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Load, convert, and manipulate Hi-C contact matrices using cooler format. Read .cool/.mcool files, convert from .hic format, access matrix data, and export to different formats. Use when loading or converting Hi-C contact matrices.

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Spillover compensation and data transformation for flow cytometry. Covers compensation matrix calculation, application, and biexponential/arcsinh transforms. Use when correcting spectral overlap between fluorophores or transforming data for analysis.

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Use when the user asks to "build our social crisis protocol", "mentions are exploding — what do we do first", or "when do we pause the posting queue"; produces a 1-5 severity ladder with tunable Estimated trigger thresholds (mention-velocity multiples vs the 7-day listening baseline, sentiment flip, journalist/regulator contact, employee-conduct class), the first-mechanical-action rule — pause ALL scheduled posts AND paid amplification, with dated state markers dropped to the channels proposal protocol and reconciled post-incident — a pre-approved holding-statement library with committed update cadences, when-NOT-to-post rules, a spokesperson/approval matrix, and a post-crisis retro template; re-runs the social-quality-auditor pre-publish gate before un-pausing the queue. Not for email deliverability incidents (blocklist, spam-rate spikes) — use deliverability-qa; inside a launch window launch-day-conductor owns incident handling. 社媒危机预案/暂停队列/声明库/发言人矩阵

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Use when the user asks to "triage our comments, DMs, and mentions", "draft replies to this thread", "can we repost this fan post", or "set up inbox SLAs and an escalation path"; produces a ranked triage queue with register detection (sincere / ironic / performative / parasocial, sentiment-inversion table included — "this is so bad" under a comedy register is praise), a commenter taxonomy (troll monitor-only / rager / misguided / unhappy-customer / advocate) with a response-tier ladder and per-channel SLAs, an escalation matrix ending at the crisis path, a moderation ladder plus house rules for owned spaces, and a UGC curation-and-rights mode whose dated permission entries route to the channel registry — every reply is a ranked DRAFT a human posts; nothing is ever auto-sent. Not for launch-window feedback triage — use launch-feedback-synthesizer. 评论私信提及分诊/语域识别/回复草稿/UGC授权

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Use when the user asks to "pick which social channels to run", "should we be on X platform or 小红书", or "plan our organic social channel portfolio"; produces an audience/objective-first portfolio with capability/access matrix, cadence-budget reality check, declared ECHO operating profile, boundary routing, and proposed-state registry events. Not for recording canonical channel facts — use channel-registry. 社媒渠道选择/渠道组合规划/平台能力矩阵/自然社媒

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Use when the user asks to "launch on Product Hunt / Hacker News", "prepare community or directory launch submissions", or "plan the launch submission waves"; produces per-platform submission packages — a Product Hunt tagline / gallery / first-comment skeleton, a factual Show HN title and text, per-subreddit posts with a self-promotion rules table, tiered directory waves, and a regional channel matrix including Chinese communities — plus a platform red-line check (never solicit votes or organize voting rings) and T-0 submission-status lines for the launch registry. Not for paid amplification — use content-amplifier; not for creator channels — use campaign-planner; not for launch telemetry readouts — use launch-monitor; not for ongoing community presence or pre-launch karma-building outside the launch window — use participation-warmup-planner. 社区发布/PH提交包/Show HN/目录波次/平台红线/中文渠道

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Use when the user asks to "plan my launch tier", "how big should this launch be", or "build a launch risk register with kill criteria"; produces a tier decision (Tier 1 flagship all-channel / Tier 2 targeted / Tier 3 changelog-level), a launch-type declaration (new-product / feature / relaunch / partnership with co-marketing split), an effort calibration matrix (tier to channel intensity and asset scope), D0/W1/M1 KPI targets (labeled Estimated), a risk register (likelihood x blast-radius, owners, mitigations, kill criteria / rollback thresholds), and a T-8w to T+4w timeline skeleton. Not for picking the launch date or window — use launch-window-planner; not for creator-channel launch campaigns — use campaign-planner. 发布分级/发布类型/风险登记册/kill criteria

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Use when the user asks to "design an A/B test", "set up a creative/landing test", "run an incrementality test", or "is this result statistically and practically material?"; produces a hypothesis, variant matrix, sample-size/duration/power plan, and a documented effect/uncertainty read from own exported results. It applies only a precommitted owner-approved action rule; the statistical helper never chooses a business action. Not for producing variants — use ad-creative-builder; not for reading back one shipped change — use paid-measurement-loop. 广告AB测试设计/实验设计/显著性判定/增效测试

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Use when the user asks to "write ad copy", "generate RSA headlines", or "build ad creative at volume"; produces ad units — RSA headlines/descriptions, hooks, and an angle matrix — message-matched to the destination landing page. Not for scoring an ad account — use ad-account-auditor; not for the post-click page — use landing-optimizer; not for organic articles — use content-writer. 广告创意/广告文案/RSA标题

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Use when the user asks to "build the email HTML", "make this email responsive", "fix dark-mode rendering", or "QA the email across clients"; produces the coded HTML build — a responsive table layout, dark-mode + accessibility pass, a client-render matrix, image-block fallbacks, and a plain-text parity check. Not for writing the copy — use email-creative-builder; not for scoring the email or computing EQS — use email-quality-auditor. 邮件HTML/响应式邮件/暗色模式渲染

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Use when the user asks to "analyze my target audience", "build an audience profile for influencer targeting", "research a niche community", or "deep-dive a subculture before partnering with creators"; in audience mode produces demographic/psychographic profiles, a platform-priority matrix, named personas, and an influencer-selection criteria set, and in niche mode produces a community map, culture decode (language/norms/taboos), key-voice tiers, a Brand Fit Score, and a phased entry strategy. Not for finding specific creators to contract — use influencer-discovery; not for scoring a shortlist on Suitability — use fit-scorer. 目标受众画像/人群分析 · 细分社群/亚文化调研

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Use when the user asks to "design an email A/B test", "set up a multivariate subject/CTA test", "run a send-time test", "build a hold-out group", or "is this email result statistically and practically material?"; produces a falsifiable hypothesis, one-variable-per-cell matrix, sample-size/MDE/duration/power plan, and an effect/uncertainty read from own ESP data. Applies only a precommitted owner-approved action rule; the helper never chooses a business action. Not for EQS/vetoes or writing the email. 邮件AB测试设计/多变量测试/发送时间测试/留出组/显著性判定

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Design habit-forming product loops using the Hook Model (Trigger, Action, Variable Reward, Investment). Use when the user mentions "users arent coming back", "habit formation", "engagement loops", "habit zone", or "the manipulation matrix". Also trigger when designing notification or re-engagement strategies, building streaks or progress systems, or analyzing why users stop after signup. Covers ethics evaluation and onboarding for habits. For friction reduction and B=MAP, see improve-retention. For viral sharing, see contagious.

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Audit a directory of multilingual blog content for completeness, consistency, hreflang correctness, meta-tag parity, and freshness. Builds a translation coverage matrix, flags stale translations, validates hreflang and schema, and emits a prioritized report with runnable fix commands. Use when user says "locale audit", "blog locale-audit", "check translations", "multilingual audit", "translation check", "hreflang check", "Uebersetzungen pruefen".

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Reverse-engineers any app into a recon map: screen inventory, user flows, component list, inferred data model and a feature matrix, from public pages, screenshots, app store listings, help docs and the user's own account. The first step of the Replica pack. Use when the user says "clone this app", "reverse engineer X", "how does X work", "map out X", "what screens does X have", "I want to build my own version of X", "copy this app", or pastes an app's URL or App Store link and wants to rebuild it.

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Rebuilds an app screen by screen from the recon map: app shell first, then the core flow as a vertical slice, then every screen with all its states, ticking off the feature matrix as it goes. Writes every line fresh, never the original's code, assets or copy. Use when the user says "build the clone", "build screen S07", "start building", "rebuild this screen", "implement the booking page", or after /replica-design.

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Compares an app clone against the original: a feature parity score from the feature matrix (weighted by must, should, could) with the missing list in build order, plus a screenshot layout diff that ignores colour so a rebrand does not count against you. Two standard-library Python tools. Use when the user says "how close is my clone", "compare it to the original", "what's missing", "parity check", "diff the screens", "is it ready", or after /replica-test.

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Run inference on Fireworks AI — direct, through the Leanmcp AI Gateway proxy (aigateway.leanmcp.com) for observability, or via LiteLLM / the OpenAI SDK / raw HTTP. Covers the endpoint-and-key matrix for each route, serverless vs dedicated deployments and their cold starts, browsing and filtering the model catalogue, reasoning models that return content:null with the answer in reasoning_content, function calling, concurrency and load testing, and runner scripts where many models share one protocol with a --use-proxy toggle. Use this skill whenever the user mentions Fireworks, FIREWORKS_API_KEY, api.fireworks.ai, fireworks_ai/ model ids, accounts/fireworks/models/..., a Fireworks deployment id, the Leanmcp gateway or LEANMCP_API_KEY, app.leanmcp.com observability, or gpt-oss / kimi / glm / qwen / deepseek served on Fireworks; wants to route LLM calls through a proxy for logging or cost tracking; is debugging empty responses, 404s, scope errors, cold starts, or "the gateway isn't working"; wants to pick a Fireworks model with tool calling; or wants to sweep several models over one benchmark. Reach for it even on vague asks like "why is this model returning nothing" or "set up inference for these models" when Fireworks is in play.

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Use when you need a standardized R CLI workflow to train a two-class random forest model from an expression-like feature matrix, rank variable importance, and generate reproducible error and importance plots. NOT for regression tasks, multi-class classification, missing-value imputation, preprocessing, or remote data fetching.

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Use when you need a standardized R CLI workflow to run two-class SVM-RFE feature ranking on an expression-like matrix, choose an informative feature count from cross-validated error, and generate reproducible ranking and error plots. NOT for regression, multi-class classification, missing-value imputation, or remote data fetching.

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Use when building a weighted gene co-expression network from a bulk expression matrix and a sample group file, filtering variable genes by MAD, identifying co-expression modules with WGCNA, correlating modules with traits, and exporting module-level plots and gene tables. NOT for single-cell RNA-seq, differential expression testing, methylation analysis, or datasets that are too small for WGCNA after quality control.

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Use when filtering genes with high missingness and then imputing missing values in a bulk expression matrix with group-aware KNN through DMwR2, where donor samples are restricted by one annotation column before imputation. For strata with 10 or fewer samples, the script falls back to row-wise direct filling with mean or median. NOT for: single-cell data, multi-column stratification, non-tabular inputs, network access, or interactive workflows.

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Use when identifying stable sample subtypes from bulk expression matrices with ConsensusClusterPlus, including PAC-based model selection and consensus matrix/CDF visualization. NOT for: differential expression analysis, single-cell clustering workflows, or non-expression tables.

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Use when screening differentially expressed genes from a bulk expression matrix between two user-specified groups, producing DEG tables, a volcano plot, and a clustered heatmap. Triggers include DEG analysis, volcano plot, clustered heatmap, limma-based two-group comparison, and case-vs-control screening. NOT for single-cell RNA-seq, multi-group contrasts, count-model workflows such as DESeq2/edgeR, or non-expression omics data.

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