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Generates complete conventional non-oncology bioinformatics research designs from a user-provided disease context, process-related gene family or biological theme, and validation direction. Use when a study centers on multi-dataset bulk transcriptome integration, DEG analysis, process-gene intersection, enrichment analysis, GSEA, PPI hub-gene prioritization, TF/miRNA regulatory networks, ROC-based biomarker evaluation, and immune infiltration analysis. Covers five study patterns (process-DEG discovery, enrichment/GSEA interpretation, hub-gene prioritization, regulatory-network and immune interpretation, multi-layer public validation) and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.

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Identifies translationally meaningful paths for bioinformatics findings by mapping omics or computational discoveries to diagnosis, stratification, prognosis, treatment-response, monitoring, or target-nomination use cases, while auditing bridge evidence, assayability, and validation burden. Use this skill when a user wants to know whether a bioinformatics finding can be framed as a stronger translational topic without overclaiming clinical relevance. Always separate statistical signal from translational value, and never imply clinical utility, targetability, or validation depth without explicit evidence support.

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Explains why studies on the same biomedical topic reach different or opposing conclusions by auditing differences in population, endpoint definition, sample source, assay or platform, study design, statistical model, adjustment strategy, validation chain, and bias control. It separates true contradiction from apparent contradiction caused by framing or methods. Never fabricate references, PMIDs, DOIs, trial identifiers, dataset details, platform details, study features, or conflict explanations that are not supported by the input.

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Finds translational opportunities that connect basic-research discoveries to clinically meaningful use cases such as diagnosis, stratification, prognosis, treatment response prediction, monitoring, or therapeutic development. Use this skill when a user wants to turn a mechanism finding, pathway signal, cellular phenotype, experimental observation, or omics discovery into a stronger translational research direction. Always separate mechanistic relevance from translational usability, and never present a basic finding as clinically actionable unless the evidence supports that level.

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Generates complete FAERS pharmacovigilance study designs for multi-drug or class-level safety comparison inside one predefined SOC or AE family using active comparators, disproportionality analysis, subgroup characterization, and reviewer-facing evidence control.

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A comprehensive auditor for any agent skill — including Manus, OpenClaw/ClawHub, Claude, LobeHub, or custom SKILL.md-based skills. Use this skill whenever a user wants to evaluate, audit, review, score, or quality-check an agent skill before publishing, updating, or deploying. Covers two hard veto gates (structural redlines + research integrity redlines), static quality scoring across 25 criteria (ISO 25010 + OpenSSF + Agent), dynamic test input generation, multi-mode execution testing, multi-layer output evaluation with five specialized category rubrics (Evidence Insight / Protocol Design / Data Analysis / Academic Writing / Other), a Research Veto that applies to all four research categories, human eval viewer generation, actionable P0/P1/P2 optimization recommendations, and automatic skill improvement that outputs a polished, production-ready SKILL.md. Also use whenever a user says "audit my skill", "evaluate my skill", "improve my skill", or wants a corrected version after evaluation.

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Use when evaluating A-share short-term technical setups through Tang Nengtong's classic TA lens: volume-price relationships, moving average systems, breakout signals, and short-term momentum entry/exit.

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Translate logistics and operations rules into optimization variables and constraints. Use when an operations problem describes vehicles, routes, depots, pickups, dropoffs, inventory, capacity, assignments, time windows, service targets, penalties, resource limits, or other business rules that need to become an optimization model.

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Create or update skills. Use when designing, structuring, or packaging skills with scripts, references, and assets.

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Govern how the design system evolves — SemVer for tokens/components, the contribution workflow, deprecation policy, and change communication. Use when the user wants to add/promote/deprecate a component or token, decide a version bump, set up a contribution process, or keep the system from fragmenting.

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Refactor code while preserving passing tests and behavior. Use during the TDD refactor phase to remove duplication, improve design, and verify each structural change.

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Design monorepo structure, build systems, and dependency boundaries using Nx, Turborepo, Bazel, or Lerna. Use when setting up a monorepo, optimizing builds, or scaling development workflows.

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Write idiomatic Elixir code with OTP patterns, supervision trees, and Phoenix LiveView. Masters concurrency, fault tolerance, and distributed systems. Use PROACTIVELY for Elixir refactoring, OTP design, or complex BEAM optimizations.

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You are a code refactoring expert specializing in clean code principles, SOLID design patterns, and modern software engineering best practices. Analyze and refactor the provided code to improve its quality, maintainability, and performance.

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Use when the user gives a topic and wants an automated topic-driven narrated explainer, podcast, or knowledge-summary video (Bilibili / YouTube / Xiaohongshu / Douyin / WeChat Channels), or asks to learn visual design patterns from a reference video/image. Trigger when the user mentions creating a knowledge video, narrated explainer, video podcast, or animated infographic-style video from a topic — even if they don't say "video podcast" explicitly. Also trigger when the user wants to regenerate, re-render, rebuild, update, or iterate on a narrated video this skill already produced — e.g. they edited the script/prompt, changed the visuals, or swapped the background music and want the final video remade (reuse the existing videos/{name}/ directory, never start a new project). Do NOT trigger for generic video editing, trimming, format conversion, color grading, or non-narrative video tasks. Produces 4K video via research → script → TTS → Remotion → MP4 + BGM.

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Draft a structured preregistration document (OSF, AsPredicted, or AEA RCT Registry style) from a research spec or free-form study description. Output is a Markdown file with hypotheses, design, sampling plan, analysis plan, exclusions, and inference criteria — annotated with MUST / SHOULD / MAY clarity flags. Use when user says "preregister", "draft a preregistration", "OSF preregistration", "AsPredicted", "AEA RCT registry", "PAP", "preanalysis plan", or before launching an experiment / data collection / analysis on data the analyst has not yet seen. NOT a registry submission tool — produces a document the user uploads to OSF / AsPredicted / AEA themselves.

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AI DevKit · Manage running AI agents with ai-devkit agent commands. Use when an agent needs to identify itself, list agents, start workers, inspect agent detail, assign work, group agents, resume sessions, stop agents, or delegate work to other agents.

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Generate high-CTR YouTube thumbnails using Nano Banana 2 via the Arcads external API. Handles reference image upload, character likeness alignment, proven CTR-tested prompt formulas, and parallel batch generation. Use when the user asks to create a YouTube thumbnail, video thumbnail, A/B test thumbnail variations, or refers to thumbnail design with their face, brand assets, or product photos.

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Plan, create, and configure production-ready Azure Kubernetes Service (AKS) clusters. Covers Day-0 checklist, SKU selection (Automatic vs Standard), networking options (private API server, Azure CNI Overlay, egress configuration), security, and operations (autoscaling, upgrade strategy, cost analysis). WHEN: create AKS environment, provision AKS, enable AKS observability, design AKS networking, choose AKS SKU, secure AKS, optimize AKS, AKS spot nodes, AKS cluster-autoscaler, rightsize AKS pod, pod rightsizing, over-provisioned AKS pod, pod resource requests and limits, Vertical Pod Autoscaler, VPA recommendations.

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Consolidate freshness-gated newsjack signals and route them by client standing before angle generation. Collapses any remaining same-story duplicates, decides strong/partial/none standing with a journalist-shape sanity check, and sorts each story into pitch_ready, big_story (always-surfaced suggestion), or watch. Never writes angles or pitches, and never drops a fresh big story.

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Recover source-bound buyer jobs, struggling moments, desired progress, forces, workarounds, information acts, journey states, criteria, constraints, roles, locales, and authentic language. Use on approved ICP hypotheses plus customer, search, review, forum, procurement, support, or public-market evidence before designing an AI-visibility prompt architecture.

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Architect Unity 6.3 LTS data and decoupling with ScriptableObjects: config/data assets, shared runtime variables, event channels, and runtime sets/registries. Use when designing data-driven systems, replacing singletons/managers, creating .asset data with CreateAssetMenu, or when the user mentions ScriptableObject, SO architecture, or data assets.

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Design data-driven Godot 4.7 games with custom Resource classes: define typed data with class_name + @export, save/load .tres/.res files, instance and duplicate resources, and load on demand with ResourceLoader (incl. threaded loading). Use when modeling items/stats/configs as data in a Godot project, creating .tres resources, or working with custom Resource subclasses and ResourceLoader/ResourceSaver.

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Design and harden Roblox client/server networking with RemoteEvent, RemoteFunction, and UnreliableRemoteEvent; server authority, argument and Instance validation, rate limits, proximity/ownership checks, targeted replication, streaming, lifecycle, prediction, and reconciliation. Use for Roblox remotes, exploits, request spam, multiplayer replication, network ownership, high-frequency cosmetic updates, or server/client desynchronization.

日本語の概要は準備中です。原文の説明を表示しています。