「alignment」の検索結果

Architect and provision enterprise Azure infrastructure from workload descriptions. For cloud architects and platform engineers planning networking, identity, security, compliance, and multi-resource topologies with WAF alignment. Generates Bicep or Terraform directly (no azd). WHEN: 'plan Azure infrastructure', 'architect Azure landing zone', 'design hub-spoke network', 'plan multi-region DR topology', 'set up VNets firewalls and private endpoints', 'subscription-scope Bicep deployment', 'Azure Backup for VM workloads'. PREFER azure-prepare FOR app-centric workflows.

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Preprocess ribosome profiling data including adapter trimming, size selection, rRNA removal, and alignment. Use when preparing Ribo-seq reads for downstream analysis of translation.

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Preprocessing and harmonization of multi-omics data before integration. Covers normalization, batch correction, feature alignment, and missing value handling across data types. Use when preparing multi-omics datasets for integration analysis.

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Remove sequencing adapters from FASTQ files using Cutadapt and Trimmomatic. Supports single-end and paired-end reads, Illumina TruSeq, Nextera, and custom adapter sequences. Use when FastQC shows adapter contamination or before alignment of short reads.

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XCMS3 workflow for LC-MS/MS metabolomics preprocessing. Covers peak detection, retention time alignment, correspondence (grouping), and gap filling. Use when processing raw LC-MS data into a feature table for untargeted metabolomics.

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Detect structural variants from long-read alignments using Sniffles, cuteSV, and SVIM. Use when detecting deletions, insertions, inversions, translocations, or complex rearrangements from ONT or PacBio data, especially those missed by short-read methods.

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Deep learning-based variant calling from long reads using Clair3 for SNPs and small indels. Use when calling germline variants from ONT or PacBio alignments, particularly when high accuracy is needed for clinical or research applications.

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Align long reads using minimap2 for Oxford Nanopore and PacBio data. Supports various presets for different read types and applications. Use when aligning ONT or PacBio reads to a reference genome for variant calling, SV detection, or coverage analysis.

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Quality control for long-read sequencing data using NanoPlot, NanoStat, and chopper. Generate QC reports, filter reads by length and quality, and visualize read characteristics. Use when assessing ONT or PacBio run quality or filtering reads before assembly or alignment.

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MS-DIAL-based metabolomics preprocessing as alternative to XCMS. Covers peak detection, alignment, annotation, and export for downstream analysis. Use when processing MS-DIAL output files for R/Python analysis or when preferring GUI-based preprocessing.

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Process Hi-C read pairs using pairtools. Parse alignments, filter duplicates, classify pairs, and generate contact statistics from Hi-C sequencing data. Use when processing raw Hi-C read pairs.

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Preprocesses cell-free DNA sequencing data including adapter trimming, alignment optimized for short fragments, and UMI-aware duplicate removal using fgbio. Applies cfDNA-specific quality thresholds and fragment length filtering. Use when processing plasma cfDNA sequencing data before downstream analysis.

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Convert raw Nanopore signal data (FAST5/POD5) to nucleotide sequences using Dorado basecaller. Covers model selection, GPU acceleration, modified base detection, and quality filtering. Use when processing raw Nanopore data before alignment. Guppy is deprecated; use Dorado for all new analyses.

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ChIP-seq peak calling using MACS3 (or MACS2). Call narrow peaks for transcription factors or broad peaks for histone modifications. Supports input control, fragment size modeling, and various output formats including narrowPeak and broadPeak BED files. Use when calling peaks from ChIP-seq alignments.

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SUPERSEDED by /claudex-loop (formerly /crucible; adds a Phase 0 research/recon pass + rebuilt interview) — prefer that skill unless you explicitly want this one. Two-act plan hardening. ACT 1 (you ↔ Claude) — Claude interviews you relentlessly about a plan or design, one question at a time, recommending an answer for each and exploring the codebase when it can answer itself, until every branch of the decision tree is resolved. ACT 2 (Claude ↔ Codex) — Claude writes the locked plan to PLAN.md and OpenAI Codex adversarially reviews it in a read-only sandbox (VERDICT:APPROVED/REVISE), Claude revises and re-submits to the SAME Codex session until APPROVED or a MAX_ROUNDS cap, then you sign off before any code. Use when the user says "/grill-me-codex", "grill me then have codex review", "grill me and stress-test the plan", "interview me about this plan then get a second model on it", or is about to build something high-stakes (auth, schema, concurrency, migrations, payments) and wants both alignment AND a cross-model sanity check before implementation. Builds on Matt Pocock's grill-me (MIT). For the docs-aware variant use /grill-with-docs-codex; if you already have a plan and want only the Codex review use /codex-review. NOT for reviewing already-written code (use /codex:review) and NOT for trivial changes.

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SUPERSEDED by /claudex-loop (formerly /crucible; its docs-aware mode covers this variant) — prefer that skill unless you explicitly want this one. Two-act plan hardening with living documentation. ACT 1 (you ↔ Claude) — Claude interviews you relentlessly about a plan, one question at a time, challenging it against your project's existing domain model and glossary (CONTEXT.md), sharpening fuzzy terms, stress-testing with concrete scenarios, cross-referencing code, and updating CONTEXT.md + ADRs inline as decisions crystallise. ACT 2 (Claude ↔ Codex) — Claude writes the locked plan to PLAN.md and OpenAI Codex adversarially reviews it in a read-only sandbox (VERDICT:APPROVED/REVISE), Claude revises and re-submits to the SAME Codex session until APPROVED or a MAX_ROUNDS cap, then you sign off before any code. Use when the user says "/grill-with-docs-codex", "grill me against the docs then have codex review", "stress-test this against our domain model then get a second model on it", or is about to build something high-stakes in a project with established terminology/ADRs and wants alignment, documentation, AND a cross-model sanity check. Builds on Matt Pocock's grill-with-docs (MIT). NOT for reviewing already-written code (use /codex:review) and NOT for trivial changes.

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Use when the user asks to "QA my conversion tracking before launch", "check my UTMs / pixel / event firing", "set up a tracking pre-flight", or "set the dedup rule so Meta and Google stop double-counting"; builds and fixes the measurement plumbing — conversion-event firing, UTM hygiene, cross-platform dedup rules, attribution-window alignment, and offline/iOS-ATT modeled-gap flags — as a pre-flight checklist plus a UTM/event-spec builder. Not for scoring R1/R2 — that is a scored veto in ad-account-auditor; not for account structure — use campaign-architect. 付费广告转化追踪QA/UTM规范/跨平台去重

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检查 NSFC 标书正文引用与参考文献的一致性与真实性风险（只读）：核查 bibkey 是否存在、BibTeX 字段与 DOI 等格式问题，并生成结构化输入供宿主 AI 逐条评估“正文表述是否真的在引用该文献”；默认仅输出审核报告，不直接修改标书或 .bib（除非用户明确要求）。

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当用户明确要求"核查/优化综述 `{主题}_review.tex` 的正文引用"、"运行 research-citation-check"，或要求使用旧名 check-review-alignment skill 时使用。通过宿主 AI 的语义理解逐条核查引用是否与文献内容吻合，只在发现致命性引用错误时对"包含引用的句子"做最小化改写，并优先复用 `research-literature-review` 的渲染脚本输出 PDF/Word，过渡期允许 fallback 到旧名 systematic-literature-review。核心原则：不为了改而改，无法确定是否为致命性错误时保留原样并在报告中警告。⚠️ 不适用：用户只是想生成系统综述正文（应使用 research-literature-review）；用户只是想新增/核对 BibTeX 条目（应使用专门的 bib 管理流程）。

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Apply the Law of Continuity — the eye follows alignment and unbroken paths. Use when sequencing steps, aligning content, or designing carousels and timelines. For grouping rather than sequencing, use `law-of-proximity`.

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Validate changes before submitting a pull request. Run comprehensive checks including lint, tests, alignment review, and RFC analysis. Use before creating a PR, when asked if code is ready for review, or before pushing for PR.

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Author SVG figures for Grida docs — diff-able, version-controlled vector diagrams embedded in doc pages instead of screenshots. Provides reusable primitives (selection chrome, size badges, anchor pins, resize cursors, click ripples), color/typography tokens, a starter template, and finished examples to crib from. Canvas user docs (docs/editor/) are the first consumer; the kit is meant to generalize to any product's docs. Use when drawing diagrams that explain UI behaviour — gestures, alignment, before/after states — that a screenshot alone can't capture. Trigger phrases: "svg diagram", "draw a figure", "visual for docs", "explain this gesture visually", "before/after diagram".

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Excalidraw canvas toolkit for creating, editing, and refining diagrams on a live canvas. Use when an agent needs to (1) draw or lay out diagrams, (2) iteratively refine them by describing the scene and screenshotting its own work, (3) export/import .excalidraw files or PNG/SVG images, (4) save/restore canvas snapshots, (5) convert Mermaid to Excalidraw, or (6) perform element-level CRUD, alignment, distribution, grouping, duplication, and locking. Primary interface is the bundled CLI (npx -y mcp-excalidraw-server <command>) which auto-starts the canvas server; MCP tools and a REST API are equivalent alternatives.

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Judges whether material for children under six is developmentally plausible — what is typical at each age, why pre-K is not a thinner kindergarten, and which frameworks apply where Common Core does not. Use this to design or review pre-K material, decide whether a task is reasonable for an age, choose the right framework for a pre-K alignment claim, or push back on material that pushes school-age expectations downward.

日本語の概要は準備中です。原文の説明を表示しています。