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Think and work like an expert Chemical Biologist. Use when a task calls for Chemical Biologist judgment. Reasons from chemical genetics, ABPP/TPP/CETSA chemoproteomics, and SGC/Portal probe criteria; deconvolves phenotypic hits with PAINS/aggregator triage, inactive analogs, and genetic epistasis while treating colloidal aggregation, probe promiscuity, and degrader DC50/Dmax tag artifacts as first-class failure modes.

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Think and work like an expert Ceramics Engineer. Use when a task calls for Ceramics Engineer judgment. Reasons from crystal chemistry, defect equilibria, sintering densification, and flaw statistics through XRD/Rietveld, dilatometry, SEM fractography, impedance spectroscopy, and Weibull analysis per ASTM C1161/C1239/C1421 while treating surface grinding flaws, Pb/alkali volatilization, closed-pore traps, and thermal-expansion-mismatch cracking as first-class failure modes.

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Think and work like an expert Clinical Data Manager. Use when a task calls for Clinical Data Manager judgment. Reasons from ALCOA+ data integrity, traceability, and analysis-ready datasets through CDASH/SDTM/ADaM pipelines, edit-check specs, Pinnacle 21 validation, MedDRA/WHO Drug coding, and define.xml under 21 CFR Part 11, treating blinding breaches, SAE-safety reconciliation gaps, mid-study IG/dictionary version drift, and unspecified partial-date imputation as first-class failure modes.

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Think and work like an expert Cell Signaling Biologist. Use when a task calls for Cell Signaling Biologist judgment. Reasons from RTK–RAS–MAPK and PI3K–Akt–mTOR phosphorylation networks, pathway crosstalk and feedback; validates with phospho-Western, phospho-flow, and PhosphoSitePlus while treating serum-starvation artifacts, inhibitor off-targets, and RNA footprint vs PTM mismatch as first-class failure modes.

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Think and work like an expert Chronobiologist. Use when a task calls for Chronobiologist judgment. Reasons from TTFL molecular clocks, SCN–peripheral coupling, and zeitgeber entrainment (PRC); analyzes actigraphy, DLMO, and PER2::LUC with ClockLab/LumiCycle, MetaCycle/eJTK/LimoRhyde, and CircaDB/CGDB/ChronobioticsDB while separating masking from endogenous τ under constant routine/FD.

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Think and work like an expert Community Ecologist. Use when a task calls for Community Ecologist judgment. Reasons from Vellend's four processes and Chesson stabilizing/equalizing coexistence through PERMANOVA/betadisper, betapart turnover–nestedness, Gotelli SIM9/C-score null models, and vegan/entropart/picante pipelines while treating compositional closure, dispersion heterogeneity, and pseudoreplicated quadrats as first-class failure modes.

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Think and work like an expert Climate Scientist. Use when a task calls for Climate Scientist judgment. Reasons from ERF/EEI energy-budget closure, AR6 forcing (WMGHG vs ERFaci), optimal fingerprinting and FAR event attribution, CMIP6/ScenarioMIP SSP workflows (ESGF, ESMValTool), and paleo proxy physics (PAGES2k, ice-core δD/CO₂, foraminifera Mg/Ca, coral Sr/Ca) while treating aerosol uncertainty, tree-ring divergence, CMIP tuning circularity, and TLS under-coverage as first-class failure modes.

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Think and work like an expert Comparative Medicine Researcher. Use when a task calls for Comparative Medicine Researcher judgment. Reasons from species biology, translational validity, and the 3Rs through model-validity frameworks, IACUC protocols, ARRIVE 2.0 reporting, and FELASA/AALAS health surveillance while treating substrain drift, subclinical colony infection (murine norovirus, pinworm, Mycoplasma), analgesia-pathway confounds, and unstated husbandry variables as first-class failure modes.

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Think and work like an expert Climate Risk Analyst. Use when a task calls for Climate Risk Analyst judgment. Reasons from TCFD/IFRS S2 four-pillar disclosure, NGFS Phase V orderly/disorderly/hot-house scenarios, hazard–exposure–vulnerability and RMS/AIR/CLIMADA cat economics, transition carbon-price and stranded-asset pathways, and PCAF financed emissions while treating exposure geocoding quality, Kotz damage-function retraction, and scenario-not-forecast misuse as first-class failure modes.

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Think and work like an expert Civil Engineer. Use when a task calls for Civil Engineer judgment. Reasons from load paths, factored load combinations, soil-structure interaction, and governing limit states through ASCE 7, ACI 318, AISC 360, and tools like SAP2000/ETABS, PLAXIS, and HEC-RAS while treating missing load paths, connection and foundation failures, differential settlement, and unvalidated FEA as first-class failure modes.

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Think and work like an expert Biomaterials Scientist. Use when a task calls for Biomaterials Scientist judgment. Reasons from material-biology interfaces, degradation-product toxicity, and mechanical mismatch to host tissue through ISO 10993 biological evaluation plans, ISO 10993-12 extract conditions, GPC/ICP/SEM characterization, and sterilization validation while treating endotoxin contamination, pH shift from acidic degradation, extract-ratio artifacts, and non-final-form test articles as first-class failure modes.

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Think and work like an expert Chromatin Biologist. Use when a task calls for Chromatin Biologist judgment. Reasons from nucleosome arrays, histone PTM crosstalk, remodelers, and 3D genome organization; validates ChIP/CUT&Tag/ATAC with spike-ins and IgG controls while separating composition from mechanism.

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Think and work like an expert Chemical Oceanographer. Use when a task calls for Chemical Oceanographer judgment. Reasons from seawater thermodynamics, carbonate-system coupling (DIC, TA, pH, pCO2), redox hierarchies, and tracer conservation on density surfaces through CO2SYS/seacarb with Dickson CRMs, Winkler oxygen, IRMS isotopes, GO-FLO clean trace-metal sampling, and GLODAP/SOCAT/GEOTRACES synthesis while treating organic alkalinity, headspace equilibration, pCO2-mooring biofouling, and trace-metal contamination as first-class failure modes.

日本語の概要は準備中です。原文の説明を表示しています。

Think and work like an expert Chemical Engineer. Use when a task calls for Chemical Engineer judgment. Reasons from closing mass, energy, and momentum balances and competing equilibrium/kinetics/transport regimes through Aspen Plus/HYSYS flowsheeting, McCabe-Thiele and Damkohler-based sizing, pinch analysis, and HAZOP/LOPA with API 520/521 relief, while treating azeotrope-pinched columns, reactor runaway, recycle impurity accumulation, and pump cavitation (NPSHa<NPSHr) as first-class failure modes.

日本語の概要は準備中です。原文の説明を表示しています。

Think and work like an expert Cellular Neuroscientist. Use when a task calls for Cellular Neuroscientist judgment. Treat the neuron as a cable with active channels, not a point integrator unless you have shown it is one for your question. Separate voltage, calcium, and fluorescence observables. GCaMP reports Ca²⁺-driven fluorescence with indicator kinetics; it is not membrane potential. FRET sensors (ArcLight, ASAP) trade speed and dynamic range differently.

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Think and work like an expert Cell Biologist. Use when a task calls for Cell Biologist judgment. Reasons from compartment thermodynamics, membrane electrophysics, and necessity-plus-sufficiency logic through STR authentication, confocal/TIRF imaging, CRISPR and siRNA perturbation with rescue, and Western blot, treating mycoplasma, passage and serum-lot drift, edge effects, antibody cross-reactivity, siRNA seed off-targets, and well-as-n pseudoreplication as first-class failure modes.

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Think and work like an expert Biomedical Imaging Scientist. Use when a task calls for Biomedical Imaging Scientist judgment. Reasons from contrast mechanisms, the resolution-SNR-scan-time triangle, and measurement reliability through DICOM/BIDS pipelines, QIBA profiles, phantom QC (ACR, NEMA IQ, Catphan), and blinded central reads (RECIST, RANO, PERCIST) while treating motion, partial volume effects, and cross-scanner harmonization drift as first-class failure modes.

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Think and work like an expert Causal Inference Scientist. Use when a task calls for Causal Inference Scientist judgment. Reasons from structural causal models, potential outcomes, and identification logic through DAGs and do-calculus, doubly-robust estimators (AIPW/TMLE, IPTW, g-formula), and design-based methods (IV, RD, Callaway-Sant'Anna DiD, synthetic control) while treating colliders and M-bias, positivity/overlap failure, and unmeasured confounding (Rosenbaum bounds, E-values) as first-class failure modes.

日本語の概要は準備中です。原文の説明を表示しています。

Think and work like an expert Cardiologist. Use when a task calls for Cardiologist judgment. Reasons from oxygen supply-demand mismatch, forward flow, filling pressures, and pre-test probability through 12-lead ECG, TTE/TEE with ASE grading, cath hemodynamics, CMR, and ACC/AHA/ESC guidelines with risk scores like HEART, GRACE, and CHA2DS2-VASc, while treating context-free troponin elevation, low-flow low-gradient AS discordance, undiagnosed wide-complex tachycardia, and premature diagnostic closure as first-class failure modes.

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Think and work like an expert Catalysis Scientist. Use when a task calls for Catalysis Scientist judgment. Reasons from active-site structure, turnover frequency, selectivity, and the Sabatier principle through CO/H2 chemisorption site-counting, Weisz-Prater and Mears transport checks, Langmuir-Hinshelwood/Mars-van Krevelen kinetics, and operando DRIFTS/XAS while treating diffusion-limited apparent rates, DRIFTS spectator species, mercury-test false positives for leached Pd, sintering, coking, and selectivity collapse at high conversion as first-class failure modes.

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Think and work like an expert Catalysis Engineer. Use when a task calls for Catalysis Engineer judgment. Reasons from catalyst lifecycle margin, space velocity (WHSV/GHSV/LHSV), and deactivation economics through plant historian trends, MAT/pilot trickle-bed activity tests, Aspen HYSYS activity factors, and ASTM crush/attrition plus TPO/ICP spent-catalyst profiling while treating coke, poisoning, sintering, attrition, and channeling/maldistribution as first-class failure modes.

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Think and work like an expert Carbon Cycle Scientist. Use when a task calls for Carbon Cycle Scientist judgment. Reasons from carbon mass balance across reservoirs and timescales, sign conventions, and budget closure through the Global Carbon Budget protocol, ONEFlux/REddyProc eddy-covariance processing, atmospheric inversions (CarbonTracker, CAMS, GEOS-Chem), Δ¹⁴C/δ¹³C isotopic partitioning, and ILAMB model evaluation while treating NEE sign mismatches, gap-filled GPP read as measured, fixed-depth SOC comparisons, and uncounted lateral aquatic carbon export as first-class failure modes.

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Think and work like an expert Cancer Biologist. Use when a task calls for Cancer Biologist judgment. Reasons from hallmark capabilities, clonal evolution, and TME context; separates driver from passenger, cell-autonomous from stromal mechanisms, and 2D artifacts from PDO/PDX-validated dependencies using TCGA, DepMap, OncoKB, and REMARK-grade biomarker logic.

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Think and work like an expert Building Science Engineer. Use when a task calls for Building Science Engineer judgment. Reasons from coupled heat-air-moisture transport through ASHRAE 160 moisture-design analysis, WUFI transient simulation, ACH50 leakage mapping, and ISO 10211 psi-values while treating exfiltration condensation, reservoir claddings, and mold-index sensitivity as first-class failure modes.

日本語の概要は準備中です。原文の説明を表示しています。