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Analyzes alternative splicing at single-cell resolution. The first decision is library chemistry — 10X 3' is fundamentally limited (RT primes from poly-A, R2 falls in 3' UTR, <0.1 junction read per cell per AS event). Plate-based full-length methods (Smart-seq3, FLASH-seq, VASA-seq, STORM-seq) and single-cell long-read (MAS-Iso-seq, scISOr-Seq2) are the chemistries that give per-cell isoform structure. Tools include MARVEL (R, Smart-seq integrated), BRIE2 (Bayesian PSI with regulatory features and ELBO_gain test), scQuint (junction-cluster, plate-based; not for 10X), SpliZ (annotation-free Z-score), Psix (graph-smoothness regulated AS), and Sierra (alternative polyadenylation, often confused with AS). Use when analyzing isoform usage in scRNA-seq, identifying cell-type-specific splicing, or determining whether scRNA-seq chemistry supports splicing analysis at all.

日本語の概要は準備中です。原文の説明を表示しています。

Test whether two or more traits share a causal variant at a locus using Bayesian colocalization (coloc.abf, coloc.susie, HyPrColoc, moloc, eCAVIAR, SMR/HEIDI, PWCoCo, SharePro). Use when integrating GWAS with eQTL/sQTL/pQTL/mQTL, distinguishing shared causal variants from LD-driven coincidence, handling allelic heterogeneity, choosing between single-causal vs multi-causal methods, picking PP.H4 thresholds, running sensitivity over p12, or harmonising summary statistics for colocalization.

日本語の概要は準備中です。原文の説明を表示しています。

Decompose total effects into direct and indirect paths through mediators using mediation, CMAverse 4-way, HIMA/HIMA2 high-dimensional, BAMA, two-step / MVMR mediation, or double-ML medDML. Use when testing whether a molecular phenotype (expression, methylation, protein) mediates a treatment-outcome relationship, decomposing exposure-mediator interaction via VanderWeele 4-way, screening high-dimensional EWAS mediators, or running MR-based mediation when sequential ignorability is implausible.

日本語の概要は準備中です。原文の説明を表示しています。

Use when asking about Axiom skills or axbuild build/test capture, xclog console, xcsym .ips/MetricKit/.crash symbolication, xcui simulator UI/accessibility, or xcprof xctrace/CPU profiles.

日本語の概要は準備中です。原文の説明を表示しています。

Use when the user wants to run XCUITests, parse test results, view test failures, or export test attachments.

日本語の概要は準備中です。原文の説明を表示しています。

Use when the user mentions security review, App Store submission prep, Privacy Manifest requirements, hardcoded credentials, or sensitive data storage.

日本語の概要は準備中です。原文の説明を表示しています。

Use when storing credentials securely, encrypting data, implementing passkeys, securing AI/agentic features against prompt injection, code signing, or managing certificates and provisioning profiles.

日本語の概要は準備中です。原文の説明を表示しています。

Use when writing ANY test, debugging flaky tests, making tests faster, or choosing Swift Testing vs XCTest. Covers unit tests, UI tests, async testing, test architecture.

日本語の概要は準備中です。原文の説明を表示しています。

Use when the user mentions simulator testing, visual verification, push notification testing, location simulation, screenshot capture, OR live accessibility validation (VoiceOver announcements, Dynamic Type, ADA checks) on the simulator.

日本語の概要は準備中です。原文の説明を表示しています。

Use when the user mentions battery drain, energy optimization, power consumption audit, or pre-release energy check — timer abuse, polling patterns, continuous location, animation leaks, and background mode misuse.

日本語の概要は準備中です。原文の説明を表示しています。

Use when the user mentions SwiftUI architecture review, separation of concerns, testability issues, or "logic in view" problems.

日本語の概要は準備中です。原文の説明を表示しています。

Use when the user mentions SwiftData review, @Model issues, SwiftData migration safety, or SwiftData performance checking.

日本語の概要は準備中です。原文の説明を表示しています。

Use when the user mentions Liquid Glass review, iOS 26 UI updates, toolbar improvements, or visual effect migration.

日本語の概要は準備中です。原文の説明を表示しています。

Use when the user mentions memory leak prevention, code review for memory issues, or proactive leak checking — retain cycles, leaks, and Timer/observer patterns.

日本語の概要は準備中です。原文の説明を表示しています。

Use this agent for closed-loop test debugging - automatically analyzes test failures, suggests fixes, and re-runs tests until passing.

日本語の概要は準備中です。原文の説明を表示しています。

Use when the user mentions database schema review, migration safety, GRDB migration audit, or SQLite schema checking.

日本語の概要は準備中です。原文の説明を表示しています。

Use when the user mentions iCloud sync issues, CloudKit errors, ubiquitous container problems, or asks to audit cloud sync.

日本語の概要は準備中です。原文の説明を表示しています。

Use when the user mentions UX flow issues, dead-end views, dismiss traps, missing empty states, broken user journeys, or wants a UX audit of their iOS app.

日本語の概要は準備中です。原文の説明を表示しています。

Use when the user wants to audit test quality, find flaky test patterns, speed up test execution, or prepare for Swift Testing migration.

日本語の概要は準備中です。原文の説明を表示しています。

Use when the user mentions networking review, deprecated APIs, connection issues, or App Store submission prep.

日本語の概要は準備中です。原文の説明を表示しています。

Use when ANY iOS or macOS build fails, a crash log needs diagnosing, a test run crashes, Xcode misbehaves, or an environment issue blocks work before code is the suspect. Covers build failures, dependency conflicts, simulator diagnostics.

日本語の概要は準備中です。原文の説明を表示しています。

Use when the user wants to audit SpriteKit game code for common issues — physics bitmask issues, draw call waste, node accumulation, and action leaks.

日本語の概要は準備中です。原文の説明を表示しています。

Use when the user mentions Codable review, JSON encoding/decoding issues, data serialization audit, or modernizing legacy code.

日本語の概要は準備中です。原文の説明を表示しています。

Use when the user mentions window resizing support, resizable-window readiness, iPhone Mirroring compatibility, iPhone Duo readiness, scene-lifecycle migration checking, or preparing an app for the 27-cycle resizing model.

日本語の概要は準備中です。原文の説明を表示しています。