNA-RNA interactions via ViennaRNA Python bindings. Pipeline: sequence → MFE → partition function and pair-probability matrix → dot-bracket → duplex. Use for siRNA/sgRNA targeting, ribozyme design, RNA accessibility. Use RNAfold CLI for batch use without Python.
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Three-tiered sgRNA design guide using validated Addgene sequences, CRISPick pre-computed datasets, or de novo design rules for CRISPR experiments
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Domain-Driven Design architecture for claude-flow v3. Implements modular, bounded context architecture with clean separation of concerns and microkernel pattern.
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Comprehensive guidance for building web apps with opinionated defaults for tech stack, design system, and code standards. Use when user wants to create a new web application, dashboard, or interactive interface. Provides tech choices, styling guidance, project structure, and design philosophy to get users up and running quickly with a fully functional, beautiful web app.
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Best practices, design patterns, and common pitfalls for ROS1 (Robot Operating System 1) development. Use this skill when building ROS1 nodes, packages, launch files, or debugging ROS1 systems. Trigger whenever the user mentions ROS1, catkin, rospy, roscpp, roslaunch, roscore, rostopic, tf, actionlib, message types, services, or any ROS1-era robotics middleware. Also trigger for migrating ROS1 code to ROS2, maintaining legacy ROS1 systems, or building ROS1-ROS2 bridges. Covers catkin workspaces, nodelets, dynamic reconfigure, pluginlib, and the full ROS1 ecosystem.
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Foundational software design principles applied specifically to robotics module development. Use this skill when designing robot software modules, structuring codebases, making architecture decisions, reviewing robotics code, or building reusable robotics libraries. Trigger whenever the user mentions SOLID principles for robots, modular robotics software, clean architecture for robots, dependency injection in robotics, interface design for hardware, real-time design constraints, error handling strategies for robots, configuration management, separation of concerns in perception-planning- control, composability of robot behaviors, or any discussion of software craftsmanship in a robotics context. Also trigger for code reviews of robotics code, refactoring robot software, or designing APIs for robotics libraries.
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Architecture patterns, design principles, and proven recipes for building robust robotics software. Use this skill when designing robot software architectures, choosing between behavioral frameworks, structuring perception-planning-control pipelines, implementing state machines, designing safety systems, or architecting multi-robot systems. Trigger whenever the user mentions behavior trees, finite state machines, subsumption architecture, sensor fusion, robot safety, watchdogs, heartbeats, graceful degradation, hardware abstraction layers, real-time constraints, or software architecture for robots. Also applies to sim-to-real transfer, digital twins, and robot fleet management.
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Provides complete shadcn/ui component library patterns including installation, configuration, and implementation of accessible React components. Use when setting up shadcn/ui, installing components, building forms with React Hook Form and Zod, customizing themes with Tailwind CSS, or implementing UI patterns like buttons, dialogs, dropdowns, tables, and complex form layouts.
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Provides comprehensive Tailwind CSS utility-first styling patterns including responsive design, layout utilities, flexbox, grid, spacing, typography, colors, and modern CSS best practices. Use when styling React/Vue/Svelte components, building responsive layouts, implementing design systems, or optimizing CSS workflow.
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Provides comprehensive NestJS best practices including modular architecture, dependency injection scoping, exception filters, DTO validation with class-validator, and Drizzle ORM integration. Use when designing NestJS modules, implementing providers, creating exception filters, validating DTOs, or integrating Drizzle ORM within NestJS applications.
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Provides TypeScript patterns for DynamoDB-Toolbox v2 including schema/table/entity modeling, .build() command workflow, query/scan access patterns, batch and transaction operations, and single-table design with computed keys. Use when implementing type-safe DynamoDB access layers with DynamoDB-Toolbox v2 in TypeScript services or serverless applications.
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Provides implementation patterns for Clean Architecture, Hexagonal Architecture (Ports & Adapters), and Domain-Driven Design in Python applications with FastAPI or Flask. Use when designing maintainable backends with separation of concerns, implementing repository patterns, creating entities/value objects/aggregates, or structuring domain logic independent of frameworks for testability.
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Skill for creating and managing a Design System using Tailwind CSS and shadcn/ui. Use when defining design tokens, setting up theming with CSS variables, building a consistent UI component library, initializing a design system configuration, or wrapping shadcn/ui components into design system primitives.
日本語の概要は準備中です。原文の説明を表示しています。
Provides implementation patterns for Clean Architecture, Hexagonal Architecture (Ports & Adapters), and Domain-Driven Design in PHP 8.3+ with Symfony 7.x. Use when architecting enterprise PHP applications with entities/value objects/aggregates, refactoring legacy code to modern patterns, implementing domain-driven design with Symfony, or creating testable backends with clear separation of concerns.
日本語の概要は準備中です。原文の説明を表示しています。