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How to use the Adaptyv Bio Foundry API and Python SDK for protein experiment design, submission, and results retrieval. Use this skill whenever the user mentions Adaptyv, Foundry API, protein binding assays, protein screening experiments, BLI/SPR assays, thermostability assays, or wants to submit protein sequences for experimental characterization. Also trigger when code imports `adaptyv`, `adaptyv_sdk`, or `FoundryClient`, or references `foundry-api-public.adaptyvbio.com`.

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Write Ruby gems following Andrew Kane's proven patterns and philosophy. Use when creating new Ruby gems, refactoring existing gems, designing gem APIs, or when the user wants clean, minimal, production-ready Ruby library code. Triggers on requests like "create a gem", "write a Ruby library", "design a gem API", or mentions of Andrew Kane's style.

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Implement proven backend architecture patterns including Clean Architecture, Hexagonal Architecture, and Domain-Driven Design. Use when architecting complex backend systems or refactoring existing applications for better maintainability.

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Validate protein designs using AlphaFold2 structure prediction. Use this skill when: (1) Validating designed sequences fold correctly, (2) Predicting binder-target complex structures, (3) Calculating confidence metrics (pLDDT, pTM, ipTM), (4) Self-consistency validation of designs, (5) Multi-chain complex prediction with AlphaFold-Multimer. For faster single-chain prediction, use esm. For QC thresholds, use protein-qc.

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Time-blind friendly planning, executive function support, and daily structure for ADHD brains. Specializes in realistic time estimation, dopamine-aware task design, and building systems that actually work for neurodivergent minds.

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Suite of tools for creating elaborate, multi-component claude.ai HTML artifacts using modern frontend web technologies (React, Tailwind CSS, shadcn/ui). Use for complex artifacts requiring state management, routing, or shadcn/ui components - not for simple single-file HTML/JSX artifacts.

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This skill determines whether an adolescent or adult patient meets DSM-5 criteria for gender dysphoria (gender incongruence) by evaluating the presence of at least two of six specified criteria over a minimum 6-month duration, accompanied by clinically significant distress or impairment. It is triggered when a clinician queries whether the patient's reported symptoms align with gender dysphoria, such as persistent incongruence between experienced/expressed gender and designated gender.

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Workflow Phase 6 — TDD coordinator. Decides the scenario recipe and the implementation contract in main context, writes them to a state file, seeds per-worker tasks (scenario, implement, verify-tick, design-ui-tick) into the TaskList, and yields with harness_state continue so the harness invokes each worker as its own tick. No subagent delegation; no nested Skill calls.

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Preflight a spec draft without saving. Runs the same checks as the write-boundary hooks — PlantUML syntax, required diagram presence, AC-to-sequence traceability, Design calls quality floor, and System delta row resolution — and prints a compact pass/fail table. Use while iterating so the hooks don't bite on save.

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Capture what someone actually said without contaminating it with your own inference. Invoke when eliciting intent in conversation (design discussion, requirement interview, decision surfacing) and when turning a conversation into a durable record (ADR, decision node, memory entry, spec `## Decisions` row). Enforces quote-before-critique, keeps illustration separate from commitment, and holds interpretation subordinate to verbatim. Prevents the failure where unspecified space is filled by the recorder and then evaluated as if the speaker had specified it.

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Orchestrates `impeccable` for every design task inside a workflow phase. Captures intent in natural language, classifies it (design / development / copy), translates design intents into a sequence of impeccable subcommand invocations, runs them in main context with state persistence at `.claude/state/design/<slug>.json`, and returns a structured report. ALWAYS invokes `impeccable` under the hood for the underlying design move; never picks aesthetic direction itself; never writes product code directly. Per CLAUDE.md Article X.2, all design tasks in workflow phases route through this skill.

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로컬 품질 검증과 실패 원인 분류. AGENTS.md/DESIGN.md 준수 확인, pnpm 기반 검증, PR 전 점검

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로컬 품질 검증과 실패 원인 분류. AGENTS.md/DESIGN.md 규칙 준수 확인, pnpm 기반 검증, PR 전 점검

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Use for prioritization, or when there are more tasks than capacity: "what should we do first?", "rank this backlog", "cut scope for the MVP", "RICE score these". Picks a method (RICE, ICE, MoSCoW, impact-effort), scores items and sets a cut line. Skip for choosing between two designs.

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Use for design thinking, or when a product or service problem needs user understanding before solutions: "what do users really need?", "how might we...", "plan a discovery sprint", "validate this concept". Skip when the spec is frozen or the task is code maintenance.

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You MUST use this before any creative work - creating features, building components, adding functionality, or modifying behavior. Explores user intent, requirements and design before implementation.

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Generate multiple radically different interface designs for a module using parallel sub-agents. Use when user wants to design an API, explore interface options, compare module shapes, or mentions "design it twice".

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Throwaway HTML mockups: 2-3 design variants to compare.

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Control a running TouchDesigner instance via twozero MCP — create operators, set parameters, wire connections, execute Python, build real-time visuals. 36 native tools.

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Design one-off HTML artifacts (landing, deck, prototype).

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Author/validate/export Google's DESIGN.md token spec files.

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Guides stable API and interface design. Use when designing APIs, module boundaries, or any public interface. Use when creating REST or GraphQL endpoints, defining type contracts between modules, or establishing boundaries between frontend and backend.

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Use when building creative browser demos with @chenglou/pretext — DOM-free text layout for ASCII art, typographic flow around obstacles, text-as-geometry games, kinetic typography, and text-powered generative art. Produces single-file HTML demos by default.

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Builds production-quality UIs. Use when building or modifying user-facing interfaces. Use when creating components, implementing layouts, managing state, or when the output needs to look and feel production-quality rather than AI-generated.

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