「observe」の検索結果

Calculates statistical power for high-dimensional genomics experiments (bulk RNA-seq, scRNA-seq, ATAC-seq, ChIP-seq, methylation, proteomics) under negative-binomial count models using RNASeqPower, PROPER, and simulation via powsimR, distinguishing per-gene from marginal (transcriptome-wide) power, the role of mean expression and dispersion, and the sequencing-depth-versus-replicate tradeoff. Covers simulation as the honest default for overdispersed counts, FDR-aware average power versus single-test power, observed/post-hoc power as an anti-pattern, and the winner's-curse / Type-S / Type-M consequences of underpowering. Use when planning replicate number for a sequencing experiment, deciding whether to add depth or samples, choosing closed-form versus simulation power, estimating power from pilot dispersions, or justifying replication in a grant. For clinical-trial power see clinical-biostatistics/power-and-sample-size; for the inverse sample-size question see experimental-design/sample-size.

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Designs and analyzes combinatorial CRISPR screens covering paired-Cas9 (Big Papi, Najm 2018), enhanced AsCas12a multiplex (enCas12a, DeWeirdt 2021), in4mer 4-guide-array Cas12a (Esmaeili Anvar N et al 2024 Nat Commun 15:3577) and the Inzolia paralog-pair library, paralog-buffering detection (Dede 2020 Genome Biol; Thompson 2021 Nat Commun 12:1302), genetic-interaction (GI) scoring as observed_double_LFC minus expected_additive_double_LFC, synthetic-lethal and synthetic-rescue interaction interpretation, the half-of-essentiality buffered by paralogs phenomenon, multiplex screen statistical analysis with MAGeCK MLE interaction terms, and the relationship to single-cell combinatorial Perturb-seq. Use when designing a paralog or pathway-pair screen, choosing between paired-Cas9 (Big Papi) and Cas12a multiplex (Inzolia), interpreting genetic interaction scores, identifying synthetic-lethal targets for drug development, or scaling beyond single-gene CRISPR screens.

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Sequence-based deep learning for ATAC-seq using chromBPNet, BPNet, scBasset, or Enformer. Use when correcting Tn5 bias with neural networks beyond k-mer models, predicting per-base accessibility profiles, scoring in silico variant effects at GWAS or rare-variant SNPs, discovering motifs via DeepLIFT/TF-MoDISco from a trained model, or generating cell-type-specific accessibility predictions for unobserved cell states.

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Observe the user's screen via screenpipe, detect repeated research workflows, match them against existing scientific-agent-skills, and draft new skills (or composition recipes that chain existing ones) for the patterns not yet covered. Use when the user asks to analyze their recent work and propose skills based on what they actually do. Requires the screenpipe daemon (https://github.com/screenpipe/screenpipe) running locally on port 3030 — the skill has no other data source and will refuse to run if screenpipe is unreachable. All detection runs locally; only redacted cluster summaries reach the LLM.

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Naturalistic causal reasoning for failures and disputed attribution. Use when postmortems or root-cause debates need reframing. NOT for causal inference, fault trees, or fully observed failures.

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How to design contextual inputs for an always-on AI agent with episodic memory. Covers what data to feed the agent, how to structure observations and triggers, ambient context capture (screen, audio, calendar), context window budgeting, and retrieval strategies that keep the agent grounded in what's actually happening. Activate on: "what should the agent observe", "context inputs for agent", "ambient context capture", "agent triggers", "agent input design", "screenpipe integration", "context window budget", "what data to feed my agent", "/always-on-agent-inputs". NOT for: memory architecture and storage (use always-on-agent-architecture), application ideas (use always-on-agent-applications), safety concerns (use always-on-agent-safety).

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Determines whether a hypertensive patient should be screened for primary aldosteronism based on clinical features associated with higher PA prevalence. Triggered when a clinician asks 'Should I screen this hypertensive patient for PA?' or observes spontaneous hypokalemia, resistant hypertension, hypertension onset before age 40, adrenal tumor, young-onset stroke, or sleep apnea syndrome.

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Recommends denosumab for adults with refractory or recurrent hypercalcemia of malignancy who have persistent or relapsed hypercalcemia despite intravenous bisphosphonate therapy. Triggered when a clinician observes recurrent hypercalcemia after bisphosphonate treatment or considers next‑line agents for HCM.

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Recommends immediate IV hydrocortisone stress dosing for patients with suspected adrenal crisis presenting with severe adrenal insufficiency symptoms such as hypotension, hyponatremia, hyperkalemia, or acute abdominal pain. Use when clinician observes signs of adrenal crisis (e.g., syncope, delirium, marked abdominal tenderness) prior to diagnostic test results.

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Separates signal from noise in metrics you cannot observe directly, updating a belief from evidence instead of reacting to the latest reading - Bayesian updates over competing explanations, and a filter that says whether this week's move is real. Use when a metric moves and someone wants to act, when diagnosing why traffic or revenue changed, when a dashboard number contradicts intuition, or when deciding whether a trend is real yet.

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Harness-first workflow for evaluating and improving terminal UIs through real interaction. Use this whenever the user wants to review a TUI experience, compare before/after behavior, identify UX friction, validate navigation or filtering flows, inspect visual stability, or turn observed interaction problems into concrete follow-up tests and improvement recommendations. Prefer this skill any time a TUI should be exercised through a reproducible PTY/session harness instead of only reading code.

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Day-to-day operation runbook for nuxt-crouton apps — boot any app/POC locally with auth working, seed and inspect the local database (including the miniflare-vs-.data split that makes seeded data "disappear"), turn on the review overlay / eruda, observe deployed staging (tail, smoke, row counts), and capture screenshots. Use when asked to "run the app", "boot velo/fanfare/a poc locally", "why can't I log in locally", "seed the database", "the seed data doesn't show up", "look at the local db", "check what's on staging", "screenshot the app", or "where do the artifacts land".

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Observe the harness itself — (WS1) measure context budget as a deterministic, trendable inventory (tokens per CLAUDE.md / skill / agent, lexical redundancy, per-CI cold-write totals; committed history.jsonl), (WS2) reconstruct the real invocation trace (which skills/agents/tools fired and how they nested) from session transcripts, and (WS-A) roll the per-run CI traces up into a committed weekly usage record (per-skill invocation counts; usage.jsonl) — the usage side of the dead-weight join. Use for "context budget", "how big is CLAUDE.md / our skills", "is the harness bloating", "how do our agent loops actually run", "which skills actually get used", "trace this session", "loop station".

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Configure Azure API Management (APIM) as AI Gateway to secure, observe, control AI models, MCP servers, agents. Helps with rate limiting, semantic caching, content safety, load balancing. USE FOR: AI Gateway, APIM, setup gateway, configure gateway, add gateway, model gateway, MCP server, r...

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Executes malware samples in Cuckoo Sandbox to observe runtime behavior including process creation, file system modifications, registry changes, network communications, and API calls. Generates comprehensive behavioral reports for malware classification and IOC extraction. Activates for requests involving dynamic malware analysis, sandbox detonation, behavioral analysis, or automated malware execution.

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Create, verify, transfer, and resume compact project handoff packets for long-running Codex work. Use after a second observed automatic context compaction, immediately after a third compaction, when attention or constraints degrade, a major phase ends, the user asks to move work into a fresh task, work must pause, or an existing handoff needs to be imported. Do not interrupt after the first normal compaction. Always ask before creating a new task, transfer the global roadmap only after explicit consent, preserve the old task title when available, then require the fresh task to ask what work matters most. Preserve objectives, constraints, decisions, evidence, approval boundaries, workspace state, validation, and risks without treating an old summary as current truth.

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Econometrics skill for panel data models. Activates when the user asks about: "panel data", "fixed effects", "random effects", "Hausman test", "within estimator", "between estimator", "two-way fixed effects", "clustered standard errors panel", "FE model", "RE model", "pooled OLS", "unobserved heterogeneity", "panel regression", "first difference estimator", "entity fixed effects", "time fixed effects", "面板数据", "固定效应", "随机效应", "豪斯曼检验", "双向固定效应", "面板回归", "个体效应", "时间效应", "一阶差分"

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Synthesises training survey responses and manager notes into a DRAFT training needs report by role: coded needs with record counts per role (n of N), the evidence type behind each count, anonymised quotes cited to record codes, disagreements between what staff report and what managers observe, gaps where a role is under-represented or a required skill has no evidence, and follow-up questions to settle before any course is designed. Never rates an individual, ranks a team or turns a count into a competence verdict. Use when the user asks to "analyse this training survey", "what training do our teams need", "summarise the manager feedback on skills gaps", "build a training needs analysis by role" or "which roles have the biggest skill gaps". Do not use for turning an agreed need into a course, use course-outline-builder instead; for exit interviews, use exit-interview-synthesis. Drafts for human review; never approves, authorises or signs off.

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Builds a DRAFT data dictionary from a schema export, table definition, sample rows or a partial existing dictionary: one row per field with the name as stated, type as stated or observed, meaning quoted from the documentation supplied, owner, allowed values, and UNKNOWN wherever no source defines the field, plus a gap list for the data owner. Never infers a definition from a column name. Use when the user asks to "build a data dictionary for this table", "document these columns", "what does each field mean", "turn this schema export into a dictionary" or "fill in the field definitions from these documents". Do not use for profiling values or finding patterns in the data, use dataset-insight-pack instead; for metric definitions, use kpi-definition-sheet; for logging data defects, use data-quality-issue-log. Drafts for human review; never approves, authorises or signs off.

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Reconstruct a daily or weekly worklog from observed activity and outcomes.

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Plan draft video-ad variations from supplied performance evidence, preserving the distinction between observed data and creative hypotheses.

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Integrates Sentry error tracking and performance monitoring into Flutter apps using `sentry_flutter`. Use when setting up crash reporting in Flutter, calling `SentryFlutter.init`, adding `SentryNavigatorObserver` to GoRouter, tracing HTTP requests with `sentry_dio`, capturing handled exceptions via `Sentry.captureException`, adding breadcrumbs, configuring session replay (`replay.onErrorSampleRate`), tuning `tracesSampleRate` or `profilesSampleRate`, controlling PII with `sendDefaultPii`, or setting user context after login and logout.

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Apply Gang of Four design patterns to solve architectural problems in TypeScript. Use when refactoring code architecture, implementing extensible systems, decoupling components, or following SOLID principles. Covers all 22 GoF patterns: Creational (Factory Method, Abstract Factory, Builder, Prototype, Singleton), Structural (Adapter, Bridge, Composite, Decorator, Facade, Flyweight, Proxy), and Behavioral (Chain of Responsibility, Command, Iterator, Mediator, Memento, Observer, State, Strategy, Template Method, Visitor).

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Improve AI application with evaluation-driven development. Define eval criteria, instrument the application, build golden datasets, observe and evaluate application runs, analyze results, and produce a concrete action plan for improvements. ALWAYS USE THIS SKILL when the user asks to set up QA, add tests, add evals, evaluate, benchmark, fix wrong behaviors, improve quality, or do quality assurance for any Python project that calls an LLM model.

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