「variants」の検索結果

Drive structured autoresearch iteration after evo:discover and the baseline commit. Use when the user invokes /evo:optimize or asks to try ideas, try variants, run experiments, use available GPUs, improve the current best/frontier, continue an evo search, or compare candidate changes in an evo workspace. The orchestrator plans and spawns optimization subagents; candidate edits/runs belong to those subagents. Width is set via subagents=N (1 for serial workloads, larger for parallel); the loop's structural value applies at any width.

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Build boolean and X-ray search strings to source candidates. Use when asked to build a boolean search, source candidates on LinkedIn/Google, write an X-ray search, or find people with specific skills. Produces ready-to-paste boolean strings (with synonyms, must-haves, and exclusions), X-ray variants for LinkedIn/GitHub, and a refinement plan to widen or narrow the result set.

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Write platform-native paid ad copy with multiple angles to test. Use when asked to write ad copy, Google/Facebook/LinkedIn/Instagram ads, PPC headlines, or paid social creative copy. Produces ready-to-ship variants per platform (headlines, primary text, descriptions, CTAs) across distinct angles, sized to each platform's limits, with a note on what each variant tests.

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When a spec under specs/<feature>/ is done shipping (a write-spec build, or any planned task that produced a spec), archive it to specs/done/ and rewrite it from a build-plan into a durable rationale — the why, the principles, the invariants — pointing back to the real code for the how. Use when implementation has landed and the plan no longer matches what shipped, or the user says a feature/spec is finished. Pairs with [write-spec](../write-spec/SKILL.md) (the plan this closes) and [review](../review/SKILL.md) (run before closing).

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Explore UI and visual design with image generation, then iterate the real implementation against the user-selected concept. Use when brainstorming visual directions, offering mockup variants, or implementing an approved generated design; do not stop at the mockups or the first code approximation.

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Context-led frontend design: art direction derived from product, audience, brand and the existing system, not generic defaults. Named mood variants listed inside. Triggers: frontend, UI, CSS, styling, visual, theme, component, layout, responsive, accessibility, animation.

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Analyze Swift Package Manager dependencies, package plugins, module variants, and CI-oriented build overhead that slow Xcode builds. Use when a developer suspects packages, plugins, or dependency graph shape are hurting clean or incremental build performance, mentions SPM slowness, package resolution time, build plugin overhead, duplicate module builds from configuration drift, circular dependencies between modules, oversized modules needing splitting, or modularization best practices.

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Render pixel-accurate iMessage screenshot mockups (DM or group) from a thread JSON. Supports minimal, with-keyboard, and full iPhone 15 Pro frame variants. Outputs HTML + PNG.

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Take a new feature or product update and generate the full launch kit: changelog entry, email announcement, LinkedIn post variants, in-app banner text, Twitter/X thread, and internal sales enablement one-pager. Pure reasoning skill that chains product context with audience-specific copy generation. Use when a product marketing team needs to turn a feature spec into launch-ready assets fast.

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Generate 3-5 messaging variants for a value proposition, design structured A/B tests, and analyze results to determine which framing resonates most with ICP. Tests can run via LinkedIn organic posts, cold email subject line splits, or both. Pure reasoning for variant generation and analysis — the user deploys the tests through their own tools. Use when a team can't decide between messaging angles and needs data, not opinions.

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End-to-end Google Search Ads campaign builder. Performs deep keyword research (competitor SEO, review language mining, Reddit/HN community terminology, site audit), builds keyword architecture with funnel mapping and intent classification, creates ad group structure, generates headline/description variants, builds negative keyword lists, recommends bid strategy, and exports a campaign-ready CSV for Google Ads Editor import.

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Navigate e-commerce sites to extract products, pricing, categories, and inventory. Handles pagination, variants, and JS-heavy storefronts.

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Generates an x-ray.md pre-audit report covering overview, enhanced threat model (protocol-type profiling, git-weighted attack surfaces, temporal risk analysis, composability dependency mapping), invariants, integrations, docs quality, test analysis, and developer/git history. Triggers on 'x-ray', 'audit readiness', 'readiness report', 'pre-audit report', 'prep this protocol', 'protocol prep', 'summarize this protocol'.

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Configure Simulink models for Embedded Coder (ERT), Simulink Coder (GRT rapid-prototyping), or AUTOSAR code generation. Use when the user asks to generate embedded C or C++ code, run a full build of a model, produce a code generation report, configure a model for production/ECU deployment or rapid-prototyping code, target ARM or x86 hardware, apply MISRA C/C++ compliance (ERT/AUTOSAR only — Simulink Coder does not ship MISRA profiles), or set up GRT, ERT, AUTOSAR, or shared-library targets. Handles target selection, hardware mapping, model hierarchy propagation, and constraint introspection via the configure_for_codegen function. Do NOT use for GRT shared-library variants (grt_malloc.tlc), DDS, or ROS, or for iterative optimization workflows that measure baseline metrics, apply targeted changes, and re-measure to confirm improvement.

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Identify tumor neoantigens from somatic variants with pVACtools (pVACseq/pVACfuse/pVACbind/pVACvector/pVACview) for personalized cancer vaccines and checkpoint biomarkers. Encodes the field's hard truth that binding prediction is the easy, near-solved part and single-digit-percent PPV lives downstream — so it centers clonality/CCF, HLA LOH (the silent invalidator), expression, proximal-variant phasing, agretopicity/foreignness quality, and the predicted->presented->immunogenic validation tiers. Use when nominating vaccine targets, ranking neoantigens, or building a tumor-to-candidate pipeline. Binding details in mhc-binding-prediction; ranking in immunogenicity-scoring.

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Designs and ranks guide RNAs (sgRNAs) for CRISPR-Cas9/Cas12a gene knockout by scanning a target for PAM sites (NGG SpCas9, NNGRRT SaCas9, TTTV Cas12a, NG SpCas9-NG, near-PAMless SpRY), enumerating candidate spacers, applying hard filters (Pol-III TTTT terminator, 5' G, GC), ranking on-target activity with the context-appropriate model (Rule Set 2/Azimuth for U6/lentiviral, CRISPRscan for T7/embryo, DeepHF for high-fidelity variants, DeepCpf1 for Cas12a), and predicting the indel/frameshift outcome (Bae out-of-frame score, inDelphi, FORECasT, Lindel). Use when selecting sgRNAs to knock out a gene, choosing a nuclease/PAM for a constrained locus, picking which exon to target, or shortlisting guides before an off-target check. Off-target specificity, base/prime editing, and HDR donors are separate skills.

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Performs proximity operations on genomic intervals with bedtools (closest, window, flank, slop) and pybedtools - nearest-feature queries with signed/strand-aware distance, fixed-radius window searches, strand-aware promoter construction, and interval extension. Covers the closest -d/-D a/b/ref/-t/-k/-io/-iu/-id flags, the -D ref strand sign-flip, silent chromosome-end clipping in slop/flank, -t all tie double-counting, and the critical distinction between a geometry answer (nearest TSS) and a biology answer (which gene an element regulates). Use when assigning peaks or variants to genes, defining promoters from a gene model, building distance-to-TSS distributions, finding features within a window, or extending intervals - and when deciding whether nearest-gene is a fair prior (GWAS locus) or a trap (distal enhancer).

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Handles BED-format genomic intervals (BED3 through BED12, narrowPeak/broadPeak) and the coordinate-system substrate the whole interval category rests on, with bedtools (CLI) and pybedtools/pyranges/pandas (Python). Covers the 0-based half-open vs 1-based-closed convention boundary and the start-1/end-unchanged conversion, the silent failures (chrom-name mismatch, CRLF, lexicographic-vs-version sort under -sorted), genome/chrom.sizes generation, sorting contracts, BED12 block invariants, validation, makewindows, cross-assembly liftover (liftOver/CrossMap), and BED<->VCF/BAM/FASTA conversion. Use when reading, creating, validating, sorting, lifting between genome builds, or converting interval files, preparing inputs for bedtools/tabix/bigBed, or debugging an off-by-one or empty-overlap result.

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Detects somatic mutations in circulating tumor DNA, treating low-VAF detection as a signal-versus-noise problem set by error suppression and molecules sampled, not by the choice of caller. Distinguishes de novo CALLING (scanning a panel for unknown variants, bounded by per-locus error and multiple testing) from tumor-informed DETECTION (tracking a pre-specified variant set, where panel integration reaches single-ppm). Covers VarDict and Mutect2 for de novo calling, UMI-aware callers, and a pysam-based known-variant VAF tracker, with matched-WBC subtraction as the mandatory defense against clonal hematopoiesis (the dominant false positive). Use when calling or tracking tumor mutations from plasma cfDNA, setting a VAF threshold, or deciding whether a low-VAF call is tumor versus CHIP.

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Build local BLAST databases and run searches using NCBI BLAST+ command-line tools. Use when running >50 queries, building custom databases with -parse_seqids and -taxid, downloading prebuilt NCBI databases via update_blastdb.pl, choosing -task variants (megablast/dc-megablast/blastn/blastn-short), tuning soft/hard masking, scaling threads, or extracting hits with blastdbcmd. Encodes BLAST v5 vs v4 database format, taxonomy filtering, makeblastdb pitfalls.

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Build circular genome visualizations using circlize (R), pyCirclize (Python), or Circos (Perl CLI) with ideogram tracks, multi-data tracks (scatter, histogram, heatmap), chord/link arcs for interactions, and explicit circos.clear() between plots. Covers when circular is appropriate vs when Cartesian wins (Cleveland-McGill 1984), karyograms, and chromosome adjacency in chord diagrams. Use when adjacency on the circle conveys meaning — chromosome-level overview, structural variants, Hi-C interactions, cross-genome comparisons.

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Build Sankey, alluvial, river, and CONSORT-style flow diagrams to visualize cohort transitions, cell-state changes, or pipeline filtering using ggalluvial, networkD3, plotly, and consort. Use when showing how entities move between categories across timepoints (cell states, drug response classes, patient flow through a trial) or filtering pipelines (variants filtered through QC stages).

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Find cross-database references between NCBI databases using Biopython Bio.Entrez (ELink). Use when navigating gene to protein/structure, sequence to publication, PubMed to GEO, BioProject to SRA runs, or discovering all link relationships for a record. Covers linkname semantics, cmd= variants, asymmetric link warnings, neighbor_history for >200 input IDs, and per-database link tables.

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Detect single-nucleotide crosslink (CL) sites in CLIP-seq data using truncation patterns (iCLIP/eCLIP CITS), crosslink-induced mutations (HITS-CLIP CIMS deletions, PAR-CLIP T-to-C), or HMM/kernel-density methods (PureCLIP, PARalyzer, CTK). Use when single-nucleotide resolution is required for motif registration (mCross), allele-specific binding (BEAPR), variant-effect prediction, or comparing crosslink chemistry across CLIP variants.

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