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Implements multiplicity control for confirmatory clinical trials using graphical procedures (Bretz-Maurer-Hommel), gatekeeping (parallel, serial, mixed), Hochberg/Hommel/Holm with PRDS, and the closed-testing principle (Marcus-Peritz-Gabriel; Goeman 2021 admissibility). Covers FDA Multiple Endpoints Final Guidance (October 2022), graphical procedures via R gMCP, primary + key-secondary + subgroup hierarchies, and FWER vs FDR distinction. Use when designing the multiplicity strategy for confirmatory trials with multiple primary or key secondary endpoints.

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Implements missing-data sensitivity analyses for confirmatory clinical trials including MMRM under MAR (with Kenward-Roger correction), reference-based multiple imputation (J2R, CR, CIR, LMCF per Carpenter-Roger 2013), Permutt delta-adjustment / tipping-point analysis, pattern-mixture identifying restrictions (CCMV, NCMV, ACMV), and the Cro vs Bartlett variance debate. Use when handling missing primary or secondary endpoint data in regulatory submissions following NRC 2010 and ICH E9(R1).

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Reads, validates, and prepares CDISC SDTM and ADaM clinical trial data for analysis. Covers SDTM domain joins (DM, AE, EX, VS, LB, DS), ADaM architecture (ADSL, BDS, OCCDS, ADTTE) with traceability, treatment-emergent AE conventions, baseline derivation, SUPPQUAL/NSV handling, Define-XML 2.1, and Pinnacle 21 / CORE validation. Use when working with clinical trial datasets in CDISC SDTM/ADaM format, preparing analysis-ready data, or validating for regulatory submission.

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Installs 425 bioinformatics skills covering sequence analysis, RNA-seq, single-cell, variant calling, metagenomics, structural biology, and 56 more categories. Use when setting up bioinformatics capabilities or when a bioinformatics task requires specialized skills not yet installed.

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Quantifies alternative splicing as PSI (percent spliced in) from RNA-seq using rMATS-turbo (BAM-based event), SUPPA2 (TPM-based event), MAJIQ V3 (LSV-based Bayesian), leafcutter (annotation-free intron clusters), VAST-TOOLS (cross-species with microexon support), Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage), or IRFinder-S (intron retention coverage-aware). Distinguishes the five canonical event classes (SE, A5SS, A3SS, MXE, RI), special classes (microexons, exitrons, AFE/ALE), intron retention subtypes (canonical RI vs detained introns), and applies effective-length normalization. Use when measuring splice-site usage or isoform inclusion ratios from short-read RNA-seq.

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Harden iOS/Android apps you ship: storage, TLS pinning policy, IPC, and backend trust. You still enforce authz on the server.

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Orientación legal y guía de procesos contractuales para el equipo de Vambe (Chile/MX). Usar SIEMPRE ante preguntas legales o de contratos: 'quiero enviar un contrato', 'cómo mando el NDA', 'el cliente quiere cambios', 'cliente M vs L', '¿me pueden demandar?', 'el cliente no paga', 'cómo finiquito a un empleado', 'protección de datos', 'qué le digo al cliente sobre sus datos', 'nos acusan de incumplimiento', 'me llegó carta de abogados', 'quién puede firmar', 'quién es dueño del código', o cualquier consulta sobre contratos, NDAs, reclamos, laboral, RRHH, PI o cumplimiento normativo.

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Construye o actualiza el corpus y el perfil técnico de un reviewer real a partir de sus comentarios en PRs de GitHub. Usar cuando se pida "crear el agente reviewer de X", "armar el perfil de X", "actualizar el corpus de X", "agregar el frontend al perfil de X", o "/generate-github-coder-profile <dir> <Nombre> <login>".

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Revisa cambios de performance de queries ClickHouse y Postgres (vambe-datascience, CRM, réplicas) contra los errores y aprendizajes de la ronda

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Expert security auditor for AI Skills and Bundles. Performs non-intrusive static analysis to identify malicious patterns, data leaks, system stability risks, and obfuscated payloads across Windows, macOS, Linux/Unix, and Mobile (Android/iOS).

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Build comprehensive attack trees to visualize threat paths. Use when mapping attack scenarios, identifying defense gaps, or communicating security risks to stakeholders.

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AI-powered E2E web testing — eyes and hands for AI coding tools. Declarative YAML scenarios, Playwright execution, visual matching (OpenCV + OCR), platform auto-detection (Flutter/React/Vue), learning DB. Install: npx skills add ksgisang/awt-skill --skill awt -g

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Expert in building 3D experiences for the web - Three.js, React Three Fiber, Spline, WebGL, and interactive 3D scenes. Covers product configurators, 3D portfolios, immersive websites, and bringing depth to web experiences.

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Accessibility implementation guide for SwiftUI apps. Use when implementing VoiceOver support, adding accessibilityLabel/Hint/Value, supporting Dynamic Type, ensuring color contrast, testing accessibility, or reviewing accessibility in PRs. Covers iOS accessibility APIs, WCAG guidelines, and testing tools.

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Implements SwiftUI Views from Figma designs using Figma MCP tools (figma:get_design_context, figma:get_screenshot, figma:get_variable_defs, figma:get_metadata). Splits large designs into appropriately-sized components, respects existing codebase conventions, and adds previews for each component. Use when implementing SwiftUI from Figma design URLs (e.g., figma.com/design/...), converting designs to code, or building iOS UI from Figma mockups. Do NOT call Figma MCP tools directly without reading this skill first.

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Core coding guidelines for iOS, iPadOS, macOS, watchOS, tvOS, and visionOS app development using SwiftUI and Swift. Use when implementing Views, working with @State/@Binding/@Observable/@StateObject, using NavigationStack/List/LazyVStack, designing components, or asking about SwiftUI patterns (infinite scroll, pull-to-refresh, search). Covers best practices, implementation patterns, and anti-patterns to avoid.

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Single-track / single-episode music-player mockup template — glassmorphic iOS-Music style player card with ambient album-art wash, for showcasing one song, one podcast episode, or one audio jingle as a shareable interactive surface.

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Pro-camera HUD mockup template — full-viewport black canvas wrapping a real video with monospace overlays (corner brackets, top status bar, side AF/exposure columns, bottom timecode + aperture/shutter/ISO row, vertical 8-filter wheel, animated reticle). For cinematographer portfolios, camera-app demos, LUT pack previews, filter-look auditions. NOT a TikTok/Reels mockup, NOT a storyboard, NOT a shot list, NOT a script document. The chrome wraps real footage — never a div placeholder.

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Issues, busca, comentários, tags, artigos e registro de trabalho no YouTrack Cloud via MCP oficial. Use quando o usuário disser "YouTrack", "criar issue", "minhas issues", "buscar tarefas", "comentar na issue", "atribuir para", "mudar o estado", "registrar horas", "artigo da knowledge base", ou citar um ID tipo PROJ-123. Boards e sprints são da skill youtrack-rest.

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Agile boards, sprints, relatórios de tempo, anexos e operações em lote no YouTrack via REST API direta — o que o MCP oficial não cobre. Use quando o usuário disser "board", "quadro", "sprint", "sprint atual", "mover para o sprint", "horas registradas", "relatório de tempo", "anexar arquivo", "aplicar comando em várias issues". Requer YOUTRACK_BASE_URL e token.

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Create, revise, or resolve applicability for SDD Composy user stories (US/SC) from an approved PRD and domain evidence, stopping at the human gate. Use after the PRD is approved — 'gerar as histórias de usuário', 'cenários de aceite', 'stories for prd-SLUG', 'is stories NOT_APPLICABLE here'. Do NOT use before the PRD is approved, for the TechSpec, or for user-story writing outside SDD.

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Design platform-specific Android and iOS checks with explicit SDK, driver, device, lifecycle, and evidence prerequisites.

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Use when the user wants to evolve the features of a PRD roadmap with user stories — 'refinar as histórias da feature', 'escrever histórias de usuário', 'critérios de aceite', 'regras de negócio da feature', 'deixar a feature pronta', 'user stories for FT01' — one feature at a time, interviewing the human until each story meets the Definition of Ready: persona, value, INVEST, CA (Gherkin, happy and error paths) and RN from the PRD. Do NOT use to create the roadmap (prd-roadmap) or to change requirements without stories (prd-refine).

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Use when the user wants tests planned for existing code or a test audit — unit, integration, E2E scenarios exportable to Playwright, playwright-cli UI checks, a coverage matrix — 'criar testes para o UserService', 'plano de testes E2E do login', 'auditar a cobertura'. Writes .planning/feat/features/{slug}/plan.md. Do NOT use for code review (feat-review), for implementing features (feat-feature) or to run an existing plan (feat-exec).

日本語の概要は準備中です。原文の説明を表示しています。