「enrichment」の検索結果

Assesses ChIP-seq quality across antibody specificity, fragmentation, enrichment, replicate concordance, and library complexity. Computes FRiP, NSC/RSC (phantompeakqualtools), library complexity (NRF/PBC1/PBC2), deepTools plotFingerprint (JS distance, AUC, synthetic JS), ChIPQC, IDR with ENCODE Nself/Nt rules, and detects hyper-ChIPable artifacts. Use when validating an antibody, diagnosing failed peak calls, deciding whether to proceed with downstream analysis, grading against ENCODE thresholds, or auditing replicate concordance.

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Discover RBP binding motifs from CLIP-seq peaks or single-nucleotide crosslink sites using HOMER, MEME/STREME, kpLogo, mCross (CL-position-registered motifs), PEKA (positional k-mer enrichment), RBPamp (affinity), and RNA Bind-n-Seq (RBNS) cross-validation. Use when characterizing RBP sequence specificity, registering motifs to crosslink positions, validating in vivo CLIP motifs against in vitro RBNS Kd, reconciling motif disagreements across tools, or correcting for the uracil crosslinking bias that contaminates raw CLIP motif logos.

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Identifies essential genes from CRISPR-Cas9 fitness screens using BAGEL2 (Kim & Hart 2021 Genome Med), a Bayesian classifier scoring per-gene Bayes Factors via log-likelihood ratios over per-sgRNA fold changes, calibrated against CEGv2 core-essentials (Hart 2017 G3, ~684 genes) and NEGv1 non-essentials (Hart 2014, ~927 genes). Covers the fc + bf + pr workflow, the linear-extrapolation improvement over BAGEL1 truncation, multi-target off-target correction, tumor-suppressor sensitivity (BAGEL2 detects enrichment), and BF-to-FDR calibration (BF >6 ≈ FDR 0.05 from Hart 2017). Use when classifying essential vs non-essential genes, calibrating BAGEL2 thresholds against PR curves, identifying tumor suppressors alongside essentials, comparing BAGEL2 hits to MAGeCK / drugZ, or generating publication-quality essentiality calls.

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ATAC-seq library quality control -- TSS enrichment, FRiP, fragment-size periodicity, library complexity (NRF/PBC1/PBC2), mitochondrial fraction, and ENCODE 4 thresholds. Use when assessing whether an ATAC-seq library passes ENCODE acceptance criteria, diagnosing transposition artefacts, comparing Omni-ATAC vs standard prep quality, or selecting which replicates to drop before peak calling.

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Designs adaptive clinical trials including group-sequential (O'Brien-Fleming, Pocock, Lan-DeMets spending), sample-size re-estimation (blinded Friede-Kieser, unblinded Cui-Hung-Wang, Mehta-Pocock promising zone), seamless Phase 2/3 with treatment-arm selection, population enrichment, and response-adaptive randomisation. Covers FDA 2019 Final Adaptive Designs Guidance, FDA 2022 Master Protocols, and ICH E20 Step 2b/3 draft (June 2025, NOT final). Use when planning interim analyses, sample-size re-estimation, or master/platform-trial designs.

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Workflow for enrichment testing, ranked-gene analysis, pathway scoring, and pathway-focused visualization across omics outputs.

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Hoyeon Google/chromux search workflow for Codex. Use when the user invokes "$hoyeon-google-search" or needs real-browser Google search, site-specific search, time filters, or body/comment enrichment. This adapter loads the canonical google-search skill and follows its Codex runtime surface.

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Generates a fully structured SEO content **outline** (not a finished brief) and exports it as a formatted .docx Word document. The output is a skeleton for a writer to fill in — section headings, topic prompts, angles — not pre-written paragraphs. Use this skill whenever a user provides a blog title, focus keyword, domain URL, or any combination of those and asks to generate an outline, brief, blog brief, SEO brief, article structure, or content plan. Also trigger when the user says "create a brief for X", "generate an outline for [topic]", "make a content brief", "I need a brief for [URL or keyword]", or pastes a title and asks what the structure should look like. This skill handles input validation, domain analysis, keyword enrichment, audience inference, archetype-aware section selection, and full .docx generation — always use it rather than writing ad-hoc outlines.

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Write and improve documentation for ComfyUI nodes in per-node JSON files. Use when asked to document nodes, write node descriptions, add tips to nodes, improve node docs, enrich node content, fill in empty node descriptions, or batch-write documentation for new/updated nodes. Also triggers on "write docs for nodes", "document the new nodes", "improve node tips", "fill in node descriptions", "enrich nodes", "node content pass", "update nodes", "sync comfyui nodes", "new comfyui version", or "node enrichment".

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CRM integration patterns for Close CRM, HubSpot, and Salesforce. Use when: Close CRM, HubSpot, Salesforce, CRM API, lead sync, deal sync, activity logging, CRM webhook, pipeline automation, contact enrichment.

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Prospect discovery, enrichment, scoring, and reporting against an Ideal Customer Profile

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Perform image-based visual product search on Amazon across 8 marketplaces. Use an image URL to find visually similar products, with optional Nexscope enrichment for sales data. Triggered when users mention Amazon image search, Amazon visual search, find similar products on Amazon, reverse image lookup Amazon, Amazon search by photo, or competitor image search. Even if the user does not explicitly mention "image search," this skill should be triggered whenever a user provides an image URL and wants to find visually matching or similar products on Amazon.

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Use when the user asks for a literature review, academic deep dive, research report, state-of-the-art survey, topic scoping, comparative analysis of methods/papers, grant background, or any request that needs multi-source scholarly evidence with citations. Also trigger proactively when a user question clearly requires academic grounding (e.g. "what's known about X", "compare approach A vs B in the literature", "summarize the field of Y"). Runs an 8-phase (Phase 0..7), script-driven research workflow across 7 federated sources (OpenAlex, arXiv, Crossref, PubMed, DBLP, bioRxiv, Exa) with optional Semantic Scholar / Brave MCP enrichment, with deduplication, transparent ranking, dual-backend citation chasing (OpenAlex + Semantic Scholar), self-critique, and structured report output with verifiable citations.

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Analyze indicators of compromise — enrichment, attribution, and response recommendations. Use when asked to "analyze these IOCs", "enrich these indicators", or "what is this hash".

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Configures structured logging with ILogger<T> and ILoggerFactory following Microsoft best practices. Includes Serilog setup, log enrichment, and logging source generators for high-performance logging.

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Use this skill when answering business analytics, RevOps, GTM metric, pipeline, revenue, funnel, customer, or warehouse questions with Deepline. Triggers on phrases like 'query Snowflake', 'analyze pipeline', 'total ACV', 'break down by quarter', 'use the semantic layer', 'run a semantic query', or any use of snowflake_get_semantic_layer / snowflake_run_semantic_query. Skip prospecting, enrichment, contact finding, outbound, or personalization workflows; use deepline-gtm for those.

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Use when the user wants a last30days-style pre-research pass in Deepline: discover the critical public, private, CRM, workflow, social, and web data sources for a research/enrichment job; compare provider coverage; estimate Deepline credit cost; recommend the source plan before building or running the workflow; or build custom language/messaging from buyer, competitor, community, and CRM evidence. Triggers: pre-research, source discovery, provider strategy, research data sources, ScrapeCreators, X/Twitter data, Reddit comments, public and private datasets, CRM data, workflow data, custom language, messaging language, pain language.

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GTM prospecting, enrichment, outreach, and Deepline Play work/audits. Providers: adyntel,affinity,ai_ark,akta,allegrow,amplemarket,apify,attention,attio,aviato,bettercontact,bigquery,bluesky,bounceban,brave,browserbase,builtwith,cbinsights,clay,clickhouse,cloudflare,contactout,contextdev,crunchbase,crustdata-v3,customer_db,databricks,dataforseo,datagma,dealroom,deepline_ip_to_company,deepline_native,deeplineagent,discolike,dropleads,edges,emailbison,emailguard,enformion,enigma,exa,findymail,firecrawl,fireflies,firmable,forager,fullenrich,fundable,generic_http,getleads,gong,google_ads_audiences,google_workspace,govfiles,grain,hackernews,harvestapi,heyreach,hubspot,hunter,icypeas,instantly,intercom,ipqs,kaspr,kernel,leadmagic,lemlist,limadata,linkedin_ads_audiences,luma,lusha,meta_audiences,millionverifier,nooks,notion,openmart,opensosdata,openwebninja,outreach,parallel,peopledatalabs,pitchbook,podscan,polymarket,postgres,predictleads,prospeo,quickenrich,rapidapi,redshift,rocketreach,salesforce,salesforge,….

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Maintain required external authorization decisions, gatekeeper and validator hooks, the HTTP JSON plugin, reusable parsers, and protected-request E2E coverage. Excludes credential authentication and claims enrichment.

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Build a plug-in-ready SDR operator package for sales development and outbound pipeline work: ICP definition, compliant lead-source plan, enrichment/research workflow, account scoring, outbound assets, CRM handoff, reply triage, meeting prep, approval gates, and loop memory. Use when "SDR", "sales development", "outbound SDR", "operator room", "lead gen pipeline", "prospecting pipeline", "ICP targeting", "Apify", "RapidAPI", "Clay", "Apollo", "agentic SDR workflow", "sales operating loop", "sales dashboard handoff", or any request to package outbound sales workflows that can later connect to data tools, CRMs, or operator surfaces.

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Expert customer health scoring and analytics guidance. Use when designing health scores, building churn prediction models, analyzing usage metrics, identifying at-risk accounts, creating executive dashboards, or performing cohort analysis. Use for leading indicator development, customer data enrichment, risk escalation frameworks, and retention analytics.

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Pattern for adding derived edge types in the Grafema Rust orchestrator (main.rs). Use when: (1) need to create new graph edges derived from existing edges (e.g., MODULE-level DEPENDS_ON from IMPORTS_FROM), (2) Datalog joins on large edge sets time out, (3) adding enrichment steps that combine data from multiple resolver outputs, (4) need to understand how resolver outputs flow through the orchestrator pipeline.

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Build AI data enrichment systems. TRIGGERS - Use when user needs help with ai-data-enricher related tasks.

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Use when you need to check an IP, domain, file hash, or URL against VirusTotal's reputation database. Returns detection ratio, verdict, community score, and key findings. Commonly invoked by investigation skills (/ip-investigation, /domain-investigation, /hash-investigation, /url-investigation) and by analysts enriching IOCs. Other agents/skills can chain this for VirusTotal enrichment.

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