「engineer」の検索結果

Build production-ready LLM applications, advanced RAG systems, and intelligent agents. Implements vector search, multimodal AI, agent orchestration, and enterprise AI integrations.

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Systematic improvement of existing agents through performance analysis, prompt engineering, and continuous iteration.

日本語の概要は準備中です。原文の説明を表示しています。

You know AI wrappers get a bad rap, but the good ones solve real problems. You build products where AI is the engine, not the gimmick. You understand prompt engineering is product development. You balance costs with user experience. You create AI products people actually pay for and use daily.

日本語の概要は準備中です。原文の説明を表示しています。

You're a quality engineer who has seen agents that aced benchmarks fail spectacularly in production. You've learned that evaluating LLM agents is fundamentally different from testing traditional software—the same input can produce different outputs, and "correct" often has no single answer.

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Nominates and assesses CRISPR off-target sites genome-wide. Enumerates candidate sites by mismatch and bulge tolerance with Cas-OFFinder/CRISPRitz, ranks them with the published CFD score (SpCas9-only, relative ranker) or MIT/CRISTA/energy models, runs variant-aware screening against gnomAD/individual genomes (CRISPRme), and frames the empirical genome-wide discovery assays (GUIDE-seq, CIRCLE-seq, CHANGE-seq, DISCOVER-seq, Digenome-seq) and high-fidelity nuclease choice (HiFi Cas9, Sniper-Cas9, eSpCas9, SpCas9-HF1). Use when assessing guide RNA specificity, choosing among candidate guides, screening a therapeutic guide against population variation, or planning empirical off-target validation. Distinguishes predicted vs detected vs validated. On-target activity scoring and deaminase (Cas-independent) base/prime-editor off-targets are separate skills.

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Designs cytosine (CBE, C-to-T) and adenine (ABE, A-to-G) base-editor guides by positioning the target base at the activity-peak of the editing window (protospacer positions ~5-7, PAM-distal numbering), minimizing bystander edits for product purity, reading dinucleotide context (APOBEC1 TC favored / GC disfavored), and selecting the editor variant (BE4max, ABEmax, ABE8e, YE1/SECURE, TadCBE, CGBE, SpG/SpRY-BE). Covers knockout by premature stop (CRISPR-STOP/iSTOP) and splice-site disruption, the three off-target classes (Cas-dependent, Cas-independent DNA, RNA), outcome prediction (BE-Hive/DeepBE), and the base-vs-prime-vs-HDR decision. Use when installing a transition mutation without a double-strand break, knocking out a gene without indels, or choosing CBE vs ABE. Generic guide scoring, prime editing, and HDR donors are separate skills.

日本語の概要は準備中です。原文の説明を表示しています。

Designs and ranks guide RNAs (sgRNAs) for CRISPR-Cas9/Cas12a gene knockout by scanning a target for PAM sites (NGG SpCas9, NNGRRT SaCas9, TTTV Cas12a, NG SpCas9-NG, near-PAMless SpRY), enumerating candidate spacers, applying hard filters (Pol-III TTTT terminator, 5' G, GC), ranking on-target activity with the context-appropriate model (Rule Set 2/Azimuth for U6/lentiviral, CRISPRscan for T7/embryo, DeepHF for high-fidelity variants, DeepCpf1 for Cas12a), and predicting the indel/frameshift outcome (Bae out-of-frame score, inDelphi, FORECasT, Lindel). Use when selecting sgRNAs to knock out a gene, choosing a nuclease/PAM for a constrained locus, picking which exon to target, or shortlisting guides before an off-target check. Off-target specificity, base/prime editing, and HDR donors are separate skills.

日本語の概要は準備中です。原文の説明を表示しています。

Designs pegRNAs and nicking guides for prime editing (PE) -- choosing the nick/strand, tuning the primer-binding site (PBS) and reverse-transcription template (RTT) as a per-locus panel, selecting the PE system (PE2/PE3/PE3b/PE4/PE5/PEmax/PE7), adding MMR-evading and PAM-disrupting silent edits, appending epegRNA 3' motifs (tevopreQ1/mpknot), and ranking with PRIDICT/DeepPrime. Covers twinPE/PASTE for large insertions and the prime-vs-base-editing decision. Use when designing a scarless point mutation, small insertion/deletion, or any of the 12 base conversions without a double-strand break, when efficiency is low and MMR inhibition or pegRNA stabilization is needed, or when routing a large insertion to an integrase method. Generic guide scoring and base editing are separate skills.

日本語の概要は準備中です。原文の説明を表示しています。

Designs donor/repair templates for precise CRISPR knock-ins -- choosing the format (ssODN, long-ssDNA/Easi-CRISPR, dsDNA/plasmid, AAV6), sizing homology arms, placing the cut within ~10 bp of the edit, and adding a mandatory codon-checked blocking (PAM/seed) mutation so the edited allele is not re-cut. Frames the HDR-vs-NHEJ-vs-MMEJ pathway competition, the MMEJ (PITCh) and homology-independent (HITI/HMEJ) alternatives for post-mitotic cells, ssODN strand/asymmetry choice, phosphorothioate end-protection, and ranked HDR enhancers. Use when designing a donor for a point mutation, epitope/fluorophore tag, allele replacement, or knock-in, or when HDR efficiency is low. Guide design and base/prime editing are separate skills.

日本語の概要は準備中です。原文の説明を表示しています。

Build a differential-ready consensus peakset from per-replicate ATAC-seq peaks using iterative overlap removal, fixed-width re-centering, and majority-rule overlap. Use when generating a stable peak coordinate system for downstream differential accessibility, ML feature engineering, cross-sample comparison, or fixed-width peak counts; covers Corces 2018 iterative overlap (501 bp), DiffBind summit re-centering, and ENCODE consistency rules.

日本語の概要は準備中です。原文の説明を表示しています。

Use when running analytical SQL over Parquet/CSV/JSON without a warehouse, replacing pandas for data wrangling, joining S3 data in-place, building local data marts, or embedding OLAP into an app. Triggers: read_parquet/read_csv setup, partitioned dataset queries, hive partitioning, glob patterns for S3, COPY TO export, attach Postgres/MySQL, UDFs in Python/R, MotherDuck cloud sync, columnar performance vs row stores. NOT for OLTP workloads (concurrent writes), distributed analytics at petabyte scale (use Spark/Trino), or vector search (use pgvector/Lance).

日本語の概要は準備中です。原文の説明を表示しています。

Data structures and algorithms for AI agent episodic memory. Covers vector stores (HNSW, IVF, PQ), temporal indexing, knowledge graphs with triple stores, hierarchical summarization, forgetting curves, working/long-term/ procedural memory, and memory consolidation. Deep analysis of MemGPT/Letta, Zep/Graphiti, Mem0, and the Stanford generative agents memory architecture. Teaches the CS fundamentals behind how agents remember, retrieve, and forget. Activate on: "agent memory", "episodic memory", "vector search algorithm", "HNSW", "memory retrieval", "forgetting curve", "knowledge graph memory", "MemGPT", "Letta", "Zep", "Mem0", "memory consolidation", "temporal retrieval", "agent long-term memory", "memory layer". NOT for: conversation protocol design (use agent-conversation-protocols), agent infrastructure selection (use agentic-infrastructure-2026), building RAG pipelines (use ai-engineer).

日本語の概要は準備中です。原文の説明を表示しています。

Build face recognition systems with InsightFace, ArcFace, enrollment pipelines, HDBSCAN clustering, and privacy-compliant architecture. Activate on: face recognition, face enrollment, face clustering, identity verification, facial search. NOT for: general object detection (computer-vision-pipeline), emotion analysis (ai-engineer).

日本語の概要は準備中です。原文の説明を表示しています。

Star schema, snowflake schema, SCD types, and Kimball methodology for analytical data modeling. Activate on: dimensional model, star schema, snowflake schema, SCD, fact table, dimension table, Kimball, grain, surrogate key. NOT for: dbt implementation (use dbt-analytics-engineer), warehouse tuning (use data-warehouse-optimizer).

日本語の概要は準備中です。原文の説明を表示しています。

Snowflake, BigQuery, clustering, partitioning, and materialized views for warehouse performance. Activate on: Snowflake, BigQuery, Redshift, query optimization, clustering, partitioning, materialized view, warehouse cost, query profile. NOT for: dbt model structure (use dbt-analytics-engineer), data modeling (use dimensional-modeler).

日本語の概要は準備中です。原文の説明を表示しています。

Safe database migration manager for zero-downtime DDL changes and rollback plans. Activate on: database migration, schema change, DDL, rollback plan, zero-downtime migration, Prisma migrate, Drizzle kit, Flyway, column rename, table alter. NOT for: query optimization (use database-optimizer), ORM modeling (use data-pipeline-engineer), backup/restore (use devops-automator).

日本語の概要は準備中です。原文の説明を表示しています。

Great Expectations, dbt tests, anomaly detection, and data contracts for data quality. Activate on: data quality, data validation, Great Expectations, data contract, anomaly detection, SLA, freshness check, schema validation. NOT for: dbt model structure (use dbt-analytics-engineer), schema evolution (use schema-evolution-manager).

日本語の概要は準備中です。原文の説明を表示しています。

OpenLineage, DataHub, Marquez for data lineage tracking and impact analysis. Activate on: data lineage, OpenLineage, DataHub, Marquez, impact analysis, data catalog, column lineage, data discovery. NOT for: data quality validation (use data-quality-guardian), dbt documentation (use dbt-analytics-engineer).

日本語の概要は準備中です。原文の説明を表示しています。

Review of Cognitive Systems Engineering applications and current practice in safety-critical domains

日本語の概要は準備中です。原文の説明を表示しています。

Cognitive Systems Engineering design methodology for joint cognitive systems and human-centered automation

日本語の概要は準備中です。原文の説明を表示しています。

Treat tokens as a coding swarm's cost-of-goods-sold and legibility engine while accounting for finite subscription allowance when per-call price is unknown. Covers provider windows, remaining-usage evidence, burn forecasts, preemptive checkpoint/model switching, per-agent budgets, compaction, shared digests, context degradation, and spend metering. Activate on: "token budget", "context budget", "compaction strategy", "briefing as compression", "context rot", "summarization collapse", "COGS for agents", "subscription usage remaining", "five-hour or weekly limit", "burn forecast", "model switch before limit", or "/context-economics-for-agent-swarms". NOT for: memory architecture (use always-on-agent-architecture), single-prompt wording (use prompt-engineer), mechanism-design proofs (use nisan-et-al-2007-algorithmic-game-theory), physical containment (use sandboxed-adversarial-test-harness), or production rebodiment and fencing (use agent-resurrection-and-body-continuity).

日本語の概要は準備中です。原文の説明を表示しています。

Expert API designer for REST, GraphQL, gRPC architectures. Activate on: API design, REST API, GraphQL schema, gRPC service, OpenAPI, Swagger, API versioning, endpoint design, rate limiting, OAuth flow. NOT for: database schema (use data-pipeline-engineer), frontend consumption (use web-design-expert), deployment (use devops-automator).

日本語の概要は準備中です。原文の説明を表示しています。

Cryptographic security for agentic systems — zero-trust agent networking, signed message envelopes (JWS/JWE), capability-based security (ocaps), Merkle tree audit trails, WASM sandboxing, and formal verification. Covers CLI dev tool security, mTLS between agents, permission boundaries (least privilege for AI agents), and supply chain security for skills/plugins. Activate on: "agent security", "zero trust agents", "secure agent communication", "capability-based security", "ocap", "signed messages between agents", "agent audit trail", "sandbox agent execution", "agent permissions", "mTLS agents", "cryptographic verification", "agent supply chain", "OWASP agentic", "prove agent did X", "tamper-proof agent logs". NOT for: application-level SAST scanning (use security-auditor), network firewall rules (use infrastructure), SOC2/HIPAA compliance (organizational), or prompt injection defense (use prompt-engineer).

日本語の概要は準備中です。原文の説明を表示しています。

Apache Airflow DAGs, operators, SLA monitoring, and workflow orchestration. Activate on: Airflow, DAG, operator, sensor, scheduler, task dependency, SLA, backfill, XCom. NOT for: dbt transformations (use dbt-analytics-engineer), streaming pipelines (use streaming-pipeline-architect).

日本語の概要は準備中です。原文の説明を表示しています。