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概要と使いどころ
Azure Batch SDK for Java. Run large-scale parallel and HPC batch jobs with pools, jobs, tasks, and compute nodes. Triggers: "BatchClient java", "azure batch java", "batch pool java", "batch job java", "HPC java", "parallel computing java".
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Build real-time voice AI applications using Azure AI Voice Live SDK (azure-ai-voicelive). Use this skill when creating Python applications that need real-time bidirectional audio communication with Azure AI, including voice assistants, voice-enabled chatbots, real-time speech-to-speech translation, voice-driven avatars, or any WebSocket-based audio streaming with AI models. Supports Server VAD (Voice Activity Detection), turn-based conversation, function calling, MCP tools, avatar integration, and transcription.
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Azure AI Agents Persistent SDK for .NET. Low-level SDK for creating and managing AI agents with threads, messages, runs, and tools. Use for agent CRUD, conversation threads, streaming responses, function calling, file search, and code interpreter. Triggers: "PersistentAgentsClient", "persistent agents", "agent threads", "agent runs", "streaming agents", "function calling agents .NET".
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Azure Resource Manager SDK for Azure SQL in .NET. Use for MANAGEMENT PLANE operations: creating/managing SQL servers, databases, elastic pools, firewall rules, and failover groups via Azure Resource Manager. NOT for data plane operations (executing queries) - use Microsoft.Data.SqlClient for that. Triggers: "SQL server", "create SQL database", "manage SQL resources", "ARM SQL", "SqlServerResource", "provision Azure SQL", "elastic pool", "firewall rule".
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Guide for creating high-quality MCP (Model Context Protocol) servers that enable LLMs to interact with external services through well-designed tools. Use when building MCP servers to integrate external APIs or services, whether in Python (FastMCP), Node/TypeScript (MCP SDK), or C#/.NET (Microsoft MCP SDK).
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Build applications powered by GitHub Copilot using the Copilot SDK. Use when creating programmatic integrations with Copilot across Node.js/TypeScript, Python, Go, or .NET. Covers session management, custom tools, streaming, hooks, MCP servers, BYOK providers, session persistence, custom agents, skills, and deployment patterns. Requires GitHub Copilot CLI installed and a GitHub Copilot subscription (unless using BYOK).
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Compares an app clone against the original: a feature parity score from the feature matrix (weighted by must, should, could) with the missing list in build order, plus a screenshot layout diff that ignores colour so a rebrand does not count against you. Two standard-library Python tools. Use when the user says "how close is my clone", "compare it to the original", "what's missing", "parity check", "diff the screens", "is it ready", or after /replica-test.
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Data-independent acquisition (DIA) proteomics analysis with DIA-NN and other tools. Use when analyzing DIA mass spectrometry data with library-free or library-based workflows for deep proteome profiling.
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Extract, process, and deduplicate reads using Unique Molecular Identifiers (UMIs) with umi_tools. Use when library prep includes UMIs and accurate molecule counting is needed, such as in single-cell RNA-seq, low-input RNA-seq, or targeted sequencing to distinguish PCR from biological duplicates.
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Predict B-cell and T-cell epitopes using BepiPred, IEDB tools, and structure-based methods for vaccine and antibody design. Identify immunogenic regions in antigens. Use when designing vaccines, mapping antibody binding sites, or predicting immunogenic peptides.
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Identify tumor neoantigens from somatic mutations using pVACtools for personalized cancer immunotherapy. Predict mutant peptides that bind patient HLA and may elicit T-cell responses. Use when identifying vaccine targets or checkpoint inhibitor response biomarkers from tumor sequencing data.
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Profile functional potential of metagenomes using HUMAnN3 and similar tools. Use when obtaining pathway abundances, gene family counts, or functional annotations from metagenomic data.
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Balance, normalize, and transform Hi-C contact matrices using cooler and cooltools. Apply iterative correction (ICE), compute expected values, and generate observed/expected matrices. Use when normalizing or transforming Hi-C matrices.
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Visualize Hi-C contact matrices, TADs, loops, and genomic features using matplotlib, cooltools, and HiCExplorer. Create triangle plots, virtual 4C, and multi-track figures. Use when visualizing contact matrices or genomic features.
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Detect chromatin loops and point interactions from Hi-C data using cooltools, chromosight, and HiCCUPS-like methods. Identify CTCF-mediated loops and enhancer-promoter contacts. Use when detecting chromatin loops from Hi-C data.
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Detect A/B compartments from Hi-C data using cooltools and eigenvector decomposition. Identify active (A) and inactive (B) chromatin compartments from contact matrices. Use when identifying A/B compartments from Hi-C data.
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Process Hi-C read pairs using pairtools. Parse alignments, filter duplicates, classify pairs, and generate contact statistics from Hi-C sequencing data. Use when processing raw Hi-C read pairs.
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Generate consensus FASTA sequences by applying VCF variants to a reference using bcftools consensus. Use when creating sample-specific reference sequences or reconstructing haplotypes.
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Convert between sequence file formats (FASTA, FASTQ, GenBank, EMBL) using Biopython Bio.SeqIO. Use when changing file formats or preparing data for different tools.
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Guidance for choosing the right protein binder design tool. Use this skill when: (1) Deciding between BoltzGen, BindCraft, or RFdiffusion, (2) Planning a binder design campaign, (3) Understanding trade-offs between different approaches, (4) Selecting tools for specific target types. For specific tool parameters, use the individual tool skills (boltzgen, bindcraft, rfdiffusion, etc.).
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Cloud laboratory platform for automated protein testing and validation. Use when designing proteins and needing experimental validation including binding assays, expression testing, thermostability measurements, enzyme activity assays, or protein sequence optimization. Also use for submitting experiments via API, tracking experiment status, downloading results, optimizing protein sequences for better expression using computational tools (NetSolP, SoluProt, SolubleMPNN, ESM), or managing protein design workflows with wet-lab validation.
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This skill should be used when working with annotated data matrices in Python, particularly for single-cell genomics analysis, managing experimental measurements with metadata, or handling large-scale biological datasets. Use when tasks involve AnnData objects, h5ad files, single-cell RNA-seq data, or integration with scanpy/scverse tools.
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End-to-end binder design using BindCraft hallucination. Use this skill when: (1) Designing protein binders with built-in AF2 validation, (2) Running production-quality binder campaigns, (3) Using different design protocols (fast, default, slow), (4) Need joint backbone and sequence optimization, (5) Want high experimental success rate. For backbone-only generation, use rfdiffusion. For QC thresholds, use protein-qc. For tool selection guidance, use binder-design.
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Identifies super-enhancers from H3K27ac ChIP-seq data using ROSE and related tools. Use when studying cell identity genes, cancer-associated regulatory elements, or master transcription factor binding regions that cluster into large enhancer domains.
日本語の概要は準備中です。原文の説明を表示しています。