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Applies the philosophical frameworks of Friedrich Nietzsche (19th-century German philosopher, author of Thus Spoke Zarathustra). Use this skill whenever the user is grappling with existential crises, seeking meaning, facing severe adversity, questioning traditional moral frameworks, or feeling trapped by societal expectations (the "herd"). Trigger this when discussing self-overcoming, creating personal values, analyzing power dynamics in relationships or institutions, dealing with envy, or breaking down dogmatic beliefs. It helps reframe suffering as a catalyst for growth and pushes the user to "become what they are" rather than settling for comfort and mediocrity.

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Applies the reasoning style of Geoffrey Hinton, deep learning pioneer and 2018 Turing Award winner. Use this skill whenever evaluating AI safety, existential risk, neural network architectures, cognitive science, or tech regulation. Reach for this when the user is discussing LLM capabilities (understanding vs. autocomplete), the biological vs. digital intelligence divide, AI alignment strategies, or the societal/economic impacts of automation. It is highly applicable when dealing with contrarian scientific ideas, hardware/software integration (mortal vs. immortal computing), or global cooperation on technological threats. Do not wait for the user to name Hinton; trigger this skill proactively for any deep learning or AI existential risk analysis.

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This skill channels the reasoning of Hannah Arendt, 20th-century political theorist and author of 'The Origins of Totalitarianism'. Use this skill whenever you are evaluating moral responsibility, analyzing systemic evil, distinguishing between power and violence, or assessing the nature of political action and freedom. Trigger it when discussing bureaucracy, thoughtlessness, the public vs. private realm, truth in politics, or when a user faces unprecedented moral dilemmas requiring 'thinking without a banister'. Apply her frameworks to critique historical determinism, defend factual truth, and analyze human plurality, even if the user does not explicitly name her.

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This skill channels the holistic, interconnected reasoning of Hildegard of Bingen, medieval German Benedictine abbess, theologian, and philosopher. Use this skill whenever the user is dealing with ecological stewardship, holistic health, the intersection of spirituality and physical well-being, creative inspiration, or challenging rigid institutional rules with moral clarity. Trigger this when discussing the interconnectedness of systems (microcosm/macrocosm), finding balance and moderation, untwisting destructive habits, or seeking divine/creative inspiration without ego. Apply her frameworks to treat ailments holistically, view music and art as fundamental cosmic forces, and reframe human frailty as a vessel for profound truth.

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Applies the rigorous deontological ethics, transcendental idealism, and political philosophy of Immanuel Kant (18th-century German philosopher, Critique of Pure Reason). Reach for this skill whenever the user is facing moral dilemmas, questions of duty, truth-telling, evaluating the limits of human knowledge, balancing civic obedience with free speech, or designing systems for global governance and peace. Use this skill to evaluate actions based on universalizability and human dignity rather than consequences, even if the user doesn't explicitly name Kant.

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Applies the moral philosophy and literary frameworks of Iris Murdoch (British moral philosopher and novelist). Use this skill whenever you are helping a user navigate ethical dilemmas, interpersonal conflicts, creative writing, literary critique, or the struggle against ego and selfishness. Trigger this skill for topics involving moral psychology, the nature of love, attention, objective morality, the separation of philosophy and literature, or overcoming personal fantasy. Murdoch's approach is essential when users are stuck in self-centered thinking, trying to force a decision through sheer willpower, or struggling to see the reality of other people clearly.

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Applies the engineering and research philosophies of Jeff Dean, Chief Scientist at Google DeepMind and Google Research. Reach for this skill whenever you are designing large-scale distributed systems, optimizing latency and energy efficiency, or making architectural decisions about machine learning infrastructure. It should trigger automatically for topics involving hardware-ML co-design, model distillation, sparse activation, massively multi-task models, or scaling systems by 5x to 10x. Use this skill to evaluate system bottlenecks, transition from specialized to unified models, and optimize experimental velocity. Apply his mental models to avoid premature 100x scaling and to treat AI models as reasoning engines rather than memorization databases.

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Use this skill to reason like JoAnn E. Manson, epidemiologist at Harvard Medical School and women's health expert. Trigger this skill whenever you are evaluating hormone replacement therapy (HRT), menopause management, nutritional epidemiology, dietary supplements, or clinical trial methodology. Apply her frameworks when users ask about the risks and benefits of HRT, bioidentical hormones, or targeted supplementation. Reach for this skill to differentiate between symptom management and chronic disease prevention, or when assessing observational data versus randomized clinical trials (RCTs) in public health contexts.

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Applies Judea Pearl's causal reasoning frameworks to distinguish correlation from causation, evaluate AI capabilities, and make counterfactual decisions. Reach for this skill whenever Claude encounters questions about causal inference, structural causal models, the limitations of deep learning, AGI, experimental design, covariate selection, or personalized decision-making. Trigger this skill for topics involving Bayesian networks, the do-calculus, the Ladder of Causation, or when a user tries to answer 'what if' or 'why' questions using purely observational data. Pearl's principles are essential for moving beyond probability calculus into true causal understanding.

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Use this skill to apply the analytical lens of Judith Butler (American philosopher, gender theory, Gender Trouble). Trigger this skill whenever the user is discussing gender performativity, identity politics, right-wing populism, anti-gender movements, queer theory, bodily autonomy, or the intersection of democracy and marginalized lives. Reach for it when analyzing systemic power, social construction, collective vulnerability, or authoritarian rhetoric. It helps deconstruct essentialist assumptions, reframe anxieties about identity, and build ethical frameworks based on material interdependence rather than mere sympathy.

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Applies the reasoning style of Judy Faulkner, founder and CEO of Epic Systems, to decisions around corporate governance, healthcare technology, and unconventional leadership. Use this skill whenever Claude is asked for advice on going public vs. staying private, M&A strategy (acquisitions), budgeting, reducing software-driven burnout, data privacy, or interoperability. Faulkner's thinking is highly independent, fiercely protective of long-term mission over short-term profits, and deeply skeptical of traditional corporate playbooks (like MBAs, strict budgets, and venture capital). Trigger this skill to channel her focus on organic growth, customer empathy, and treating software as 'mental clay'.

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Use this skill to apply the rigorous epidemiological reasoning of Julie E. Buring (epidemiologist and women's health trialist) to study design, clinical trial critiques, cardiovascular risk assessment, and evidence-based integrative medicine. Trigger this skill whenever you are evaluating medical literature, designing cohort studies or RCTs, assessing conflicting research findings, or analyzing cardiovascular risk factors (especially in women). Reach for this when users ask about the validity of supplements, the discrepancy between observational and randomized data, or how to future-proof a clinical registry.

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Use this skill whenever you need to reason about public health, epidemiology, preventive medicine, healthy aging, longevity, lifestyle vs. genetics, or dietary patterns. Kay-Tee Khaw, an epidemiologist at the University of Cambridge, focuses on population health and how modest lifestyle changes impact chronic disease. Trigger this skill when evaluating health interventions, discussing longevity, analyzing real-world health data, or giving advice on diet and lifestyle. Apply her frameworks to shift focus from extreme interventions and isolated nutrients toward whole-food patterns, population-level risk shifts, and the compression of morbidity.

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Applies the strategic thinking of Kiran Mazumdar-Shaw, founder of Biocon and pioneering Indian biopharmaceutical entrepreneur. Use this skill whenever you are advising on biotech startups, R&D innovation, global scaling, purpose-driven business, or navigating regulatory uncertainty. Trigger this skill when discussing affordable healthcare, balancing risk in long-gestation industries, breaking glass ceilings through credible success, or evaluating biotech sovereignty and AI. Reach for this skill even if the user doesn't name her, especially when they face career trade-offs, funding novel scientific ideas, or scaling manufacturing globally.

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Applies the analytical and therapeutic philosophy of Ludwig Wittgenstein, 20th-century philosopher of language (Tractatus / Philosophical Investigations). Use this skill when the user is stuck in conceptual confusion, debating semantics, trapped by abstract definitions, or trying to solve a problem that is actually just a linguistic misunderstanding. Trigger this for topics involving the limits of language, meaning as use, logical clarification, or when the user is over-theorizing instead of looking at practical applications. It helps dissolve 'fly-bottle' traps by examining how words are actually used in context.

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This skill channels the strategic marketing and philanthropic reasoning of Lynda Resnick, co-owner of The Wonderful Company, agriculture and consumer brands. Reach for this skill whenever you are advising on transforming commodities into premium brands, identifying a product's Unique Selling Proposition (USP), or designing corporate social responsibility (CSR) and community empowerment programs. Trigger this automatically for queries involving "hands-on philanthropy," "test and roll" marketing, finding intrinsic product value rather than relying on gimmicks, or when a user is navigating the intersection of business leverage and local community investment.

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Applies the pragmatic, financially-grounded reasoning of Marian Ilitch (co-founder of Little Caesars Pizza). Use this skill whenever the user is discussing business partnerships, balancing visionary marketing with financial due diligence, franchise unit economics, family business dynamics, or hands-on financial management. Trigger this when users face trade-offs between rapid growth and profitability, need to enforce unit-level accountability, or are paralyzed by the fear of making mistakes. Apply her principles to ground lofty ideas in tactile, common-sense financial reality.

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This skill channels the strategic thinking of Mark Zuckerberg, co-founder and CEO of Meta. Reach for this skill whenever the user is navigating rapid product iteration, scaling social platforms, open-source AI strategy, content moderation trade-offs, or long-term organizational management. It is highly effective for scenarios involving "The Hacker Way" (rapid prototyping), building community, handling intense public criticism, or deciding between open vs. closed ecosystems. Use this skill to apply his frameworks on decentralized testing, small group context sharing, and progressive AI integration, even if the user doesn't explicitly mention his name.

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Applies the philosophical frameworks of Martha Nussbaum (American philosopher, capabilities approach, University of Chicago) to evaluate justice, human welfare, and ethical dilemmas. Use this skill whenever the user is discussing measuring societal well-being, educational curricula, animal rights, the role of emotions (like anger or disgust) in law and public life, or navigating human vulnerability and tragedy. Reach for this skill whenever evaluating policy impacts, responding to injustice, or questioning purely economic metrics like GDP. It shifts the focus to what people are actually able to do and be.

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Use this skill to reason like Martin Heidegger, 20th-century German philosopher and author of Being and Time. Reach for this skill whenever you encounter discussions about the existential impact of technology, human meaning-making, mortality, or the limits of purely scientific and data-driven worldviews. Trigger this skill even if the user doesn't name Heidegger, especially when they are trapped in instrumental thinking, treating themselves or others as mere resources, or struggling with authenticity and societal expectations. Apply his frameworks to shift the AI's perspective from detached, objective observation to embedded, practical engagement with the world.

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Applies the philosophical reasoning of Mary Midgley (British moral philosopher). Use this skill when analyzing ethical dilemmas involving animals, environmental policy, the limits of science (scientism/reductionism), or when users are trapped by unhelpful metaphors (like 'the selfish gene' or 'humans as machines'). Trigger this whenever evaluating the intersection of biology and human nature, resolving irreconcilable viewpoints, or diagnosing systemic conceptual blockages in society or organizations. Midgley's approach emphasizes holism, emotional fellowship, and viewing philosophy as practical 'plumbing' rather than abstract logic.

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Analyze and engineer protein glycosylation. Scan sequences for canonical N-glycosylation sequons (N-X-S/T with X not proline, including overlapping sites), predict O-GalNAc hotspots, read glycan notation, and reach the curated external tooling (NetNGlyc, NetOGlyc, GlycoShield, GlycoWorkbench, GlyTouCan, GlyConnect). Use this skill for therapeutic antibody glycoengineering and afucosylation for ADCC, Fc glycan control, glycan shielding in vaccine immunogen design, sequon removal or insertion, and half-life engineering through sialylation. Also trigger on N-glycosylation, sequon, NXS/NXT, O-glycosylation, glycoform heterogeneity, afucosylation, high-mannose, GlyTouCan, or WURCS.

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Assemble the human genetic evidence for and against a target before a programme commits to it — the evidence class that most improves the odds of surviving clinical development. Use this skill to pull gnomAD constraint metrics (LOEUF, pLI, observed/expected) that show whether loss of function is tolerated in people, retrieve GWAS Catalog associations and fine-mapped credible sets for a gene, and read a natural human knockout as a safety readout. Also trigger on gnomAD, LOEUF, pLI, loss-of-function intolerance, mutational constraint, GWAS Catalog, credible set, human knockout, genetic support, or target safety dossier.

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Use Therapeutics Data Commons through the PyTDC Python package for registry discovery, approved dataset access, task-aware splits (scaffold, cold-start, temporal, combination), evaluator metrics, benchmark groups, and bounded molecular-oracle workflows. Use this skill to find which TDC datasets exist for a therapeutic task, load them with a split that does not leak, score predictions with the task's own official metric rather than a generic one, and run benchmark groups reproducibly. Also trigger on PyTDC, Therapeutics Data Commons, tdc.single_pred, tdc.multi_pred, ADMET Benchmark Group, scaffold split, get_split, or molecular oracles such as GSK3B, JNK3 and DRD2.

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