Corrects the gene-independent copy-number artifact in CRISPR-Cas9 screens (Aguirre 2016 / Munoz 2016 Cancer Discov) where amplified loci appear essential from DNA-damage burden of simultaneous cuts. Covers the p53-dependent G2-arrest mechanism, CRISPRcleanR (Iorio 2018) unsupervised pre-hoc correction, CERES (Meyers 2017) joint CN + gene-effect model, Chronos (Dempster 2021) DepMap-standard population-dynamics + CN model with lowest residual bias, the decision tree by data availability, the Spearman LFC-vs-CN diagnostic, focal-amplification examples (ERBB2 in HER2+, MYC in colorectal, FGFR1 in head and neck), and CRISPRi/a alternatives that bypass the artifact. Use when screening cancer cell lines, diagnosing essentiality at amplified loci, choosing CRISPRcleanR / CERES / Chronos, deciding whether CN correction is needed before MAGeCK / BAGEL2 / drugZ, or switching from Cas9 to CRISPRi.
日本語の概要は準備中です。原文の説明を表示しています。
BioTender-max/awesome-bio-agent-skills☆ 2012026年7月2日 更新
Design one-off HTML artifacts (landing, deck, prototype).
日本語の概要は準備中です。原文の説明を表示しています。
skillmds/skillmd☆ 1982026年10月9日 更新
Iterative rubric-based evaluation and self-improvement loop. Builds a scoring rubric interactively, evaluates an artifact with multiple models in parallel (Codex, Gemini, Claude), then autonomously improves the artifact one criterion at a time until a score threshold is met or circuit breaker fires. "/rulph", "rubric evaluate", "rubric score", "multi-model evaluate", "score and improve", "evaluate and iterate", "grade this", "루브릭 루프", "채점 루프", "자율 개선", "개선 루프", "루브릭 평가"
日本語の概要は準備中です。原文の説明を表示しています。
team-attention/hoyeon☆ 1732026年5月21日 更新
Challenges a recommendation, design, large change, or any artifact submitted for hard review (spec, proposal, policy, plan) across 5 dimensions (consistency, completeness, actionability, alignment, risk), from the standards of a named senior expert in the artifact's domain and ideally from a fresh context or a different model. Searches assuming defects exist and reports only those that survive evidence. Panel mode runs several independent lenses in parallel on a release candidate, verifies every finding against the current head, and routes confirmed ones to file owners. Use before shipping a significant recommendation, design, large branch, or multi-agent release, or when asked to tear something apart, be brutally honest, or poke holes in it.
日本語の概要は準備中です。原文の説明を表示しています。
ash1794/vibe-engineering☆ 1642026年10月8日 更新
Composes single-file HTML artifacts (PR review writeups, status reports, incident postmortems, slide decks, design systems, prototypes, flowcharts, module maps, feature explainers, kanban boards, prompt tuners) from a small JSON spec instead of hand-written HTML/CSS/JS. Use when the user asks to "compare options side-by-side", requests an HTML version of a report or review or deck, asks for a flowchart, status update, postmortem, design system reference, interactive prototype, custom editor — or explicitly says "HTML artifact", "single HTML file", "self-contained HTML". Skip for ad-hoc HTML snippets (forms, emails, embedded widgets) where there's no template fit.
日本語の概要は準備中です。原文の説明を表示しています。
oaustegard/claude-skills☆ 1512026年10月13日 更新
Use when a batch (desktop or mobile) release reaches awaiting_verdict or was rolled back - read-only checks that the published artifact really exists and is served, and the exact yank step for a bad tag
日本語の概要は準備中です。原文の説明を表示しています。
makifbaysal/tasktrooper☆ 1132026年10月12日 更新
Fast-forward through OpenSpec artifact creation. Use when the user wants to quickly create all artifacts needed for implementation without stepping through each one individually.
日本語の概要は準備中です。原文の説明を表示しています。
tautcony/ChapterTool☆ 1132026年10月14日 更新
Continue working on an OpenSpec change by creating the next artifact. Use when the user wants to progress their change, create the next artifact, or continue their workflow.
日本語の概要は準備中です。原文の説明を表示しています。
tautcony/ChapterTool☆ 1132026年10月14日 更新
Detects common LLM coding agent artifacts across four categories (tests, dead code, abstraction, style) over the project or changed files — using parallel subagents when the agent supports them, otherwise four sequential passes. Scans files changed since main by default; use --all for full-project scan. Triggers on LLM cruft cleanup, agent-generated code review, dead code sweeps, test-quality passes, or when the user asks to scan the whole repo.
日本語の概要は準備中です。原文の説明を表示しています。
existential-birds/beagle☆ 822026年9月16日 更新
Detects common LLM coding agent artifacts in codebases. Identifies test quality issues, dead code, over-abstraction, and verbose LLM style patterns. Use when cleaning up AI-generated code or reviewing for agent-introduced cruft.
日本語の概要は準備中です。原文の説明を表示しています。
existential-birds/beagle☆ 822026年9月16日 更新
Update an OpenSpec change by revising its existing planning artifacts and keeping them coherent with one another. Use when the user wants to revise a change's plan, fold new decisions into it, or reconcile its artifacts after an edit. Never edits code.
日本語の概要は準備中です。原文の説明を表示しています。
po4yka/RIPDPI☆ 792026年10月14日 更新
Act as a product-manager copilot that turns evidence into product decisions and artifacts: backlogs and prioritization, PRDs and user stories, metrics and OKRs, experiments, launch plans, feedback triage, and pricing/packaging, kept in a per-product workspace. Use whenever the user wants to decide what to build, spec it, or ship it: "write a PRD for…", "prioritize our backlog", "what should we build next", "plan OKRs", "define our north star metric", "design an A/B test", "plan the launch", "triage this customer feedback", "platform or feature?", in any language ("viết PRD", "ưu tiên tính năng nào", "quản lý sản phẩm", "プロダクト管理", "产品经理"), even when they never say "product manager". Also use when the user returns to a product workspace this skill created (a directory holding `product.md`, `state.md`, and `decisions.md`). Not for deep user discovery (design-thinking), desk market facts (market-researcher), or company-level bets (strategy-board).
tronghieu/agent-skills☆ 772026年10月12日 更新
Inspect and explain bmad-loop run artifacts under `.bmad-loop/runs/`. Use for live health checks ("is it stuck?", "is the loop alive?", "what is the agent doing?") and post-run forensics ("what happened?", "why did story X fail?", "where did the tokens go?"). Also triggers on "monitor/check/summarize the loop", "why did the run pause?", Vietnamese "theo dõi bmad loop", "phân tích run", "đọc log của run", and equivalent requests in other languages. Use only for bmad-loop's own run artifacts, not application runtime logs or CI-provider build logs.
日本語の概要は準備中です。原文の説明を表示しています。
tronghieu/agent-skills☆ 772026年10月12日 更新
The low-level on-chain probes for identifying what an owner address is — cast code → EOA / EIP-7702-delegated EOA / contract, VERSION() → Gnosis Safe, read-only get-owner-ica.ts derive → ICA derivation, getAccountInfo → Sealevel account existence — with how to interpret each result. The primitive layer beneath validate-owners / resolve-artifacts / update-owners, which each apply their own per-chain or per-artifact policy on top.
日本語の概要は準備中です。原文の説明を表示しています。
hyperlane-xyz/hyperlane-monorepo☆ 762026年10月14日 更新
Survey existing compliance artifacts — policies, audits, certifications. Use when asked "what compliance docs do we have", "survey our policies", or "inventory our compliance artifacts".
日本語の概要は準備中です。原文の説明を表示しています。
tonone-ai/tonone☆ 762026年10月5日 更新
Survey legal artifacts for audit readiness. Use when asked "are we audit ready", "what legal artifacts exist", or "survey our legal docs".
日本語の概要は準備中です。原文の説明を表示しています。
tonone-ai/tonone☆ 762026年10月5日 更新
Use when GSD commands are failing or .planning/ artifacts look inconsistent. Run before any GSD execute-phase or verify-work attempt to catch cross-artifact mismatches early.
日本語の概要は準備中です。原文の説明を表示しています。
Tibsfox/gsd-skill-creator☆ 712026年7月20日 更新
Use the moment a request is underspecified and you are about to act on an ASSUMED goal. Enumerate the candidate goals the request could mean, project the action or artifact each one implies, and check whether they diverge: if two or more plausible goals lead to materially different actions or artifacts, ask exactly ONE targeted clarifying question; otherwise proceed on the most-likely goal and state the assumption in one line. Clarification is an evidence-producing action, not a delay — but one question, never an interrogation. Distinct from gsd-spec-phase (GSD-phase-bound, emits a heavy SPEC.md) and intent-router (fetch strategy, not goal disambiguation). Backed by agent goal-state inference (arxiv 2606.16813v1). Triggers on acting under an assumed goal when the request admits more than one materially different reading.
日本語の概要は準備中です。原文の説明を表示しています。
Tibsfox/gsd-skill-creator☆ 712026年7月20日 更新
Use when Stage 1 Discovery is complete and design must begin — transforms the ARTIFACT:DISCOVERY into an actionable ARTIFACT:PLAN via RT-ICA prerequisite verification. Produces approach, components, success criteria, acceptance tests, and risks. Blocks on missing prerequisites before design proceeds.
日本語の概要は準備中です。原文の説明を表示しています。
Jamie-BitFlight/claude_skills☆ 672026年10月13日 更新
Executes SAM Stage 5 — opens an attempt on a single ARTIFACT:TASK, dispatches it to a fresh stateless agent session, runs quality gates, and records an ARTIFACT:EXECUTION with implementation results and verification output on the task. Use when Stage 4 Task Decomposition is complete and tasks are ready for execution, when re-executing a task after Stage 6 returns NEEDS_WORK, or when dispatching a task to a language-appropriate specialist agent via the development harness pipeline.
日本語の概要は準備中です。原文の説明を表示しています。
Jamie-BitFlight/claude_skills☆ 672026年10月13日 更新
Use when the PLAN artifact from SAM Stage 2 needs contextualization against actual codebase state — grounds the design plan in reality by performing scope analysis (NEW/MODIFY/COMPLETE classification), conflict detection between plan assumptions and codebase patterns, and resource mapping to concrete file paths and integration points. Produces an updated ARTIFACT:PLAN registered via MCP with a Contextualization section appended.
日本語の概要は準備中です。原文の説明を表示しています。
Jamie-BitFlight/claude_skills☆ 672026年10月13日 更新
Update an OpenSpec change by revising its existing planning artifacts and keeping them coherent with one another. Use when the user wants to revise a change's plan, fold new decisions into it, or reconcile its artifacts after an edit. Never edits code.
日本語の概要は準備中です。原文の説明を表示しています。
Brain-up/brn☆ 652026年10月12日 更新
Classifies raw pilot request → structured JSON {task_type, class, artifact, budget_estimate, confidence, routing_tag, resolution_path, schema_version, result_type, expected_result_kind, result_kind_resolution, hypothesis_relation}. Keyword-fast (<200ms) or Haiku fallback (<60s). Does NOT create WP or call executor.
日本語の概要は準備中です。原文の説明を表示しています。
TserenTserenov/FMT-exocortex-template☆ 632026年10月14日 更新
Import information from foreign sources into a set of artifact kinds (the target), generating or updating them to reflect the imported information. Use when the user wants to "import", "ingest", or "bring in" external sources like files, URLs, or pasted text into artifacts like SPEC, CODE, DOCS, TASK, INFR, or OTHR.
日本語の概要は準備中です。原文の説明を表示しています。
rse/ase☆ 602026年10月13日 更新