474 件 ・ 関連度順
概要と使いどころ
Governs models and AI systems in production — intended use, evaluation, monitoring, human oversight, documentation, and the decision to deploy or retire. Use this before deploying a model or AI feature, when defining evaluation criteria, when a model's behavior has drifted, when assessing AI risk or regulatory exposure, or when deciding whether an AI system is fit for a consequential decision.
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Generates CIOMS I-compliant ICSR narratives from adverse event case data for FDA and EMA regulatory submission. Includes temporal analysis, MedDRA coding, causality assessment using WHO-UMC or Naranjo criteria, and multi-format output.
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Use when building a ceRNA regulatory network from a key gene list by combining bundled miRNA-mRNA and miRNA-lncRNA database files, with flat-file CSV exports and PDF visualization in a single output directory. NOT for: differential expression, single-cell analysis, enrichment analysis, or workflows without a key gene list.
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You are a compliance expert specializing in regulatory requirements for software systems including GDPR, HIPAA, SOC2, PCI-DSS, and other industry standards. Perform compliance audits and provide implementation guidance.
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Draft privacy policies, terms of service, disclaimers, and legal notices. Creates GDPR-compliant texts, cookie policies, and data processing agreements. Use PROACTIVELY for legal documentation, compliance texts, or regulatory requirements.
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Generate a prioritised compliance checklist for GDPR, SOC 2, ISO 27001, FCA, HIPAA, or other frameworks with a gap analysis. Use when asked for a compliance checklist, gap analysis, readiness assessment, or audit preparation for any regulatory framework. Produces a structured checklist with prioritised gaps, quick wins, and evidence requirements. Optimised for Opus 4.7 and newer models. Not a substitute for legal or compliance professional advice.
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Write an AI usage policy people can actually follow — approved tools, data rules, disclosure duties, and review obligations, in one page instead of legal fog. Use when asked for a company AI policy, acceptable-use rules for ChatGPT/Claude/Copilot at work, guidance on what data may go into AI tools, or to fix a policy nobody reads. Produces a one-page usable policy plus the decision log behind it. Not a substitute for legal advice; pairs with compliance-checklist for regulatory mapping and ai-ethics-review for system-level assessments.
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Tests whether two genomic interval sets overlap (colocalize) more than expected by chance using a permutation test against a structured-genome null model. Covers bedtools fisher (analytic 2x2 screen), bedtools shuffle + jaccard permutation, GAT (isochore/GC-conditioned simulation with FDR), regioneR (flexible permutation, randomizeRegions vs circularRandomizeRegions, localZScore), LOLA (universe-relative Fisher against a region database), and GREAT/rGREAT (regulatory-domain binomial + hypergeometric for ontology-from-regions). Stresses the universe/background choice, matched background, blacklist exclusion, and multiple-testing control. Use when asking whether peaks/regions are enriched at enhancers/TFBS/features, scoring region-set colocalization or region-set enrichment, comparing CNV/SV concordance, or turning an overlap count into a defensible p-value.
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Infer transcription factor regulons from single-cell RNA-seq with pySCENIC by combining GRNBoost2 co-expression, cisTarget motif-enrichment pruning, and AUCell per-cell activity scoring. Covers the motif-pruning-as-directionality principle, regulon specificity scoring, run-to-run stability, and database/species matching. Use when identifying TF regulons, scoring TF activity per cell, finding master regulators of cell identity, or comparing regulon activity across conditions. For enhancer-driven multiomic GRNs see multiomics-grn; for bulk inference and VIPER protein-activity see grn-inference.
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Simulate transcription factor perturbation effects on cell state in silico with CellOracle and Dynamo, and predict transcriptional responses to genetic perturbations with GEARS, scGen, and CPA. Covers the direction-not-magnitude principle, local-linear validity, the GRN/velocity error it inherits, baseline discipline (mean and additive baselines), and the validation gap. Use when predicting TF knockout or overexpression effects, ranking driver TFs for fate transitions, or planning perturbation experiments. For GRN construction see multiomics-grn; for experimental Perturb-seq see single-cell/perturb-seq.
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Build weighted gene co-expression networks to identify modules of co-regulated genes, relate them to phenotypes, and find hub genes using WGCNA, hdWGCNA, MEGENA, CEMiTool, and Gaussian graphical models. Covers signed-network choice, soft-threshold selection, module preservation, and the marginal-vs-partial-correlation distinction. Use when finding co-expression modules, identifying hub genes, relating gene networks to clinical or experimental traits, or building single-cell co-expression networks. For directed TF-target inference see scenic-regulons and grn-inference; for condition rewiring see differential-networks.
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Query the Ensembl REST API for gene/transcript/protein lookup, sequence retrieval, comparative genomics (Compara), variant effect prediction (VEP), regulatory features, and cross-species ortholog/paralog calls. Use when pulling Ensembl-native data (Ensembl Gene IDs, version-pinned releases, archive endpoints for reproducibility), gene/transcript/exon structure with stable IDs, or VEP for variant annotation. Encodes the 15 req/sec rate limit, archive (e110.rest.ensembl.org) for reproducibility, Ensembl divisions (vertebrates / plants / fungi / metazoa / bacteria), and the symbol-vs-ID stability problem.
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Visualize biological networks (PPI, gene-regulatory, co-expression, pathway) with layout algorithm choice (ForceAtlas2, Fruchterman-Reingold, Kamada-Kawai, hive plots), edge bundling, community-based coloring, and reproducible seeds using NetworkX, PyVis, igraph, and Cytoscape automation. Use when rendering biological networks for static publication, interactive HTML exploration, or Cytoscape-format export.
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Implements missing-data sensitivity analyses for confirmatory clinical trials including MMRM under MAR (with Kenward-Roger correction), reference-based multiple imputation (J2R, CR, CIR, LMCF per Carpenter-Roger 2013), Permutt delta-adjustment / tipping-point analysis, pattern-mixture identifying restrictions (CCMV, NCMV, ACMV), and the Cro vs Bartlett variance debate. Use when handling missing primary or secondary endpoint data in regulatory submissions following NRC 2010 and ICH E9(R1).
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Prepares statistical reports for clinical trials following CONSORT 2025, SPIRIT 2025, ICH E9(R1) estimands, and FDA 2023 covariate adjustment guidance. Covers Table 1 generation, analysis populations (ITT/FAS/PP/Safety), the 5 ICH E9(R1) intercurrent-event strategies, MMRM under MAR (mmrm), reference-based MI (rbmi J2R/CR/CIR), Permutt tipping-point sensitivity, and Rubin's-rules vs frequentist variance debate. Use when preparing regulatory submissions, defining estimands, or implementing missing-data sensitivity analyses.
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Performs subgroup and heterogeneous treatment effect (HTE) analyses for clinical trials. Covers Mantel-Haenszel pooling, Breslow-Day, interaction tests in regression, RERI for additive interaction, modern data-adaptive HTE methods (STEPP, SIDES, causal forests, X/R-learners), Bayesian shrinkage (Dixon-Simon, MAP, EXNEX), graphical multiplicity (Bretz-Maurer), and credibility frameworks (Sun BMJ, EMA 2019). Use when analyzing treatment effects across patient subgroups for regulatory submissions or precision-medicine claims.
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Reads, validates, and prepares CDISC SDTM and ADaM clinical trial data for analysis. Covers SDTM domain joins (DM, AE, EX, VS, LB, DS), ADaM architecture (ADSL, BDS, OCCDS, ADTTE) with traceability, treatment-emergent AE conventions, baseline derivation, SUPPQUAL/NSV handling, Define-XML 2.1, and Pinnacle 21 / CORE validation. Use when working with clinical trial datasets in CDISC SDTM/ADaM format, preparing analysis-ready data, or validating for regulatory submission.
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Detect allele-specific chromatin accessibility from ATAC-seq using WASP, GATK ASEReadCounter, or RASQUAL. Use when mapping cis-regulatory genetic variants from heterozygous SNPs, separating cis from trans regulation, building chromatin QTL (caQTL) maps, validating GWAS variant function with allelic imbalance, or detecting reference allele mapping bias before downstream analysis.
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Analyzes alternative splicing at single-cell resolution. The first decision is library chemistry — 10X 3' is fundamentally limited (RT primes from poly-A, R2 falls in 3' UTR, <0.1 junction read per cell per AS event). Plate-based full-length methods (Smart-seq3, FLASH-seq, VASA-seq, STORM-seq) and single-cell long-read (MAS-Iso-seq, scISOr-Seq2) are the chemistries that give per-cell isoform structure. Tools include MARVEL (R, Smart-seq integrated), BRIE2 (Bayesian PSI with regulatory features and ELBO_gain test), scQuint (junction-cluster, plate-based; not for 10X), SpliZ (annotation-free Z-score), Psix (graph-smoothness regulated AS), and Sierra (alternative polyadenylation, often confused with AS). Use when analyzing isoform usage in scRNA-seq, identifying cell-type-specific splicing, or determining whether scRNA-seq chemistry supports splicing analysis at all.
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Cross-border e-commerce expansion advisor. Scores target markets on 8 weighted dimensions (market size, ecommerce penetration, competition, regulatory complexity, logistics infrastructure, payment ecosystem, cultural distance, IP protection), compares 5 fulfillment models with cost and transit data, provides country-by-country tax/duty compliance guides (EU VAT/IOSS, UK VAT, US sales tax, CA GST, AU GST, JP consumption tax), maps local payment preferences by market, and builds a phased expansion roadmap. No API key required.
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United Arab Emirates Governance, Risk & Compliance advisor — a jurisdiction-first compliance router. In the UAE, WHERE an organization sits determines its law: mainland (Federal PDPL, Decree-Law 45/2021 — executive regulations still pending), DIFC (DP Law No. 5 of 2020 as amended 2025, with a private right of action), ADGM (DP Regulations 2021), CBUAE-licensed financial institutions (consumer-data residency, outsourcing approvals), healthcare (ICT Health Law data localization), and government/CNI (UAE IA Regulation, Cyber Security Council; Dubai ISR, ADHICS). Use for any UAE / Dubai / Abu Dhabi / Emirates compliance question: UAE data protection, DIFC or ADGM privacy, free-zone vs mainland obligations, health-data residency, CBUAE cyber and outsourcing rules, market entry ("expanding to the UAE"), breach notification, gap assessments, and mapping UAE requirements to ISO 27001 / NIST CSF / SOC 2. Trigger for any UAE privacy, cybersecurity, or regulatory question even if no framework is named.
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Expert GDPR compliance assistant covering all four core workflows: (1) auditing code and systems for GDPR violations, (2) drafting GDPR-compliant documents such as privacy policies, Data Processing Agreements (DPAs), and consent notices, (3) answering GDPR compliance questions with authoritative article citations, and (4) reviewing data flows and PII handling practices. Use this skill whenever the user mentions GDPR, data protection, privacy compliance, lawful basis, data subject rights, DPA, privacy notices, consent management, data breaches, DPIAs, controller/ processor relationships, cross-border data transfers, or any EU/UK data privacy topic. Also trigger for questions like "is this GDPR compliant?", "how do I handle personal data?", "what does a privacy policy need?", or any request involving PII, personal data, or data retention in a regulatory context.
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Expert ISO 42001 AI Management System (AIMS) compliance advisor. Use this skill whenever a user asks about ISO/IEC 42001:2023, AI governance, AI management systems, AI risk assessment, AI system impact assessment, Annex A controls for AI, Statement of Applicability for AI systems, AI policy, responsible AI, AI lifecycle management, AI incident management, AI transparency, AI bias, AI certification readiness, or any topic related to implementing or auditing an AI Management System. Also trigger for questions like "how do I become ISO 42001 certified?", "what controls does ISO 42001 require?", "how do I assess AI risk under 42001?", "what is an AIMS?", or any request involving organisational governance of AI systems, responsible AI frameworks, or AI regulatory compliance aligned to an ISO standard.
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Genomic interval machine learning for regulatory element analysis
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