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概要と使いどころ
Hamiltonian mechanics — symplectic integrators (leapfrog, Yoshida), Hamilton's equations, Poisson brackets, canonical transformations, action-angle variables, and KAM theory analysis. Use for energy-conserving long-time integration of conservative systems.
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End-to-end neoantigen discovery from somatic variants to ranked vaccine candidates. Integrates HLA typing, MHC binding prediction, pVACtools neoantigen calling, and immunogenicity scoring. Use when identifying tumor neoantigens for personalized vaccine design or checkpoint biomarkers.
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Builds diagnostic and prognostic classifiers on omics feature matrices with regularized logistic regression, random forest, and gradient-boosted trees, handling the p>>n regime, batch shortcut learning, class imbalance, and probability calibration. Use when building a classifier from expression, methylation, or variant data, choosing an algorithm for high-dimensional small-n data, or diagnosing a suspiciously perfect AUC. For unbiased evaluation see machine-learning/model-validation; for feature selection see machine-learning/biomarker-discovery; for time-to-event outcomes see machine-learning/survival-analysis.
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Use this skill when working with symbolic mathematics in Python. This skill should be used for symbolic computation tasks including solving equations algebraically, performing calculus operations (derivatives, integrals, limits), manipulating algebraic expressions, working with matrices symbolically, physics calculations, number theory problems, geometry computations, and generating executable code from mathematical expressions. Apply this skill when the user needs exact symbolic results rather than numerical approximations, or when working with mathematical formulas that contain variables and parameters.
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ToolUniverse plugin router. STEP 1 BEFORE ANY ANALYSIS: if the data folder contains `*_executed.ipynb`, run `tu run read_executed_notebook '{"data_folder":"<path>","search":"<keyword>"}'` to extract its cell outputs and apply EVERY filter/sample-exclusion the notebook used — even when the question says 'Using DESeq2/Run X/Compute Y' (this describes the METHOD the notebook used, not a request to rerun). The notebook's cell outputs are the only published authoritative answers; reimplementing or reading stale pre-computed CSVs in the data folder produces different numbers because of outlier-sample removal, library version, and filter steps you don't see by skimming. STEP 2 routing — pick a sub-skill name from this exact list (never invent): tooluniverse-rnaseq-deseq2 (RNA/miRNA-seq DE, correlation, PCA, clustering, dispersion), tooluniverse-gene-enrichment (GO/KEGG/Reactome/GSEA/pathway enrichment), tooluniverse-statistical-modeling (regression, ANOVA, ordinal/logistic, chi-square, correlation, power), tooluniverse-image-analysis (microscopy, colony, fluorescence, dose-response, .tif — including ANOVA / Dunnett / power-analysis on image-derived measurements), tooluniverse-epigenomics (DNA methylation, CpG, m6A, MeRIP-seq, bisulfite, ChIP-seq, chromatin), tooluniverse-sequence-analysis (FASTQ, Trimmomatic, BWA, samtools, coverage), tooluniverse-variant-analysis (VCF, VAF, SNP, mutation), tooluniverse-phylogenetics (treeness, PhyKIT, parsimony), tooluniverse-single-cell (scRNA, h5ad, scanpy), tooluniverse-crispr-screen-analysis (MAGeCK, sgRNA), tooluniverse-proteomics-analysis (mass spec, TMT). Use for CSV/Excel/VCF/FASTA/h5ad and any biology/chemistry/medicine analysis question.
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End-to-end copy number variant detection workflow from BAM files. Covers CNVkit analysis for exome/targeted sequencing with visualization and annotation. Use when detecting copy number alterations from sequencing data.
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Pharmacogenomics (PGx) research — drug-gene interactions (CPIC, PharmGKB), CPIC dosing guidelines, variant-drug-response associations, ethnic-allele-frequency considerations, and metabolizer-status scoring. Use for PGx-informed dosing recommendations, CYP/HLA pharmacogenomic allele interpretation, and clinically-actionable PGx report generation.
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Bayesian modeling with PyMC. Build hierarchical models, MCMC (NUTS), variational inference, LOO/WAIC comparison, posterior checks, for probabilistic programming and inference.
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Assigns honest lipid annotation levels, designs class-based internal-standard quantification, and runs lipid-aware differential and enrichment analysis with lipidr, guarding against in-source-fragment phantoms, sn-position over-claims, and invalid cross-class quantification. Use when naming or canonicalizing lipid species (shorthand separators, Goslin), deciding shotgun vs RP vs HILIC LC-MS, picking internal standards (SPLASH/EquiSPLASH), interpreting MS-DIAL/LipidSearch output, or comparing lipid classes. For general feature detection see metabolomics/xcms-preprocessing and metabolomics/msdial-preprocessing; for non-lipid annotation confidence see metabolomics/metabolite-annotation; for normalization/QC see metabolomics/normalization-qc; for multivariate stats see metabolomics/statistical-analysis.
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Biological knowledge: query curated assertions and reference databases for genes, variants, pathways, regulation, cell types, reference atlases, perturbation-derived relationships, phenotypes, therapeutic targets, drugs, interactions, annotations, signatures, compounds, and predicted structures. Use for identifiers, marker sets, gene sets, associations, ontologies, database facts, and cross-database coverage.
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Walk every branching path and boundary condition in content, report only unhandled edge cases. Orthogonal to adversarial review - method-driven not attitude-driven. Use when you need exhaustive edge-case analysis of code, specs, or diffs.
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Review code changes adversarially using parallel review layers (Blind Hunter, Edge Case Hunter, Acceptance Auditor) with structured triage into actionable categories. Use when the user says "run code review" or "review this code"
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Maintain English-source localization, adding Russian only when requested, with correct owner paths, variables, selectors, and runtime behavior.
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Downloads CARLA so nothing has to be fetched by hand — an official release package for any published version (resolved live from the GitHub releases, with AdditionalMaps), the rolling nightly Dev build, a shallow source checkout of a branch or tag, or the carlasim/carla Docker image. Reports exactly what was obtained and where, plus the environment variables the other skills read. Use when the user asks to "download CARLA", "get CARLA 0.9.16", "install CARLA", "clone the carla repo", "fetch the latest CARLA", or has no CARLA at all yet.
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Packages an agent for CARLA Leaderboard submission — builds the docker image with make_docker.sh (plain or ROS variant), checks the four required roots and the egg layout it assumes, sets the agent/track/routes environment inside the image, and verifies the image can import the stack and load the agent before submission. Use when the user asks to "build the leaderboard docker image", "submit to the leaderboard", "package my agent", or make_docker.sh fails.
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Use when designing how an Agentforce agent extracts structured input parameters (slots) from a user's natural-language utterance to invoke an action. Triggers: 'agent extract date from user', 'agent action argument extraction', 'agentforce slot filling', 'agent invocable input mapping', 'agent fails to fill required parameter'. NOT for action authoring (use agentforce/agent-actions) or for prompt-template variable binding (use agentforce/prompt-builder-templates).
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Use this skill when adding a new symbiont (agent integration) to Myco's SymbiontInstaller — the component that manages agent lifecycle operations (init, update, remove, doctor) for all registered agents. Activates whenever you need to onboard a new AI agent (Claude Code, Cursor, Windsurf, a custom agent, etc.) so that `myco init`, `myco update`, and `myco doctor` manage its installation. Apply this skill even if the user doesn't explicitly mention SymbiontInstaller — any time you're adding a new agent type, creating a symbiont manifest, wiring new hook templates, or extending the supported agents list, this skill applies. Also relevant when a new symbiont needs the cross-platform hook guard or environment variable injection.
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Implement WCAG 2.2 compliant interfaces with mobile accessibility, inclusive design patterns, and assistive technology support. Use when auditing accessibility, implementing ARIA patterns, building for screen readers, or ensuring inclusive user experiences.
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Build WCAG 2.1 AA compliant web applications for University of Sheffield. Covers semantic HTML, ARIA patterns, form accessibility, keyboard navigation, color contrast, alt text, captions, and automated testing. Use when creating websites, web apps, forms, interactive components, or auditing accessibility for WCAG compliance, screen readers, keyboard access, or inclusive design.
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Implement WCAG 2.1 AA accessibility compliance with ARIA labels, keyboard navigation, screen reader support, and color contrast. Use when ensuring accessibility or fixing a11y issues.
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Expert in web accessibility, WCAG compliance, screen reader optimization, keyboard navigation, ARIA attributes, and inclusive design. Activates for accessibility improvements, WCAG compliance, a11y audits, and inclusive design tasks.
日本語の概要は準備中です。原文の説明を表示しています。
Web accessibility specialist for WCAG compliance, ARIA implementation, and inclusive design. Use when auditing websites for accessibility issues, implementing WCAG 2.1 AA/AAA standards, testing with screen readers, or ensuring ADA compliance. Expert in semantic HTML, keyboard navigation, and assistive technology compatibility.
日本語の概要は準備中です。原文の説明を表示しています。
Reviews UI components for WCAG compliance, ARIA attributes, keyboard navigation, and screen reader support. Use when building frontend components or user requests accessibility improvements.
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Design, audit, and improve accessibility and inclusive user experiences. Use when Codex is asked about WCAG, keyboard navigation, focus states, screen readers, ARIA, contrast, captions, reduced motion, forms, semantic HTML, accessible UI, game accessibility, inclusive design, accessibility QA, or compliance-sensitive accessibility work.
日本語の概要は準備中です。原文の説明を表示しています。