「core」の検索結果

Commission a project to the Programme SDLC bundle. Tailored entry point with Programme-specific audience guidance; equivalent to /sdlc-core:commission --option programme.

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Audits websites for AI search visibility (GEO/SEO) and generates deployable artifacts (llms.txt, schema JSON-LD, robots.txt). 7-dimension scorecard tailored by site type and size, grounded in Princeton KDD 2024, Toronto 2025, and ICLR 2026 research. This skill should be used when optimizing for ChatGPT, Perplexity, Google AI Overviews, or other AI search engines. Also triggered by queries about AI search optimization, generative engine optimization, llms.txt, AI crawler configuration, schema markup for AI, citation optimization, or Google AI Mode.

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Audit a repo's test, lint, type-check, static analysis, build, and debug infrastructure for AI coding agents. Generate scored reports and optimized configs for the lint-on-write hook. Triggers on audit tests, test harness, lint setup, check test infrastructure, entering a new repo.

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Run technical quality checks across accessibility, performance, responsive design, theming, and anti-patterns. Generate a scored report with P0-P3 severity ratings. Report-only — documents issues for other skills to fix. Triggers on audit the design, check accessibility, technical review, performance audit, a11y check.

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Build complete userModels for people Claudicle collaborates with. Creates core persona files, social dossiers with voice analysis, content archives, and INDEX registration. Use when asked to create a user model, build a persona, or document someone's voice and identity.

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Svelte best practices for writing, editing, or reviewing Svelte/SvelteKit components and modules. Use when touching Svelte reactivity, props, events, snippets, each blocks, styling, context, actions/attachments, stores, or Svelte 5 runes.

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Find and score legitimate external authority and backlink opportunities as a dry-run register, using relevance, platform rules, risk, target-page fit, and explicit user approval gates. Use this skill when the user asks where links to a target site could be placed effectively, but never post, submit, DM, email, open PRs, or edit external accounts without separate explicit approval.

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Convert a semantic core into crawlable SEO and LLM-friendly information architecture. Use this skill when the user asks for URL structure, page taxonomy, canonical rules, hreflang groups, page roles, pillar/topic/news/article/blog/project separation, multilingual route strategy, or a durable content model such as one short brief plus one longform article. It prevents duplicate public content bodies and hands link-graph work to internal-link-graph-architect.

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Coordinate SEO, LLM-readable site architecture, UX, content, monitoring, security, and external authority work as a task-plan-driven sequence. Use this skill when the user asks to plan, execute, validate, or route multi-skill website growth work; asks what to do next across semantic core, URL structure, internal linking, schema, llms.txt, UX journeys, analytics, citation monitoring, or white-hat link placement; or wants a central architect that preserves evidence, alarms, handoffs, and tests.

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CORE learning workflow — use this whenever the user has a source note open (paper, post, book, lecture, course, clipping) and wants to extract knowledge, understand what they just read, or build it into their vault. Triggers on "process this note", "process this paper", "extract concepts", "what can I learn from this", "atomize this", "add this to my vault", "what's important here", or when the user shares a note and asks for help understanding it. Do NOT wait for an explicit /process command — if the user is engaging with a source note and wants to go deeper, this skill applies.

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Audits and optimizes the five global Claude layers (User Preferences, Styles, Global Memory, Skills, MCP Connectors) using the Global Layer Scorecard (six dimensions, anchored 1-5 rubrics). Detects eight cross-layer failure modes and produces evolutionary recommendations (Promotion, Demotion, Codification, Skill Extraction). Use when user says "audit my global setup," "optimize my preferences," "review my Claude configuration," "check my cross-project setup," "are my preferences working," "clean up my global memory," or "what should be in my preferences vs my project." Also use when a user has 3+ Projects and wants to improve their shared foundation. Do NOT use for single-Project audits, Project Memory optimization, or full-stack audits (use rootnode-project-audit, rootnode-memory-optimization, or rootnode-full-stack-audit respectively, if available). Run on Opus 5 or Sonnet 5 at `high` effort (both defaults); depth reduces on legacy models.

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Analyzes Claude Project context budget under the automatic-RAG-by-window model: knowledge files vs. threshold-exempt overhead (Skills, MCPs, CI, Memory). Two modes: Quick Diagnostic and Full Budget Audit. Use when user says "check my context budget," "how much context am I using," "is my project too big," "optimize my token usage," "tier my files," "optimize for RAG," "improve retrieval quality," "should I keep compressing," "am I over-compressing," "should I accept RAG mode." Also trigger on context pressure symptoms: "Claude forgets my instructions," "responses getting generic," "content not found in my knowledge files." Also use when a project audit scores Knowledge Architecture ≤ 3. Do NOT use for content placement decisions (use rootnode-memory-optimization if available), full project audits (use rootnode-project-audit if available), or behavioral tuning (use rootnode-behavioral-tuning if available). Run on Opus 5 or Sonnet 5 at `high` effort (both defaults); depth reduces on legacy models.

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Audit recent high-relevance papers from a target venue to identify claim-relevant experimental evidence gaps after core P0 results exist. Use for venue completeness and reviewer-risk analysis; not for redefining the research question or running experiments.

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Compute relative and absolute binding free energies with the Open Free Energy toolkit — the rigorous alchemical alternative to docking scores when a congeneric series needs reliable potency ranking. Use this skill to plan a perturbation network over a ligand set, choose atom mappings, run hybrid-topology or separated-topology protocols, and analyse the result — per-edge ΔΔG with uncertainty, cycle-closure error, and mean unsigned error against measured affinities. Also trigger on OpenFE, alchemical transformation, thermodynamic cycle, RBFE, ABFE, SepTop, lambda window, MBAR, cycle closure, or perturbation map.

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Query the Open Targets Platform GraphQL API for target-disease associations, genetic and clinical evidence, tractability and safety liabilities, target prioritisation metrics, known drugs and mechanisms of action, and disease ontology. Use this skill for target identification and validation, target-disease evidence review, druggability assessment, drug repurposing, and resolving gene, disease, and drug names to Ensembl, MONDO, and ChEMBL identifiers. Also trigger when a query mentions Open Targets, platform.opentargets.org, association scores, tractability buckets, or api.platform.opentargets.org.

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Query the FDA's public openFDA APIs for post-market drug data — FAERS adverse-event reports, Drugs@FDA approval and submission history, Structured Product Labels including boxed warnings, the National Drug Code directory, recall enforcement reports, and drug shortages. Use this skill to check what a regulator has already concluded about a molecule or its class, to date an approval and count its efficacy supplements, to read an approved indication or boxed warning, and to score a drug-event pair for disproportionate reporting with PRR, ROR, and chi-squared. Also trigger on openFDA, api.fda.gov, FAERS, Drugs@FDA, SPL, NDC, pharmacovigilance, boxed warning, adverse event report, drug recall, or safety signal.

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Estimate how likely a protein therapeutic is to provoke an anti-drug antibody response, and locate the sequence regions responsible. Use this skill to tile a sequence into peptides, predict class II MHC presentation across a population-representative allele panel, aggregate predicted binders into a per-region and whole-molecule risk score, compare a candidate against its closest human germline, and decide which liabilities are worth deimmunising. Also trigger on immunogenicity, anti-drug antibody, ADA, T-cell epitope, MHC class II, HLA-DRB1, NetMHCIIpan, NetMHCpan, deimmunisation, tregitope, or population coverage.

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Use Therapeutics Data Commons through the PyTDC Python package for registry discovery, approved dataset access, task-aware splits (scaffold, cold-start, temporal, combination), evaluator metrics, benchmark groups, and bounded molecular-oracle workflows. Use this skill to find which TDC datasets exist for a therapeutic task, load them with a split that does not leak, score predictions with the task's own official metric rather than a generic one, and run benchmark groups reproducibly. Also trigger on PyTDC, Therapeutics Data Commons, tdc.single_pred, tdc.multi_pred, ADMET Benchmark Group, scaffold split, get_split, or molecular oracles such as GSK3B, JNK3 and DRD2.

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Generate and optimise novel small molecules with REINVENT 4 — de novo sampling from a chemical language model, scaffold decoration with LibInvent, fragment linking with LinkInvent, and similarity-constrained analogue generation with Mol2Mol. Use this skill to set up reinforcement-learning or curriculum runs, compose a multi-parameter scoring function from docking scores, predictive models, and physicochemical desirability, and read the resulting sampled sets. Also trigger on REINVENT, LibInvent, LinkInvent, Mol2Mol, scaffold hopping, R-group replacement, linker design, chemical language model, or reinforcement-learning molecule optimisation.

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Cheminformatics toolkit for fine-grained molecular control. Parse and write SMILES, SDF, MOL and InChI; compute descriptors (MW, LogP, TPSA, QED, Bertz); build fingerprints (Morgan/ECFP, RDKit, MACCS, atom pair, torsion) and score Tanimoto, Dice or cosine similarity; run SMARTS substructure search and reaction SMARTS; generate 2D depictions and ETKDG 3D conformers; extract Murcko scaffolds and canonical hashes; control sanitization and stereochemistry directly. Also trigger on rdkit, Chem.MolFromSmiles, rdFingerprintGenerator, SDMolSupplier, SMARTS query, ETKDG, or FilterCatalog. For standard workflows with a simpler interface use the datamol skill, which wraps RDKit; use rdkit for advanced control, custom sanitization, and specialized algorithms.

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Query the ChEMBL database web services for measured bioactivity data, compound records and calculated properties, targets, assays, mechanisms of action, drug indications and warnings. Use this skill to build curated SAR or QSAR datasets for a target, look compounds up by SMILES, InChIKey, name, or ChEMBL id, run similarity and substructure searches, and check what chemistry is already known against a protein. Also trigger when a query mentions ChEMBL ids (CHEMBL...), pChEMBL values, IC50/Ki/Kd/EC50 retrieval, assay confidence scores, or ebi.ac.uk/chembl.

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Cofold protein-ligand, protein-protein, and nucleic-acid complexes with Boltz-2, and predict binding affinity with its trained affinity head. Use this skill to build Boltz input YAML, run structure prediction with MSAs, pocket constraints, templates, and modified residues, screen compound libraries by cofolding, and interpret confidence scores (pLDDT, pTM, ipTM, PDE) and affinity output (binder probability and log10 IC50). Also trigger on Boltz, Boltz-1, Boltz-2, cofolding, boltz predict, affinity_pred_value, affinity_probability_binary, ipTM, or open-weights AlphaFold3 alternatives.

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Decide whether a protein has a pocket worth targeting, and where it is, before committing to a docking or design campaign. Use this skill to run fpocket cavity detection, rank cavities by druggability and volume, compare apo and holo conformations to spot induced fit, identify allosteric and cryptic cavities that only open in simulation, and convert a chosen cavity into the search box coordinates a docking run needs. Also trigger on fpocket, cavity detection, druggability score, alpha sphere, cryptic pocket, allosteric site, pocket volume, hotspot mapping, or undruggable target assessment.

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Medicinal chemistry filters for compound triage. Apply drug-likeness rules (Lipinski rule of five, Veber, Oprea, CNS, lead-like, rule of three), structural alert catalogs (PAINS a/b/c, NIBR screening-deck severity, Brenk, BMS, Glaxo, Dundee, ChEMBL common alerts), ZINC-15 percentile complexity metrics (Bertz, SAscore, QED, Whitlock, Barone), chemical-group detection, Lilly demerits, and the medchem query language (MATCHRULE, HASALERT, HASPROP, HASGROUP) for filtering a library at scale. Also trigger on medchem, `import medchem as mc`, RuleFilters, NIBRFilters, CommonAlertsFilters, NamedCatalogs, QueryFilter, PAINS filtering, or structural alerts.

日本語の概要は準備中です。原文の説明を表示しています。