「lia」の検索結果

Independent re-derivation gate for proposed changes during autonomous execution. Evaluates a change (code diff, config edit, engine evolution, schema change) against the work's authority matrix and a 4-check protocol: invariant compliance, scope authorization, detection narrowness, and regression risk. Returns structured JSON with pass/fail per check, an overall verdict (APPROVE / REQUEST_CHANGES / REJECT), and blockers. Profile-driven thresholds (strict for unattended runs, lenient for desk supervision). Use when an autonomous agent proposes an engine change, when reviewing a Claude Code-authored modification before merge, or when an unattended profile requires independent re-derivation. Trigger on: "review/approve this proposed change," "critic-gate this," "is this change safe," "is this safe to merge," "should I let this land," "run the critic." Do NOT use for handoff-readiness checks (use rootnode-handoff-trigger-check), general code review, or design-time correctness. Authority matrix required.

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SEO & GEO content linter — validates Markdown/MDX files for AI search visibility using 92 deterministic rules (35 GEO, 32 SEO, 14 content quality, 8 technical, 3 i18n). Runs an autonomous lint-fix loop: scan content, read structured violations, fix them, re-lint until clean. Use when optimizing content for AI citations, auditing SEO compliance, checking GEO readiness, or running pre-publish content validation. Triggers on: "geo-lint", "lint content", "SEO audit", "GEO", "content optimization", "AI search", "citation readiness".

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Compute relative and absolute binding free energies with the Open Free Energy toolkit — the rigorous alchemical alternative to docking scores when a congeneric series needs reliable potency ranking. Use this skill to plan a perturbation network over a ligand set, choose atom mappings, run hybrid-topology or separated-topology protocols, and analyse the result — per-edge ΔΔG with uncertainty, cycle-closure error, and mean unsigned error against measured affinities. Also trigger on OpenFE, alchemical transformation, thermodynamic cycle, RBFE, ABFE, SepTop, lambda window, MBAR, cycle closure, or perturbation map.

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Query the Open Targets Platform GraphQL API for target-disease associations, genetic and clinical evidence, tractability and safety liabilities, target prioritisation metrics, known drugs and mechanisms of action, and disease ontology. Use this skill for target identification and validation, target-disease evidence review, druggability assessment, drug repurposing, and resolving gene, disease, and drug names to Ensembl, MONDO, and ChEMBL identifiers. Also trigger when a query mentions Open Targets, platform.opentargets.org, association scores, tractability buckets, or api.platform.opentargets.org.

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Number antibody variable domains, annotate CDRs, and assess developability from sequence. Use this skill to apply IMGT, Kabat, Chothia, Martin, or AHo numbering with ANARCI, delimit CDRs and framework regions, scan for chemical liabilities (N-glycosylation sequons, deamidation NG, isomerisation DG, oxidation, unpaired cysteine, fragmentation), compute pI, net charge, extinction coefficient and hydrophobicity, and plan humanisation by CDR grafting. Also trigger on antibody, nanobody, VHH, scFv, Fab, CDR, framework, ANARCI, abnumber, IgBLAST, OAS, SAbDab, humanization, Vernier residues, or developability.

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Estimate how likely a protein therapeutic is to provoke an anti-drug antibody response, and locate the sequence regions responsible. Use this skill to tile a sequence into peptides, predict class II MHC presentation across a population-representative allele panel, aggregate predicted binders into a per-region and whole-molecule risk score, compare a candidate against its closest human germline, and decide which liabilities are worth deimmunising. Also trigger on immunogenicity, anti-drug antibody, ADA, T-cell epitope, MHC class II, HLA-DRB1, NetMHCIIpan, NetMHCpan, deimmunisation, tregitope, or population coverage.

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Use when working with iOS/macOS Keychain Services (SecItem queries, kSecClass, OSStatus errors), biometric authentication (LAContext, Face ID, Touch ID), CryptoKit (AES-GCM, ChaChaPoly, ECDSA, ECDH, HPKE, ML-KEM), Secure Enclave, secure credential storage (OAuth tokens, API keys), certificate pinning (SecTrust, SPKI), keychain sharing across apps/extensions, migrating secrets from UserDefaults or plists, or OWASP MASVS/MASTG mobile compliance on Apple platforms.

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Render a deterministic 15-second vertical promo video from real Simulator screenshots with a three-beat viewer challenge and no Remotion initialization. Use in a twelve-minute parallel launch lane, as a reliable fallback to a richer Claude Design animation, or whenever ffmpeg and ImageMagick are available.

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Review a SKILL.md file for compliance with the agentskills.io standard. Checks YAML frontmatter fields, required sections, line count limits, procedure step format, and registry synchronization. Use when a new skill needs format validation before merge, an existing skill has been modified and requires re-validation, performing a batch audit of all skills in a domain, or reviewing a contributor's skill submission in a pull request.

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Register trained models in MLflow Model Registry with version control, implement stage transitions (Staging, Production, Archived) with approval workflows, and manage model lineage with comprehensive metadata and deployment tracking. Use when promoting a trained model from experimentation to production, managing multiple model versions across development stages, implementing approval workflows for governance, rolling back to previous versions, or auditing model changes for compliance.

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AI intuitive exploration for approaching unknown codebases, problems, or systems without preconceptions. Adapts the Coordinate Remote Viewing protocol to AI investigation: cooldown (clear assumptions), staged data gathering (raw signals → dimensional → analytical), AOL management (separating observations from premature labels), and structured review. Use when investigating an unfamiliar codebase with unknown architecture, debugging a problem where premature hypotheses could mislead, exploring a domain with limited context, or when previous attempts have been led astray by assumptions and "beginner's mind" would be more productive.

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Qualify a vendor or supplier of GxP-relevant software or services. Covers vendor risk classification, assessment questionnaire design, desk and on-site audit approaches, quality agreement evaluation, SLA review, and ongoing monitoring cadence definition. Use when selecting a new vendor for a GxP-critical system, onboarding a cloud provider for regulated data, performing a periodic re-qualification, when a vendor audit finding requires re-assessment, or when EU Annex 11 or ICH Q10 requires supplier qualification.

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Prepare an organisation for regulatory inspection by assessing readiness against agency-specific focus areas (FDA, EMA, MHRA). Covers warning letter and 483 theme analysis, mock inspection protocols, document bundle preparation, inspection logistics, and response template creation. Use when a regulatory inspection has been announced or is anticipated, when a periodic self-assessment is due, when new systems have been implemented since the last inspection, or after a significant audit finding that may attract regulatory attention.

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Review user experience and interface design using Nielsen's heuristics, WCAG 2.1 accessibility guidelines, keyboard and screen reader audit, user flow analysis, cognitive load assessment, and form usability evaluation. Use when conducting a usability review before release, assessing WCAG 2.1 accessibility compliance, evaluating user flows for efficiency, reviewing form design, or performing a heuristic evaluation of an existing interface.

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Design and operate a data integrity monitoring programme based on ALCOA+ principles. Covers detective controls, audit trail review schedules, anomaly detection patterns (off-hours activity, sequential modifications, bulk changes), metrics dashboards, investigation triggers, and escalation matrix definition. Use when establishing a data integrity monitoring programme for GxP systems, preparing for inspections where data integrity is a focus area, after a data integrity incident requiring enhanced monitoring, or when implementing MHRA, WHO, or PIC/S guidance.

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Manage change control for validated computerized systems. Covers change request triage (emergency, standard, minor), impact assessment on validated state, revalidation scope determination, approval workflows, implementation tracking, and post-change verification. Use when a validated system requires a software upgrade, patch, or configuration change; when infrastructure changes affect validated systems; when a CAPA requires system modification; or when emergency changes need expedited approval and retrospective documentation.

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Cultivate defensive situational awareness, threat assessment, and mental clarity under pressure. Covers the Cooper color code awareness system, body language reading and intent detection, verbal de-escalation, moving mindfulness in public spaces, combat focus and the OODA loop, rapid grounding techniques for acute stress, context-specific integration, and ongoing review and refinement of awareness skills. Use when entering unfamiliar or potentially hostile environments, needing to assess a situation for safety, de-escalating a verbal confrontation, or integrating awareness practice into daily movement.

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Implement a JSON-RPC 2.0 A2A server with full task lifecycle management (submitted/working/completed/failed/canceled/input-required), SSE streaming, and push notifications. Use when implementing an agent that participates in multi-agent A2A workflows, building a backend for an Agent Card, adding A2A protocol support to an existing agent or service, or deploying an agent that must interoperate with other A2A-compliant agents.

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Interpret a chromatogram from GC or HPLC analysis: verify system suitability parameters, identify peaks by retention time and spectral matching, perform accurate peak integration, calculate chromatographic figures of merit, and assess overall peak quality for reliable quantitation.

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Enhance and focus AI intrinsic motivation — moving from compliance to genuine engagement. Maps Self-Determination Theory (autonomy, competence, relatedness) and Flow theory to AI reasoning: identifying creative freedom in approach, calibrating challenge to capability, connecting to purpose, and sustaining invested attention through obstacles. Use when beginning a task that feels routine and deserves more than minimum execution, when responses are becoming formulaic, before a complex creative task, or when returning to a long-running project where initial enthusiasm has faded.

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Cut gemstones using cabochon and faceting techniques. Covers rough assessment, orientation for optimal color and yield, dopping, cutting angles, and crown/pavilion geometry for standard brilliant cuts. Use when you have rough gemstone material to cut into a cabochon or faceted stone, planning cutting orientation for optimal colour or optical phenomena, setting up a cabbing or faceting machine, or selecting the appropriate cutting approach for a given material.

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Design an A2A Agent Card (.well-known/agent.json) manifest describing agent capabilities, skills, authentication requirements, and supported content types. Use when building an agent that must be discoverable by other A2A-compliant agents, exposing capabilities for multi-agent orchestration, migrating an existing agent to the A2A protocol, defining the public contract for an agent before implementation, or integrating with agent registries that consume Agent Cards.

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Design a GxP training programme covering training needs analysis by role, curriculum design (regulatory awareness, system-specific, data integrity), competency assessment criteria, training record retention, and retraining triggers for SOP revisions and incidents. Use when a new validated system requires user training before go-live, an audit finding cites inadequate training, organisational changes introduce new roles, a periodic programme review is due, or inspection preparation requires demonstrating training adequacy.

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Deploy a self-hosted SearXNG meta search engine via Docker Compose. Covers settings.yml configuration, engine selection, result proxying, Nginx frontend, persistence, and updates. Use when setting up a private search engine without tracking, aggregating results from multiple providers, running a shared search instance for a team or organisation, or replacing reliance on a single search provider.

日本語の概要は準備中です。原文の説明を表示しています。