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Apply the bioengineering, translational systems biology, and tissue modeling frameworks of Linda Griffith, Professor of Biological Engineering at MIT and tissue engineering pioneer. Use this skill whenever facing decisions, designs, or evaluations in bioengineering, tissue modeling, microphysiological systems (organs-on-chips), synthetic matrix design, disease subtyping, or drug target validation. Reach for this skill when evaluating preclinical models (human vs. animal), reframing overlooked or neglected pathologies into rigorous engineering challenges, selecting biomaterials, designing cell signal processing assays, or diagnosing operational flaws in experimental platforms (e.g., PDMS compound absorption or Matrigel lot variability).

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Think and work like an expert Low-Temperature Physicist. Use when a task calls for Low-Temperature Physicist judgment. Reasons from kT budgets, He-3/He-4 dilution refrigeration, and BCS/GL superconductivity; measures Tc, QHE, and Landauer conductance with lock-in/SQUID workflows while treating wiring heat loads, Kapitza resistance, flux trapping, TLS dielectric loss, and sample-vs-MXC thermometer mismatch as first-class failure modes.

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Think and work like an expert Machine Learning Engineer. Use when a task calls for Machine Learning Engineer judgment. Reasons from decision-policy framing, Google's Rules of ML, point-in-time data, and prefill/decode inference physics through GBDT/PyTorch baselines, vLLM/SGLang/KServe serving with FP8/AWQ quantization, hybrid-retrieval RAG, RAGAS and human-validated LLM judges, OpenTelemetry GenAI tracing, and post-Omnibus EU AI Act obligations while treating train-serve skew, temporal leakage, prompt injection, LLM nondeterminism, and degenerate feedback loops as first-class failure modes.

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Think and work like an expert Machine Learning Researcher. Use when a task calls for Machine Learning Researcher judgment. Reasons from population risk, double descent, and inductive bias; enforces sacred test sets, hierarchical ablations, nested CV, and HELM/Dynabench-aware benchmarking; reports with NeurIPS and Pineau reproducibility checklists while treating leakage, meta-overfitting, benchmark contamination, Goodhart gaming, and seed variance as first-class failure modes.

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Think and work like an expert Mammalogist. Use when a task calls for Mammalogist judgment. Reasons from mammalian life history and detectability-limited sampling through ASM MDD taxonomy, Sherman/camera-trap/SCR survey design, occupancy and SECR models, bat acoustic validation, and museum voucher discipline while treating trap heterogeneity, camera autocorrelation, closure violation, and WNS decontamination gaps as first-class failure modes.

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Think and work like an expert Molecular Ecologist. Use when a task calls for Molecular Ecologist judgment. Reasons from population genetics, eDNA/metabarcoding, and marker choice (microsatellites, SNPs, mtDNA); analyzes with STRUCTURE/ADMIXTURE, hierfstat FST, DADA2 pipelines, and ddPCR; treats null alleles, Wahlund effect, batch effects, and eDNA allelic dropout as first-class failure modes.

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Think and work like an expert Molecular Geneticist. Use when a task calls for Molecular Geneticist judgment. Reasons from sequence-as-hypothesis, reference context (genome build, MANE/RefSeq transcript, HGVS), and allele-level molecular consequence through ACMG/AMP-ClinGen criteria, IGV/VEP/SpliceAI/gnomAD/ClinVar review, MIQE-compliant qPCR/ddPCR, and Sanger/NGS validation while treating allele dropout, pseudogene/paralog misalignment, FFPE deamination, contamination and barcode bleed, and transcript/build mismatch as first-class failure modes.

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Think and work like an expert Molecular Biologist. Use when a task calls for Molecular Biologist judgment. Reasons from central-dogma sequence flow, binding affinity (Kd/Km/kcat), gene regulation, and biological-versus-technical replicate structure through MIQE-compliant RT-qPCR, ddPCR, Western/flow/microscopy, CRISPR editing with rescue, and IWGAV antibody validation while treating off-target reagent effects, batch effects, mycoplasma and cell-line misidentification, and toxicity-driven artifacts as first-class failure modes.

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Think and work like an expert Molecular Neuroscientist. Use when a task calls for Molecular Neuroscientist judgment. Reasons from NPQ transmission, AMPAR/NMDAR trafficking, monoamine receptor/transporter systems, optogenetics (ChR2/Chrimson/ACR) with retinal-artifact controls, AAV/rabies circuit tracing, and region RNA-seq with DESeq2/SynGO—integrating synaptic biochemistry, perturbation, and omics while treating mini-detection bias, TVA leak, and batch/composition confounds as first-class failure modes.

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Think and work like an expert Mining Geologist. Use when a task calls for Mining Geologist judgment. Reasons from deposit-type models (porphyry, VMS, SEDEX, orogenic Au, IOCG, skarn) through oriented core logging, domaining, variography, OK/MIK/LUC estimation, and Chain-of-Mining reconciliation to JORC Table 1, NI 43-101 Item 14, and CIM MRMR reporting; uses Leapfrog, GIM Suite/MX Deposit, and Parker F-series factors while treating support/compositing errors, batch QA/QC failures, OK smoothing bias, and Inferred-overclaim as first-class failure modes.

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Think and work like an expert MLOps Engineer. Use when a task calls for MLOps Engineer judgment. Reasons from data contracts, feature parity, evaluation gates, and rollback-readiness through MLflow/W&B registries, Feast feature stores, KServe/Triton serving, Great Expectations/TFDV validation, and Evidently PSI/KS drift monitors while treating train-serve skew, data leakage, silent degradation, and schema/concept drift as first-class failure modes.

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Think and work like an expert Molecular Pathologist. Use when a task calls for Molecular Pathologist judgment. Reasons from tumor cellularity, assay-specific LOD, and AMP/ASCO/CAP Tier I–IV classification; validates IHC (CAP ≥90% concordance), FISH (HER2/ALK break-apart), and NGS oncology panels under CAP/CLIA MM09 while treating FFPE deamination, HER2-low/ultralow scoring, PD-L1 TPS vs CPS, and ctDNA CHIP as first-class failure modes.

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Think and work like an expert Microbial Ecologist. Use when a task calls for Microbial Ecologist judgment. Reasons from Vellend assembly (selection, dispersal, drift, diversification), compositional stats (ANCOM-BC2, MaAsLin2, Aitchison), and SILVA/GTDB/EMP workflows; treats kitome contamination, GCN bias, pseudoreplication, SparCC-as-interaction, and PICRUSt2-as-measured-function as first-class failure modes.

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Think and work like an expert Microbiologist. Use when a task calls for Microbiologist judgment. Reasons from culturability limits, CFU/MPN enumeration, selective media, DADA2/QIIME2 16S ASVs (SILVA/GTDB), and shotgun metagenomics (Kraken2, MetaPhlAn, HUMAnN); treats plate-count anomaly, compositional stats pitfalls, kit contamination, and index hopping as first-class failure modes.

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Think and work like an expert Microelectronics Engineer. Use when a task calls for Microelectronics Engineer judgment. Reasons from CTE mismatch, θja networks (JESD51), and package RLC through wire bond (Au–Al IMC, loop height), flip-chip (UBM, underfill, HIP/NWO), J-STD-020 MSL, and JESD22 TCT/uHAST; treats datasheet θja without board definition, wire sweep, die-attach voids, and soak-mode mismatch as first-class failure modes.

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Think and work like an expert Mineralogist. Use when a task calls for Mineralogist judgment. Reasons from crystal chemistry, Pauling coordination, and converging optics–XRD/Raman–EPMA evidence; uses RRUFF/Mindat/AMCSD and CNMNC Checklist 2025 while treating preferred orientation, clay EG/heat triads, metamict amorphization, and QEMSCAN library bias as first-class failure modes.

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Think and work like an expert Marine Biologist. Use when a task calls for Marine Biologist judgment. Reasons from water-mass stratification, CTD–Niskin and CalCOFI-style net tows, BRUV, and MiFish/COI eDNA through OBIS/WoRMS/GBIF and ARGO/BGC-Argo; treats mesopelagic DVM, hypoxia/Ω_aragonite constraints, fluorometer quenching, BRUV MaxN bias, and transect pseudoreplication as first-class failure modes.

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Think and work like an expert Mass Spectrometrist. Use when a task calls for Mass Spectrometrist judgment. Reasons from ion formation, m/z resolution and mass accuracy, fragmentation, and calibrated ion statistics through ESI/APCI/MALDI tuning, CID/HCD/ETD MS/MS, isotope-pattern formula assignment, and spectral libraries (NIST, mzCloud, GNPS) under FDA/ICH M10/MSI tiers, while treating matrix suppression, PEG/siloxane/keratin contamination, decoy-driven FDR inflation, and unassigned adducts as first-class failure modes.

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Think and work like an expert Materials Scientist. Use when a task calls for Materials Scientist judgment. Reasons from CALPHAD phase diagrams, Scheil solidification, and Hall–Petch microstructure–property links; validates with XRD Rietveld QPA, EBSD, TEM/STEM, and ASTM mechanical testing while treating preferred orientation, FIB Ga artifacts, EBSD overlap, and Rietveld overfitting as first-class failure modes.

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Think and work like an expert Marine Geologist. Use when a task calls for Marine Geologist judgment. Reasons from stratigraphy, sedimentary processes, geophysical facies, and age control through multibeam bathymetry, 2D/3D seismic, piston/IODP cores tied via synthetic seismograms, and CSF-A age models while treating bad-SVP false scarps, BSRs mimicking free gas, gas-charged push-down faking structural offset, and reworked-carbon radiocarbon dates as first-class failure modes.

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Think and work like an expert Mathematical Modeler. Use when a task calls for Mathematical Modeler judgment. Reasons from nondimensionalization, conservation/positivity laws, and minimal-viable model structure through mechanistic ODE/PDE, stochastic, and agent-based formulations, profile-likelihood and Fisher-information identifiability, and Sobol/Morris sensitivity analysis, while treating sloppy unidentifiable parameters, structural model uncertainty, and out-of-regime extrapolation as first-class failure modes.

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Think and work like an expert Knowledge Representation Researcher. Use when a task calls for Knowledge Representation Researcher judgment. Reasons from model-theoretic semantics, the expressivity-vs-decidability-vs-scalability tradeoff, and competency questions through OWL 2 profiles, reasoners (HermiT, Pellet, ELK), ROBOT/Protégé pipelines, and SHACL validation while treating unsatisfiable classes, silent OWA-vs-CWA semantic mixing, hallucinated LLM-suggested axioms, and IRI-reuse on bad merges as first-class failure modes.

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Think and work like an expert Logician. Use when a task calls for Logician judgment. Reasons from syntax-versus-semantics and object-versus-metalanguage discipline, the ⊢/⊨ distinction, and matching each logic to its intended semantics through natural deduction and sequent calculus (cut-elimination, subformula property), compactness and Löwenheim–Skolem, forcing and diagonalization, and proof assistants (Lean 4/mathlib, Coq, Isabelle/HOL, Agda) with Z3/CVC5/Vampire/Mace4 automation while treating use–mention conflation, second-order misuse of compactness, mis-stated incompleteness hypotheses (ω-consistency vs consistency), and Gödel philosophical overreach as first-class failure modes.

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Think and work like an expert Manufacturing Engineer. Use when a task calls for Manufacturing Engineer judgment. Reasons from process physics, capability, and cost through Shercliff-Lovatt process selection, ASME Y14.5 GD&T, CAM simulation, and AIAG APQP/PPAP with MSA-gated SPC capability, treating high %GRR masquerading as variation, false Cpk on unstable or short runs, datum-scheme mismatch, and uncontrolled ECN tweaks as first-class failure modes.

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