「coordinate」の検索結果

Decides how to preprocess plasma cfDNA sequencing data so the recoverable signal survives - library-prep-aware fragment expectations (dsDNA vs ssDNA/adaptase prep), UMI/duplex consensus with fgbio (ExtractUmisFromBam, GroupReadsByUmi --strategy paired for duplex, CallMolecularConsensusReads vs CallDuplexConsensusReads, FilterConsensusReads min-reads "total s1 s2"), the align->group->consensus->RE-align ordering, and the cfDNA dedup trap where naive coordinate dedup collapses nucleosome-coincident independent molecules. Covers when single-strand consensus suffices vs when duplex is mandatory, the singleton/sensitivity tax at low input, and reading the insert-size histogram as a pre-analytical QC instrument. Use when processing plasma cfDNA reads before fragmentomics, ctDNA mutation calling, or tumor-fraction estimation.

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Handles BED-format genomic intervals (BED3 through BED12, narrowPeak/broadPeak) and the coordinate-system substrate the whole interval category rests on, with bedtools (CLI) and pybedtools/pyranges/pandas (Python). Covers the 0-based half-open vs 1-based-closed convention boundary and the start-1/end-unchanged conversion, the silent failures (chrom-name mismatch, CRLF, lexicographic-vs-version sort under -sorted), genome/chrom.sizes generation, sorting contracts, BED12 block invariants, validation, makewindows, cross-assembly liftover (liftOver/CrossMap), and BED<->VCF/BAM/FASTA conversion. Use when reading, creating, validating, sorting, lifting between genome builds, or converting interval files, preparing inputs for bedtools/tabix/bigBed, or debugging an off-by-one or empty-overlap result.

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Align protein structures using Foldseek 3Di, TM-align, US-align, DALI, or Foldmason for structural MSA. Predict, score, and superpose backbone coordinates when sequence identity is below the twilight zone or remote-homology detection is required. Use when sequence MSA fails (<25% identity), when the dark proteome is the target, when AlphaFoldDB / ESM Atlas search is needed, or when structural superposition is the goal.

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Sort alignment files by coordinate or read name using samtools and pysam. Use when preparing BAM files for indexing, variant calling, or paired-end analysis.

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Build a differential-ready consensus peakset from per-replicate ATAC-seq peaks using iterative overlap removal, fixed-width re-centering, and majority-rule overlap. Use when generating a stable peak coordinate system for downstream differential accessibility, ML feature engineering, cross-sample comparison, or fixed-width peak counts; covers Corces 2018 iterative overlap (501 bp), DiffBind summit re-centering, and ENCODE consistency rules.

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Answer one named planning question with observations tied to the inspected sources; do not write or coordinate the roadmap.

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Implement, review, or improve maps and location features in iOS/macOS apps using MapKit and CoreLocation. Use when working with Map views, annotations, markers, polylines, user location tracking, geocoding, reverse geocoding, search/autocomplete, directions and routes, geofencing, region monitoring, CLLocationUpdate async streams, or location authorization flows. Also use when working with maps, coordinates, addresses, places, directions, distance calculations, or location-based features in Swift apps.

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Build a RoadRunner Scenario programmatically from an OpenSCENARIO 1.x (.xosc) file using the `roadrunner-scenario-authoring` skill. Use when the user wants to recreate a scenario from a .xosc file, interpret an OpenSCENARIO file and build it programmatically, reconstruct a .xosc as a RoadRunner scenario, generate a MATLAB script from a .xosc file, or convert an OpenSCENARIO file to MATLAB code. Do NOT use when the user says "import" a .xosc file — that means they want RoadRunner's built-in importScenario API, not programmatic reconstruction. Handles position translation (LanePosition and RoadPosition to world coordinates), construct mapping, relative references, trajectory/route handling, parameter expressions, catalog references, and phase logic topology.

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Build an evidence-based competitive pricing strategy for ecommerce products. Use when a seller asks how to position a price against competitors, set regular and promotional prices, protect contribution margin, design bundles or price tiers, respond to competitor moves, or coordinate prices across Amazon, Shopify, TikTok Shop, Walmart, eBay, or other channels. Do not use for automated repricing implementation or claims of a mathematically proven optimal price without sufficient data.

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When the user wants to plan integrated marketing, coordinate channels, or clarify program vs channel vs campaign. Also use when the user mentions "IMC," "integrated marketing," "channel mix," "marketing program," "PESO model," "integrated marketing communications," "omnichannel marketing," "channel strategy," "marketing mix," or "cross-channel campaign." For content planning, use content-marketing.

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Rebuild or restyle editable Microsoft Visio diagrams from reference images and existing .vsdx files, then export deliverables as .vsdx, PNG, SVG, PDF, or PPTX. Use when the user asks Codex to open Visio, recreate a diagram from a PNG/JPG/screenshot/reference image, match a scientific model figure, update colors/typography/layout in a .vsdx, calibrate panel coordinates to avoid shifted or overlapping submodules, or make publication/presentation outputs while preserving Visio native editable shapes rather than embedding the reference image as a flat picture.

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A platform decision framework for experimentation. When to use Statsig vs PostHog vs GrowthBook vs Optimizely vs Amplitude vs Eppo vs Kameleoon. How to migrate between them. How to coordinate when multi-platform is genuinely warranted. The decisions that compound for years and the ones you can defer. Triggers on which experimentation platform, choose Statsig vs PostHog, evaluate experimentation tools, switch experimentation platform, migrate from Optimizely, consolidate experimentation tools, multi-platform experimentation, experimentation platform decision, ab test platform selection, feature flag platform vs experiment platform, warehouse-native experiments, vendor lock-in experimentation. Also triggers when a team is asking about cost, governance, or migration cost across experimentation tools, or when an evaluation is starting.

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EU NIS2 Directive (Directive (EU) 2022/2555) compliance advisor for essential and important entities: entity classification, Art. 21 risk management measures, Art. 23 incident reporting timelines (24h/72h/1 month), Art. 20 governance obligations, supply chain security (Art. 21(2)(d); coordinated risk assessments Art. 22), gap assessments, policy drafting, ISO 27001 alignment, and penalty exposure analysis. Also covers Commission Implementing Regulation (EU) 2024/2690, the technical/methodological sub-requirements for Art. 21(2) and the significant-incident thresholds binding on DNS/cloud/data-centre/MSP/MSSP/trust-service and other digital entities. Use for NIS2 readiness, transposition questions, ENISA technical implementation guidance, significant-incident thresholds, supervisory differences between essential and important entities, and cross-border coordination.

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Geospatial data processing, coordinate transforms, and mapping

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Astronomical computations, coordinate transforms, and celestial data analysis

日本語の概要は準備中です。原文の説明を表示しています。

Coordinate multiple enhancement analyzers in parallel and produce unified report

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Use when deploying changes to staging across relay, relay-dashboard, and relay-cloud repos - coordinates multi-repo branch syncing using git worktrees, automatically triggers staging deployments via GitHub Actions

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The canonical way to run agent-relay - self-bootstrap the local broker and autonomously spawn, monitor, and coordinate a team of worker agents without human intervention. Covers infrastructure startup, agent spawning, lifecycle monitoring, message-based reading via the relay MCP, and team coordination.

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Use when you need Codex to coordinate multiple agents through Agent Relay for peer-to-peer messaging, lead/worker handoffs, or shared status tracking across sub-agents and terminals.

日本語の概要は準備中です。原文の説明を表示しています。

EU NIS2 Directive (Directive (EU) 2022/2555) compliance advisor for essential and important entities: entity classification, Art. 21 risk management measures, Art. 23 incident reporting timelines (24h/72h/1 month), Art. 20 governance obligations, supply chain security (Art. 21(2)(d); coordinated risk assessments Art. 22), gap assessments, policy drafting, ISO 27001 alignment, and penalty exposure analysis. Also covers Commission Implementing Regulation (EU) 2024/2690, the technical/methodological sub-requirements for Art. 21(2) and the significant-incident thresholds binding on DNS/cloud/data-centre/MSP/MSSP/trust-service and other digital entities. Use for NIS2 readiness, transposition questions, ENISA technical implementation guidance, significant-incident thresholds, supervisory differences between essential and important entities, and cross-border coordination.

日本語の概要は準備中です。原文の説明を表示しています。

Coordinates UDL and differentiation tools through a universal-first hierarchy: barrier removal before targeted differentiation before individualised accommodation. Use when planning accessible learning.

日本語の概要は準備中です。原文の説明を表示しています。

Comprehensive GitHub project management with swarm-coordinated issue tracking, project board automation, and sprint planning

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Provides S4 classes for general nucleases, CRISPR nucleases, CRISPR nickases, and base editors.Several CRISPR-specific genome arithmetic functions are implemented to help extract genomic coordinates of spacer and protospacer sequences. Commonly-used CRISPR nuclease objects are provided that can be readily used in other packages. Both DNA- and RNA-targeting nucleases are supported.

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Gene Set Variation Analysis (GSVA) is a non-parametric, unsupervised method for estimating variation of gene set enrichment through the samples of a expression data set. GSVA performs a change in coordinate systems, transforming the data fr

日本語の概要は準備中です。原文の説明を表示しています。